1. Debrunner AM: Orthopädie, Orthopädische Chirurgie. 3., vollständig überarbeitete Auflage. Bern, Göttingen, Toronto, Seattle: Verlag Hans Huber; 1994; Seite: 630-634, 650-657, 666-667, 6723-456-81962-5

2. Davis H: Increasing rates of cervical and lumbar spine surgery in the United States, 1979-1990. Spine. 1994; Seite: 1117-1123

3. Hopf C, Reichel W, Brost F: Orthopädische Operationen. Hrsg.: Dick, Encke, Schuster: Prä- und postoperative Behandlung. Stuttgart: Wissenschaftliche Verlagsgesellschaft mbH; 1995; Seite: 454

4. Inthorn D, Hartl WH: Chirurgischer Stress, parenterale Ernährung. Hrsg.: Denecke H, Reichart B, Muhr G: Saegesser Spezielle chirurgische Therapie. 11., vollständig überarbeitete Auflage. Bern, Göttingen, Toronto, Seattle: 1996; Seite: 69-78

5. Bauer M, Rensing H, Ziegenfuß T: Anästhesie und perioperative Immunfunktion. Anaesthesist. 1998; 47; Seite: 538-556

6. Chrousos GP: Seminars in Medicine of the Beth Israel Hospital, Boston: The Hypothalamic-Pituitary-Adrenal Axis and Immune-Medicated Inflammation. Massachusetts Medical Society. 1995; 332(20); Seite: 1351-1362

7. Dahanukar SA, Thatte UM, Deshmukh UD, Kulkarni MK, Bapat RD: The influence of surgical stress on the psychoneuro-endocrine-immune axis. J Postgrad Med. 1996; 42; Seite: 12-14

8. Ogawa K, Hirai M, Katsube T et al.: Suppression of cellular immunity by surgical stress. Surgery. 2000; 127(3); Seite: 329-336

9. Delogu G, Moretti S, Antonucci A et al.: Apoptosis and Surgical Trauma - Dysregulated Expression of Death and Survival Factors on Peripheral Lymphocytes. Arch Surg. 2000; 135; Seite: 1141-1147

10. Baigrie RJ, Lamont PM, Kwiatkowski D, Dallmann MJ, Morris PJ: Systemic cytokine response after major surgery. Br J Surg. 1992; 79; Seite: 757-760

11. Munford RS, Pugin J: Normal Responses to Injury Prevent Systemic Inflammation and Can Be Immunosuppressive. Am J Respir Crit Care Med. 2001; 163; Seite: 316-321

12. Naito Y, Tamai S, Shingu K et al.: Responses of plasma adrenocorticotropic hormone, cortisol, and cytokines during and after upper abdominal surgery. Anesthesiology. 1992; 77(3); Seite: 426-431

13. Elenkov IJ, Wilder RL, Chrousos GP, Sylvester Vizi E: The Sympathetic Nerve-An Integrative Interface between Two Supersystems: The Brain and the Immune System. Pharmacol Rev. 2000; 52; Seite: 595-638

14. Greisen J, Hokland M, Grofte T et al.: Acute pain induces an instant increase in natural killer cell cytotoxity in humans and this response is abolished by local anaesthesia. British Journal of Anaesthesia. 1999; 83(2); Seite: 235-240

15. Päth G, Bornstein SR, Ehrhart-Bornstein M, Scherbaum WA: Interleukin-6 and the Interleukin-6 Receptor in the Human Adrenal Gland: Expression and Effects on Steroidogenesis. The Journal of Clinical Endocrinology and Metabolism. 1997; 82(7); Seite: 2343-2349

16. Päth G, Bornstein SR, Spath-Schwalbe E, Scherbaum WA: Direct effects of interleukin-6 on human adrenal cells. Endocr Res. 1996; 22(4); Seite: 867-873

17. Call GB, Husein OF, McIlmiol CJ, Adams A, Heckmann RA, Judd AM: Bovine Adrenal Cells Secrete Interleukin-6 and Tumor Necrosis Factor in Vitro. General and Comparative Endocrinology. 2000; 118; Seite: 249-261

18. Darling G, Goldstein DS, Stull R, Gorschboth CM, Norton JA: Tumor necrosis factor: immune endocrine interaction. Surgery. 1989; 106(6); Seite: 1155-1160

19. Panuncio AL, De La Pena S, Gualco G, Reissenweber N: Adrenergic innervation in reactive human lymph nodes. J Anat. 1999; 194(Pt1); Seite: 143-146

20. Alito AE, Romeo HE, Baler R, Chuluyan HE, Braun M, Cardinali DP: Autonomic nervous system regulation of murine immune responses as assessed by local surgical sympathetic and parasympathetic denervation. Acta Physiol Pharmacol Latinoam.. 1987; 37(3); Seite: 305-319

21. Sanders VM, Baker RA, Ramer-Quinn DS, Kasprowicz DJ, Fuchs BA, Street NE: Differential Expression of the ß2-Adrenergic Receptor by Th1 and Th2 Clones - Implications for Cytokine Production and B Cell Help. The Journal of Immunology. 1997; 158; Seite: 4200-4210

22. Mills PJ, Berry CC, Dimsdale JE, Ziegler MG, Nelesen RA, Kennedy BP: Lmphocyte Subset Redistribution in Response to Acute Experimental Stress: Effects of Gender, Ethnicity, Hypertension, and the Sympathetic Nervous System. Brain, Behavior, And Immunity. 1995; 9; Seite: 61-69

23. Torres KCL, Antonelli LRV, Souza ALS, Teixeira MM, Dutra WO, Gollob KJ: Norepinephrine, dopamine and dexamethasone modulate discrete leukocyte subpopulations and cytokine profiles from human PBMC. Journal of Neuroimmunology. 2005; 166; Seite: 144-157

24. Tabardel Y, Duchateau J, Schmartz D, Marecaux G, Shahla M, Barvais L, Leclerc JL, Vincent JL: Corticosteroids increase blood interleukin-10 levels during cardiopulmonary bypass in men. Surgery. 1996; 119(1); Seite: 76-80

25. Bloemena E, Weinreich S, Schellekens PT: The influence of prednisolone on the recirculation of peripheral blood lymphocytes in vivo. Clin Exp Immunol. 1990; 80(3); Seite: 460-466

26. Pountain GD, Keogan MT, Hazleman BL, Brown DL: Effects of single dose compared with three days' prednisolone treatment of healthy volunteers: contrasting effects on circulating lymphocyte subsets. J Clin Path. 1993; 46(12); Seite: 1089-1092

27. Ramierz F, Fowell DJ, Puklavec M, Simmonds S, Mason D: Glucocorticoids promote a TH2 cytokine response by CD4+ T cells in vitro. J Immunol. 1996; 156(7); Seite: 2406-2412

28. Calandra T, Bernhagen J, Metz CN et al.: MIF as a glucocorticoid-induced modulator of cytokine production. Nature. 1995; 377(6544); Seite: 68-71

29. Gelin JL, Moldawer LL, Iresjo BM, Lundholm KG: The role of the adrenals in the acute phase response to interleukin-1 and tumor necrosis factor-alpha. J Surg Res. 1993; 54(1); Seite: 70-78

30. Rhodes J, Ivanyi J, Cozens P: Antigen presentation by human monocytes: effects of modifying major histocompatibility complex class II antigen expression and interleukin 1 production by using recombinant interferons and corticosteroids. Eur J Immunol. 1986; 16(4); Seite: 370-375

31. Davis JM, Albert JD, Tracy KJ et al.: Increased neutrophil mobilization and decreased chemotaxis during cortisol and epinephrine infusions. J Trauma. 1991; 31(6); Seite: 725-731

32. Hogevold HE, Lyberg T, Kähler H, Haug E, Reikeras O: Changes in Plasma IL-1beta, TNF-alpha and IL-6 after Total Hip Replacement Surgery in General or Regional Anaesthesia. Cytokine. 2000; 12(7); Seite: 1156-1159

33. Koltun WA, Bloomer MM, Tilberg AF et al.: Awake epidural anesthesia is associated with improved natural killer cell cytotoxity and a reduced stress response. American Journal of Surgery. 1996; 171(1); Seite: 68-72

34. Hashimoto T, Hashimoto S, Hori Y, Nakagawa H, Hosokawa T: Epidural anaesthesia blocks changes in peripheral lymphocytes subpopulation during gastrectomy for stomach cancer. Acta Anaesthesiol Scand. 1995; 39; Seite: 294-298

35. Rem J, Brandt MR, Kehlet H: Prevention of postoperative lymphopenia and granulocytosis by epidural analgesia. Lancet. 1980; 1(8163); Seite: 283-284

36. Hollmann MW, Durieux ME: Local Anesthetics and the Inflammatory Response - A New Therapeutic Indication? Anesthesiology. 2000; 93; Seite: 858-875

37. Eisenstein TK, Hilburger ME: Opioid modulation of immune responses: effects on phagocyte and lymphoid cell populations. Journal of Neuroimmunology. 1998; 83; Seite: 36-44

38. Bar-Yosef S, Melamed R, Page GG, Shakhar G, Shakhar K, Ben-Eliyahu S: Attenuation of the Tumor-promoting Effect of Surgery by Spinal Blockade in Rats. Anesthesiology. 2001; 94; Seite: 1066-1073

39. Koga C, Itoh K, Aoki M et al.: Anxiety and pain suppress the natural killer cell activity in oral surgery outpatients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001; 91; Seite: 654-658

40. Marshall GD, Agarwal SK, Lloyd C, Cohen L, Henninger EM, Morris GJ: Cytokine Dysregulation Associated with Exam Stress in Healthy Medical Students. Brain, Behavior, And Immunity. 1998; 12; Seite: 297-307

41. Schulte am Esch J, Kochs E, Bause H: Duale Reihe, Anästhesie und Intensivmedizin. 2. Auflage. Stuttgart: Georg Thieme; 2000, 2002; Seite: 271-272

42. Ready B: Acute Postoperative Pain. Hrsg.: Miller RD: Anesthesia. Band 2.; New York, Edinburgh, London, Madrid, Melbourne, Milan, Tokyo: Verlag Churchill-Livingstone; 1994; Seite: 2328-2329, 2334

43. Duggan J, Drummond GBF: Activity of lower intercostal and abdominal muscle after surgery in humans. Anesth Analg. 1987; 66; Seite: 852-855

44. Ford GT, Whitelaw WA, Rosenal TW, Cruse PJ, Guenter CA: Diaphragm function after upper abdominal surgery in humans. Am Rev Resp Dis. 1983; 127; Seite: 431-436

45. Larsen R: Anästhesie. 7. Auflage. München, Jena: Verlag Urban und Fischer; 2001; Seite: 788

46. Heine G, Gabriel H, Weindler J, Ruprecht KW, Kindermann W: Painful regional anaesthesia induces an immunologic stress reaction: the model of retrobulbar anaesthesia. European Journal of Anaesthesiology. 2001; 18; Seite: 505-510

47. Sato N, Kikuchi S, Sato K: Quantifying the stress induced by distress in patients with lumbar disc herniation in terms of natural killer cell activity measurements: chronium release assay versus multiparameter flow cytometric assay. Spine. 2002; 27(19); Seite: 2095-2100

48. Schütz-Steinbach: Postoperative Analgesie. Hrsg.: Dick, Encke, Schuster: Prä- und Postoperative Behandlung. Stuttgart: Wissenschaftliche Verlagsgesellschaft mbH Stuttgart; 1995; Seite: 257, 262-263, 267-269

49. Lehmann KA: Recent Developments in Patient-Controlled Analgesia. J Pain Symptom Manage. 2005; 29(5S); Seite: S72-S89

50. Brill S, Gurman GM, Fisher A: A history of neuraxial administration of local analgesics and opioids. European Journal of Anaesthesiology. 2003; 20; Seite: 682-689

51. Büch HP, Rummel W: Lokalanästhetika, Lokalanästhesie. Hrsg.: Forth W, Henschler D, Rummel W, Starke K: Allgemeine und spezielle Pharmakologie und Toxikologie. 7. Auflage. Heidelberg, Berlin, Oxford: Spektrum Akademischer Verlag; 1996; Seite: 227

52. Scherer R, Schmutzler M, Erhard J, Lenz A, Stocker L: The integration of thoracic epidural anesthesia into anesthesia for intra-abdominal surgery. Anaesthesist. 1992; 41(5); Seite: 260-265

53. Royakkers AANM, Willigers H, Van Der Ven AJ, Wilmink J, Durieux M, Van Kleef M: Catheter-related epidural abscesses - Don't wait for neurological deficits. Acta Anaesthesiol Scand. 2002; 46; Seite: 611-615

54. Kehlet H, Holte K: Effect of postoperative analgesia on surgical outcome. Br J Anaesth. 2001; 87(1); Seite: 62-72

55. Liu SS, Allen HW, Olsson GL: Patient-controlled Epidural Analgesia with Bupivacaine and Fentanyl on Hospital Wards: Prospective Experience with 1,030 Surgical Patients. Anesthesiology. 1998; 88(3); Seite: 688-695

56. Rigg JRA, Jamrozik K, Myles PS et al.: Epidural anaesthesia and analgesia and outcome of major surgery: a randomised trial. Lancet. 2002; 359; Seite: 1276-1282

57. Dolin SJ, Cashman JN, Bland JM: Effectiveness of acute postoperative pain management: I. Evidence from published data. Br J Anaesth. 2002; 89(3); Seite: 409-423

58. Joshi GP, McCarroll SM, O'Rourke K: Postoperative Analgesia After Lumbar Laminectomy: Epidural Fentanyl Infusion Versus Patient-Controlled Intravenous Morphine. Anesth Analg. 1995; 80; Seite: 511-514

59. Gottschalk A, Freitag M, Tank S et al.: Quality of Postoperative Pain Using an Intraoperatively Placed Epidural Catheter after Major Lumbar Spinal Surgery. Anesthesiology. 2004; 101; Seite: 175-180

60. Azad SC, Groh J, Beyer A, Schneck D, Dreher E, Peter K: Kontinuierliche Periduralanalgesie versus patientenkontrollierte intravenöse Analgesie - Schmerztherapie nach Thorakotomien Anaesthesist. 2000; 49; Seite: 9-17

61. Hübler M, Litz RJ, Sengebusch KH et al.: A comparison of five solutions of local anaesthetics and/or sufentanil for continuous, postoperative epidural analgesia after major urological surgery. European Journal of Anaesthesiology. 2001; 18; Seite: 450-457

62. Chestnut DH: Efficacy and Safety of Epidural Opioids for Postoperative Analgesia. Anesthesiology. 2005; 102; Seite: 221-223

63. Niiyama Y, Kawamata T, Shimizu H, Omote K, Namiki A: The addition of epidural morphine to ropivacaine improves epidural analgesia after lower abdominal surgery. Can J Anesth. 2005; 52(2); Seite: 181-185

64. Pouzeratte Y, Delay JM, Brunat G et al.: Patient-Controlled Epidural Analgesia After Abdominal Surgery: Ropivacaine Versus Bupivacaine. Anesth Analg. 2001; 93; Seite: 1587-1592

65. Torda TA, Hann P, Mills G, De Leon G, Penman D: Comparison of extradural fentanyl, bupivacaine and two fentanyl-bupivacaine mixtures for pain relief after abdominal surgery. Br J Anaesth. 1995; 74; Seite: 35-40

66. Tsuji H, Shirasaka C, Asoh T, Uchida I: Effects of epidural administration of local anaesthetics or morphine on postoperative nitrogen loss and catabolic hormones. Br J Surg. 1987; 74(5); Seite: 421-425

67. Christensen P, Brandt MR, Rem J, Kehlet H: Influence of extradural morphine on the adrenocortical and hyperglycaemic response to surgery. Br J Anaesth. 1982; 54(1); Seite: 23-27

68. Rutberg H, Hakanson E, Anderberg B, Jorfeldt L, Martensson J, Schildt B: Effects of the extradural administration of morphine, or bupivacaine, on the endocrine response to upper abdominal surgery. Br J Anaesth. 1984; 56(3); Seite: 233-238

69. Engquist A, Brandt MR, Fernandes A, Kehlet H: The blocking effect of epidural analgesia on the adrenocortical and hyperglycemic responses to surgery. Acta Anaesthesiol Scand. 1977; 21(4); Seite: 330-335

70. Kehlet H: The stress response to surgery: release mechanisms and the modifying effect of pain relief. Acta Chir Scand Suppl. 1988; 550; Seite: 22-28

71. Liu S, Carpenter RL, Neal JM: Epidural Anesthesia and Analgesia: Their Role in Postoperative Outcome. Anesthesiology. 1995; 82(6); Seite: 1474-1506

72. Moss NM, Gough DB, Jordan AL et al.: Temporal correlation of impaired immune response after thermal injury with susceptibility to infection in a murine model. Surgery. 1988; 104(5); Seite: 882-887

73. Lundy J, Lovett EJ 3rd, Hamilton S, Conran P: Halothane, surgery, immunosuppression and artificial pulmonary metastases. Cancer. 1978; 41(3); Seite: 827-830

74. Tanemura H, Sakata K, Kunieda T, Saji S, Yamamoto S, Takekoshi T: Influences of operative stress on cell-mediated immunity and on tumor metastasis and their prevention by nonspecific immunotherapy: experimental studies in rats. J Surg Oncol. 1982; 21(3); Seite: 189-195

75. Beilin B, Shavit Y, Trabekin E et al.: The Effects of postoperative Pain Management on Immune Response to Surgery. Anesth Analg. 2003; 97; Seite: 822-827

76. Yeager MP, Glass DD, Neff RK, Brinck-Johnsen T: Epidural anesthesia and analgesia in high-risk surgical patients. Anesthesiology. 1987; 66(6); Seite: 729-736

77. Cuschieri RJ, Morran CG, Howie JC, McArdle CS: Postoperative pain and pulmonary complications: comparison of three analgesic regimens. Br J Surg. 1985; 72(6); Seite: 495-498

78. Ballantyne JC, Carr DB, deFerranti S et al.: The comparative effects of postoperative analgesic therapies on pulmonary outcome: cumulative meta-analyses of randomized, controlled trials. Reg Anesth. 1994; 19(5); Seite: 307-315

79. Jayr C, Mollie A, Bourgain JL et al.: Postoperative pulmonary complications: general anesthesia with postoperative parenteral morphine compared with epidural analgesia. Surgery. 1988; 104(1); Seite: 57-63

80. Brodner G, Mertes N, Van Aken H et al.: What Concentration of Sufentanil Should be Combined with Ropivacaine 0.2% wt/vol for Postoperative Patient-Controlled Epidural Analgesia? Anesth Analg. 2000; 90; Seite: 649-657

81. De Cosmo G, Primieri P, Adducci E, Fiorenti M, Beccia G: Epidural analgesia in abdominal surgery: 0.2% ropivacaine with sufentanil. Minerva Anestesiol. 2004; 70(6); Seite: 503-508

82. Casati A, Santorsola R, Cerchierini E, Moizo E: Ropivacaine. Minerva Anestesiol. 2001; 67(9 Suppl 1); Seite: 15-19

83. Scholz J, Steinfath M, Koch C, Rundshagen I: Pharmakologische Grundlagen der postoperativen Schmerztherapie - Epidurale Opioidapplikation Anaesthesist. 1997; 46[Suppl 3]; Seite: S154-S158

84. Bone RC: Sir Isaac Newton, sepsis, SIRS, and CARS Crit Care Med. 1996; 24(7); Seite: 1125-1128

85. Guirao X, Lowry SF: Biologic Control of Injury and Inflammation: Much More than Too Little or Too Late. Workl J Surg. 1996; 20(4); Seite: 437-446

86. Lin E, Calvano SE, Lowry SF: Inflammatory cytokines and cell response in surgery. Surgery. 2000; 127(2); Seite: 117-126

87. Polk HC Jr, George CD, Wellhausen SR et al.: A systematic study of host defense processes in badly injured patients. Ann Surg. 1986; 204(3); Seite: 282-299

88. Faist E: Der Einfluß der ausgedehnten operativen Intervention auf die zellvermittelte Immunantwort. Gynäkologe. 1995; 28; Seite: 72-83

89. Aosasa S, Ono S, Mochizuki H et al.: Activation of Monocytes and Endothelial Cells Depends on the Severity of Surgical Stress. World J Surg. 2000; 24(1); Seite: 10-16

90. Ziegenfuß T, Wanner GA, Grass G et al.: Mixed agonistic-antagonistic cytokine response in whole blood from patients undergoing abdominal aortic aneurysm repair. Intensive Care Med. 1999; 25; Seite: 279-287

91. Yokoyama M, Itano Y, Mizobuchi S et al.: The Effects of Epidural Block on the Distribution of Lymphocyte Subsets and Natural-Killer Cell Activity in Patients with and without pain. Anesth Analg. 2001; 92; Seite: 463-469

92. Novak-Jankovic V, Paver-Erzen V, Bovill JG, Ihan A, Osredkar J: Effect of epidural and intravenous clonidine on the neuro-endocrine and immune stress response in patients undergoing lung surgery. European Journal of Anaesthesiology. 2000; 17; Seite: 50-56

93. Kato M, Suzuki H, Murakami M, Akama M, Matsukawa S, Hashimoto Y: Elevated Plasma Levels of Interleukin-6, Interleukin-8, and Granulocyte Colony-Stimulating Factor During and After Major Abdominal Surgery. J Clin Anesth. 1997; 9; Seite: 293-298

94. Shimaoka M, Hosotsubo K, Sugimoto M et al.: The influence of surgical stress on T cells: enhancement of early phase lymphocyte activation. Anesth Analg. 1998; 87; Seite: 1431-1435

95. Akural EI, Salomäki TE, Bloigu AH et al.: The effects of pre-emptive epidural sufentanil on human immune function. Acta Anaesthesiol Scand. 2004; 48; Seite: 750-755

96. Toft P, Tonnesen E, Helbo-Hansen HS, Lillevang ST, Rasmussen JW, Christensen NJ: Redistribution of granulocytes in patients after major surgical stress. APMIS. 1994; 102(1); Seite: 43-48

97. Toft P, Svendsen P, Tonnesen E, Rasmussen JW, Christensen NJ: Redistribution of lymphocytes after major surgical stress. Acta Anaesthesiol Scand. 1993; 37(3); Seite: 245-249

98. Oka M, Hirazawa K, Yamamoto K et al.: Induction of Fas-Mediated Apoptosis on Circulating Lymphocytes by Surgical Stress. Ann Surg. 1996; 223(4); Seite: 434-440

99. Cheadle WG, Hershman MJ, Wellhausen SR, Polk HC Jr.: HLA-DR antigen expression on peripheral blood monocytes correlates with surgical infection. Am J Surg. 1991; 161(6); Seite: 639-645

100. Wakefield CH, Carey PD, Foulds S, Monson JR, Guillou PJ: Changes in major histocompatibility complex class II expression in monocytes and T cells of patients developing infection after surgery. Br J Surg. 1993; 80(2); Seite: 205-209

101. Ho CSK, Lopez JA, Vuckovic S, Pyke CM, Hockey RL, Hart DNJ: Surgical and physical stress increases circulating blood dendritic cell counts independently of monocyte counts. Blood. 2001; 98(1); Seite: 140-145

102. Kawasaki T, Ogata M, Kawasaki C, Tomihisa T, Okamoto K, Shigematsu A: Surgical Stress Induces Endotoxin Hyporesponsiveness and an Early Decrease of Monocyte mCD14 and HLA-DR Expression During Surgery. Anesth Analg. 2001; 92; Seite: 1322-1326

103. Volk T, Döpfmer UR, Schmutzler M et al.: Stress induced IL-10 does not seem to be essential for early monocyte deactivation following cardiac surgery. Cytokine. 2003; 24; Seite: 237-243

104. de Metz J, Romijn JA, Endert E et al.: Interferon-gamma increases monocyte HLA-DR expression without effects on glucose and fat metabolism in postoperative patients. J Appl Physiol. 2004; 96; Seite: 597-603

105. Klava A, Windsor AC, Farmery SM et al.: Interleukin-10. A role in the development of postoperative immunosuppression. Arch Surg. 1997; 132(4); Seite: 425-429

106. de Waal Malefyt R, Haanen J, Spits H et al.: Interleukin 10 (IL-10) and Viral IL-10 Strongly Reduce Antigen-specific Human T Cell Proliferation by Diminishing the Antigen-presenting Capacity of Monocytes via Downregulation of Class II Major Histocompatibility Complex Expression. J Exp Med. 1991; 174; Seite: 915-924

107. Guo Y, Dickerson C, Chrest FJ, Adler WH, Munster AM, Winchurch RA: Increased levels of circulating interleukin 6 in burn patients. Clin Immunol Immunopathol. 1990; 54(3); Seite: 361-371

108. Tilg H, Dinarello CA, Mier JW: IL-6 and APPs: anti-inflammatory and immunosuppressive mediators. Immunology Today. 1997; 18(9); Seite: 428-432

109. Zhou D, Kusnecov AW, Shurin MR, DePaoli M, Rabin BS: Exposure to Physical and Psychological Stressors Elevates Plasma Interleukin 6: Relationship to the Activation of Hypothalamic-Pituitary-Adrenal Axis Endocrinology. 1993; 133; Seite: 2523-2530

110. Keller P, Keller C, Robinson LE, Pedersen BK: Epinephrine infusion increases adipose interleukin-6 gene expression and systemic levels in humans. Journal of Applied Physiology. 2004; 97; Seite: 1309-1312

111. Shalaby MR, Waage A, Aarden L, Espevik T: Endotoxin, tumor necrosis factor-alpha and interleukin 1 induce interleukin 6 production in vivo. Clin Immunol Immunopathol. 1989; 53(3); Seite: 488-498

112. DeRijk R, Michelson D, Karp B et al.: Exercise and Circadian Rhythm-Induced Variations in Plasma Cortisol Differentially Regulate Interleukin-1beta (IL-1beta), IL-6, and Tumor Necrosis Factor-alpha (TNFalpha) Production in Humans: High Sensitivity of TNFalpha and Resistance of IL-6. J Clin Endocrinol Metab. 1997; 82; Seite: 2182-2191

113. Sapolsky RM, Romero LM, Munck AU: How Do Glucocorticoids Influence Stress Responses? Integrating Permissive, Suppressive, Stimulatory, and Preparative Actions. Endocrine Reviews. 2000; 21(1); Seite: 55-89

114. Hagiwara E, Abbasi F, Mor G, Ishigatsub Y, Klinman DM: Phenotye and Frequency of Cells secreting IL-2, IL-4, IL-6, IL-10, IFN AND TNF-alpha in Human Peripheral Blood. Cytokine. 7(8); 1995; Seite: 815-822

115. Shalaby MR, Waage A, Espevik T: Cytokine regulation of interleukin 6 production by human endothelial cells. Cell Immunol. 1989; 121(2); Seite: 372-382

116. Gloddek J, Lohrer P, Stalla J, Arzt E, Stalla GK, Renner U: The intrapituitary stimulatory effect of lipopolysaccharide on ACTH secretion is mediated by paracrine-acting IL-6. Exp Clin Endocrinol Diabetes. 2001; 109; Seite: 410-415

117. Gonzalez-Hernandez JA, Bornstein SR, Ehrhart-Bornstein M, Spath-Schwalbe E, Jirikowski G, Scherbaum WA: Interleukin-6 messenger ribonucleic acid expression in human adrenal gland in vivo: new clue to a paracrine or autocrine regulation of adrenal function. J Clin Endocrinol Metab. 1994; 79(5); Seite: 1492-1497

118. Steensberg A, Fischer CP, KellerC, Møller K, Pedersen BK: IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans. Am J Physiol Endocrinol Metab. 2003; 285;

119. Van Snick J: Interleukin-6: An Overview. Annu Rev lmmunol. 1990; 8; Seite: 253-278

120. Bethin KE, Vogt SK, Muglia LJ: Interleukin-6 is an essential, corticotropin-releasing hormone-independent stimulator of the adrenal axis during immune system activation. PNAS. 2000; 97(16); Seite: 9317 - 9322

121. Sheeran P, Hall GM: Cytokines in anaesthesia. Br J Anaesth. 1997; Seite: 201-219

122. Netea MG, Kullberg BJ, Van der Meer JWM: Circulating Cytokines as Mediators of Fever. Clinical Infectious Diseases. 2000; 31(Suppl 5); Seite: S178–S184

123. Wu CT, Jao SW, Bores CO et al.: The Effect of Epidural Clonidine on Perioperative Cytokine Response, Postoperative Pain, and Bowel Function in Patients Undergoing Colorectal Surgery. Anesth Analg. 2004; 99; Seite: 502-509

124. Ertel W, Morrison MH, Ayala A, Perrin MM, Chaudry IH: Anti-TNF monoclonal antibodies prevent haemorrhage-induced suppression of Kupffer cell antigen presentation and MHC class II antigen expression. Immunology. 1991; 74(2); Seite: 290-297

125. Welters I: Opioide und Immunsuppression - Klinische Relevanz? Anaesthesist. 2003; 52; Seite: 442-452

126. Bernardini R, Kamilaris TC, Calogero AE et al.: Interactions between tumor necrosis factor-alpha, hypothalamic corticotropin-releasing hormone, and adrenocorticotropin secretion in the rat. Endocrinology. 1990; 126(6); Seite: 2876-2881

127. Watanobe H, Takebe K: Intravenous administration of tumor necrosis factor-alpha stimulates corticotropin releasing hormone secretion in the push-pull cannulated median eminence of freely moving rats. Neuropeptides. 1992; 22(2); Seite: 81-84

128. Barney M, Call GB, McIlmoil CJ et al.: Stimulation by interleukin-6 and inhibition by tumor necrosis factor of cortisol release from bovine adrenal zona fasciculata cells through their receptors. Endocrine. 2000; 13(3); Seite: 369-377

129. Foex BA: Systemic responses to trauma. British Medical Bulletin. 1999; 55(4); Seite: 726-743

130. Damas P, Canivet J-L, De Groote D et al.: Sepsis and serum cytokine concentrations. Crit Care Med. 1997; 25(3); Seite: 405-412

131. Helmy SAK, Wahby MAM, El-Nawaway M: The effect of anaesthesia and surgery on plasma cytokine production. Anaesthesia. 1999; 54; Seite: 733-738

132. Nishino T, Bernhagen J, Shiiki H, Calandra T, Dohi K, Bucala R: Localization of macrophage migration inhibitory factor (MIF) to secretory granules within the corticotrophic and thyrotrophic cells of the pituitary gland. Mol Med. 1995; 1(7); Seite: 781-788

133. Bacher M, Meinhardt A, Lan HY et al.: Migration inhibitory factor expression in experimentally induced endotoxemia. Am J Pathol. 1997; 150(1); Seite: 235-246

134. Baugh JA, Bucala R: Macrophage migration inhibitory factor. Crit Care Med. 2002; 30(Suppl. 1); Seite: S27-S35

135. Bernhagen J, Calandra T, Mitchell RA et al.: MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia. Nature. 1993; 365(6448); Seite: 756-759

136. Calandra T, Bernhagen J, Mitchell RA, Bucala R: The Macrophage Is an Important and Previously Unrecognized Source of Macrophage Migration Inhibitory Factor. J Exp Med. 1994; 179; Seite: 1895-1902

137. Bacher M, Metz CN, Calandra T et al.: An essential regulatory role for macrophage migration inhibitory factor in T-cell activation. Proc Natl Acad Sci USA. 1996; 93; Seite: 7849-7854

138. Koebernick H, Grode L, David JR et al.: Macrophage migration inhibitory factor (MIF) plays a pivotal role in immunity against Salmonella typhimurium. PNAS. 2002; 99(21); Seite: 13681–13686

139. Calandra T, Spiegel LA, Metz CN, Bucala R: Macrophage migration inhibitory factor is a critical mediator of the activation of immune cells by exotoxins of Gram-positive bacteria. Proc Natl Acad Sci USA. 1998; 95; Seite: 11383–11388

140. Gando S, Nishihira J, Kobayashi S, Morimoto Y, Nanzaki S, Kemmotsu O: Macrophage migration inhibitory factor is a critical mediator of systemic inflammatory response syndrome. Intensive Care Med. 2001; 27; Seite: 1187-1193

141. Lehmann LE, Novender U, Schroeder S et al.: Plasma levels of macrophage migration inhibitory factor are elevated in patients with severe sepsis. Intensive Care Med. 2001; 27; Seite: 1412-1415

142. Beishuizen A, Thijs L, Haanen C, Vermes I: Macrophage Migration Inhibitory Factor and Hypothalamo-Pituitary-Adrenal Function during Critical Illness. J Clin Endocrinol Metab. 2001; 86; Seite: 2811–2816

143. Gando S, Nishihira J, Kobayashi S, Morimoto Y, Matsushita M, Kemmotsu K: Systemic Macrophage Migration Inhibitory Factor Release Following Hepatic Resection. Surg Today. 2001; 31; Seite: 605–609

144. Hira E, Ono T, Dhar DK et al.: Overexpression of Macrophage Migration Inhibitory Factor Induces Angiogenesis and Deteriorates Prognosis after Radical Resection for Hepatocellular Carcinoma. Cancer. 2005; 103; Seite: 588–598

145. Meyer-Siegler K, Hudson PB: Enhanced expression of macrophage migration inhibitory factor in prostatic adenocarcinoma metastasis. Urology. 1996; 48; Seite: 448-452

146. Akbar AMF, Abe M, Murakami H et al.: Macrophage migration inhibitory factor in hepatocellular carcinoma and liver cirrhosis; relevance to pathogenesis. Cancer Letters. 2001; 171; Seite: 125-132

147. Hogaboam CM, Lukacs NW, Chensue SW, Strieter RM, Kunkel SL: Monocyte Chemoattractant Protein-1 Synthesis by Murine Lung Fibroblasts Modulates CD4+ T Cell Activation. The Journal of Immunology. 1998; 160; Seite: 4606-4614

148. Volk T, Hensel M, Schuster H, Kox WJ: Secretion of MCP-1 and IL-6 by cytokine stimulated production of reactive oxygen species in endothelial cells. Mol Cell Biochem. 2000; 206; Seite: 105–112

149. al-Mughales J, Blyth TH, Hunter JA, Wilkinson PC: The chemoattractant activity of rheumatoid synovial fluid for human lymphocytes is due to multiple cytokines. Clin Exp Immunol. 1996; 106(2); Seite: 230-236

150. Tonouchi H, Miki C, Ohmori Y et al.: Serum Monocyte Chemoattractant Protein-1 in Patients with Postoperative Infectious Complications from Gastrointestinal Surgery for Cancer. World J Surg. 2004; 28(2); Seite: 130-136

151. Hermanowski-Vosatka A, Mundt SS, Ayala JM et al.: Enzymatically Inactive Macrophage Migration Inhibitory Factor Inhibits Monocyte Chemotaxis and Random Migration. Biochemistry. 1999; 38; Seite: 12841-12849

152. Carr MW, Roth SJ, Luther E, Rose SS, Springer TA: Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. Proc Natd Acad Sci USA. 1994; 91; Seite: 3652-3656

153. Gu L, Tseng S, Horner RM, Tam C, Loda M, Rollins BJ: Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1. Nature. 2000; 404; Seite: 407-411

154. Zisman DA, Kunkel SL, Strieter RM et al.: MCP-1 Protects Mice in Lethal Endotoxemia. J Clin Invest. 1997; 99(12); Seite: 2832–2836

155. Penson RT, Kronish K, Duan Z et al.: Cytokines IL-1beta, IL-2, IL-6, IL-8, MCP-1, GM-CSF and TNFalpha in patients with epithelial ovarian cancer and their relationship to treatment with paclitaxel. Int J Gynecol Cancer. 2000; 10; Seite: 33-41

156. Kawahito K, Adachi H, Ino T: Influence of Surgical Procedures on Interleukin-6 and Monocyte Chemotactic and Activating Factor Responses: CABG vs. Valvular Surgery. Journal of Interferon and Cytokine Research. 2000; 20; Seite: 1-6

157. Jedynak M, Siemiatkowski A, Gacko M, Mroczko B, Borkowski J: Serum concentrations of MCP-1 and RANTES in patients during aortic surgery: the relationship with ischemia-reperfusion. Arch Immunol Ther Exp. 2004; 52; Seite: 201–207

158. Huang T-J, Hsu RW-W, Li Y-Y, Cheng C-C: Less systemic cytokine response in patients following microendoscopic versus open lumbar discectomy. Journal of Orthopaedic Research. 2005; 23; Seite: 406–411

159. Sari R, Sevinc A: The effects of laparascopic cholecystectomy operation on C-reactive protein, hormones, and cytokines. J Endocrinol Invest. 2004; 27; Seite: 106-110

160. Wrigge H, Uhlig U, Zinserling J et al.: The Effects of Different Ventilatory Settings on Pulmonary and Systemic Inflammatory Responses During Major Surgery. Anesth Analg. 2004; 98; Seite: 775–781

161. Kato M, Honda I, Suzuki H, Murakami M, Matsukawa S, Hashimoto Y: Interleukin-10 Production During and After Upper Abdominal Surgery. Journal of Clinical Anesthesia. 1998; 10; Seite: 184 –188

162. Opal SM, Wherry JC, Grint P: Interleukin-10: Potential Benefits and Possible Risks in Clinical Infectious Diseases. Clinical Infectious Diseases. 1998; 27; Seite: 1497–1507

163. Taga K, Tosato G: IL-10 Inhibits Human T Cell Proliferation and IL-2 Production. The Journal of Immunology. 1992; 148(4); Seite: 1143-1148

164. Mocellin S, Panelli M, Wang E et al.: IL-10 stimulatory effects on human NK cells explored by gene profile analysis. Genes Immun. 2004; 5(8); Seite: 621-630

165. Rousset F, Garcia E, Defrance T et al.: Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc Nati Acad Sci USA. 1992; 89; Seite: 1890-1893

166. Westendorp RGJ, Langermans JAM, Huizinga TWJ et al.: Genetic influence on cytokine production and fatal meningococcal disease. Lancet. 1997; 349; Seite: 170–173

167. Gomez-Jimenez J, Martin MC, Sauri R et al.: Interleukin-10 and the monocyte/macrophage-induced inflammatory response in septic shock. J Infect Dis. 1995; 171(2); Seite: 472-475

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