Publikationen

Tagungsbeiträge

Glinski, M., Walther, M. & Zocher, R. (1996): "Cyclosporin synthetase: Kinetic measurements of the binding sites of D-Ala, L-Ala, and L-Leu." Frühjahrstagung der VAAM, 24.-27.03.1996, Bayreuth, Deutschland

Glinski, M., Walther, M. & Zocher, R. (1996): "Cyclosporin Synthetase: Kinetic Analysis of Cyclo-(D-Ala-MeLeu) and Cyclo-(L-Ala-MeLeu) Formation and Studies on the Mechanism of Cyclosporin Biosynthesis." Symposium: Enzymology of Bi o synthesis of Natural Products, 22.-25.09.1996, Berlin, Deutschland

Walther, M., Ivanov, I. & Kühn, H. (2000): "Oxygenation of omega-branched fatty acids by wild-type and mutant rabbit 15-lipoxygenase species." 11 ^th International Confe r ence on Advances in Prostaglandin and Leukotriene Research, 04.-08.06.2000, Florenz, Italien

Veröffentlichungen in Fachzeitschriften

Hornung, E., Walther, M., Kühn, H. & Feussner, I. (1999): "Conversion of cucumber linoleate 13-lipoxygenase to a 9-lipoxygenating species by site-directed mutagenesis." Proc Natl Acad Sci 96: 4192-4197.

Kühn, H., Kuban, R., Walther, M. & Veldink, G. A. (1999): "X-ray absorption studies into the iron ligand sphere of plant and animal lipoxygenases." Adv Exp Med Biol 469: 99-104.

Walther, M., Holzhütter, H. G., Kuban, R. J., Wiesner, R., Rathmann, J. & Kühn, H. (1999): "The inhibition of mammalian 15-lipoxygenases by the anti-inflammatory drug ebselen: dual-type mechanism involving covalent linkage and alteration of the iron ligand sphere." Mol Pharmacol 56: 196-203.

Schwarz, K., Walther, M., Anton, M., Gerth, C., Feussner, I. & Kühn, H. (2001): "Structural basis for lipoxygenase specificity. Conversion of the human leukocyte 5-lipoxygenase to a 15-lipoxygenating enzyme species by site-directed mutagenesis." J Biol Chem 276: 773-779.

Walther, M., Ivanov, I., Myagkova, G. & Kühn, H. (2001): "Alterations of lipoxygenase specificity by targeted substrate modification and site-directed mutagenesis." Chem Biol 8: 779-790.

Walther, M., Anton, M., Wiedmann, M., Fletterick, R. & Kühn, H. (2002): "The N-terminal domain of the reticulocyte-type 15-lipoxygenase is not essential for enzymatic activity but contains determinants for membrane binding." J Biol Chem 277: 27360-27366.

Kühn, H., Walther, M. & Kuban, R.-J. (2002): "Mammalian arachidonate 15-lipoxygenases: structure, function, and biological implications." Prostaglandins Other Lipid Mediat 68-69: 263-290.

Wiesner, R., Suzuki, H., Walther, M., Yamamoto, S. & Kühn, H. (2003): "Suicidal inactivation of the rabbit 15-lipoxygenase by 15S-HpETE is paralleled by covalent modification of active site peptides." Free Rad Biol Med 34: 304-315.