Untersuchungen zur Enzym-Ligand- Wechselwirkung bei tierischen LipoxygenasenMatthias Walther11.11234561.21.2.171.2.2891.2.310111.2.412131.2.51.31415161.417181.51.5.1191.5.22021221.5.323241.5.4252627281.6291.6.130311.7322322.12.1.13334352.1.2363738392.1.32.1.4404142432.1.52.2442.2.145462.2.22.3472.3.12.3.22.3.3482.3.4492.3.5502.3.6512.3.7522.42.4.12.4.1.12.4.1.253542.4.22.4.2.1552.4.2.22.4.2.356572.4.32.4.4582.4.52.52.5.12.5.2592.5.32.62.6.1602.6.2612.6.32.6.42.6.52.6.5.162632.6.5.2642.6.5.3652.6.62.72.7.1662.7.22.7.3672.82.8.12.8.2682.8.3693693.13.1.1703.1.2713.23.2.1723.2.1.1733.2.1.27475763.2.1.37778793.2.1.48081823.2.1.5838485863.2.2873.2.2.188893.2.2.290913.2.2.392933.2.2.4943.2.2.595969798993.33.3.11001011021033.3.21041053.3.31061071081091101111121133.3.411441144.14.21154.2.11164.2.21174.2.31181194.2.41204.34.3.11214.3.21224.44.4.14.4.21234.4.34.4.4124AbkürzungsverzeichnisLiteraturverzeichnisErklärungTabellarischer LebenslaufPublikationenDanksagungdeInhaltsverzeichnisHilfe Literaturverzeichnis Aharony, D. und Stein, R. L.; (1986): Kinetic mechanism of guinea pig neutrophil 5-lipoxygenase, J Biol Chem; 261 [25], Seite 11512-9. Anderson, K. M.; Seed, T.; Meng, J.; Ou, D.; Alrefai, W. A. und Harris, J. E.; (1998): Five-lipoxygenase inhibitors reduce Panc-1 survival: the mode of cell death and synergism of MK886 with gamma linolenic acid, Anticancer Res; 18 [2A], Seite 791-800. Andre, E. und Hou, K.W.; (1932): The presence of a lipid oxidase in soybean Glycine soya., Acad Sci; 194, Seite 645-647. Anton, R. und Vila, L.; (2000): Stereoselective biosynthesis of hepoxilin B3 in human epidermis, J Invest Dermatol; 114 [3], Seite 554-9. Avis, I.; Hong, S. H.; Martinez, A.; Moody, T.; Choi, Y. H.; Trepel, J.; Das, R.; Jett, M. und Mulshine, J. L.; (2001): Five-lipoxygenase inhibitors can mediate apoptosis in human breast cancer cell lines through complex eicosanoid interactions, Faseb J; 15 [11], Seite 2007-9. Belkner, J.; Stender, H.; Holzhutter, H. G.; Holm, C. und Kuhn, H.; (2000): Macrophage cholesteryl ester hydrolases and hormone-sensitive lipase prefer specifically oxidized cholesteryl esters as substrates over their non-oxidized counterparts, Biochem J; 352 Pt 1, Seite 125-33. l Belkner, J.; Stender, H. und Kuhn, H.; (1998): The rabbit 15-lipoxygenase preferentially oxygenates LDL cholesterol esters, and this reaction does not require vitamin E, J Biol Chem; 273 [36], Seite 23225-32. Belkner, J.; Wiesner, R.; Rathman, J.; Barnett, J.; Sigal, E. und Kuhn, H.; (1993): Oxygenation of lipoproteins by mammalian lipoxygenases, Eur J Biochem; 213 [1], Seite 251-61. Benz, D. J.; Mol, M.; Ezaki, M.; Mori-Ito, N.; Zelan, I.; Miyanohara, A.; Friedmann, T.; Parthasarathy, S.; Steinberg, D. und Witztum, J. L.; (1995): Enhanced levels of lipoperoxides in low density lipoprotein incubated with murine fibroblast expressing high levels of human 15-lipoxygenase, J Biol Chem; 270 [10], Seite 5191-7. l Berger, M.; Schwarz, K.; Thiele, H.; Reimann, I.; Huth, A.; Borngraber, S.; Kuhn, H. und Thiele, B. J.; (1998): Simultaneous expression of leukocyte-type 12-lipoxygenase and reticulocyte-type 15-lipoxygenase in rabbits, J Mol Biol; 278 [5], Seite 935-48. Bisakowski, B.; Perraud, X. und Kermasha, S.; (1997): Characterization of hydroperoxides and carbonyl compounds obtained by lipoxygenase extracts of selected microorganisms, Biosci Biotechnol Biochem; 61 [8], Seite 1262-9. Bligh, E.G. und Dyer, W.J.; (1959): A rapid method of total lipid extraction and purification., Canad J Biochem Physiol; 37, Seite 911-917. Bocan, T. M.; Rosebury, W. S.; Mueller, S. B.; Kuchera, S.; Welch, K.; Daugherty, A. und Cornicelli, J. A.; (1998): A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit, Atherosclerosis; 136 [2], Seite 203-16. Boeglin, W. E.; Kim, R. B. und Brash, A. R.; (1998): A 12R-lipoxygenase in human skin: mechanistic evidence, molecular cloning, and expression, Proc Natl Acad Sci U S A; 95 [12], Seite 6744-9. Borgeat, P.; Hamberg, M. und Samuelsson, B.; (1976): Transformation of arachidonic acid and homo-gamma-linolenic acid by rabbit polymorphonuclear leukocytes. Monohydroxy acids from novel lipoxygenases, J Biol Chem; 251 [24], Seite 7816-20. Borngraber, S.; (1996): Untersuchungen zur ortsgerichteten Mutagenese und zur Expression der Kaninchen 15-Lipoxygenase.;,

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