Einfluss von all-trans-Retinsäure (ATRA) auf die Expression von Differenzierungsmarkern bei humanen Mastzellen unterschiedlicher ReifegradeFriedrich ThienemannWidmung 11.11.1.1121.1.231.1.341.1.41.1.51.1.651.21.2.161.2.21.2.371.2.41.2.51.2.5.11.2.5.281.31.3.191.3.2101.3.31.41.4.111121.4.2131.4.31.4.4141521516171833.13.1.118193.1.23.1.3203.1.43.1.5213.1.63.1.7223.1.83.23.2.1233.2.23.2.2.13.2.2.2243.2.2.33.2.33.2.3.13.2.3.2253.2.4263.2.5273.33.3.13.3.2283.3.329303.3.4313.43.4.1323.4.233343.4.335363.53.5.13738393.5.23.5.2.1403.5.2.23.5.2.33.5.2.4413.5.3423.5.44344453.5.53.644.1464.1.1474.1.24.1.348494.2504.2.14.2.251524.2.353544.2.4554.3564.3.157584.3.259604.3.361624.3.46364654.3.56667684.3.669704.3.771724.3.8737455.1747576775.2785.3795.480818283845.585SynopsisAbkürzungsverzeichnisLiteraturverzeichnisDanksagungErklärungdeInhaltsverzeichnisHilfe Literaturverzeichnis Agis H, Füreder W, Bankl HC, et al. Comparative immunophenotypic analysis of human mast cells, blood basophils and monocytes. Immunology 1996;87:535-43. Akin C & Metcalfe DD. The biology of Kit in disease and the application of pharmacogenetics. J Allergy Clin Immunol 2004;114:13-9. Alexandrakis MG, Kyriakou DS, Seretakis D, et al. Inhibitory effect of retinoic acid on proliferation, maturation and tryptase level in human leukemic mast cells (HMC-1). Int J Immunopathol Pharmacol 2003;16:43-47. Ashman LK. The biology of stem cell factor and its receptor C-kit. Int J Biochem Cell Biol 1999;31:1037-51. Babina M, Guhl S, Stärke A, Kirchhof L, Zuberbier T & Henz BM. Comparative cytokine profile of human skin mast cells from two compartments - strong resemblance with monocytes at baseline, but induction of IL-5 by IL-4 priming. J Leukoc Biol 2004;75:244-52. Babina M & Henz BM. All-trans retinoic acid down-regulates expression and function of β 2 integrins by human monocytes: opposite effects on monocytic cell lines. Eur J Immunol 2003;33:616-25. Babina M, Mammeri K & Henz BM. Retinoic acid up-regulates myeloid ICAM-3 expression and function in a cell-specific fashion – evidence for retinoid signaling pathways in the mast cell lineage. J Leukoc Biol 2001;69:361-72. Babina M, Schulke Y, Kirchhof L, et al. The transcription factor profile of human mast cells in comparison with monocytes and granulocytes. Cell Mol Life Sci 2005a;62:214-26. Babina M, Thienemann F, Guhl S, et al. All-trans retinoic Acid is dedifferentiating to human maszcells. Brit J Haemtol 2005b. Zur Publikation eingereicht. Babina M, Weber S & Henz BM. CD43 (leukosialin, sialophorin) expression is differentially regulated by retinoic acids. Eur J Immunol 1997a;27:1147-51. Babina M, Weber S & Henz BM. Retinoic acids and dexamethasone alter cell-surface density of β 2-integrins and ICAM-1 on human leukemic (HMC-1) mast cells. Arch Dermatol Res 1997b;289:111-15. Balmer JE & Blomhoff R. Gene expression regulation by retinoic acid. J Lipid Res 2002;43:1773-808. Barnes JA, Singh S & Gomes AV. Protease activated receptors in cardiovascular function and disease. Mol Cell Biochem 2004;263:227-39. Beil WJ, Schulz M & Wefelmeyer U. Mast cell granule composition and tissue location--a close correlation. Histol Histopathol 2000;15 :937-46. Benthin M, Dallmann I & Atzpodien J. 13cis- and all-trans retinoic acid have antiproliferative effects on CML cells and render IFN alpha antiproliferative potency after combined treatment in vitro. Cancer Biother Radiopharm 2001;16:323-31. Berg JM, Tymoczko JL, Stryer L, eds. Biochemistry. 5th ed. International Version.

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