Auswirkungen der Bestrahlung mit UVB, UVA-1 und PUVA-1 auf das Funktionsverhalten humaner dermaler Mastzellen nach Stimulation mit anti-IgE und Substanz PMarc StrathmannI111.11.221.31.4345623#6981.561.5.1781.5.21.5.391.6101.7111.812132143153.11617183.1.1193.1.22021623#8453.2223.2.1233.2.224605#1613.2.33.2.43.2.525263.2.63.2.727627#24428605#303.2.8293.2.9303.3314324.133594#30834594#300594#30035615#3374.23637594#2844.33839594#31840594#324594#3144.44142483#387483#38743483#387483#388483#40344476#387481#38745483#385481#387481#3854.546475484950515253545556575865960 Abkürzungsverzeichnis61 Literaturverzeichnis626364656667686970 Erklärung an Eides Statt71 Danksagung72 Lebenslauf73deInhaltsverzeichnisHilfe Abkürzungsverzeichnis

8-MOP

8-Methoxypsoralen

AP1

Activator Protein 1

BSA

Bovine Serum Albumine

Btk

Bruton’s tyrosine kinase

C

Chymase

CD

Cluster of Differentiation

CRAC

Calcium Release Activated Calcium

CTMC

Connective Tissue-type Mast Cell

DAG

Diazylglyzerin

FCS

Fetal Calf Serum

ICAM

Intercellular Adhesion Molecule

IgE

Immunglobulin E

IL

Interleukin

IP3

Inositoltriphosphat

ITAM

Immunotyrosine based Activation Motif

LAMP

Lysosome Associated Membrane Protein

LDH

Lactatdehydrogenase

LT

Leukotrien

MAPK

Mitogen Activated Protein Kinase

MC

Mast Cell

MHC

Major Histocompatibility Complex

MMC

Mucosal Mast Cell

MW

Mittelwert

NF-AT

Nuclear Factor of Activated T-cells

NGF

Nerve growth factor

NK-Rezeptor

Neurokininrezeptor

NK-Zelle

Natürliche Killer-Zellen

OPDA

o-Phthaldialdehyd

p53

Tumor-Suppressor-Protein

PIP2

Phosphatidylinositol 4,5-bisphosphat

PKC

Proteinkinase C

PLC

Phospholipase C

PUVA-1

Psoralen + UVA-1

SCF

Stem cell factor

SEM

Standard Error of the Mean

SNARE

Soluble N-ethylmaleimide-sensitive factor attachment protein receptor

SP

Substance P

T

Tryptase

TNF-α

Tumornekrosefaktor-α