| Unger , Christian: Analyse funktioneller Domänen von SEC71 und SEC72 im posttranslationalen Translokationsprozeß Saccharomyces cerevisiae |
Andersson, H. and Heijne, G. von (1994 ). "Membrane protein topology: effects of delta µ H+ on the translocation of charged residues explain the ’positive inside‘ rule" . EMBO J., Vol. 13, 2267-2272 .
Atencio, D.A. and Yaffee, M.P. (1992 ). "MAS5, a yeast homolog of DnaJ involved in mitochondrial protein import." Mol. Cell. Biol ., Vol. 12, 283-291 .
Becker, J. et al. (1996 "). Functional interaction of cytosolic hsp70 and a DnaJ-related protein, Ydj1p, in protein translocation in vivo" . Mol. Cell. Biol ., Vol. 16, 4378-4386 .
Beckmann, R. et al. (1997 ). "Alignment of conduits for the nascent polypeptide chain in the ribosome-Sec61 complex." Science , Vol. 278, 2123-2126 .
Brizzio, V. et al. (1999 ). "Genetic interactions between KAR7/SEC71, KAR8/JEM1, KAR5, and KAR2 during nuclear fusion in Saccharomyces cerevisiae." Mol. Biol. Cell , Vol. 10, 609-626 .
Brocard, C. et al. (1994 ). "The tetratricopeptide repeat domain of the PAS10 protein of Saccharomyces cerevisiae is essential for binding the peroxisomal targeting signal - SKL." Biochem. Biophys. Res. Commun ., Vol. 204, 1016-22 .
Brundage, L. et al. (1990 ). "The purified E.coli integral membrane protein SecY/E is sufficient for reconstitution of SecA-dependent precursor protein translocation" . Cell , Vol. 62, 649-57 .
Brundage, L. et al. (1992 ). "SecY, SecE, and band 1 form the membrane-embedded domain of Escherichia coli preprotein translocase" ., J. Biol. Chem ., Vol. 267, 4166-4170 .
Brunelli, J.P. and Pall, M.I. (1993 ). "A series of yeast shuttle vectors for exression of cDNAs and other DANN sequences." Yeast , Vol. 9, 1299-1308 .
Caplan, A.J. and Douglas, M.G. (1991 "). Characterization of YDJ1: A yeast homologue of the bacterial dnaJ protein. " J. Cell Biol ., Vol. 114 , 609-621 .
Chirico, W. J. et al. (1988 "). 70K heat shock related proteins stimulate protein translocation into microsomes." Nature , Vol. 322 , 805-810 .
Connolly, T. and Gilmore, R. (1989 ). "The signal recognition particle receptor mediates the GTP-dependent displacement of SRP from the signal sequence of the nascent polypeptide. " Cell , Vol. 57 , 599-610 .
Connolly, T. et al. (1989b ). "Access of proteinase K to partially translocated nascent polypeptides in intact and detergent-solubilized membranes" . J. Cell. Biol ., Vol.108 , 299-307 .
82
Dahmann, C. et al. (1995 ). "S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state" . Curr. Biol ., Vol. 5 , 1257-1169 .Deshaies, R. J. and Schekman, R. (1987 ). "A yeast mutant defective at an early stage in import of secretory protein precursors into the endoplasmic reticulum" .. J. Cell Biol ., Vol. 105(2), 633-645 .
Deshaies, R. J. and Schekman, R. (1989 ). "SEC62 encodes a putative membrane protein required for protein translocation into the yeast endoplasmic reticulum." J. Cell Biol. , Vol. 109 , 2653-2664 .
Deshaies, R. J. and Schekman, R. (1990 "). Structural and functional dissection of Sec62p, a membrane-bound component of the yeast Endoplasmic Reticulum protein import machinery." Mol. Cell. Biol ., Vol 10 , 6024-35 .
Deshaies, R. J. et al. (1988 ). "A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides." Nature , Vol. 322 , 800-805 .
Deshaies, R. J. et al. (1991 ). "Assembly of yeast Sec proteins involved in translocation into the endoplasmic reticulum into a membrane-bound multisubunit complex." Nature , Vol. 349 , 806-808 .
Driessen, A.J. (1992 ). "Precursor protein translocation by the Escherichia coli translocase is directed by the protonmotive force." EMBO J., Vol. 11 , 847-853 .
Dünnwald, M. et al. (1999 ). "Detection of transient in vivo interactions between substrate and transporter during protein translocation into the endoplasmic reticulum." Mol. Cell. Biol., Vol. 10 , 329-344 .
Duong, F. and Wickner, W. (1997 ). "The SecDFyajC domain of preprotein translocase controls preprotein movement by regulating SecA membrane cycling." EMBO J ., Vol. 16 , 4871-79 .
Economou, A. and Wickner, W. (1994 ). "SecA promotes preprotein translocation by undergoing ATP-driven cycles of membrane insertion and deinsertion." Cell , Vol. 78 , 835-843 .
Economou, A. et al. (1995 ). "SecA membrane cycling at Sec YEG is driven by distinct ATP binding and hydrolysis events and is regulated by SecD and SecF." Cell , Vol. 83 , 1171-1181 .
Eichler, J. and Wickner, W. (1997 ). "Both an N-terminal 65-kDa domain and a C-terminal 30-kDa domain of SecA cycle into the membrane at SecYEG during translocation." Proc. Natl. Acad. Sci. USA , Vol. 94 , 5574-81 .
83
Eichler, J. et al. (1998 ). "Endogenous SecA catalyzes preprotein translocation at SecYEG. " J. Biol. Chem., Vol. 273 , 21675-81 .Esnault, Y. et al. (1993 ). "The yeast SSS1 gene is essential for secretory protein translocation and encodes a conserved protein of the endoplasmic reticulum." EMBO J., Vol. 12 , 4083-4093 .
Evans, E.A. et al. (1986 ). "Purification of microsomal signal peptdase as a complex." Proc. Natl. Acad. Sci. USA , Vol. 83 , 581-585 .
Fang, H. and Green, N. (1994 ). "Nonlethal sec71-1 and sec72-1 mutations eliminate proteins associated with the Sec63p-BiP complex from S. cerevisiae." Mol. Biol. Cell , Vol. 5 , 933-942 .
Feldheim, D. and Schekman, R. (1994 ). "Sec72p contributes to the selective recognition of signal peptides by the secretory polypeptide translocation complex." J. Cell Biol., Vol. 126 , 935-943 .
Feldheim, D. et al. (1992 ). "Topology and functional domains of Sec63p, an Endoplasmic Reticulum membrane protein required for secretory protein translocation." Mol. Cell. Biol., Vol. 12 , 3288-96 .
Feldheim, D. et al. (1993 ). "Structural and functional characterization of Sec66p, a new subunit of the polypeptide translocation apparatus in the yeast Endoplasmic Reticulum." Mol. Biol. Cell , Vol. 4 , 931-939 .
Finke, K. et al. (1996 ). "A second trimeric complex containing homologs of the Sec61p complex functions in protein transport across the ER membrane of S.cerevisiae." EMBO J., Vol. 15 , 1482-1494 .
Gietz, R.D. et al. (1995 ). "Studies on the transformation of intact yeast cells by the LiAc/SS-DANN/PEG procedure." Yeast , Vol. 11 , 355-360 .
Gilmore, R. et al. (1982 "). Protein translocation across the endoplasmic reticulum. Isolation and characterization of the signal recognition particle receptor." J. Cell Biol., Vol. 95 , 470-77 .
Goebl, M. and Yanagida, M. (1991 "). The TPR snap helix: a novel protein repeat motif from mitosis to transcription." TIBS , Vol. 16 , 173-177 .
Görlich, D. and Rapoport, T.A. (1993 ). "Protein translocation into proteoliposomes reconstituted from purified components of the Endoplasmic Reticulum membrane." Cell , Vol. 75 , 1-20 .
Görlich, D. et al. (1992 ). "A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation." Cell , Vol. 71 , 489-503 .
84
Green, N. et al. (1992 ). "Mutants in three novel complementation groups inhibit membrane protein insertion into and soluble protein translocation across the Endoplasmic Reticulum membrane of Saccharomyces cerevisiae." J. Cell Biol., Vol 116, 597-604 .Haeuptle, M.T. et al. (1989 ). "A tripartie structure of the signals that determine protein insertion into the Endoplasmic Reticulum membrane." J. Cell Biol ., Vol. 108 , 1227-1236 .
Hamman B.D. et al. (1998 ). "BiP maintains the permeability barrier of the ER membrane by sealing the lumenal end of the translocon pore before and early in translocation." Cell , Vol. 92 , 747-758 .
Hamman, B.D. et al. (1997 ). "The aqueous pore through the translocon has a diameter of 40-60 Å during cotranslational protein translocation at the ER membrane." Cell , Vol. 89 , 535-544 .
Hanada, M. et al. (1994 ). "Reconstitution of an efficient protein translocation machinery comprising SecA and the three membrane proteins SecY, SecE and SecG (p12)." J. Biol. Chem ., Vol. 269 , 23625-31 .
Hanein, D. et al. (1996 ). "Oligomeric rings of the Sec61p complex induced by ligands required for protein translocation." Cell , Vol. 87 , 721-732 .
Hartmann, E. et al. (1994 ). "Evolutionary conservation of components of the protein translocation complex." Nature , Vol. 367 , 654-657 .
Heijne, G. von (1985 ). "Signal sequences. The limits of variations." J. Mol. Biol ., Vol 184 , 99-105 .
Heijne, G. von (1990 ). "The signal peptide." J. Membrane Biol ., Vol. 115 , 195-201 .
Huffacker, T.C. et al. (1987 ). "Genetic analysis of the yeast cytoskeleton." Annu. Rev. Genet ., Vol. 21 , 259-294 .
Johnsson, N. and Varshavsky, A. (1994 "). Split ubiquitin as a sensor of protein interactions in vivo. " Proc. Natl. Acad. Sci. USA , Vol. 91 , 10340-10344 .
Jungnickel, B. and Rapoport, T.A. (1995 ). "A posttargeting signal sequence recognition event in the Endoplasmic Reticulum membrane. " Cell , Vol. 82 , 261-270 .
Kalies, K.U. et al. (1998 ). "The ß-subunit of the Sec61 complex facilitates cotranslational protein transport and interacts with the signal peptidase during translocation. " J. Cell Biol ., Vol. 141 , 887-894 .
Kim, Y.J. et al. (1994 ). "SecA protein is exposed to the periplasmic surface of the E.coli inner membrane in ist active state." Cell , Vol. 78 , 845-53 .
85
Kranz, J.E. and Holm, C. (1990 ). "Cloning by function: An alternative approach for identifying yeast homologs of genes from other organisms." Proc. Natl. Acad. Sci. USA , Vol. 87 , 6629-6633 .Kurihara, T. and Silver, P. (1993 ). "Suppression of a sec63 mutation identifies a novel component of the yeast Endoplasmic Reticulum translocation apparatus." Mol. Biol Cell ., Vol. 4 , 919-930 .
Laird, V. and High, S. (1997 ). "Discrete cross-linking products identified during membrane protein biosynthesis" . J. Biol. Chem ., Vol 272 , 1983-1989 .
Lipp, J. et al. (1989 ). "Structural requirements for membrane assembly of proteins spanning the membrane several times." J. Cell Biol ., Vol. 109 , 2013-2022 .
Lütcke, H. (1995 ). "Signal recognition particle (SRP), a ubiquitous initiator of protein translocation." FEBS , Vol. 228 , 531-550 .
Lyman, S. K. and Schekman, R. (1995 ). "Interaction between BiP and Sec63p is required for the completion of the protein translocation into the ER of Saccharomyces cerevisiae." J. Cell Biol ., Vol 131 , 1163-1171 .
Lyman, S.K. and Schekman, R. (1997 ). "Binding of secretory precursor polypeptides to a translocon subcomplex is regulated by BiP." Cell , Vol. 88 , 85-96 .
Matlack, K. E. S. et al. (1997 "). Protein transport by purified yeast Sec-complex and Kar2p without membranes. " Science , Vol. 277 , 938-941 .
Matlack, K. E. S. et al. (1999 ). "BiP acts as a molecular ratchet during posttranslational transport of prepro-? Factor across the ER membrane." Cell , Vol. 97 , 553-564 .
Menzel, R. et al. (1996 ). "Topogenesis of a microsomal cytochrome P450 and induction of Endoplasmic Reticulum membrane proliferation in Saccharomyces cerevisiae." Archives of Biochemistry and Biophysics , Vol. 330 , 97-109 .
Meyer, D. et al. (1982 ). "Secretory protein translocation across membranes: the role of the ’docking protein‘." Nature , Vol. 297 , 647-650 .
Meyer, T. H. et al. (1999 "). The bacterial Sec Y/E translocation complex forms channel-like structures similar to those of the eukaryotic Sec61p complex." J. Mol. Biol ., Vol. 285 , 1789-1800 .
Misselwitz, B. et al. (1998 ). "J proteins catalytically activate Hsp70 molecules to trap a wide range of peptide sequences." Mol. Cell ., Vol. 2 , 593-603 .
Möller, I. et al. (1998 ). "Unregulated exposure of the ribosomal M-site caused by NAC depletion results in delivery of non-secretory polypeptides to the Sec61 complex." FEBS , Vol. 441 , 1-5 .
86
Neuhof, A. et al. (1998 ). "Binding of signal recognition particle gives ribosome/nascent chain complexes a competitive advantage in endoplasmic reticulum membrane interaction." Mol. Biol. Cell , Vol. 9 , 103-115 .Ng, D.T.W. and Walter, P. (1996 "). ER membrane protein complex required for nuclear fusion." J. Cell Biol ., Vol. 132 , 499-509 .
Ng, D.T.W. et al. (1996 ). "Signal sequences specify the targeting route to the Endoplasmic Reticulum membrane." J. Cell Biol ., Vol. 134 , 269-278 .
Nishiyama, K. et al. (1996 ). "Inversion of the membrane topology of SecG coupled with SecA-dependent preprotein translocation." Cell , Vol. 85 , 71-81 .
Noel, P. and Cartwright, I.L. (1994 ). "A Sec62p-related component of the secretory protein translocon from Drosophila displays developmentally complex behavior." EMBO J ., Vol. 13 , 5253-61 .
Osborne, R.S. and Silhavy, T.J. (1993 ). "PrlA suppressor mutations cluster in regions corresponding to three distinct topological domains." EMBO J ., Vol. 12 , 3391-98 .
Palade, G. (1975 ). "Intracellular aspects of the process of protein synthesis." Science , Vol. 189 , 347-358 .
Panzner, S. et al. (1995 ). "Posttranslational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2p." Cell , Vol. 81 , 561-570 .
Plath, K. et al. (1998 ). "Signal sequence recognition on posttranslational protein transport across the yeast ER membrane." Cell , Vol. 94 , 795-807 .
Pohlschröder, M. et al. (1997 "). Protein translocation in the three domains of life: Variations on a theme. " Cell , Vol. 91 , 563-566 .
Radanyi, C. et al. (1994 ). "The ability of the immunophilin FKBP59-HBI to interact with the 90-kDa heat shock protein is encoded by ist tetratricopeptide repeat domain" . Proc. Natl. Acad. Sci. USA , Vol. 91 , 11197-11201 .
Raden, D. and Gilmore, R. (1998 ). "Signal recognition particle-dependent targeting of ribosomes to the rough Endoplasmic Reticulum in the absence and presence of the nascent polypeptide-associated complex." Mol. Biol. Cell , Vol. 8 , 117-130 .
Ramamurthy, V. and Oliver, D. (1997 "). Topology of the integral membrane form of E.coli SecA protein reveals multiple periplasmically exposed regions and modulation by ATP binding. " J. Biol. Chem ., Vol 272 , 23239-46 .
Rapiejko, P.J. and Gilmore, R. (1994 ). "Signal sequence recognition and targeting of ribosomes to the Endoplasmic Reticulum by the signal recognition particle do not require GTP." Mol. Biol. Cell , Vol. 5(8) , 887-897 .
87
Rothe, C. and Lehle, L. (1998 ). "Sorting of invertase signal peptide mutants in yeast dependent and independent on the signal-recognition particle." FEBS , Vol. 252 , 16-24 .Sadler, I. et al. (1989 ). "A yeast gene important for protein assembly into the ER and the nucleus has homology to DnaJ, an E.coli heat shock protein." J. Cell Biol ., Vol. 109 , 2665-75 .
Sambrook et al ., 2nd edition, 1989 . "Molecular Cloning" . Cold Spring Harbor Laboratory Press .
Schatz, P.J. et al. (1991 )."One of three transmembrane streches is sufficient for the functioning of the SecE protein, a membrane component of the E.coli secretion machinery." EMBO J ., Vol. 10 , 1749-57 .
Scidmore, M.A. et al. (1993 ). "Genetic interactions between KAR2 and SEC63, encoding eukaryotic homologues of Dank and DnaJ in the Endoplasmic Reticulum." Mol. Biol. Cell , Vol. 4 , 1145-1159 .
Skowronek, M.H. et al. (1999 ). "Molecular characterization of a novel mammalian DnaJ-like Sec63p homolog. " Biol. Chem ., Vol. 380 , 1133-1138 .
Spiess, M. (1995 ). "Heads or tails - what determines the orientation of proteins in the membrane." FEBS Lett , Vol. 369 , 76-79 .
Tajima, S. et al. (1986 ). "The signal recognition particle receptor is a complex that contains two distinct polypeptide chains." J. Cell Biol ., Vol. 103 , 1167-1178 .
Voigt, S. et al. (1996 ). "Signal sequence-dependent function of the TRAM protein during early phases of protein transport across the Endoplasmic reticulum membrane." J. Cell Biol ., Vol. 134 , 25-35 .
Walter, P. and Blobel, G. (1980 ). "Purification of a membrane-associated protein complex required for protein translocation across the Endoplasmic Reticulum." Proc. Natl. Acad. Sci. USA , Vol. 77 , 7112-7116 .
Walter, P. and Blobel, G. (1981 ). "Translocation of proteins across the Endoplasmic Reticulum. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes." J. Cell Biol ., Vol. 91 , 557-561 .
Wang, S. et al. (1995 ). "NAC covers ribosome-associated nascent chains thereby forming a protective environment for regions of nascent chains just emerging from the peptidyl transferase Center." J. Cell Biol ., Vol. 130 , 519-528 .
Wickner, W.T. and Lodish, H.F. (1985 ). "Multiple mechanismen of protein insertion into and across membranes. " Science , Vol. 230 , 400-407 .
88
Wiedmann, B. et al. (1994 ). "A protein complex required for signal-sequence-specific sorting and translocation." Nature , Vol. 370 , 434-440 .Wilkinson, B.M. et al. (1996 ). "Molecular architecture of the ER translocase probed by chemical crosslinking of Sss1p to complementary fragments of Sec61p." EMBO J ., Vol. 16 , 4549-4559 .
Wilkinson, B.M. et al. (1996b ). "Determination of the transmembrane topology of yeast Sec61p, an essential component of the Endoplasmic Reticulum translocation complex." J. Biol. Chem ., Vol. 271 , 25590-97 .
Wittke, S. et al. (1999 ). "Probing the molecular enviroment of membrane proteins in vivo. " Mol. Biol. Cell , Vol. 10 , 2519-2530 .
Woolford, J.L. (1989 ). "Nuclear pre-mRNA splicing in yeast." Yeast , Vol. 5 , 439-457 .
Woollatt, E. et al. (1999 "). Human Sec63 endoplasmic reticulum membrane protein, map position 6q21." Chromosome Res ., 1999, 77 .
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