<?xml version="1.0" encoding="ISO-8859-1"?><cms:container xmlns:cms="http://edoc.hu-berlin.de/diml/module/cms"><cms:document><cms:meta><cms:entry id="front" part="front" ref="front" type="front"/><cms:entry type="title">Untersuchung somatischer Chromosomenveränderungen bei amyotropher Lateralsklerose </cms:entry><cms:entry type="author">Juliane Christin Wappler</cms:entry><cms:entry id="_Toc138471133" part="front" ref="_Toc138471133" type="link"/><cms:entry id="_Toc138471134" part="front" ref="_Toc138471134" type="link"/><cms:entry id="N10067" part="front" ref="N10067" type="dedication">
            Widmung</cms:entry><cms:entry id="_Toc138471135" part="front" ref="_Toc138471135" type="link"/><cms:entry id="N10076" part="N10076" ref="N10076" type="preface">Vorwort </cms:entry><cms:entry id="N1007D" part="N10076" ref="N1007D" type="citenumber">1</cms:entry><cms:entry id="chapter1" part="chapter1" ref="chapter1" type="chapter">1</cms:entry><cms:entry id="_Toc138471138" part="chapter1" ref="_Toc138471138" type="link"/><cms:entry id="N10090" part="chapter1" ref="N10090" type="helpercitenumber">1</cms:entry><cms:entry id="N10095" part="chapter1" ref="N10095" type="citenumber">2</cms:entry><cms:entry id="N100A7" part="chapter1" ref="N100A7" type="citenumber">3</cms:entry><cms:entry id="N100B1" part="chapter1" ref="N100B1" type="section">1.1</cms:entry><cms:entry id="_Toc138471139" part="chapter1" ref="_Toc138471139" type="link"/><cms:entry id="N100BB" part="chapter1" ref="N100BB" type="citenumber">4</cms:entry><cms:entry id="N100C4" part="chapter1" ref="N100C4" type="table"/><cms:entry id="N103A6" part="chapter1" ref="N103A6" type="citenumber">5</cms:entry><cms:entry id="_Toc138471140" part="chapter1" ref="_Toc138471140" type="link"/><cms:entry id="N103B1" part="chapter1" ref="N103B1" type="section">1.2</cms:entry><cms:entry id="N103BB" part="chapter1" ref="N103BB" type="mm">621#328</cms:entry><cms:entry id="N103C6" part="chapter1" ref="N103C6" type="citenumber">6</cms:entry><cms:entry id="N103D5" part="chapter1" ref="N103D5" type="citenumber">7</cms:entry><cms:entry id="N103F0" part="chapter1" ref="N103F0" type="citenumber">8</cms:entry><cms:entry id="N10405" part="chapter1" ref="N10405" type="citenumber">9</cms:entry><cms:entry id="N10411" part="chapter1" ref="N10411" type="citenumber">10</cms:entry><cms:entry id="N1041D" part="chapter1" ref="N1041D" type="citenumber">11</cms:entry><cms:entry id="N10420" part="chapter1" ref="N10420" type="table"/><cms:entry id="N10502" part="chapter1" ref="N10502" type="section">1.3</cms:entry><cms:entry id="_Toc138471141" part="chapter1" ref="_Toc138471141" type="link"/><cms:entry id="N10512" part="chapter1" ref="N10512" type="citenumber">12</cms:entry><cms:entry id="chapter2" part="chapter2" ref="chapter2" type="chapter">2</cms:entry><cms:entry id="_Toc138471142" part="chapter2" ref="_Toc138471142" type="link"/><cms:entry id="N10526" part="chapter2" ref="N10526" type="section">2.1</cms:entry><cms:entry id="_Toc138471143" part="chapter2" ref="_Toc138471143" type="link"/><cms:entry id="N1052E" part="chapter2" ref="N1052E" type="helpercitenumber">12</cms:entry><cms:entry id="N10533" part="chapter2" ref="N10533" type="citenumber">13</cms:entry><cms:entry id="N10536" part="chapter2" ref="N10536" type="table"/><cms:entry id="N11180" part="chapter2" ref="N11180" type="table"/><cms:entry id="N1186B" part="chapter2" ref="N1186B" type="table"/><cms:entry id="_Toc138471144" part="chapter2" ref="_Toc138471144" type="link"/><cms:entry id="N11ABD" part="chapter2" ref="N11ABD" type="section">2.2</cms:entry><cms:entry id="N11AC4" part="chapter2" ref="N11AC4" type="citenumber">14</cms:entry><cms:entry id="N11AC7" part="chapter2" ref="N11AC7" type="table"/><cms:entry id="_Toc138471145" part="chapter2" ref="_Toc138471145" type="link"/><cms:entry id="N11CBE" part="chapter2" ref="N11CBE" type="section">2.3</cms:entry><cms:entry id="N11CC5" part="chapter2" ref="N11CC5" type="table"/><cms:entry id="_Toc138471146" part="chapter2" ref="_Toc138471146" type="link"/><cms:entry id="N121E5" part="chapter2" ref="N121E5" type="section">2.4</cms:entry><cms:entry id="N121EF" part="chapter2" ref="N121EF" type="citenumber">15</cms:entry><cms:entry id="N121F4" part="chapter2" ref="N121F4" type="section">2.5</cms:entry><cms:entry id="_Toc138471147" part="chapter2" ref="_Toc138471147" type="link"/><cms:entry id="N12201" part="chapter2" ref="N12201" type="mm">624#549</cms:entry><cms:entry id="N1220B" part="chapter2" ref="N1220B" type="section">2.6</cms:entry><cms:entry id="_Toc138471148" part="chapter2" ref="_Toc138471148" type="link"/><cms:entry id="N12215" part="chapter2" ref="N12215" type="citenumber">16</cms:entry><cms:entry id="N1221E" part="chapter2" ref="N1221E" type="mm">624#178</cms:entry><cms:entry id="N1222B" part="chapter2" ref="N1222B" type="section">2.7</cms:entry><cms:entry id="_Toc138471149" part="chapter2" ref="_Toc138471149" type="link"/><cms:entry id="N1223E" part="chapter2" ref="N1223E" type="citenumber">17</cms:entry><cms:entry id="N12244" part="chapter2" ref="N12244" type="mm">617#386</cms:entry><cms:entry id="N12255" part="chapter2" ref="N12255" type="citenumber">18</cms:entry><cms:entry id="N12258" part="chapter2" ref="N12258" type="table"/><cms:entry id="chapter3" part="chapter3" ref="chapter3" type="chapter">3</cms:entry><cms:entry id="_Toc138471150" part="chapter3" ref="_Toc138471150" type="link"/><cms:entry id="N123AA" part="chapter3" ref="N123AA" type="section">3.1</cms:entry><cms:entry id="_Toc138471151" part="chapter3" ref="_Toc138471151" type="link"/><cms:entry id="N123B2" part="chapter3" ref="N123B2" type="helpercitenumber">18</cms:entry><cms:entry id="N123B7" part="chapter3" ref="N123B7" type="citenumber">19</cms:entry><cms:entry id="N123EA" part="chapter3" ref="N123EA" type="citenumber">20</cms:entry><cms:entry id="N123ED" part="chapter3" ref="N123ED" type="mm">620#502</cms:entry><cms:entry id="N123F8" part="chapter3" ref="N123F8" type="mm">620#474</cms:entry><cms:entry id="N12407" part="chapter3" ref="N12407" type="citenumber">21</cms:entry><cms:entry id="N1240D" part="chapter3" ref="N1240D" type="table"/><cms:entry id="_Toc138471152" part="chapter3" ref="_Toc138471152" type="link"/><cms:entry id="N12830" part="chapter3" ref="N12830" type="section">3.2</cms:entry><cms:entry id="N1283A" part="chapter3" ref="N1283A" type="citenumber">22</cms:entry><cms:entry id="N12845" part="chapter3" ref="N12845" type="mm">624#485</cms:entry><cms:entry id="N12853" part="chapter3" ref="N12853" type="citenumber">23</cms:entry><cms:entry id="N12859" part="chapter3" ref="N12859" type="table"/><cms:entry id="N12B89" part="chapter3" ref="N12B89" type="mm">621#378</cms:entry><cms:entry id="N12B94" part="chapter3" ref="N12B94" type="citenumber">24</cms:entry><cms:entry id="N12B9A" part="chapter3" ref="N12B9A" type="mm">625#406</cms:entry><cms:entry id="N12BA4" part="chapter3" ref="N12BA4" type="section">3.3</cms:entry><cms:entry id="_Toc138471153" part="chapter3" ref="_Toc138471153" type="link"/><cms:entry id="N12BB4" part="chapter3" ref="N12BB4" type="citenumber">25</cms:entry><cms:entry id="N12BB7" part="chapter3" ref="N12BB7" type="mm">622#589</cms:entry><cms:entry id="N12BC5" part="chapter3" ref="N12BC5" type="table"/><cms:entry id="N12E68" part="chapter3" ref="N12E68" type="citenumber">26</cms:entry><cms:entry id="N12E6E" part="chapter3" ref="N12E6E" type="mm">618#342</cms:entry><cms:entry id="N12E7C" part="chapter3" ref="N12E7C" type="citenumber">27</cms:entry><cms:entry id="N12E7F" part="chapter3" ref="N12E7F" type="table"/><cms:entry id="N1305E" part="chapter3" ref="N1305E" type="mm">625#508</cms:entry><cms:entry id="N1306F" part="chapter3" ref="N1306F" type="citenumber">28</cms:entry><cms:entry id="N13072" part="chapter3" ref="N13072" type="table"/><cms:entry id="N13141" part="chapter3" ref="N13141" type="mm">618#330</cms:entry><cms:entry id="N1314F" part="chapter3" ref="N1314F" type="citenumber">29</cms:entry><cms:entry id="N13152" part="chapter3" ref="N13152" type="table"/><cms:entry id="N13224" part="chapter3" ref="N13224" type="mm">618#409</cms:entry><cms:entry id="N1322E" part="chapter3" ref="N1322E" type="section">3.4</cms:entry><cms:entry id="_Toc138471154" part="chapter3" ref="_Toc138471154" type="link"/><cms:entry id="N13244" part="chapter3" ref="N13244" type="citenumber">30</cms:entry><cms:entry id="N1324D" part="chapter3" ref="N1324D" type="table"/><cms:entry id="N13B69" part="chapter3" ref="N13B69" type="citenumber">31</cms:entry><cms:entry id="N13B6F" part="chapter3" ref="N13B6F" type="mm">622#464</cms:entry><cms:entry id="chapter4" part="chapter4" ref="chapter4" type="chapter">4</cms:entry><cms:entry id="_Toc138471155" part="chapter4" ref="_Toc138471155" type="link"/><cms:entry id="N13B82" part="chapter4" ref="N13B82" type="helpercitenumber">31</cms:entry><cms:entry id="N13B87" part="chapter4" ref="N13B87" type="citenumber">32</cms:entry><cms:entry id="N13B8B" part="chapter4" ref="N13B8B" type="section">4.1</cms:entry><cms:entry id="_Toc138471156" part="chapter4" ref="_Toc138471156" type="link"/><cms:entry id="N13B9A" part="chapter4" ref="N13B9A" type="section">4.2</cms:entry><cms:entry id="_Toc138471157" part="chapter4" ref="_Toc138471157" type="link"/><cms:entry id="N13BA4" part="chapter4" ref="N13BA4" type="citenumber">33</cms:entry><cms:entry id="N13BB0" part="chapter4" ref="N13BB0" type="citenumber">34</cms:entry><cms:entry id="N13BBF" part="chapter4" ref="N13BBF" type="citenumber">35</cms:entry><cms:entry id="_Toc138471158" part="chapter4" ref="_Toc138471158" type="link"/><cms:entry id="N13BD6" part="chapter4" ref="N13BD6" type="section">4.3</cms:entry><cms:entry id="N13BE3" part="chapter4" ref="N13BE3" type="citenumber">36</cms:entry><cms:entry id="_Toc138471159" part="chapter4" ref="_Toc138471159" type="link"/><cms:entry id="N13BEE" part="chapter4" ref="N13BEE" type="section">4.4</cms:entry><cms:entry id="N13BF7" part="chapter4" ref="N13BF7" type="section">4.5</cms:entry><cms:entry id="_Toc138471160" part="chapter4" ref="_Toc138471160" type="link"/><cms:entry id="N13C04" part="chapter4" ref="N13C04" type="citenumber">37</cms:entry><cms:entry id="N13C10" part="chapter4" ref="N13C10" type="citenumber">38</cms:entry><cms:entry id="N13C2E" part="chapter4" ref="N13C2E" type="citenumber">39</cms:entry><cms:entry id="N13C3D" part="chapter4" ref="N13C3D" type="citenumber">40</cms:entry><cms:entry id="N13C4C" part="chapter4" ref="N13C4C" type="citenumber">41</cms:entry><cms:entry ref="N13C5C" type="back"/><cms:entry ref="N13C5E" type="abbreviation">
            Abkürzungsverzeichnis</cms:entry><cms:entry ref="_Toc138471136" type="link"/><cms:entry ref="N13C69" type="table"/><cms:entry ref="_Toc138471137" type="link"/><cms:entry id="N13EF9" part="N13EF9" ref="N13EF9" type="bibliography">
            Literaturverzeichnis </cms:entry><cms:entry id="_Toc138471161" part="N13EF9" ref="_Toc138471161" type="link"/><cms:entry id="_Toc138471163" part="N13EF9" ref="_Toc138471163" type="link"/><cms:entry id="N1429F" part="N1429F" ref="N1429F" type="acknowledgement">Danksagung </cms:entry><cms:entry id="N142B4" part="N142B4" ref="N142B4" type="declaration">
            Eidesstattliche Erklärung </cms:entry><cms:entry id="_Toc138471164" part="N142B4" ref="_Toc138471164" type="link"/><cms:entry part="N13C5E" type=":current"/><cms:entry type=":lang">de</cms:entry><cms:entry id=":contents" part="front" ref=":contents" type=":contents">Inhaltsverzeichnis</cms:entry><cms:entry type=":help"><url href="http://...">Hilfe</url></cms:entry></cms:meta><cms:content><abbreviation id="N13C5E">
         <head>
            <link id="_Toc138471136"/>Abkürzungsverzeichnis<br/></head>
         <p>
            <table frame="all" id="N13C69" orient="port" tocentry="1">
               <tgroup align="left" char="" charoff="50" cols="2">
                  <colspec colname="1" colnum="1"/>
                  <colspec colname="2" colnum="2"/>
                  <tbody valign="top">
                     <row>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>ALS </p>
                        </entry>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>amyotrophe Lateralsklerose </p>
                        </entry>
                     </row>
                     <row>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>AMPA </p>
                        </entry>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>
                              <em>&#945;</em>
                              <em>-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid </em>
                           </p>
                        </entry>
                     </row>
                     <row>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>AT </p>
                        </entry>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>Adenin-Thymin </p>
                        </entry>
                     </row>
                     <row>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>BrdU </p>
                        </entry>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>Bromodesoxyuracil </p>
                        </entry>
                     </row>
                     <row>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>B/EZ </p>
                        </entry>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>Brüche/Einzelzelle </p>
                        </entry>
                     </row>
                     <row>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>B/Z </p>
                        </entry>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>Brüche/Zelle </p>
                        </entry>
                     </row>
                     <row>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>COX-2 </p>
                        </entry>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>Cyclooxygenase-2 </p>
                        </entry>
                     </row>
                     <row>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>csb </p>
                        </entry>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>
                              <em>chromosome break </em>(Chromosomenbruch) </p>
                        </entry>
                     </row>
                     <row>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>ctb </p>
                        </entry>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>
                              <em>chromatid break </em>(Chromatidbruch) </p>
                        </entry>
                     </row>
                     <row>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>ctg </p>
                        </entry>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>
                              <em>chromatid gap </em>(Färbelücke) </p>
                        </entry>
                     </row>
                     <row>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>DAPI </p>
                        </entry>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>Diamidinophenylindol </p>
                        </entry>
                     </row>
                     <row>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>DNA </p>
                        </entry>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>
                              <em>desoxyribonucleic acid </em>(Desoxyribonukleinsäure) </p>
                        </entry>
                     </row>
                     <row>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>fALS </p>
                        </entry>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>familiäre ALS </p>
                        </entry>
                     </row>
                     <row>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>FISH </p>
                        </entry>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>Fluoreszenz <em>in situ </em>Hybridisierung </p>
                        </entry>
                     </row>
                     <row>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>GC </p>
                        </entry>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>Guanin-Cytosin </p>
                        </entry>
                     </row>
                     <row>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>GluR </p>
                        </entry>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>Glutamatrezeptor </p>
                        </entry>
                     </row>
                     <row>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>GTG </p>
                        </entry>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>G-Banden nach Trypsinierung mit Giemsa </p>
                        </entry>
                     </row>
                     <row>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>MN </p>
                        </entry>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>Motoneuron </p>
                        </entry>
                     </row>
                     <row>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>NMDA </p>
                        </entry>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>
                              <em>N-methyl-D-aspartate </em>
                           </p>
                        </entry>
                     </row>
                     <row>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>PBS </p>
                        </entry>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>
                              <em>phosphate buffered salin </em>(Phosphatpuffer) </p>
                        </entry>
                     </row>
                     <row>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>RPMI </p>
                        </entry>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>Roswell Park Memorial Institute Medium (Zellkulturmedium) </p>
                        </entry>
                     </row>
                     <row>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>sALS </p>
                        </entry>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>sporadische ALS </p>
                        </entry>
                     </row>
                     <row>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>SCE </p>
                        </entry>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>
                              <em>sister chromatid exchanges </em>
                           </p>
                        </entry>
                     </row>
                     <row>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>SOD-1 </p>
                        </entry>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>Superoxiddismutase-1 </p>
                        </entry>
                     </row>
                     <row>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>U-Test </p>
                        </entry>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>nach Mann und Whitney durchgeführter Vergleich von zwei </p>
                        </entry>
                     </row>
                     <row>
                        <entry morerows="0" rotate="0" valign="top">
                           <p/>
                        </entry>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>unabhängigen Stichproben </p>
                        </entry>
                     </row>
                     <row>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>VEGF </p>
                        </entry>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>
                              <em>vascular endothelial growth factor </em>
                           </p>
                        </entry>
                     </row>
                     <row>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>WCP </p>
                        </entry>
                        <entry morerows="0" rotate="0" valign="top">
                           <p>
                              <em>whole chromosome painting </em>
                           </p>
                        </entry>
                     </row>
                  </tbody>
               </tgroup>
            </table>
         </p>
         <p>
            <link id="_Toc138471137"/>
         </p>
      </abbreviation></cms:content></cms:document></cms:container>