[Seite 102↓]


Abbas AK, Lichtman AH, Pober JS (1996): Immunologie (übersetzt von Stadler BM und Hess M), Bern, Verlag Hans Huber, S. 203.

Altman A, Mally MI, Isakov N (1992): Phorbol ester synergizes with Ca2+ ionophore in activation of protein kinase C (PKC)alpha and PKC beta isoenzymes in human T cells and in induction of related cellular functions, Immunology 76(3): 465-471.

Altman A, Mustelin T, Coggeshall KM (1990): T lymphocyte activation: a biological model of signal transduction, Crit Rev Immunol 10(4): 347-391.

Andersen V, Birch-Andersen A, Skovbjerg H, Hellung-Larsen P (1970): Number and structure of mitochondria in lymphocytes cultured at different oxygen tensions, Acta Pathol Microbiol Scand [A] 78(5): 537-544.

Arai T, Yamada H, Namba T, Mori H, Ishii H, Yamashita K, Sasada M, Makino K, Fukuda K (2004): Effects of intracellular reactive oxygen species generated by 6-formylpterin on T cell functions, Biochem Pharmacol 67(6): 1185-1193.

Ardawi MS (1988): Glutamine and glucose metabolism in human peripheral lymphocytes, Metabolism 37(1): 99-103.

Aulwurm UR and Brand KA (2000): Increased formation of reactive oxygen species due to glucose depletion in primary cultures of rat thymocytes inhibits proliferation, Eur J Biochem 267(18): 5693-5698.

Authier F, Posner BI, Bergeron JJ (1996): Endosomal proteolysis of internalized proteins, FEBS Lett 389(1): 55-60.

Babior BM (1999): NADPH oxidase: an update, Blood 93(5): 1464-1476.

Babior BM (1992): The respiratory burst oxidase, Adv Enzymol Relat Areas Mol Biol 65: 49-95.

Baierlein JL and Foster JM (1968): Studies on the energy metabolism of human leukocytes. II. Mechanism of the Pasteur effect in human leukocytes, Blood 32(3): 412-422.

Baran J, Kowalczyk D, Ozog M, Zembala M (2001): Three-color flow cytometry detection of intracellular cytokines in peripheral blood mononuclear cells: comparative analysis of phorbol myristate acetate-ionomycin and phytohemagglutinin stimulation, Clin Diagn Lab Immunol 8(2): 303-313.

Benichou G, Kanellopoulos JM, Mitenne F, Galanaud P, Leca G (1989): T-cell chemiluminescence. A novel aspect of T-cell membrane activation studied with a Jurkat tumour cell line, Scand J Immunol 30(2): 265-269.

Bental M and Deutsch C (1993): Metabolic changes in activated T cells: an NMR study of human peripheral blood lymphocytes, Magn Reson Med 29(3): 317-326.

Berridge MJ (1993): Inositol trisphosphate and calcium signalling, Nature 361(6410): 315-325.

Bielka H (1963): Metabolism of the leukocytes of virus-induced leukemia. IV. The Crabtree effect, Z Krebsforsch 65: 196-200.

[Seite 103↓]

Bjornheden T, Levin M, Evaldsson M, Wiklund O (1999): Evidence of hypoxic areas within the arterial wall in vivo, Arterioscler Thromb Vasc Biol 19(4): 870-876.

Bondeson K and McCabe M (1992): Apparent heterogeneity between leukemic lymphocyte cell lines, Adv Exp Med Biol 316: 393-398.

Borsook H, Jiggins S, Wilson RT (1971): Two inducers of rapid erythroblast multiplication in vitro, Nature 230(5292): 328-330.

Böyum A (1968): Isolation of mononuclear cells and granulocytes from human blood. Isolation of mononuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g, Scand J Clin Lab Invest Suppl 97: 77-89.

Brand K (1997): Aerobic glycolysis by proliferating cells: protection against oxidative stress at the expense of energy yield, J Bioenerg Biomembr 29(4): 355-364.

Brand K, Leibold W, Luppa P, Schoerner C, Schulz A (1986): Metabolic alterations associated with proliferation of mitogen-activated lymphocytes and of lymphoblastoid cell lines: evaluation of glucose and glutamine metabolism, Immunobiology 173(1): 23-34.

Brealey D, Karyampudi S, Jacques TS, Novelli M, Stidwill R, Taylor V, Smolenski RT, Singer M (2004): Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure, Am J Physiol Regul Integr Comp Physiol 286(3): R491-R497.

Brown GC (1999): Nitric oxide and mitochondrial respiration, Biochim Biophys Acta 1411(2-3): 351-369.

Bruick RK and McKnight SL (2001): A conserved family of prolyl-4-hydroxylases that modify HIF, Science 294(5545): 1337-1340.

Burke B, Giannoudis A, Corke KP, Gill D, Wells M, Ziegler-Heitbrock L, Lewis CE (2003): Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapy, Am J Pathol 163(4): 1233-1243.

Buttgereit F and Brand MD (1995): A hierarchy of ATP-consuming processes in mammalian cells, Biochem J 312 (Pt 1): 163-167.

Buttgereit F, Brand MD, Müller M (1992): ConA induced changes in energy metabolism of rat thymocytes, Biosci Rep 12(5): 381-386.

Buttgereit F, Brand MD, Müller M (1993): Effects of methylprednisolone on the energy metabolism of quiescent and ConA-stimulated thymocytes of the rat, Biosci Rep 13(1): 41-52.

Buttgereit F, Burmester GR, Brand MD (2000): Bioenergetics of immune functions: fundamental and therapeutic aspects, Immunol Today 21(4): 192-199.

Buttgereit F, Müller M, Rapoport SM (1991): Quantification of ATP-producing and consuming processes in quiescent pig spleen lymphocytes, Biochem Int 24(1): 59-67.

Calder PC (1995): Fuel utilization by cells of the immune system, Proc Nutr Soc 54(1): 65-82.

Calder PC and Kew S (2002): The immune system: a target for functional foods?, Br J Nutr 88 Suppl 2: 165-177.

[Seite 104↓]

Caldwell CC, Kojima H, Lukashev D, Armstrong J, Farber M, Apasov SG, Sitkovsky MV (2001): Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions, J Immunol 167(11): 6140-6149.

Chamulitrat W (1999): Activation of the superoxide-generating NADPH oxidase of intestinal lymphocytes produces highly reactive free radicals from sulfite, Free Radic Biol Med 27(3-4): 411-421.

Chamulitrat W, Miller HI, McDonough KH (1999): Priming of Peyer’s patch lymphoid cells by hemorrhagic shock and resuscitation to produce superoxide radical, Shock 11(2): 136-142.

Chandel NS, McClintock DS, Feliciano CE, Wood TM, Melendez JA, Rodriguez AM, Schumacker PT (2000): Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing, J Biol Chem 275(33): 25130-25138.

Chun YS, Lee KH, Choi E, Bae SY, Yeo EJ, Huang LE, Kim MS, Park JW (2003): Phorbol ester stimulates the nonhypoxic induction of a novel hypoxia-inducible factor 1alpha isoform: implications for tumor promotion, Cancer Res 63(24): 8700-8707.

Chvapil M, Stankova L, Bernhard DS, Weldy PL, Carlson EC, Campbell JB (1977): Effect of zinc on peritoneal macrophages in vitro, Infect Immun 16(1): 367-373.

Cline MJ and Lehrer RI (1968): Phagocytosis by human monocytes, Blood 32(3): 423-435.

Conforti L, Petrovic M, Mohammad D, Lee S, Ma Q, Barone S, Filipovich AH (2003): Hypoxia regulates expression and activity of Kv1.3 channels in T lymphocytes: a possible role in T cell proliferation, J Immunol 170(2): 695-702.

Crabtree HG (1929): Observations on the carbohydrate metabolism of tumours, Biochem J 23: 536–545.

Cramer T, Yamanishi Y, Clausen BE, Forster I, Pawlinski R, Mackman N, Haase VH, Jaenisch R, Corr M, Nizet V, Firestein GS, Gerber HP, Ferrara N, Johnson RS (2003): HIF-1alpha is essential for myeloid cell-mediated inflammation, Cell 112(5): 645-657.

Crouser ED, Julian MW, Blaho DV, Pfeiffer DR (2002): Endotoxin-induced mitochondrial damage correlates with impaired respiratory activity, Crit Care Med 30(2): 276-284.

Crowley JP, Skrabut EM, Valeri CR (1975): The determination of leukocyte phagocytic oxidase activity by measurement of the initial rate of stimulated oxygen consumption, J Lab Clin Med 86(4): 586-594.

Culic O, Gruwel ML, Schrader J (1997): Energy turnover of vascular endothelial cells, Am J Physiol 273(1 Pt 1): C205-C213.

Culvenor JG and Weidemann MJ (1976): Phytohaemagglutinin stimulation of rat thymus lymphocytes glycolysis, Biochim Biophys Acta 437(2): 354-363.

Davey GP and Clark JB (1996): Threshold effects and control of oxidative phosphorylation in nonsynaptic rat brain mitochondria, J Neurochem 66(4): 1617-1624.

Devadas S, Zaritskaya L, Rhee SG, Oberley L, Williams MS (2002): Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: selective regulation of mitogen-activated protein kinase activation and fas ligand expression, J Exp Med 195(1): 59-70.

[Seite 105↓]

Diehn M, Alizadeh AA, Rando OJ, Liu CL, Stankunas K, Botstein D, Crabtree GR, Brown PO (2002): Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation, Proc Natl Acad Sci U S A 99(18): 11796-11801.

Distler JH, Wenger RH, Gassmann M, Kurowska M, Hirth A, Gay S, Distler O (2004): Physiologic responses to hypoxia and implications for hypoxia-inducible factors in the pathogenesis of rheumatoid arthritis, Arthritis Rheum 50(1): 10-23.

Doenecke C (1973): In vitro studies on glycogen metabolism of blood lymphocytes, Verh Dtsch Ges Inn Med 79: 534-536.

Douglas SD, Cohnen G, König E, Brittinger G (1973): Ultrastructural features of phytohemagglutinin and concanavalin A-responsive lymphocytes in chronic lymphocytic leukemia, Acta Haematol 50(3): 129-142.

Dziurla R (2004): Untersuchung zur Wirkung von Hypoxie auf Energiehaushalt und bioenergetisch relevante Funktionen von Immunzellen, Dissertation, in preparation, Medizinische Fakultät der Charité - Universitätsmedizin Berlin.

Eagle H (1955): Propagation in a fluid medium of a human epidermoid carcinoma, strain KB, Proc Soc Exp Biol Med 89(3): 362-364.

Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O’Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ (2001): C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation, Cell 107(1): 43-54.

Erickson KL, Medina EA, Hubbard NE (2000): Micronutrients and innate immunity, J Infect Dis 182 Suppl 1: 5-10.

Farge G, Touraille S, Debise R, Alziari S (2002): The respiratory chain complex thresholds in mitochondria of a Drosophila subobscura mutant strain, Biochimie 84(12): 1189-1197.

Ferrari D, Wesselborg S, Bauer MK, Schulze-Osthoff K (1997): Extracellular ATP activates transcription factor NF-kappaB through the P2Z purinoreceptor by selectively targeting NF-kappaB p65, J Cell Biol 139(7): 1635-1643.

Fink MP (2002): Cytopathic hypoxia. Is oxygen use impaired in sepsis as a result of an acquired intrinsic derangement in cellular respiration?, Crit Care Clin 18(1): 165-175.

Fiorucci S, Mencarelli A, Distrutti E, Baldoni M, del Soldato P, Morelli A (2004): Nitric oxide regulates immune cell bioenergetic: a mechanism to understand immunomodulatory functions of nitric oxide-releasing anti-inflammatory drugs, J Immunol 173(2): 874-882.

Fleischmann W und Kubowitz F (1927): Über den Stoffwechsel von Leucozyten, Biochem Z 181: 395-399.

Frauwirth KA and Thompson CB (2004): Regulation of T lymphocyte metabolism, J Immunol 172(8): 4661-4665.

Frauwirth KA, Riley JL, Harris MH, Parry RV, Rathmell JC, Plas DR, Elstrom RL, June CH, Thompson CB (2002): The CD28 signaling pathway regulates glucose metabolism, Immunity 16(6): 769-777.

[Seite 106↓]

Gaber T, Dziurla R, Tripmacher R, Burmester GR, Buttgereit F (2004): Hypoxia inducible factor (HIF) in Rheumatology: LOW O2! SEE WHAT HIF CAN DO!, Ann Rheum Dis, in revision.

Gellerich FN, Trumbeckaite S, Opalka JR, Gellerich JF, Chen Y, Neuhof C, Redl H, Werdan K, Zierz S (2002): Mitochondrial dysfunction in sepsis: evidence from bacteraemic baboons and endotoxaemic rabbits, Biosci Rep 22(1): 99-113.

Germann T, Szeliga J, Hess H, Storkel S, Podlaski FJ, Gately MK, Schmitt E, Rude E (1995): Administration of interleukin 12 in combination with type II collagen induces severe arthritis in DBA/1 mice, Proc Natl Acad Sci U S A 92(11): 4823-4827.

Glasser L and Fiederlein RL (1990): The effect of various cell separation procedures on assays of neutrophil function. A critical appraisal, Am J Clin Pathol 93(5): 662-669.

Gleichmann U and Lübbers DW (1960): Measurement of the oxygen tension in gases and fluids with the Pt-electrode with special reference to measurement in the blood, Pfügers Arch Gesamte Physiol Menschen Tiere 271: 431-455.

Goyal P, Weissmann N, Grimminger F, Hegel C, Bader L, Rose F, Fink L, Ghofrant HA, Schermuly RT, Schmidt HH, Seeger W, Hänze J (2004): Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxia-inducible factor 1 via increase in reactive oxygen species, Free Radic Biol Med 36(10): 1279-1288.

Groettrup M, Soza A, Kuckelkorn U, Kloetzel PM (1996): Peptide antigen production by the proteasome: complexity provides efficiency, Immunol Today 17(9): 429-435.

Grützkau A (2003), Deutsches Rheuma-Forschungszentrum Berlin, unpublished data.

Gunzer U, Gerner P, Nurnberger R, Horl WH (1978): Glycogen metabolism in isolated peripheral lymphocytes and thrombocytes in hair cell leukemia (HCL), chronic myelocytic leukemia (CML) and normal controls, Verh Dtsch Ges Inn Med 84: 190-196.

Guppy M, Greiner E, Brand K (1993): The role of the Crabtree effect and an endogenous fuel in the energy metabolism of resting and proliferating thymocytes, Eur J Biochem 212(1): 95-99.

Hagen T, Taylor CT, Lam F, Moncada S (2003): Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha, Science 302(5652): 1975-1978.

Hedeskov CJ and Esmann V (1966): Respiration and glycolysis of normal human lymphocytes, Blood 28(2): 163-174.

Hedfors E, Holm G, Pettersson D (1975): Activation of human peripheral blood lymphocytes by concanavalin A dependence of monocytes, Clin Exp Immunol 22(2): 223-229.

Hem E (1979): Modulation by macrophages of lymphocyte responses to phytohaemagglutinin, concanavalin A and semiallogeneic cells, Acta Pathol Microbiol Scand [C] 87C(1): 17-21.

Hossain MA, Bouton CM, Pevsner J, Laterra J (2000): Induction of vascular endothelial growth factor in human astrocytes by lead. Involvement of a protein kinase C/activator protein-1 complex-dependent and hypoxia-inducible factor 1-independent signaling pathway, J Biol Chem 275(36): 27874-27882.

[Seite 107↓]

Huang LE, Gu J, Schau M, Bunn HF (1998): Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway, Proc Natl Acad Sci U S A 95(14): 7987-7992.

Hume DA, Radik JL, Ferber E, Weidemann MJ (1978): Aerobic glycolysis and lymphocyte transformation, Biochem J 174(3): 703-709.

Isakov N and Altman A (2002): Protein kinase C(theta) in T cell activation, Annu Rev Immunol 20: 761-794.

Iyer NV, Kotch LE, Agani F, Leung SW, Laughner E, Wenger RH, Gassmann M, Gearhart JD, Lawler AM, Yu AY, Semenza GL (1998): Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha, Genes Dev 12(2): 149-162.

Jackson SH, Devadas S, Kwon J, Pinto LA, Williams MS (2004): T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation, Nat Immunol 5(8): 818-827.

Jung T, Schauer U, Heusser C, Neumann C, Rieger C (1993): Detection of intracellular cytokines by flow cytometry, J Immunol Methods 159(1-2): 197-207.

Jung Y, Isaacs JS, Lee S, Trepel J, Liu ZG, Neckers L (2003): Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor kappa B activation, Biochem J 370(Pt 3): 1011-1017.

Kallio PJ, Wilson WJ, O’Brien S, Makino Y, Poellinger L (1999): Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway, J Biol Chem 274(10): 6519-6525.

Kato H and Walz W (2000): The initiation of the microglial response, Brain Pathol 10(1): 137-143.

Kawaguchi T, Veech RL, Uyeda K (2001): Regulation of energy metabolism in macrophages during hypoxia. Roles of fructose 2,6-bisphosphate and ribose 1,5-bisphosphate, J Biol Chem 276(30): 28554-28561.

Kawahara H, Houdou S, Inoue T (1991): Scanning electron microscopic observations on muscle cells of experimental mitochondrial myopathy produced by 2, 4-dinitrophenol, J Submicrosc Cytol Pathol 23(3): 397-403.

Kay NE, Bumol TF, Douglas SD (1980): Effects of 2-deoxy-D-glucose on human monocyte metabolism and function, J Reticuloendothel Soc 28(4): 367-379.

Kelleter R, Seiler D, Drings P (1973): Glycogen metabolism of blood lymphocytes of patients with chronic lymphatic leukemia, Verh Dtsch Ges Inn Med 79: 538-541.

Kempner W (1939): The nature of leukemic blood cells as determined by their metabolism, J Clin Invest 18: 291-300.

Keusch GT (2003): The history of nutrition: malnutrition, infection and immunity, J Nutr 133(1): 336S-340S.

Kirschner RH, Getz GS, Evans AE (1972): Leukocyte mitochondria: function and biogenesis, Enzyme 13(1): 56-76.

[Seite 108↓]

Kittlick PD (1986): Inflammation, glycolytic metabolism, and glycosaminoglycans, Exp Pathol 30(1): 1-19.

Kivisaari J (1975): Oxygen and carbon dioxide tensions in healing tissue, Acta Chir Scand 141(8): 693-696.

Kojima H, Sitkovsky MV, Cascalho M (2003): HIF-1 alpha deficiency perturbs T and B cell functions, Curr Pharm Des 9(23): 1827-1832.

Krauss S and Brand MD (2000): Quantitation of signal transduction, FASEB J 14(15): 2581-2588.

Krauss S, Brand MD, Buttgereit F (2001): Signaling takes a breath - new quantitative perspectives on bioenergetics and signal transduction, Immunity 15(4): 497-502.

Krauss S, Buttgereit F, Brand MD (1999): Effects of the mitogen concanavalin A on pathways of thymocyte energy metabolism, Biochim Biophys Acta 1412(2): 129-138.

Kuhnke A (2000): Bilanzierung des lymphozytären Energiestoffwechsels von Patienten mit entzündlich - rheumatischen Erkrankungen, Dissertation, Humboldt-Universität zu Berlin, Medizinische Fakultät Charité.

Kuhnke A, Burmester GR, Krauss S, Buttgereit F (2003): Bioenergetics of immune cells to assess rheumatic disease activity and efficacy of glucocorticoid treatment, Ann Rheum Dis 62(2): 133-139.

Kumagai N, Benedict SH, Mills GB, Gelfand EW (1987): Requirements for the simultaneous presence of phorbol esters and calcium ionophores in the expression of human T lymphocyte proliferation-related genes, J Immunol 139(5): 1393-1399.

Kuna GB, Collipp PJ, Katkocin D, Sherwyn J, Amin S, Maddaiah VT (1979): Effect of growth hormone on lymphocyte respiration and growth rate of children, Metabolism 28(12): 1239-1243.

Kwon J, Devadas S, Williams MS (2003): T cell receptor-stimulated generation of hydrogen peroxide inhibits MEK-ERK activation and lck serine phosphorylation, Free Radic Biol Med 35(4): 406-417.

Lakin-Thomas PL and Brand MD (1988): Stimulation of respiration by mitogens in rat thymocytes is independent of mitochondrial calcium, Biochem J 256(1): 167-173.

Langston HP, Ke Y, Gewirtz AT, Dombrowski KE, Kapp JA (2003): Secretion of IL-2 and IFN-gamma, but not IL-4, by antigen-specific T cells requires extracellular ATP, J Immunol 170(6): 2962-2970.

Laszlo J (1967): Energy metabolism of human leukemic lymphocytes and granulocytes, Blood 30(2): 151-167.

Lehner PJ (2003): The calculus of immunity: quantitating antigen processing, Immunity 18(3): 315-317.

Leikin SL (1961): Glycogen content of normal lymphocytes, Proc Soc Exp Biol Med 106: 286-288.

Levene PA and Meyer GM (1912a): The action of leucocytes on glucose, J Biol Chem 11(4): 361-370.

[Seite 109↓]

Levene PA and Meyer GM (1912b): On the action of leucocytes on glucose, second communication, J Biol Chem 12(2): 265-273.

Lewis JS, Lee JA, Underwood JC, Harris AL, Lewis CE (1999): Macrophage responses to hypoxia: relevance to disease mechanisms, J Leukoc Biol 66(6): 889-900.

Loeffler DA, Keng PC, Baggs RB, Lord EM (1990): Lymphocytic infiltration and cytotoxicity under hypoxic conditions in the EMT6 mouse mammary tumor, Int J Cancer 45(3): 462-467.

Lu DJ and Grinstein S (1989): Concanavalin A stimulation of O2 consumption in electropermeabilized neutrophils via a pertussis toxin-insensitive G protein, FEBS Lett 253(1-2): 151-156.

Lukashev D, Caldwell C, Ohta A, Chen P, Sitkovsky M (2001): Differential regulation of two alternatively spliced isoforms of hypoxia-inducible factor-1 alpha in activated T lymphocytes, J Biol Chem 276(52): 48754-48763.

Lünemann JD, Buttgereit F, Tripmacher R, Baerwald CG, Burmester GR, Krause A (2001): Norepinephrine inhibits energy metabolism of human peripheral blood mononuclear cells via adrenergic receptors, Biosci Rep 21(5): 627-635.

Lyamzaev KG, Izyumov DS, Avetisyan AV, Yang F, Pletjushkina OY, Chernyak BV (2004): Inhibition of mitochondrial bioenergetics: the effects on structure of mitochondria in the cell and on apoptosis, Acta Biochim Pol 51(2): 553-562.

MacDonald HR and Koch CJ (1977): Energy metabolism and T-cell-mediated cytolysis. I. Synergism between inhibitors of respiration and glycolysis, J Exp Med 146(3): 698-709.

Maddock EO, Maddock SW, Kelley VE, Strom TB (1985): Rapid stereospecific stimulation of lymphocytic metabolism by interleukin 2, J Immunol 135(6): 4004-4008.

Maeda T, Yamada H, Nagamine R, Shuto T, Nakashima Y, Hirata G, Iwamoto Y (2002): Involvement of CD4+,CD57+ T cells in the disease activity of rheumatoid arthritis, Arthritis Rheum 46(2): 379-384.

Marriage BJ, Clandinin MT, Macdonald IM, Glerum DM (2004): Cofactor treatment improves ATP synthetic capacity in patients with oxidative phosphorylation disorders, Mol Genet Metab 81(4): 263-272.

Marsin AS, Bouzin C, Bertrand L, Hue L (2002): The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase, J Biol Chem 277(34): 30778-30783.

Mateo J, Garcia-Lecea M, Cadenas S, Hernandez C, Moncada S (2003): Regulation of hypoxia-inducible factor-1alpha by nitric oxide through mitochondria-dependent and -independent pathways, Biochem J 376(Pt 2): 537-544.

Matsuo T, Hazeki K, Hazeki O, Katada T, Ui M (1996): Activation of phosphatidylinositol 3-kinase by concanavalin A through dual signaling pathways, G-protein-coupled and phosphotyrosine-related, and an essential role of the G-protein-coupled signals for the lectin-induced respiratory burst in human monocytic THP-1 cells, Biochem J 315(Pt 2): 505-512.

Mayhew TM and Williams MA (1974): A quantitative morphological analysis of macrophage stimulation, Z Zellforsch 147: 567-588.

[Seite 110↓]

McLaughlin KA, Osborne BA, Goldsby RA (1996): The role of oxygen in thymocyte apoptosis, Eur J Immunol 26(5): 1170-1174.

Merlo-Pich M, Deleonardi G, Biondi A, Lenaz G (2004): Methods to detect mitochondrial function, Exp Gerontol 39(3): 277-281.

Miltenyi S, Muller W, Weichel W and Radbruch A (1990): High gradient magnetic cell separation with MACS, Cytometry 11(2): 231-238.

Miyamoto S, Kimball SR, Safer B (2000): Signal transduction pathways that contribute to increased protein synthesis during T-cell activation, Biochim Biophys Acta 1494(1-2): 28-42.

Monneret G, Debard AL, Venet F, Bohe J, Hequet O, Bienvenu J, Lepape A (2003): Marked elevation of human circulating CD4+CD25+ regulatory T cells in sepsis-induced immunoparalysis, Crit Care Med 31(7): 2068-2071.

Morita Y, Yamamura M, Kawashima M, Harada S, Tsuji K, Shibuya K, Maruyama K, Makino H (1998): Flow cytometric single-cell analysis of cytokine production by CD4+ T cells in synovial tissue and peripheral blood from patients with rheumatoid arthritis, Arthritis Rheum 41(9): 1669-1676.

Müller M, Siems W, Buttgereit F, Dumdey R, Rapoport SM (1986): Quantification of ATP-producing and consuming processes of Ehrlich ascites tumour cells, Eur J Biochem 161(3): 701-705.

Mullis K, Faloona F, Scharf S, Saiki R, Horn G, Erlich H (1986): Specific enzymatic amplification of DNA in vitro: the polymerase chain reaction, Cold Spring Harb Symp Quant Biol 51 Pt 1: 263-273.

Nagy G, Barcza M, Gonchoroff N, Phillips PE, Perl A (2004): Nitric oxide-dependent mitochondrial biogenesis generates Ca2+ signaling profile of lupus T cells, J Immunol 173(6): 3676-3683.

Nagy G, Koncz A, Perl A (2003): T cell activation-induced mitochondrial hyperpolarization is mediated by Ca2+- and redox-dependent production of nitric oxide, J Immunol 171(10): 5188-5897.

Naldini A and Carraro F (1999): Hypoxia modulates cyclin and cytokine expression and inhibits peripheral mononuclear cell proliferation, J Cell Physiol 181(3): 448-454.

Naldini A, Carraro F, Silvestri S, Bocci V (1997): Hypoxia affects cytokine production and proliferative responses by human peripheral mononuclear cells, J Cell Physiol 173(3): 335-342.

Naumann L (2004): Untersuchungen zum differenzierten Wirkungsprofil von Glucocorticoiden auf humane mononukleäre Zellen des peripheren Blutes, Dissertation, Medizinische Fakultät der Charité - Universitätsmedizin Berlin.

Newsholme EA, Crabtree B, Ardawi MS (1985a): Glutamine metabolism in lymphocytes: its biochemical, physiological and clinical importance, Q J Exp Physiol 70(4): 473-489.

Newsholme EA, Crabtree B, Ardawi MS (1985b): The role of high rates of glycolysis and glutamine utilization in rapidly dividing cells, Biosci Rep 5(5): 393-400.

Nisoli E, Clementi E, Moncada S, Carruba MO (2004): Mitochondrial biogenesis as a cellular signaling framework, Biochem Pharmacol 67(1): 1-15.

[Seite 111↓]

Nisoli E, Clementi E, Paolucci C, Cozzi V, Tonello C, Sciorati C, Bracale R, Valerio A, Francolini M, Moncada S, Carruba MO (2003): Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide, Science 299(5608): 896-899.

Oren R, Farham AE, Saito K, Milofsky E, Karnovsky ML (1963): Metabolic patterns in three types of phagocytizing cells, J Cell Biol 17: 487-501.

Pasteur L (1876): Études sur la Bièr, Gauthier-Villars Paris.

Petty HR and Ware BR (1979): Macrophage response to concanavalin A: effect of surface crosslinking on the electrophoretic mobility distribution, Proc Natl Acad Sci U S A 76(5): 2278-2282.

Plas DR and Thompson CB (2002): Cell metabolism in the regulation of programmed cell death, Trends Endocrinol Metab 13(2): 75-78.

Princiotta MF, Finzi D, Qian SB, Gibbs J, Schuchmann S, Buttgereit F, Bennink JR, Yewdell JW (2003): Quantitating protein synthesis, degradation, and endogenous antigen processing, Immunity 18(3): 343-354.

Pugh CW and Ratcliffe PJ (2003): Regulation of angiogenesis by hypoxia: role of the HIF system, Nat Med 9(6): 677-684.

Rabesandratana H, Fournier AM, Chateau MT, Serre A, Dornand J (1992): Increased oxidative metabolism in PMA-activated lymphocytes: a flow cytometric study, Int J Immunopharmacol 14(5): 895-902.

Rabinowitz Y, Schimo I, Wilhite BA (1968): Metabolic responses to separated leucocytes to phytohaemagglutinin: effects of anaerobiasis, actinomycin D and puromycin, Br J Haematol 15(5): 455-464.

Radbruch A, Mechtold B, Thiel A, Miltenyi S, Pfluger E (1994): High-gradient magnetic cell sorting, Methods Cell Biol 42 Pt B: 387-403.

Rapoport SM (1987): Medizinische Biochemie, 9. Aufl., Berlin, VEB Verlag Volk und Gesundheit, S. 348.

Rapoport SM und Raderecht HJ (1989): Physiologisch-Chemisches Praktikum, 8. Aufl., Berlin, VEB Verlag Volk und Gesundheit, S. 156 ff.

Reiss M and Roos D (1978): Differences in oxygen metabolism of phagocytosing monocytes and neutrophils, J Clin Invest 61(2): 480-488.

Remans PH, Gringhuis SI, van Laar JM, Sanders ME, Papendrecht-van der Voort EA, Zwartkruis FJ, Levarht EW, Rosas M, Coffer PJ, Breedveld FC, Bos JL, Tak PP, Verweij CL, Reedquist KA (2004): Rap1 signaling is required for suppression of Ras-generated reactive oxygen species and protection against oxidative stress in T lymphocytes, J Immunol 173(2): 920-931.

Reth M (2002): Hydrogen peroxide as second messenger in lymphocyte activation, Nat Immunol 3(12): 1129-1134.

Rolfe DF and Brown GC (1997): Cellular energy utilization and molecular origin of standard metabolic rate in mammals, Physiol Rev 77(3): 731-758.

[Seite 112↓]

Romeo D, Zabucchi G, Rossi F (1973): Reversible metabolic stimulation of polymorphonuclear leukocytes and macrophages by concanavalin A, Nat New Biol 243(125): 111-112.

Roos D and Loos JA (1970): Changes in the carbohydrate metabolism of mitogenically stimulated human peripheral lymphocytes. I. Stimulation by phytohaemagglutinin, Biochim Biophys Acta 222(3): 565-582.

Roos D and Loos JA (1973): Changes in the carbohydrate metabolism of mitogenically stimulated human peripheral lymphocytes. II. Relative importance of glycolysis and oxidative phosphorylation on phytohaemagglutinin stimulation, Exp Cell Res 77(1): 127-135.

Roos D and Loos JA (1972): Proc Vith ann leuc cult conf (ed Schwarz MR), New York, Academic Press, p. 215.

Rossi F, Della Bianca V, Grzeskowiak M, Bazzoni F (1989): Studies on molecular regulation of phagocytosis in neutrophils. Con A-mediated ingestion and associated respiratory burst independent of phosphoinositide turnover, rise in [Ca2+]i, and arachidonic acid release, J Immunol 142(5): 1652-1660.

Rossignol R, Faustin B, Rocher C, Malgat M, Mazat JP, Letellier T (2003): Mitochondrial threshold effects, Biochem J 370(Pt 3): 751-762.

Rossignol R, Malgat M, Mazat JP, Letellier T (1999): Threshold effect and tissue specificity. Implication for mitochondrial cytopathies, J Biol Chem 274(47): 33426-33432.

Ryan HE, Lo J, Johnson RS (1998): HIF-1 alpha is required for solid tumor formation and embryonic vascularization, EMBO J 17(11): 3005-3015.

Saadi S, Wrenshall LE, Platt JL (2002): Regional manifestations and control of the immune system, FASEB J 16(8): 849-856.

Safran M and Kaelin WG Jr (2003): HIF hydroxylation and the mammalian oxygen-sensing pathway, J Clin Invest 111(6): 779-783.

Sagone AL Jr, King GW, Metz EN (1976): A comparison of the metabolic response to phagocytosis in human granulocytes and monocytes, J Clin Invest 57(5): 1352-1358.

Sagone AL Jr, LoBuglio AF, Balcerzak SP (1974): Alterations in hexose monophosphate shunt during lymphoblastic transformation, Cell Immunol 14(3): 443-452.

Sambrook J, Fritsch EF, Maniatis T (1989): Molecular cloning: a laboratory manual, 3. Aufl., Bd. 2, New York, Cold Spring Harbor Laboratory Press, p. 18.52.

Sand T, Condie R, Rosenberg A (1977): Metabolic crowding effect in suspension of cultured lymphocytes, Blood 50(2): 337-346.

Sander B, Andersson J, Andersson U (1991): Assessment of cytokines by immunofluorescence and the paraformaldehyde-saponin procedure, Immunol Rev 119: 65-93.

Saraste M (1999): Oxidative phosphorylation at the fin de siècle, Science 283(5407): 1488-1493.

Sbarra AJ and Karnovsky ML (1959): The biochemical basis of phagocytosis. I. Metabolic changes during the ingestion of particles by polymorphonuclear leukocytes, J Biol Chem 234(6): 1355-1362.

[Seite 113↓]

Schauer U, Jung T, Krug N, Frew A (1996): Measurement of intracellular cytokines, Immunol Today 17(7): 305-306.

Schmid D (2000): Bilanzierung des zellulären Energiestoffwechsels humaner Lymphozyten und die therapeutische Beeinflussung durch Glucocorticoide, Dissertation, Humboldt-Universität zu Berlin, Medizinische Fakultät Charité.

Schmid D, Burmester GR, Tripmacher R, Fici G, von Voigtlander P, Buttgereit F (2001): Short-term effects of the 21-aminosteroid lazaroid tirilazad mesylate (PNU-74006F) and the pyrrolopyrimidine lazaroid PNU-101033E on energy metabolism of human peripheral blood mononuclear cells, Biosci Rep 21(1): 101-110.

Schmid D, Burmester GR, Tripmacher R, Kuhnke A, Buttgereit F (2000): Bioenergetics of human peripheral blood mononuclear cell metabolism in quiescent, activated, and glucocorticoid-treated states, Biosci Rep 20(4): 289-302.

Schmitz G und Rothe G (1994): Durchflußzytometrie in der klinischen Zelldiagnostik,Stuttgart · New York, F. K. Schattauer Verlagsgesellschaft mbH, S. 3 ff.

Schor H, Vaday GG, Lider O (2000): Modulation of leukocyte behavior by an inflamed extracellular matrix, Dev Immunol 7(2-4): 227-238.

Schubert U, Anton LC, Gibbs J, Norbury CC, Yewdell JW, Bennink JR (2000): Rapid degradation of a large fraction of newly synthesized proteins by proteasomes, Nature 404(6779): 770-774.

Schumacher HR, Szekely IE, Park SA, Fisher DR (1973): Ultrastructural studies on the acute leukemic lymphoblast, Blut 27(6): 369-406.

Seagroves TN, Ryan HE, Lu H, Wouters BG, Knapp M, Thibault P, Laderoute K, Johnson RS (2001): Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells, Mol Cell Biol 21(10): 3436-3444.

Seiler D and Kelleter R (1973): Biochemical studies of glycogen metabolism of human blood lymphocytes, Verh Dtsch Ges Inn Med 79: 536-538.

Seitz IF (1965): Biochemistry of normal and leukemic leucocytes, thrombocytes, and bone marrow cells, Adv Cancer Res 9: 303-410.

Seitz JF and Luganova IS (1968): The biochemical identification of blood and bone marrow cells of patients with acute leukemia, Cancer Res 28(12): 2548-2555.

Sekkat C, Dornand J, Gerber M (1988): Oxidative phenomena are implicated in human T-cell stimulation, Immunology 63(3): 431-437.

Stevens CR, Williams RB, Farrell AJ, Blake DR (1991): Hypoxia and inflammatory synovitis: observations and speculation, Ann Rheum Dis 50(2): 124-132.

Tak PP and Bresnihan B (2000): The pathogenesis and prevention of joint damage in rheumatoid arthritis: advances from synovial biopsy and tissue analysis, Arthritis Rheum 43(12): 2619-2633.

Takamiya R, Takahashi M, Myint T, Park YS, Miyazawa N, Endo T, Fujiwara N, Sakiyama H, Misonou Y, Miyamoto Y, Fujii J, Taniguchi N (2003): Glycation proceeds faster in mutated Cu, Zn-superoxide dismutases related to familial amyotrophic lateral sclerosis, FASEB J 17(8): 938-940.

[Seite 114↓]

Talstad I (1972): The influence of the crowding phenomenon on the oxygen consumption of blood cells as determined by the Cartesian diver technique, Acta Physiol Scand 84(3): 332-337.

Tatla S, Woodhead V, Foreman JC, Chain BM (1999): The role of reactive oxygen species in triggering proliferation and IL-2 secretion in T cells, Free Radic Biol Med 26(1-2): 14-24.

Thierbach G and Reichenbach H (1981): Myxothiazol, a new inhibitor of the cytochrome b-c1 segment of th respiratory chain, Biochim Biophys Acta 638(2): 282-289.

Thierie J (2004): Modeling threshold phenomena, metabolic pathways switches and signals in chemostat-cultivated cells: the Crabtree effect in Saccharomyces cerevisiae, J Theor Biol 226(4): 483-501.

Thies F, Miles EA, Nebe-von-Caron G, Powell JR, Hurst TL, Newsholme EA, Calder PC (2001): Influence of dietary supplementation with long-chain n-3 or n-6 polyunsaturated fatty acids on blood inflammatory cell populations and functions and on plasma soluble adhesion molecules in healthy adults, Lipids 36(11): 1183-1193.

Thompson CB, Rathmell JC, Frauwirth KA, Lindsten T, Rudin CM, Opferman JT, Ashton-Rickardt PG, Harris MH, Chandel NS, Schumacker PT, Vander Heiden MG (1999): What keeps a resting T cell alive?, Cold Spring Harb Symp Quant Biol 64: 383-387.

Trübel H and Barnikol WK (1998): A new microprocedure for continuous and non-consuming determination of cellular oxygen uptake based on fluorescence quenching, Biomed Tech (Berl) 43(11): 302-309.

Truneh A, Albert F, Golstein P, Schmitt-Verhulst AM (1985): Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester, Nature 313(6000): 318-320.

Turner L, Scotton C, Negus R, Balkwill F (1999): Hypoxia inhibits macrophage migration, Eur J Immunol 29(7): 2280-2287.

Udilova N (1999): Vergleichende Untersuchung von Methoden zum Nachweis von Superoxidradikalen in biologischen und Modellsystemen, Dissertation, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I.

Valdez LB and Boveris A (2001): Nitric oxide and superoxide radical production by human mononuclear leukocytes, Antioxid Redox Signal 3(3): 505-513.

Van den Bogert C, Melis TE, Kroon AM (1989): Mitochondrial biogenesis during the activation of lymphocytes by mitogens: the immunosuppressive action of tetracyclines, J Leukoc Biol 46(2): 128-133.

Van den Bogert C, Muus P, Haanen C, Pennings A, Melis TE, Kroon AM (1988): Mitochondrial biogenesis and mitochondrial activity during the progression of the cell cycle of human leukemic cells, Exp Cell Res 178(1): 143-153.

Vaupel P, Kallinowski F, Okunieff P (1989): Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review, Cancer Res 49(23): 6449-6465.

Vorobjev IA and Zorov DB (1983): Diazepam inhibits cell respiration and induces fragmentation of mitochondrial reticulum, FEBS Lett 163(2): 311-314.

[Seite 115↓]

Wagner R, Meyerriecks N, Sparaco R (1956): Enzyme studies on white blood cells and blood platelets. V. Dehydrogenase activity, Arch Biochem Biophys 61(2): 278-290.

Wang GL and Semenza GL (1993): Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia, J Biol Chem 268(29): 21513-21518.

Wang GL, Jiang BH, Rue EA, Semenza GL (1995): Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension, Proc Natl Acad Sci U S A 92(12): 5510-5514.

Wang T, Marquardt C, Foker J (1976): Aerobic glycolysis during lymphocyte proliferation, Nature 261(5562): 702-705.

Warburg O, Wind F, Negelein E (1926): Über den Stoffwechsel von Tumoren, Klin Wochenschr 5(19): 829-832.

Weber K, Ridderskamp D, Alfert M, Hoyer S, Wiesner RJ (2002): Cultivation in glucose-deprived medium stimulates mitochondrial biogenesis and oxidative metabolism in HepG2 hepatoma cells, Biol Chem 383(2): 283-290.

Weening RS, Roos D, Loos JA (1974): Oxygen consumption of phagocytizing cells in human leukocyte and granulocyte preparations: a comparative study, J Lab Clin Med 83(4): 570-577.

Wells AL, Lin AW, Chen LQ, Safer D, Cain SM, Hasson T, Carragher BO, Milligan RA, Sweeney HL (1999): Myosin VI is an actin-based motor that moves backwards, Nature 401(6752): 505-508.

Wenger RH (2002): Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression, FASEB J 16(10): 1151-1162.

Wertenauer HJ (2000): Untersuchungen zur Wirkung von Methylprednisolon und Anti-CD4-Antikörpern auf die Signaltransduktion in peripheren mononukleären Zellen (PMNC), Dissertation, Humboldt-Universität zu Berlin, Medizinische Fakultät Charité.

Westermann J and Bode U (1999): Distribution of activated T cells migrating through the body: a matter of life and death, Immunol Today 20(7): 302-306.

Williams MS and Kwon J (2004): T cell receptor stimulation, reactive oxygen species, and cell signaling, Free Radic Biol Med 37(8): 1144-1151.

Wu G and Marliss EB (1993): Enhanced glucose metabolism and respiratory burst in peritoneal macrophages from spontaneously diabetic BB rats, Diabetes 42(4): 520-529.

York IA and Rock KL (1996): Antigen processing and presentation by the class I major histocompatibility complex, Annu Rev Immunol 14: 369-396.

Zhao J, Juettner B, Scheinichen D, Jaeger K, Heine J, Piepenbrock S (2003): Respiratory burst activity of polymorphonuclear cells is dependent on the cell preparation technique, Acta Anaesthesiol Scand 47(6): 702-706.

Zuckerberg AL, Goldberg LI, Lederman HM (1994): Effects of hypoxia on interleukin-2 mRNA expression by T lymphocytes, Crit Care Med 22(2): 197-203.

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