<?xml version="1.0" encoding="ISO-8859-1"?><cms:container xmlns:cms="http://edoc.hu-berlin.de/diml/module/cms"><cms:document><cms:meta><cms:entry id="front" part="front" ref="front" type="front"/><cms:entry type="title">Modulierung der NF-&#954;B-Aktivität in  T-Zellen durch den Carma1-Bcl10-Malt1 Komplex</cms:entry><cms:entry type="author">Elmar Wegener</cms:entry><cms:entry id="chapter1" part="chapter1" ref="chapter1" type="chapter">1</cms:entry><cms:entry id="N10087" part="chapter1" ref="N10087" type="citenumber">1</cms:entry><cms:entry id="_Toc124944020" part="chapter1" ref="_Toc124944020" type="link"/><cms:entry id="_Toc125100594" part="chapter1" ref="_Toc125100594" type="link"/><cms:entry id="N1009E" part="chapter1" ref="N1009E" type="section">1.1</cms:entry><cms:entry id="_Toc125107198" part="chapter1" ref="_Toc125107198" type="link"/><cms:entry id="_Toc124944021" part="chapter1" ref="_Toc124944021" type="link"/><cms:entry id="_Toc125100595" part="chapter1" ref="_Toc125100595" type="link"/><cms:entry id="N100B2" part="chapter1" ref="N100B2" type="subsection">1.1.1</cms:entry><cms:entry id="_Toc125107199" part="chapter1" ref="_Toc125107199" type="link"/><cms:entry id="N100BF" part="chapter1" ref="N100BF" type="citenumber">2</cms:entry><cms:entry id="N100C2" part="chapter1" ref="N100C2" type="mm">568#487</cms:entry><cms:entry id="OLE_LINK1" part="chapter1" ref="OLE_LINK1" type="link"/><cms:entry id="_Toc124944022" part="chapter1" ref="_Toc124944022" type="link"/><cms:entry id="_Toc125100596" part="chapter1" ref="_Toc125100596" type="link"/><cms:entry id="_Toc125107200" part="chapter1" ref="_Toc125107200" type="link"/><cms:entry id="N100E7" part="chapter1" ref="N100E7" type="subsection">1.1.2</cms:entry><cms:entry id="N100EE" part="chapter1" ref="N100EE" type="citenumber">3</cms:entry><cms:entry id="N10100" part="chapter1" ref="N10100" type="mm">480#496</cms:entry><cms:entry id="_Toc124944023" part="chapter1" ref="_Toc124944023" type="link"/><cms:entry id="_Toc125100597" part="chapter1" ref="_Toc125100597" type="link"/><cms:entry id="_Toc125107201" part="chapter1" ref="_Toc125107201" type="link"/><cms:entry id="N1011C" part="chapter1" ref="N1011C" type="subsection">1.1.3</cms:entry><cms:entry id="N10123" part="chapter1" ref="N10123" type="citenumber">4</cms:entry><cms:entry id="N10132" part="chapter1" ref="N10132" type="citenumber">5</cms:entry><cms:entry id="N10135" part="chapter1" ref="N10135" type="mm">507#63</cms:entry><cms:entry id="_Toc124944024" part="chapter1" ref="_Toc124944024" type="link"/><cms:entry id="_Toc125100598" part="chapter1" ref="_Toc125100598" type="link"/><cms:entry id="_Toc125107202" part="chapter1" ref="_Toc125107202" type="link"/><cms:entry id="N10152" part="chapter1" ref="N10152" type="section">1.2</cms:entry><cms:entry id="_Toc124944025" part="chapter1" ref="_Toc124944025" type="link"/><cms:entry id="_Toc125100599" part="chapter1" ref="_Toc125100599" type="link"/><cms:entry id="N10166" part="chapter1" ref="N10166" type="subsection">1.2.1</cms:entry><cms:entry id="_Toc125107203" part="chapter1" ref="_Toc125107203" type="link"/><cms:entry id="N10173" part="chapter1" ref="N10173" type="citenumber">6</cms:entry><cms:entry id="N10179" part="chapter1" ref="N10179" type="mm">296#506</cms:entry><cms:entry id="_Toc124944026" part="chapter1" ref="_Toc124944026" type="link"/><cms:entry id="_Toc125100600" part="chapter1" ref="_Toc125100600" type="link"/><cms:entry id="_Toc125107204" part="chapter1" ref="_Toc125107204" type="link"/><cms:entry id="N10195" part="chapter1" ref="N10195" type="subsection">1.2.2</cms:entry><cms:entry id="N1019F" part="chapter1" ref="N1019F" type="citenumber">7</cms:entry><cms:entry id="N101AB" part="chapter1" ref="N101AB" type="citenumber">8</cms:entry><cms:entry id="N101B1" part="chapter1" ref="N101B1" type="mm">475#385</cms:entry><cms:entry id="_Toc124944027" part="chapter1" ref="_Toc124944027" type="link"/><cms:entry id="_Toc125100601" part="chapter1" ref="_Toc125100601" type="link"/><cms:entry id="_Toc125107205" part="chapter1" ref="_Toc125107205" type="link"/><cms:entry id="N101D1" part="chapter1" ref="N101D1" type="section">1.3</cms:entry><cms:entry id="N101D8" part="chapter1" ref="N101D8" type="citenumber">9</cms:entry><cms:entry id="_Toc124944028" part="chapter1" ref="_Toc124944028" type="link"/><cms:entry id="_Toc125100602" part="chapter1" ref="_Toc125100602" type="link"/><cms:entry id="N101E8" part="chapter1" ref="N101E8" type="subsection">1.3.1</cms:entry><cms:entry id="_Toc125107206" part="chapter1" ref="_Toc125107206" type="link"/><cms:entry id="_Toc124944029" part="chapter1" ref="_Toc124944029" type="link"/><cms:entry id="_Toc125100603" part="chapter1" ref="_Toc125100603" type="link"/><cms:entry id="N101FC" part="chapter1" ref="N101FC" type="block">1.3.1.1</cms:entry><cms:entry id="_Toc125107207" part="chapter1" ref="_Toc125107207" type="link"/><cms:entry id="N1020C" part="chapter1" ref="N1020C" type="citenumber">10</cms:entry><cms:entry id="_Toc124944030" part="chapter1" ref="_Toc124944030" type="link"/><cms:entry id="_Toc125100604" part="chapter1" ref="_Toc125100604" type="link"/><cms:entry id="_Toc125107208" part="chapter1" ref="_Toc125107208" type="link"/><cms:entry id="N10223" part="chapter1" ref="N10223" type="block">1.3.1.2</cms:entry><cms:entry id="_Toc124944031" part="chapter1" ref="_Toc124944031" type="link"/><cms:entry id="_Toc125100605" part="chapter1" ref="_Toc125100605" type="link"/><cms:entry id="_Toc125107209" part="chapter1" ref="_Toc125107209" type="link"/><cms:entry id="N10241" part="chapter1" ref="N10241" type="block">1.3.1.3</cms:entry><cms:entry id="N10248" part="chapter1" ref="N10248" type="citenumber">11</cms:entry><cms:entry id="N10251" part="chapter1" ref="N10251" type="mm">529#251</cms:entry><cms:entry id="_Toc124944032" part="chapter1" ref="_Toc124944032" type="link"/><cms:entry id="_Toc125100606" part="chapter1" ref="_Toc125100606" type="link"/><cms:entry id="_Toc125107210" part="chapter1" ref="_Toc125107210" type="link"/><cms:entry id="N1026D" part="chapter1" ref="N1026D" type="block">1.3.1.4</cms:entry><cms:entry id="N10274" part="chapter1" ref="N10274" type="citenumber">12</cms:entry><cms:entry id="_Toc124944033" part="chapter1" ref="_Toc124944033" type="link"/><cms:entry id="_Toc125100607" part="chapter1" ref="_Toc125100607" type="link"/><cms:entry id="_Toc125107211" part="chapter1" ref="_Toc125107211" type="link"/><cms:entry id="N1028B" part="chapter1" ref="N1028B" type="block">1.3.1.5</cms:entry><cms:entry id="_Toc124944034" part="chapter1" ref="_Toc124944034" type="link"/><cms:entry id="_Toc125100608" part="chapter1" ref="_Toc125100608" type="link"/><cms:entry id="_Toc125107212" part="chapter1" ref="_Toc125107212" type="link"/><cms:entry id="N102AC" part="chapter1" ref="N102AC" type="subsection">1.3.2</cms:entry><cms:entry id="N102B3" part="chapter1" ref="N102B3" type="citenumber">13</cms:entry><cms:entry id="N102B9" part="chapter1" ref="N102B9" type="mm">291#204</cms:entry><cms:entry id="N102CA" part="chapter1" ref="N102CA" type="citenumber">14</cms:entry><cms:entry id="_Toc124944035" part="chapter1" ref="_Toc124944035" type="link"/><cms:entry id="_Toc125100609" part="chapter1" ref="_Toc125100609" type="link"/><cms:entry id="N102DA" part="chapter1" ref="N102DA" type="block">1.3.2.1</cms:entry><cms:entry id="_Toc125107213" part="chapter1" ref="_Toc125107213" type="link"/><cms:entry id="N102EA" part="chapter1" ref="N102EA" type="citenumber">15</cms:entry><cms:entry id="N102F0" part="chapter1" ref="N102F0" type="mm">434#28</cms:entry><cms:entry id="_Toc124944036" part="chapter1" ref="_Toc124944036" type="link"/><cms:entry id="_Toc125100610" part="chapter1" ref="_Toc125100610" type="link"/><cms:entry id="_Toc125107214" part="chapter1" ref="_Toc125107214" type="link"/><cms:entry id="N1030C" part="chapter1" ref="N1030C" type="block">1.3.2.2</cms:entry><cms:entry id="N10316" part="chapter1" ref="N10316" type="citenumber">16</cms:entry><cms:entry id="_Toc124944037" part="chapter1" ref="_Toc124944037" type="link"/><cms:entry id="_Toc125100611" part="chapter1" ref="_Toc125100611" type="link"/><cms:entry id="_Toc125107215" part="chapter1" ref="_Toc125107215" type="link"/><cms:entry id="N10336" part="chapter1" ref="N10336" type="subsection">1.3.3</cms:entry><cms:entry id="_Toc124944038" part="chapter1" ref="_Toc124944038" type="link"/><cms:entry id="_Toc125100612" part="chapter1" ref="_Toc125100612" type="link"/><cms:entry id="N1034A" part="chapter1" ref="N1034A" type="block">1.3.3.1</cms:entry><cms:entry id="_Toc125107216" part="chapter1" ref="_Toc125107216" type="link"/><cms:entry id="N10354" part="chapter1" ref="N10354" type="citenumber">17</cms:entry><cms:entry id="_Toc124944039" part="chapter1" ref="_Toc124944039" type="link"/><cms:entry id="_Toc125100613" part="chapter1" ref="_Toc125100613" type="link"/><cms:entry id="_Toc125107217" part="chapter1" ref="_Toc125107217" type="link"/><cms:entry id="N1036E" part="chapter1" ref="N1036E" type="block">1.3.3.2</cms:entry><cms:entry id="N10378" part="chapter1" ref="N10378" type="citenumber">18</cms:entry><cms:entry id="_Toc124944040" part="chapter1" ref="_Toc124944040" type="link"/><cms:entry id="_Toc125100614" part="chapter1" ref="_Toc125100614" type="link"/><cms:entry id="_Toc125107218" part="chapter1" ref="_Toc125107218" type="link"/><cms:entry id="N10398" part="chapter1" ref="N10398" type="block">1.3.3.3</cms:entry><cms:entry id="N1039F" part="chapter1" ref="N1039F" type="citenumber">19</cms:entry><cms:entry id="N103A5" part="chapter1" ref="N103A5" type="mm">592#172</cms:entry><cms:entry id="N103B6" part="chapter1" ref="N103B6" type="citenumber">20</cms:entry><cms:entry id="_Toc124944041" part="chapter1" ref="_Toc124944041" type="link"/><cms:entry id="_Toc125100615" part="chapter1" ref="_Toc125100615" type="link"/><cms:entry id="_Toc125107219" part="chapter1" ref="_Toc125107219" type="link"/><cms:entry id="N103D0" part="chapter1" ref="N103D0" type="block">1.3.3.4</cms:entry><cms:entry id="N103DA" part="chapter1" ref="N103DA" type="citenumber">21</cms:entry><cms:entry id="N103E3" part="chapter1" ref="N103E3" type="mm">572#305</cms:entry><cms:entry id="_Toc124944042" part="chapter1" ref="_Toc124944042" type="link"/><cms:entry id="_Toc125100616" part="chapter1" ref="_Toc125100616" type="link"/><cms:entry id="_Toc125107220" part="chapter1" ref="_Toc125107220" type="link"/><cms:entry id="N10401" part="chapter1" ref="N10401" type="section">1.4</cms:entry><cms:entry id="N10408" part="chapter1" ref="N10408" type="citenumber">22</cms:entry><cms:entry id="_Toc124944043" part="chapter1" ref="_Toc124944043" type="link"/><cms:entry id="_Toc125100617" part="chapter1" ref="_Toc125100617" type="link"/><cms:entry id="_Toc125107221" part="chapter1" ref="_Toc125107221" type="link"/><cms:entry id="chapter2" part="chapter2" ref="chapter2" type="chapter">2</cms:entry><cms:entry id="N10428" part="chapter2" ref="N10428" type="helpercitenumber">22</cms:entry><cms:entry id="_Toc124944044" part="chapter2" ref="_Toc124944044" type="link"/><cms:entry id="_Toc125100618" part="chapter2" ref="_Toc125100618" type="link"/><cms:entry id="N10434" part="chapter2" ref="N10434" type="section">2.1</cms:entry><cms:entry id="_Toc125107222" part="chapter2" ref="_Toc125107222" type="link"/><cms:entry id="N1043E" part="chapter2" ref="N1043E" type="table"/><cms:entry id="_Toc124944045" part="chapter2" ref="_Toc124944045" type="link"/><cms:entry id="_Toc125100619" part="chapter2" ref="_Toc125100619" type="link"/><cms:entry id="_Toc125107223" part="chapter2" ref="_Toc125107223" type="link"/><cms:entry id="N10887" part="chapter2" ref="N10887" type="section">2.2</cms:entry><cms:entry id="N1088E" part="chapter2" ref="N1088E" type="citenumber">23</cms:entry><cms:entry id="N10891" part="chapter2" ref="N10891" type="table"/><cms:entry id="_Toc124944046" part="chapter2" ref="_Toc124944046" type="link"/><cms:entry id="_Toc125100620" part="chapter2" ref="_Toc125100620" type="link"/><cms:entry id="_Toc125107224" part="chapter2" ref="_Toc125107224" type="link"/><cms:entry id="N10E72" part="chapter2" ref="N10E72" type="section">2.3</cms:entry><cms:entry id="N10E79" part="chapter2" ref="N10E79" type="table"/><cms:entry id="_Toc124944047" part="chapter2" ref="_Toc124944047" type="link"/><cms:entry id="_Toc125100621" part="chapter2" ref="_Toc125100621" type="link"/><cms:entry id="_Toc125107225" part="chapter2" ref="_Toc125107225" type="link"/><cms:entry id="N1104D" part="chapter2" ref="N1104D" type="section">2.4</cms:entry><cms:entry id="N11075" part="chapter2" ref="N11075" type="citenumber">24</cms:entry><cms:entry id="N110A2" part="chapter2" ref="N110A2" type="citenumber">25</cms:entry><cms:entry id="_Toc124944048" part="chapter2" ref="_Toc124944048" type="link"/><cms:entry id="_Toc125100622" part="chapter2" ref="_Toc125100622" type="link"/><cms:entry id="_Toc125107226" part="chapter2" ref="_Toc125107226" type="link"/><cms:entry id="N110C8" part="chapter2" ref="N110C8" type="section">2.5</cms:entry><cms:entry id="N110CF" part="chapter2" ref="N110CF" type="table"/><cms:entry id="_Toc124944049" part="chapter2" ref="_Toc124944049" type="link"/><cms:entry id="_Toc125100623" part="chapter2" ref="_Toc125100623" type="link"/><cms:entry id="_Toc125107227" part="chapter2" ref="_Toc125107227" type="link"/><cms:entry id="N11147" part="chapter2" ref="N11147" type="section">2.6</cms:entry><cms:entry id="N11151" part="chapter2" ref="N11151" type="citenumber">26</cms:entry><cms:entry id="N11166" part="chapter2" ref="N11166" type="citenumber">27</cms:entry><cms:entry id="N11169" part="chapter2" ref="N11169" type="mm">605#316</cms:entry><cms:entry id="N1117E" part="chapter2" ref="N1117E" type="citenumber">28</cms:entry><cms:entry id="N11181" part="chapter2" ref="N11181" type="mm">605#148</cms:entry><cms:entry id="N11194" part="chapter2" ref="N11194" type="citenumber">29</cms:entry><cms:entry id="N11197" part="chapter2" ref="N11197" type="mm">605#100</cms:entry><cms:entry id="N111AD" part="chapter2" ref="N111AD" type="citenumber">30</cms:entry><cms:entry id="N111C2" part="chapter2" ref="N111C2" type="citenumber">31</cms:entry><cms:entry id="N111D7" part="chapter2" ref="N111D7" type="citenumber">32</cms:entry><cms:entry id="N111EE" part="chapter2" ref="N111EE" type="citenumber">33</cms:entry><cms:entry id="N11200" part="chapter2" ref="N11200" type="citenumber">34</cms:entry><cms:entry id="N11203" part="chapter2" ref="N11203" type="mm">605#609</cms:entry><cms:entry id="N1120D" part="chapter2" ref="N1120D" type="mm">605#129</cms:entry><cms:entry id="N11217" part="chapter2" ref="N11217" type="mm">605#54</cms:entry><cms:entry id="_Toc124944050" part="chapter2" ref="_Toc124944050" type="link"/><cms:entry id="_Toc125100624" part="chapter2" ref="_Toc125100624" type="link"/><cms:entry id="_Toc125107228" part="chapter2" ref="_Toc125107228" type="link"/><cms:entry id="N1122F" part="chapter2" ref="N1122F" type="section">2.7</cms:entry><cms:entry id="N11239" part="chapter2" ref="N11239" type="citenumber">35</cms:entry><cms:entry id="N1123C" part="chapter2" ref="N1123C" type="table"/><cms:entry id="N114B3" part="chapter2" ref="N114B3" type="table"/><cms:entry id="_Toc124944051" part="chapter2" ref="_Toc124944051" type="link"/><cms:entry id="_Toc125100625" part="chapter2" ref="_Toc125100625" type="link"/><cms:entry id="_Toc125107229" part="chapter2" ref="_Toc125107229" type="link"/><cms:entry id="N11573" part="chapter2" ref="N11573" type="section">2.8</cms:entry><cms:entry id="_Toc124944052" part="chapter2" ref="_Toc124944052" type="link"/><cms:entry id="_Toc125100626" part="chapter2" ref="_Toc125100626" type="link"/><cms:entry id="_Toc125107230" part="chapter2" ref="_Toc125107230" type="link"/><cms:entry id="N1158E" part="chapter2" ref="N1158E" type="section">2.9</cms:entry><cms:entry id="N11598" part="chapter2" ref="N11598" type="citenumber">36</cms:entry><cms:entry id="N115AD" part="chapter2" ref="N115AD" type="citenumber">37</cms:entry><cms:entry id="N115D1" part="chapter2" ref="N115D1" type="citenumber">38</cms:entry><cms:entry id="N115F4" part="chapter2" ref="N115F4" type="citenumber">39</cms:entry><cms:entry id="N1160C" part="chapter2" ref="N1160C" type="citenumber">40</cms:entry><cms:entry id="N11623" part="chapter2" ref="N11623" type="citenumber">41</cms:entry><cms:entry id="N1163D" part="chapter2" ref="N1163D" type="citenumber">42</cms:entry><cms:entry id="N11655" part="chapter2" ref="N11655" type="citenumber">43</cms:entry><cms:entry id="_Toc124944053" part="chapter2" ref="_Toc124944053" type="link"/><cms:entry id="_Toc125100627" part="chapter2" ref="_Toc125100627" type="link"/><cms:entry id="_Toc125107231" part="chapter2" ref="_Toc125107231" type="link"/><cms:entry id="N1166E" part="chapter2" ref="N1166E" type="section">2.10</cms:entry><cms:entry id="_Toc124944054" part="chapter2" ref="_Toc124944054" type="link"/><cms:entry id="_Toc125100628" part="chapter2" ref="_Toc125100628" type="link"/><cms:entry id="N11685" part="chapter2" ref="N11685" type="subsection">2.10.1</cms:entry><cms:entry id="_Toc125107232" part="chapter2" ref="_Toc125107232" type="link"/><cms:entry id="N11692" part="chapter2" ref="N11692" type="citenumber">44</cms:entry><cms:entry id="_Toc124944055" part="chapter2" ref="_Toc124944055" type="link"/><cms:entry id="_Toc125100629" part="chapter2" ref="_Toc125100629" type="link"/><cms:entry id="_Toc125107233" part="chapter2" ref="_Toc125107233" type="link"/><cms:entry id="N116A9" part="chapter2" ref="N116A9" type="subsection">2.10.2</cms:entry><cms:entry id="_Toc124944056" part="chapter2" ref="_Toc124944056" type="link"/><cms:entry id="_Toc125100630" part="chapter2" ref="_Toc125100630" type="link"/><cms:entry id="_Toc125107234" part="chapter2" ref="_Toc125107234" type="link"/><cms:entry id="N116CA" part="chapter2" ref="N116CA" type="subsection">2.10.3</cms:entry><cms:entry id="N116D4" part="chapter2" ref="N116D4" type="citenumber">45</cms:entry><cms:entry id="N116E6" part="chapter2" ref="N116E6" type="citenumber">46</cms:entry><cms:entry id="N116F2" part="chapter2" ref="N116F2" type="mm">451#215</cms:entry><cms:entry id="_Toc124944057" part="chapter2" ref="_Toc124944057" type="link"/><cms:entry id="_Toc125100631" part="chapter2" ref="_Toc125100631" type="link"/><cms:entry id="_Toc125107235" part="chapter2" ref="_Toc125107235" type="link"/><cms:entry id="N1171A" part="chapter2" ref="N1171A" type="subsection">2.10.4</cms:entry><cms:entry id="N11721" part="chapter2" ref="N11721" type="citenumber">47</cms:entry><cms:entry id="_Toc124944058" part="chapter2" ref="_Toc124944058" type="link"/><cms:entry id="_Toc125100632" part="chapter2" ref="_Toc125100632" type="link"/><cms:entry id="_Toc125107236" part="chapter2" ref="_Toc125107236" type="link"/><cms:entry id="N1173E" part="chapter2" ref="N1173E" type="subsection">2.10.5</cms:entry><cms:entry id="N11748" part="chapter2" ref="N11748" type="citenumber">48</cms:entry><cms:entry id="N11769" part="chapter2" ref="N11769" type="mm">335#300</cms:entry><cms:entry id="N11779" part="chapter2" ref="N11779" type="citenumber">49</cms:entry><cms:entry id="N1177C" part="chapter2" ref="N1177C" type="table"/><cms:entry id="N1189C" part="chapter2" ref="N1189C" type="table"/><cms:entry id="N11922" part="chapter2" ref="N11922" type="citenumber">50</cms:entry><cms:entry id="N1192B" part="chapter2" ref="N1192B" type="table"/><cms:entry id="_Toc124944059" part="chapter2" ref="_Toc124944059" type="link"/><cms:entry id="_Toc125100633" part="chapter2" ref="_Toc125100633" type="link"/><cms:entry id="_Toc125107237" part="chapter2" ref="_Toc125107237" type="link"/><cms:entry id="N119B9" part="chapter2" ref="N119B9" type="subsection">2.10.6</cms:entry><cms:entry id="N119C6" part="chapter2" ref="N119C6" type="citenumber">51</cms:entry><cms:entry id="N119CF" part="chapter2" ref="N119CF" type="table"/><cms:entry id="N11A46" part="chapter2" ref="N11A46" type="citenumber">52</cms:entry><cms:entry id="N11A49" part="chapter2" ref="N11A49" type="table"/><cms:entry id="N11AC9" part="chapter2" ref="N11AC9" type="citenumber">53</cms:entry><cms:entry id="N11ACC" part="chapter2" ref="N11ACC" type="mm">616#193</cms:entry><cms:entry id="_Toc124944060" part="chapter2" ref="_Toc124944060" type="link"/><cms:entry id="_Toc125100634" part="chapter2" ref="_Toc125100634" type="link"/><cms:entry id="_Toc125107238" part="chapter2" ref="_Toc125107238" type="link"/><cms:entry id="N11AE8" part="chapter2" ref="N11AE8" type="subsection">2.10.7</cms:entry><cms:entry id="_Toc124944061" part="chapter2" ref="_Toc124944061" type="link"/><cms:entry id="_Toc125100635" part="chapter2" ref="_Toc125100635" type="link"/><cms:entry id="_Toc125107239" part="chapter2" ref="_Toc125107239" type="link"/><cms:entry id="N11B07" part="chapter2" ref="N11B07" type="section">2.11</cms:entry><cms:entry id="_Toc124944062" part="chapter2" ref="_Toc124944062" type="link"/><cms:entry id="_Toc125100636" part="chapter2" ref="_Toc125100636" type="link"/><cms:entry id="N11B18" part="chapter2" ref="N11B18" type="subsection">2.11.1</cms:entry><cms:entry id="_Toc125107240" part="chapter2" ref="_Toc125107240" type="link"/><cms:entry id="N11B28" part="chapter2" ref="N11B28" type="citenumber">54</cms:entry><cms:entry id="N11B2B" part="chapter2" ref="N11B2B" type="table"/><cms:entry id="_Toc124944063" part="chapter2" ref="_Toc124944063" type="link"/><cms:entry id="_Toc125100637" part="chapter2" ref="_Toc125100637" type="link"/><cms:entry id="_Toc125107241" part="chapter2" ref="_Toc125107241" type="link"/><cms:entry id="N11BEF" part="chapter2" ref="N11BEF" type="subsection">2.11.2</cms:entry><cms:entry id="N11BF6" part="chapter2" ref="N11BF6" type="citenumber">55</cms:entry><cms:entry id="N11BFF" part="chapter2" ref="N11BFF" type="table"/><cms:entry id="_Toc124944064" part="chapter2" ref="_Toc124944064" type="link"/><cms:entry id="_Toc125100638" part="chapter2" ref="_Toc125100638" type="link"/><cms:entry id="_Toc125107242" part="chapter2" ref="_Toc125107242" type="link"/><cms:entry id="N11CAD" part="chapter2" ref="N11CAD" type="subsection">2.11.3</cms:entry><cms:entry id="N11CB4" part="chapter2" ref="N11CB4" type="citenumber">56</cms:entry><cms:entry id="_Toc124944065" part="chapter2" ref="_Toc124944065" type="link"/><cms:entry id="_Toc125100639" part="chapter2" ref="_Toc125100639" type="link"/><cms:entry id="_Toc125107243" part="chapter2" ref="_Toc125107243" type="link"/><cms:entry id="N11CCB" part="chapter2" ref="N11CCB" type="subsection">2.11.4</cms:entry><cms:entry id="_Toc124944066" part="chapter2" ref="_Toc124944066" type="link"/><cms:entry id="_Toc125100640" part="chapter2" ref="_Toc125100640" type="link"/><cms:entry id="_Toc125107244" part="chapter2" ref="_Toc125107244" type="link"/><cms:entry id="N11CE6" part="chapter2" ref="N11CE6" type="subsection">2.11.5</cms:entry><cms:entry id="N11CF0" part="chapter2" ref="N11CF0" type="citenumber">57</cms:entry><cms:entry id="_Toc124944067" part="chapter2" ref="_Toc124944067" type="link"/><cms:entry id="_Toc125100641" part="chapter2" ref="_Toc125100641" type="link"/><cms:entry id="_Toc125107245" part="chapter2" ref="_Toc125107245" type="link"/><cms:entry id="N11D07" part="chapter2" ref="N11D07" type="subsection">2.11.6</cms:entry><cms:entry id="N11D11" part="chapter2" ref="N11D11" type="table"/><cms:entry id="N11D57" part="chapter2" ref="N11D57" type="citenumber">58</cms:entry><cms:entry id="_Toc124944068" part="chapter2" ref="_Toc124944068" type="link"/><cms:entry id="_Toc125100642" part="chapter2" ref="_Toc125100642" type="link"/><cms:entry id="_Toc125107246" part="chapter2" ref="_Toc125107246" type="link"/><cms:entry id="N11D6E" part="chapter2" ref="N11D6E" type="subsection">2.11.7</cms:entry><cms:entry id="_Toc124944069" part="chapter2" ref="_Toc124944069" type="link"/><cms:entry id="_Toc125100643" part="chapter2" ref="_Toc125100643" type="link"/><cms:entry id="_Toc125107247" part="chapter2" ref="_Toc125107247" type="link"/><cms:entry id="N11D98" part="chapter2" ref="N11D98" type="subsection">2.11.8</cms:entry><cms:entry id="_Toc124944070" part="chapter2" ref="_Toc124944070" type="link"/><cms:entry id="_Toc125100644" part="chapter2" ref="_Toc125100644" type="link"/><cms:entry id="_Toc125107248" part="chapter2" ref="_Toc125107248" type="link"/><cms:entry id="N11DB3" part="chapter2" ref="N11DB3" type="subsection">2.11.9</cms:entry><cms:entry id="N11DBD" part="chapter2" ref="N11DBD" type="citenumber">59</cms:entry><cms:entry id="N11DC3" part="chapter2" ref="N11DC3" type="table"/><cms:entry id="N11E0F" part="chapter2" ref="N11E0F" type="citenumber">60</cms:entry><cms:entry id="_Toc124944071" part="chapter2" ref="_Toc124944071" type="link"/><cms:entry id="_Toc125100645" part="chapter2" ref="_Toc125100645" type="link"/><cms:entry id="_Toc125107249" part="chapter2" ref="_Toc125107249" type="link"/><cms:entry id="N11E31" part="chapter2" ref="N11E31" type="subsection">2.11.10</cms:entry><cms:entry id="_Toc124944072" part="chapter2" ref="_Toc124944072" type="link"/><cms:entry id="_Toc125100646" part="chapter2" ref="_Toc125100646" type="link"/><cms:entry id="_Toc125107250" part="chapter2" ref="_Toc125107250" type="link"/><cms:entry id="N11E4C" part="chapter2" ref="N11E4C" type="subsection">2.11.11</cms:entry><cms:entry id="N11E53" part="chapter2" ref="N11E53" type="citenumber">61</cms:entry><cms:entry id="N11E5C" part="chapter2" ref="N11E5C" type="table"/><cms:entry id="_Toc124944073" part="chapter2" ref="_Toc124944073" type="link"/><cms:entry id="_Toc125100647" part="chapter2" ref="_Toc125100647" type="link"/><cms:entry id="_Toc125107251" part="chapter2" ref="_Toc125107251" type="link"/><cms:entry id="N11EE3" part="chapter2" ref="N11EE3" type="subsection">2.11.12</cms:entry><cms:entry id="N11EEA" part="chapter2" ref="N11EEA" type="citenumber">62</cms:entry><cms:entry id="_Toc124944074" part="chapter2" ref="_Toc124944074" type="link"/><cms:entry id="_Toc125100648" part="chapter2" ref="_Toc125100648" type="link"/><cms:entry id="_Toc125107252" part="chapter2" ref="_Toc125107252" type="link"/><cms:entry id="N11F10" part="chapter2" ref="N11F10" type="subsection">2.11.13</cms:entry><cms:entry id="N11F17" part="chapter2" ref="N11F17" type="citenumber">63</cms:entry><cms:entry id="N11F20" part="chapter2" ref="N11F20" type="table"/><cms:entry id="N11F93" part="chapter2" ref="N11F93" type="citenumber">64</cms:entry><cms:entry id="_Toc124944075" part="chapter2" ref="_Toc124944075" type="link"/><cms:entry id="_Toc125100649" part="chapter2" ref="_Toc125100649" type="link"/><cms:entry id="_Toc125107253" part="chapter2" ref="_Toc125107253" type="link"/><cms:entry id="N11FCF" part="chapter2" ref="N11FCF" type="section">2.12</cms:entry><cms:entry id="_Toc124944076" part="chapter2" ref="_Toc124944076" type="link"/><cms:entry id="_Toc125100650" part="chapter2" ref="_Toc125100650" type="link"/><cms:entry id="N11FE0" part="chapter2" ref="N11FE0" type="subsection">2.12.1</cms:entry><cms:entry id="_Toc125107254" part="chapter2" ref="_Toc125107254" type="link"/><cms:entry id="_Toc124944077" part="chapter2" ref="_Toc124944077" type="link"/><cms:entry id="_Toc125100651" part="chapter2" ref="_Toc125100651" type="link"/><cms:entry id="_Toc125107255" part="chapter2" ref="_Toc125107255" type="link"/><cms:entry id="N11FFE" part="chapter2" ref="N11FFE" type="subsection">2.12.2</cms:entry><cms:entry id="N12005" part="chapter2" ref="N12005" type="citenumber">65</cms:entry><cms:entry id="_Toc124944078" part="chapter2" ref="_Toc124944078" type="link"/><cms:entry id="_Toc125100652" part="chapter2" ref="_Toc125100652" type="link"/><cms:entry id="_Toc125107256" part="chapter2" ref="_Toc125107256" type="link"/><cms:entry id="N1201C" part="chapter2" ref="N1201C" type="subsection">2.12.3</cms:entry><cms:entry id="_Toc124944079" part="chapter2" ref="_Toc124944079" type="link"/><cms:entry id="_Toc125100653" part="chapter2" ref="_Toc125100653" type="link"/><cms:entry id="_Toc125107257" part="chapter2" ref="_Toc125107257" type="link"/><cms:entry id="N12037" part="chapter2" ref="N12037" type="subsection">2.12.4</cms:entry><cms:entry id="_Toc124944080" part="chapter2" ref="_Toc124944080" type="link"/><cms:entry id="_Toc125100654" part="chapter2" ref="_Toc125100654" type="link"/><cms:entry id="_Toc125107258" part="chapter2" ref="_Toc125107258" type="link"/><cms:entry id="N12052" part="chapter2" ref="N12052" type="subsection">2.12.5</cms:entry><cms:entry id="N12059" part="chapter2" ref="N12059" type="citenumber">66</cms:entry><cms:entry id="_Toc124944081" part="chapter2" ref="_Toc124944081" type="link"/><cms:entry id="_Toc125100655" part="chapter2" ref="_Toc125100655" type="link"/><cms:entry id="_Toc125107259" part="chapter2" ref="_Toc125107259" type="link"/><cms:entry id="N12070" part="chapter2" ref="N12070" type="subsection">2.12.6</cms:entry><cms:entry id="_Toc124944082" part="chapter2" ref="_Toc124944082" type="link"/><cms:entry id="_Toc125100656" part="chapter2" ref="_Toc125100656" type="link"/><cms:entry id="_Toc125107260" part="chapter2" ref="_Toc125107260" type="link"/><cms:entry id="N1208E" part="chapter2" ref="N1208E" type="subsection">2.12.7</cms:entry><cms:entry id="_Toc124944083" part="chapter2" ref="_Toc124944083" type="link"/><cms:entry id="_Toc125100657" part="chapter2" ref="_Toc125100657" type="link"/><cms:entry id="_Toc125107261" part="chapter2" ref="_Toc125107261" type="link"/><cms:entry id="N120A9" part="chapter2" ref="N120A9" type="subsection">2.12.8</cms:entry><cms:entry id="N120B0" part="chapter2" ref="N120B0" type="citenumber">67</cms:entry><cms:entry id="_Toc124944084" part="chapter2" ref="_Toc124944084" type="link"/><cms:entry id="_Toc125100658" part="chapter2" ref="_Toc125100658" type="link"/><cms:entry id="_Toc125107262" part="chapter2" ref="_Toc125107262" type="link"/><cms:entry id="N120CA" part="chapter2" ref="N120CA" type="subsection">2.12.9</cms:entry><cms:entry id="_Toc124944085" part="chapter2" ref="_Toc124944085" type="link"/><cms:entry id="_Toc125100659" part="chapter2" ref="_Toc125100659" type="link"/><cms:entry id="_Toc125107263" part="chapter2" ref="_Toc125107263" type="link"/><cms:entry id="N120E8" part="chapter2" ref="N120E8" type="subsection">2.12.10</cms:entry><cms:entry id="N120F2" part="chapter2" ref="N120F2" type="citenumber">68</cms:entry><cms:entry id="_Toc124944086" part="chapter2" ref="_Toc124944086" type="link"/><cms:entry id="_Toc125100660" part="chapter2" ref="_Toc125100660" type="link"/><cms:entry id="_Toc125107264" part="chapter2" ref="_Toc125107264" type="link"/><cms:entry id="N12112" part="chapter2" ref="N12112" type="subsection">2.12.11</cms:entry><cms:entry id="N12122" part="chapter2" ref="N12122" type="citenumber">69</cms:entry><cms:entry id="N12125" part="chapter2" ref="N12125" type="table"/><cms:entry id="_Toc124944087" part="chapter2" ref="_Toc124944087" type="link"/><cms:entry id="_Toc125100661" part="chapter2" ref="_Toc125100661" type="link"/><cms:entry id="_Toc125107265" part="chapter2" ref="_Toc125107265" type="link"/><cms:entry id="N121D3" part="chapter2" ref="N121D3" type="subsection">2.12.12</cms:entry><cms:entry id="_Toc124944088" part="chapter2" ref="_Toc124944088" type="link"/><cms:entry id="_Toc125100662" part="chapter2" ref="_Toc125100662" type="link"/><cms:entry id="_Toc125107266" part="chapter2" ref="_Toc125107266" type="link"/><cms:entry id="N121F1" part="chapter2" ref="N121F1" type="subsection">2.12.13</cms:entry><cms:entry id="N121F8" part="chapter2" ref="N121F8" type="citenumber">70</cms:entry><cms:entry id="_Toc124944089" part="chapter2" ref="_Toc124944089" type="link"/><cms:entry id="_Toc125100663" part="chapter2" ref="_Toc125100663" type="link"/><cms:entry id="_Toc125107267" part="chapter2" ref="_Toc125107267" type="link"/><cms:entry id="N12212" part="chapter2" ref="N12212" type="subsection">2.12.14</cms:entry><cms:entry id="_Toc124944090" part="chapter2" ref="_Toc124944090" type="link"/><cms:entry id="_Toc125100664" part="chapter2" ref="_Toc125100664" type="link"/><cms:entry id="_Toc125107268" part="chapter2" ref="_Toc125107268" type="link"/><cms:entry id="N1222D" part="chapter2" ref="N1222D" type="subsection">2.12.15</cms:entry><cms:entry id="N1223D" part="chapter2" ref="N1223D" type="citenumber">71</cms:entry><cms:entry id="N1224F" part="chapter2" ref="N1224F" type="mm">613#184</cms:entry><cms:entry id="N12260" part="chapter2" ref="N12260" type="citenumber">72</cms:entry><cms:entry id="N12277" part="chapter2" ref="N12277" type="mm">429#205</cms:entry><cms:entry id="_Toc124944091" part="chapter2" ref="_Toc124944091" type="link"/><cms:entry id="_Toc125100665" part="chapter2" ref="_Toc125100665" type="link"/><cms:entry id="_Toc125107269" part="chapter2" ref="_Toc125107269" type="link"/><cms:entry id="N1229C" part="chapter2" ref="N1229C" type="subsection">2.12.16</cms:entry><cms:entry id="N122A6" part="chapter2" ref="N122A6" type="citenumber">73</cms:entry><cms:entry id="N122B2" part="chapter2" ref="N122B2" type="mm">597#657</cms:entry><cms:entry id="_Toc124944092" part="chapter2" ref="_Toc124944092" type="link"/><cms:entry id="_Toc125100666" part="chapter2" ref="_Toc125100666" type="link"/><cms:entry id="_Toc125107270" part="chapter2" ref="_Toc125107270" type="link"/><cms:entry id="chapter3" part="chapter3" ref="chapter3" type="chapter">3</cms:entry><cms:entry id="N122D8" part="chapter3" ref="N122D8" type="helpercitenumber">73</cms:entry><cms:entry id="N122DD" part="chapter3" ref="N122DD" type="citenumber">74</cms:entry><cms:entry id="N122E0" part="chapter3" ref="N122E0" type="mm">327#140</cms:entry><cms:entry id="_Toc124944093" part="chapter3" ref="_Toc124944093" type="link"/><cms:entry id="_Toc125100667" part="chapter3" ref="_Toc125100667" type="link"/><cms:entry id="N122F8" part="chapter3" ref="N122F8" type="section">3.1</cms:entry><cms:entry id="_Toc125107271" part="chapter3" ref="_Toc125107271" type="link"/><cms:entry id="_Toc124944094" part="chapter3" ref="_Toc124944094" type="link"/><cms:entry id="_Toc125100668" part="chapter3" ref="_Toc125100668" type="link"/><cms:entry id="N1230C" part="chapter3" ref="N1230C" type="subsection">3.1.1</cms:entry><cms:entry id="_Toc125107272" part="chapter3" ref="_Toc125107272" type="link"/><cms:entry id="N1231A" part="chapter3" ref="N1231A" type="citenumber">75</cms:entry><cms:entry id="N1231D" part="chapter3" ref="N1231D" type="mm">548#666</cms:entry><cms:entry id="N12334" part="chapter3" ref="N12334" type="citenumber">76</cms:entry><cms:entry id="_Toc124944095" part="chapter3" ref="_Toc124944095" type="link"/><cms:entry id="_Toc125100669" part="chapter3" ref="_Toc125100669" type="link"/><cms:entry id="_Toc125107273" part="chapter3" ref="_Toc125107273" type="link"/><cms:entry id="N1234B" part="chapter3" ref="N1234B" type="subsection">3.1.2</cms:entry><cms:entry id="N12355" part="chapter3" ref="N12355" type="mm">563#256</cms:entry><cms:entry id="N12360" part="chapter3" ref="N12360" type="citenumber">77</cms:entry><cms:entry id="N12366" part="chapter3" ref="N12366" type="mm">232#283</cms:entry><cms:entry id="_Toc124944096" part="chapter3" ref="_Toc124944096" type="link"/><cms:entry id="_Toc125100670" part="chapter3" ref="_Toc125100670" type="link"/><cms:entry id="_Toc125107274" part="chapter3" ref="_Toc125107274" type="link"/><cms:entry id="N12382" part="chapter3" ref="N12382" type="subsection">3.1.3</cms:entry><cms:entry id="N1238E" part="chapter3" ref="N1238E" type="citenumber">78</cms:entry><cms:entry id="N12391" part="chapter3" ref="N12391" type="mm">231#216</cms:entry><cms:entry id="N1239F" part="chapter3" ref="N1239F" type="mm">529#269</cms:entry><cms:entry id="N123AA" part="chapter3" ref="N123AA" type="citenumber">79</cms:entry><cms:entry id="N123B0" part="chapter3" ref="N123B0" type="mm">217#240</cms:entry><cms:entry id="N123BE" part="chapter3" ref="N123BE" type="citenumber">80</cms:entry><cms:entry id="N123C1" part="chapter3" ref="N123C1" type="mm">561#503</cms:entry><cms:entry id="N123D4" part="chapter3" ref="N123D4" type="citenumber">81</cms:entry><cms:entry id="N123D7" part="chapter3" ref="N123D7" type="mm">621#512</cms:entry><cms:entry id="_Toc124944097" part="chapter3" ref="_Toc124944097" type="link"/><cms:entry id="_Toc125100671" part="chapter3" ref="_Toc125100671" type="link"/><cms:entry id="_Toc125107275" part="chapter3" ref="_Toc125107275" type="link"/><cms:entry id="N123F3" part="chapter3" ref="N123F3" type="subsection">3.1.4</cms:entry><cms:entry id="N123FD" part="chapter3" ref="N123FD" type="mm">492#200</cms:entry><cms:entry id="N12408" part="chapter3" ref="N12408" type="citenumber">82</cms:entry><cms:entry id="N1240E" part="chapter3" ref="N1240E" type="mm">259#205</cms:entry><cms:entry id="N12424" part="chapter3" ref="N12424" type="citenumber">83</cms:entry><cms:entry id="N12427" part="chapter3" ref="N12427" type="mm">589#296</cms:entry><cms:entry id="N1243D" part="chapter3" ref="N1243D" type="mm">537#249</cms:entry><cms:entry id="N12448" part="chapter3" ref="N12448" type="citenumber">84</cms:entry><cms:entry id="N12451" part="chapter3" ref="N12451" type="mm">529#253</cms:entry><cms:entry id="N12464" part="chapter3" ref="N12464" type="citenumber">85</cms:entry><cms:entry id="N12467" part="chapter3" ref="N12467" type="mm">565#375</cms:entry><cms:entry id="_Toc124944098" part="chapter3" ref="_Toc124944098" type="link"/><cms:entry id="_Toc125100672" part="chapter3" ref="_Toc125100672" type="link"/><cms:entry id="_Toc125107276" part="chapter3" ref="_Toc125107276" type="link"/><cms:entry id="N12483" part="chapter3" ref="N12483" type="subsection">3.1.5</cms:entry><cms:entry id="N1248F" part="chapter3" ref="N1248F" type="mm">339#289</cms:entry><cms:entry id="N1249A" part="chapter3" ref="N1249A" type="citenumber">86</cms:entry><cms:entry id="N124A0" part="chapter3" ref="N124A0" type="mm">272#341</cms:entry><cms:entry id="N124AD" part="chapter3" ref="N124AD" type="subsection">3.1.6</cms:entry><cms:entry id="_Toc124944099" part="chapter3" ref="_Toc124944099" type="link"/><cms:entry id="_Toc125100673" part="chapter3" ref="_Toc125100673" type="link"/><cms:entry id="_Toc125107277" part="chapter3" ref="_Toc125107277" type="link"/><cms:entry id="N124BD" part="chapter3" ref="N124BD" type="citenumber">87</cms:entry><cms:entry id="N124C3" part="chapter3" ref="N124C3" type="mm">545#255</cms:entry><cms:entry id="N124D3" part="chapter3" ref="N124D3" type="citenumber">88</cms:entry><cms:entry id="N124DE" part="chapter3" ref="N124DE" type="mm">573#441</cms:entry><cms:entry id="N124F0" part="chapter3" ref="N124F0" type="citenumber">89</cms:entry><cms:entry id="_Toc124944100" part="chapter3" ref="_Toc124944100" type="link"/><cms:entry id="_Toc125100674" part="chapter3" ref="_Toc125100674" type="link"/><cms:entry id="_Toc125107278" part="chapter3" ref="_Toc125107278" type="link"/><cms:entry id="N12507" part="chapter3" ref="N12507" type="subsection">3.1.7</cms:entry><cms:entry id="N12517" part="chapter3" ref="N12517" type="citenumber">90</cms:entry><cms:entry id="N1251A" part="chapter3" ref="N1251A" type="mm">544#208</cms:entry><cms:entry id="N1252D" part="chapter3" ref="N1252D" type="mm">563#497</cms:entry><cms:entry id="N1253B" part="chapter3" ref="N1253B" type="citenumber">91</cms:entry><cms:entry id="_Toc124944101" part="chapter3" ref="_Toc124944101" type="link"/><cms:entry id="_Toc125100675" part="chapter3" ref="_Toc125100675" type="link"/><cms:entry id="_Toc125107279" part="chapter3" ref="_Toc125107279" type="link"/><cms:entry id="N12556" part="chapter3" ref="N12556" type="section">3.2</cms:entry><cms:entry id="_Toc124944102" part="chapter3" ref="_Toc124944102" type="link"/><cms:entry id="_Toc125100676" part="chapter3" ref="_Toc125100676" type="link"/><cms:entry id="N12567" part="chapter3" ref="N12567" type="subsection">3.2.1</cms:entry><cms:entry id="_Toc125107280" part="chapter3" ref="_Toc125107280" type="link"/><cms:entry id="N12574" part="chapter3" ref="N12574" type="mm">261#124</cms:entry><cms:entry id="N1257F" part="chapter3" ref="N1257F" type="citenumber">92</cms:entry><cms:entry id="N1258D" part="chapter3" ref="N1258D" type="mm">433#383</cms:entry><cms:entry id="N1259B" part="chapter3" ref="N1259B" type="citenumber">93</cms:entry><cms:entry id="N125A4" part="chapter3" ref="N125A4" type="mm">297#225</cms:entry><cms:entry id="N125AF" part="chapter3" ref="N125AF" type="citenumber">94</cms:entry><cms:entry id="N125B5" part="chapter3" ref="N125B5" type="mm">575#148</cms:entry><cms:entry id="_Toc124944103" part="chapter3" ref="_Toc124944103" type="link"/><cms:entry id="_Toc125100677" part="chapter3" ref="_Toc125100677" type="link"/><cms:entry id="_Toc125107281" part="chapter3" ref="_Toc125107281" type="link"/><cms:entry id="N125D1" part="chapter3" ref="N125D1" type="subsection">3.2.2</cms:entry><cms:entry id="N125E1" part="chapter3" ref="N125E1" type="citenumber">95</cms:entry><cms:entry id="N125E4" part="chapter3" ref="N125E4" type="mm">239#164</cms:entry><cms:entry id="N125F2" part="chapter3" ref="N125F2" type="mm">171#189</cms:entry><cms:entry id="_Toc124944104" part="chapter3" ref="_Toc124944104" type="link"/><cms:entry id="_Toc125100678" part="chapter3" ref="_Toc125100678" type="link"/><cms:entry id="_Toc125107282" part="chapter3" ref="_Toc125107282" type="link"/><cms:entry id="N1260E" part="chapter3" ref="N1260E" type="subsection">3.2.3</cms:entry><cms:entry id="N12615" part="chapter3" ref="N12615" type="citenumber">96</cms:entry><cms:entry id="N1261D" part="chapter3" ref="N1261D" type="mm">545#235</cms:entry><cms:entry id="N1262B" part="chapter3" ref="N1262B" type="citenumber">97</cms:entry><cms:entry id="N1262E" part="chapter3" ref="N1262E" type="mm">491#297</cms:entry><cms:entry id="_Toc124944105" part="chapter3" ref="_Toc124944105" type="link"/><cms:entry id="_Toc125100679" part="chapter3" ref="_Toc125100679" type="link"/><cms:entry id="_Toc125107283" part="chapter3" ref="_Toc125107283" type="link"/><cms:entry id="N1264E" part="chapter3" ref="N1264E" type="subsection">3.2.4</cms:entry><cms:entry id="N12659" part="chapter3" ref="N12659" type="mm">510#518</cms:entry><cms:entry id="N12664" part="chapter3" ref="N12664" type="citenumber">98</cms:entry><cms:entry id="N1266D" part="chapter3" ref="N1266D" type="mm">619#324</cms:entry><cms:entry id="N12678" part="chapter3" ref="N12678" type="citenumber">99</cms:entry><cms:entry id="N1267E" part="chapter3" ref="N1267E" type="mm">624#287</cms:entry><cms:entry id="_Toc124944106" part="chapter3" ref="_Toc124944106" type="link"/><cms:entry id="_Toc125100680" part="chapter3" ref="_Toc125100680" type="link"/><cms:entry id="_Toc125107284" part="chapter3" ref="_Toc125107284" type="link"/><cms:entry id="N1269A" part="chapter3" ref="N1269A" type="subsection">3.2.5</cms:entry><cms:entry id="N126A4" part="chapter3" ref="N126A4" type="citenumber">100</cms:entry><cms:entry id="N126A7" part="chapter3" ref="N126A7" type="mm">581#153</cms:entry><cms:entry id="N126B8" part="chapter3" ref="N126B8" type="mm">600#544</cms:entry><cms:entry id="N126C3" part="chapter3" ref="N126C3" type="citenumber">101</cms:entry><cms:entry id="_Toc124944107" part="chapter3" ref="_Toc124944107" type="link"/><cms:entry id="_Toc125100681" part="chapter3" ref="_Toc125100681" type="link"/><cms:entry id="_Toc125107285" part="chapter3" ref="_Toc125107285" type="link"/><cms:entry id="N126DA" part="chapter3" ref="N126DA" type="subsection">3.2.6</cms:entry><cms:entry id="N126E4" part="chapter3" ref="N126E4" type="mm">263#171</cms:entry><cms:entry id="_Toc124944108" part="chapter3" ref="_Toc124944108" type="link"/><cms:entry id="_Toc125100682" part="chapter3" ref="_Toc125100682" type="link"/><cms:entry id="_Toc125107286" part="chapter3" ref="_Toc125107286" type="link"/><cms:entry id="N12700" part="chapter3" ref="N12700" type="subsection">3.2.7</cms:entry><cms:entry id="N12707" part="chapter3" ref="N12707" type="citenumber">102</cms:entry><cms:entry id="N1270D" part="chapter3" ref="N1270D" type="mm">565#300</cms:entry><cms:entry id="_Toc124944109" part="chapter3" ref="_Toc124944109" type="link"/><cms:entry id="_Toc125100683" part="chapter3" ref="_Toc125100683" type="link"/><cms:entry id="_Toc125107287" part="chapter3" ref="_Toc125107287" type="link"/><cms:entry id="chapter4" part="chapter4" ref="chapter4" type="chapter">4</cms:entry><cms:entry id="N12730" part="chapter4" ref="N12730" type="helpercitenumber">102</cms:entry><cms:entry id="_Toc124944110" part="chapter4" ref="_Toc124944110" type="link"/><cms:entry id="_Toc125100684" part="chapter4" ref="_Toc125100684" type="link"/><cms:entry id="N1273F" part="chapter4" ref="N1273F" type="section">4.1</cms:entry><cms:entry id="_Toc125107288" part="chapter4" ref="_Toc125107288" type="link"/><cms:entry id="N12749" part="chapter4" ref="N12749" type="citenumber">103</cms:entry><cms:entry id="N12757" part="chapter4" ref="N12757" type="citenumber">104</cms:entry><cms:entry id="_Toc124944111" part="chapter4" ref="_Toc124944111" type="link"/><cms:entry id="_Toc125100685" part="chapter4" ref="_Toc125100685" type="link"/><cms:entry id="_Toc125107289" part="chapter4" ref="_Toc125107289" type="link"/><cms:entry id="N12774" part="chapter4" ref="N12774" type="section">4.2</cms:entry><cms:entry id="N1277E" part="chapter4" ref="N1277E" type="citenumber">105</cms:entry><cms:entry id="_Toc124944112" part="chapter4" ref="_Toc124944112" type="link"/><cms:entry id="_Toc125100686" part="chapter4" ref="_Toc125100686" type="link"/><cms:entry id="_Toc125107290" part="chapter4" ref="_Toc125107290" type="link"/><cms:entry id="N12795" part="chapter4" ref="N12795" type="section">4.3</cms:entry><cms:entry id="_Toc124944113" part="chapter4" ref="_Toc124944113" type="link"/><cms:entry id="_Toc125100687" part="chapter4" ref="_Toc125100687" type="link"/><cms:entry id="_Toc125107291" part="chapter4" ref="_Toc125107291" type="link"/><cms:entry id="N127B9" part="chapter4" ref="N127B9" type="section">4.4</cms:entry><cms:entry id="N127C0" part="chapter4" ref="N127C0" type="citenumber">106</cms:entry><cms:entry id="N127CB" part="chapter4" ref="N127CB" type="mm">480#256</cms:entry><cms:entry id="_Toc124944114" part="chapter4" ref="_Toc124944114" type="link"/><cms:entry id="_Toc125100688" part="chapter4" ref="_Toc125100688" type="link"/><cms:entry id="_Toc125107292" part="chapter4" ref="_Toc125107292" type="link"/><cms:entry id="N127E7" part="chapter4" ref="N127E7" type="section">4.5</cms:entry><cms:entry id="N127EE" part="chapter4" ref="N127EE" type="citenumber">107</cms:entry><cms:entry id="N1281C" part="chapter4" ref="N1281C" type="mm">379#753</cms:entry><cms:entry id="N12827" part="chapter4" ref="N12827" type="citenumber">108</cms:entry><cms:entry id="_Toc124944115" part="chapter4" ref="_Toc124944115" type="link"/><cms:entry id="_Toc125100689" part="chapter4" ref="_Toc125100689" type="link"/><cms:entry id="_Toc125107293" part="chapter4" ref="_Toc125107293" type="link"/><cms:entry id="N12841" part="chapter4" ref="N12841" type="section">4.6</cms:entry><cms:entry id="N1284B" part="chapter4" ref="N1284B" type="citenumber">109</cms:entry><cms:entry id="_Toc124944116" part="chapter4" ref="_Toc124944116" type="link"/><cms:entry id="_Toc125100690" part="chapter4" ref="_Toc125100690" type="link"/><cms:entry id="_Toc125107294" part="chapter4" ref="_Toc125107294" type="link"/><cms:entry id="N12868" part="chapter4" ref="N12868" type="section">4.7</cms:entry><cms:entry id="N1286F" part="chapter4" ref="N1286F" type="citenumber">110</cms:entry><cms:entry id="N1287D" part="chapter4" ref="N1287D" type="citenumber">111</cms:entry><cms:entry id="_Toc124944117" part="chapter4" ref="_Toc124944117" type="link"/><cms:entry id="_Toc125100691" part="chapter4" ref="_Toc125100691" type="link"/><cms:entry id="_Toc125107295" part="chapter4" ref="_Toc125107295" type="link"/><cms:entry id="N1289A" part="chapter4" ref="N1289A" type="section">4.8</cms:entry><cms:entry id="N128A1" part="chapter4" ref="N128A1" type="citenumber">112</cms:entry><cms:entry id="N128B0" part="chapter4" ref="N128B0" type="mm">384#752</cms:entry><cms:entry id="_Toc124944118" part="chapter4" ref="_Toc124944118" type="link"/><cms:entry id="_Toc125100692" part="chapter4" ref="_Toc125100692" type="link"/><cms:entry id="_Toc125107296" part="chapter4" ref="_Toc125107296" type="link"/><cms:entry id="N128CF" part="chapter4" ref="N128CF" type="section">4.9</cms:entry><cms:entry id="N128D6" part="chapter4" ref="N128D6" type="citenumber">113</cms:entry><cms:entry id="N128E4" part="chapter4" ref="N128E4" type="citenumber">114</cms:entry><cms:entry id="N128EF" part="chapter4" ref="N128EF" type="mm">461#427</cms:entry><cms:entry id="_Toc124944119" part="chapter4" ref="_Toc124944119" type="link"/><cms:entry id="_Toc125100693" part="chapter4" ref="_Toc125100693" type="link"/><cms:entry id="_Toc125107297" part="chapter4" ref="_Toc125107297" type="link"/><cms:entry id="N1290D" part="chapter4" ref="N1290D" type="section">4.10</cms:entry><cms:entry id="N12914" part="chapter4" ref="N12914" type="citenumber">115</cms:entry><cms:entry id="_Toc124944120" part="chapter4" ref="_Toc124944120" type="link"/><cms:entry id="_Toc125100694" part="chapter4" ref="_Toc125100694" type="link"/><cms:entry id="_Toc125107298" part="chapter4" ref="_Toc125107298" type="link"/><cms:entry id="chapter5" part="chapter5" ref="chapter5" type="chapter">5</cms:entry><cms:entry id="N1293E" part="chapter5" ref="N1293E" type="citenumber">116</cms:entry><cms:entry id="N1294C" part="chapter5" ref="N1294C" type="citenumber">117</cms:entry><cms:entry id="_Toc124944121" part="chapter5" ref="_Toc124944121" type="link"/><cms:entry id="_Toc125100695" part="chapter5" ref="_Toc125100695" type="link"/><cms:entry id="_Toc125107299" part="chapter5" ref="_Toc125107299" type="link"/><cms:entry ref="N12964" type="back"/><cms:entry id="N12966" part="N12966" ref="N12966" type="declaration">Erklärung</cms:entry><cms:entry id="_Toc124944019" part="N12966" ref="_Toc124944019" type="link"/><cms:entry id="_Toc125100593" part="N12966" ref="_Toc125100593" type="link"/><cms:entry id="_Toc125107197" part="N12966" ref="_Toc125107197" type="link"/><cms:entry id="N12984" part="N12984" ref="N12984" type="abbreviation">Abkürzungen</cms:entry><cms:entry id="N1298B" part="N12984" ref="N1298B" type="table"/><cms:entry id="_Toc124944122" part="N12984" ref="_Toc124944122" type="link"/><cms:entry id="_Toc125100696" part="N12984" ref="_Toc125100696" type="link"/><cms:entry id="_Toc125107300" part="N12984" ref="_Toc125107300" type="link"/><cms:entry ref="N13699" type="bibliography">Literaturverzeichnis</cms:entry><cms:entry ref="_Toc124944124" type="link"/><cms:entry ref="_Toc125100698" type="link"/><cms:entry ref="_Toc125107302" type="link"/><cms:entry id="N14E9C" part="N14E9C" ref="N14E9C" type="appendix">Publikationen</cms:entry><cms:entry id="N14E9E" part="N14E9C" ref="N14E9E" type="head"/><cms:entry id="N14EA1" part="N14E9C" ref="N14EA1" type="p"/><cms:entry id="N14EA4" part="N14E9C" ref="N14EA4" type="p"/><cms:entry id="N14EAC" part="N14E9C" ref="N14EAC" type="p"/><cms:entry id="N14EB2" part="N14E9C" ref="N14EB2" type="p"/><cms:entry id="_Toc124944125" part="N14E9C" ref="_Toc124944125" type="link"/><cms:entry id="N14EB8" part="N14E9C" ref="N14EB8" type="p"/><cms:entry id="_Toc125100699" part="N14E9C" ref="_Toc125100699" type="link"/><cms:entry id="N14EBE" part="N14E9C" ref="N14EBE" type="p"/><cms:entry id="_Toc125107303" part="N14E9C" ref="_Toc125107303" type="link"/><cms:entry id="N14EC5" part="N14EC5" ref="N14EC5" type="vita">Lebenslauf</cms:entry><cms:entry id="N14ECC" part="N14EC5" ref="N14ECC" type="table"/><cms:entry id="N14F3C" part="N14EC5" ref="N14F3C" type="table"/><cms:entry id="N15022" part="N14EC5" ref="N15022" type="table"/><cms:entry id="_Toc124944126" part="N14EC5" ref="_Toc124944126" type="link"/><cms:entry id="_Toc125100700" part="N14EC5" ref="_Toc125100700" type="link"/><cms:entry id="_Toc125107304" part="N14EC5" ref="_Toc125107304" type="link"/><cms:entry id="N150C4" part="N150C4" ref="N150C4" type="acknowledgement">Danksagung</cms:entry><cms:entry part="N13699" type=":current"/><cms:entry type=":lang">de</cms:entry><cms:entry id=":contents" part="front" ref=":contents" type=":contents">Inhaltsverzeichnis</cms:entry><cms:entry type=":help"><url href="http://...">Hilfe</url></cms:entry></cms:meta><cms:content><bibliography id="N13699">
         <head>Literaturverzeichnis</head>
         
            <citation published="yes" workType="Journal">
               <workauthor>Acuto,</workauthor>
               <workauthor>O. and Michel, F.</workauthor>
               <pubdate>(2003)</pubdate>
               <articletitle>CD28-mediated co-stimulation: a quantitative support for TCR signalling. </articletitle>Nat Rev Immunol, <volume>3</volume>, <pages>939-951.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Adachi, O., Kawai, T., Takeda, K., Matsumoto, M., Tsutsui, H., Sakagami, M., Nakanishi, K. and Akira, S</workauthor>
               <pubdate>. (1998)</pubdate>
               <articletitle>Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.</articletitle> Immunity, <volume>9</volume>, <pages>143-150</pages>.</citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Altman, A., Isakov, N. and Baier, G.</workauthor>
               <pubdate>(2000</pubdate>
               <articletitle>) Protein kinase </articletitle>
               <articletitle>C </articletitle>
               <articletitle>&#952;</articletitle>
               <articletitle>: a new essential superstar on the T-cell stage.</articletitle> Immunol Today, <volume>21</volume>, <pages>567-573</pages>.</citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Andres, P.G., Howland, K.C., Dresnek, D., Edmondson, S., Abbas, A.K. and Krummel, M.F. </workauthor>
               <pubdate>(2004b)</pubdate>
               <articletitle>CD28 signals in the immature immunological synapse.</articletitle> J Immunol, <volume>172</volume>, <pages>5880-5886.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Andres, P.G., Howland, K.C., Nirula, A., Kane, L.P., Barron, L., Dresnek, D., Sadra, A., Imboden, J., Weiss, A. and Abbas, A.K</workauthor>
               <pubdate>. (2004a)</pubdate>
               <articletitle>Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation.</articletitle> Nat Immunol, <volume>5</volume>, <pages>435-442.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Arenzana-Seisdedos, F., Thompson, J., Rodriguez, M.S., Bachelerie, F., Thomas, D. and Hay, R.T.</workauthor>
               <pubdate>(1995)</pubdate>
               <articletitle>Inducible nuclear expression of newly synthesized I</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B</articletitle>
               <articletitle>&#945;</articletitle>
               <articletitle> negatively regulates DNA-binding and transcriptional activities of NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B.</articletitle> Mol Cell Biol, <volume>15,</volume>
               <pages>2689-2696.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Bachmaier, K., Krawczyk, C., Kozieradzki, I., Kong, Y.Y., Sasaki, T., Oliveira-dos-Santos, A., Mariathasan, S., Bouchard, D., Wakeham, A., Itie, A., Le, J., Ohashi, P.S., Sarosi, I., Nishina, H., Lipkowitz, S. and Penninger, J.M.</workauthor>
               <pubdate>(2000)</pubdate>
               <articletitle>Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b.</articletitle> Nature, <volume>403</volume>, <pages>211-216</pages>.</citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Baeuerle, P.A. and Baichwal, V.R.</workauthor>
               <pubdate>(1997)</pubdate>
               <articletitle>NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B as a frequent target for immunosuppressive and anti-inflammatory molecules.</articletitle>Adv Immunol, <volume>65</volume>, <pages>111-137.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Baier, G</workauthor>
               <pubdate>. (2003)</pubdate>
               <articletitle>The PKC gene module: molecular biosystematics to resolve its T cell functions. </articletitle>Immunol Rev, <volume>192</volume>, <pages>64-79.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Baldwin, A.S., Jr</workauthor>. <pubdate>(1996)</pubdate>
               <articletitle>The NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B and I</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B proteins: new discoveries and insights.</articletitle> Annu Rev Immunol, <volume>14</volume>, <pages>649-683.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Banchereau, J. and Steinman, R.M.</workauthor>
               <pubdate>(1998</pubdate>) <articletitle>Dendritic</articletitle>
               <articletitle> cells and the control of immunity.</articletitle> Nature, <volume>392</volume>, <pages>245-252.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Barton, G.M. and Medzhitov, R.</workauthor>
               <pubdate>(2003)</pubdate>
               <articletitle>Toll-like receptor signaling pathways.</articletitle> Science, <volume>300</volume>, <pages>1524-1525.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Bedford, M.T., Chan, D.C. and Leder, P.</workauthor>
               <pubdate>(1997)</pubdate>
               <articletitle>FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands.</articletitle> Embo J, <volume>16</volume>, <pages>2376-2383.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Bedford, M.T., Sarbassova, D., Xu, J., Leder, P. and Yaffe, M.B</workauthor>
               <pubdate>. (2000)</pubdate>
               <articletitle>A</articletitle>
               <articletitle> novel pro-Arg motif recognized by WW domains. </articletitle>J Biol Chem, <volume>275</volume>, <pages>10359-10369.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Bertin, J., Wang, L., Guo, Y., Jacobson, M.D., Poyet, J.L., Srinivasula, S.M., Merriam, S., DiStefano, P.S. and Alnemri, E.S.</workauthor>
               <pubdate>(2001)</pubdate>
               <articletitle>CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with Bcl10 and activate NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B.</articletitle> J Biol Chem, <volume>276</volume>, <pages>11877-11882.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Betts, J.C. and Nabel, G.J.</workauthor>
               <pubdate>(1996)</pubdate>
               <articletitle>Differential regulation of NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B2 (p100) processing and control by amino-terminal sequences.</articletitle> Mol Cell Biol, <volume>16</volume>, <pages>6363-6371.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Bi, K., Tanaka, Y., Coudronniere, N., Sugie, K., Hong, S., van Stipdonk, M.J. and Altman, A.</workauthor>
               <pubdate>(2001)</pubdate>
               <articletitle>Antigen-induced translocation of PKC</articletitle>
               <articletitle>&#952;</articletitle>
               <articletitle> to membrane rafts is required for T cell activation.</articletitle> Nat Immunol, <volume>2</volume>, <pages>556-563.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Bonizzi, G., Bebien, M., Otero, D.C., Johnson-Vroom, K.E., Cao, Y., Vu, D., Jegga, A.G., Aronow, B.J., Ghosh, G., Rickert, R.C. and Karin, M.</workauthor>
               <pubdate>(2004)</pubdate>
               <articletitle>Activation of IKK</articletitle>
               <articletitle>&#945;</articletitle>
               <articletitle> target genes depends on recognition of specific </articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B binding sites by RelB:p52 dimers.</articletitle> Embo J, <volume>23</volume>, <pages>4202-4210.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Bonizzi, G. and Karin, M.</workauthor>
               <pubdate>(2004)</pubdate>
               <articletitle>The</articletitle>
               <articletitle> two NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B activation pathways and their role in innate and adaptive immunity.</articletitle> Trends Immunol, <volume>25</volume>, <pages>280-288.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Bouchier-Hayes, L. and Martin, S.J</workauthor>. <pubdate>(2002)</pubdate>
               <articletitle>CARD games in apoptosis and immunity.</articletitle> EMBO Rep, <volume>3</volume>, <pages>616-621.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Bradley, L.M., Harbertson, J., Freschi, G.C., Kondrack, R. and Linton, P.J.</workauthor>
               <pubdate>(2000)</pubdate>
               <articletitle>Regulation of development and function of memory CD4 subsets.</articletitle> Immunol Res, <volume>21</volume>, <pages>149-158.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Brockman, J.A., Scherer, D.C., McKinsey, T.A., Hall, S.M., Qi, X., Lee, W.Y. and Ballard, D.W.</workauthor>
               <pubdate>(1995)</pubdate>
               <articletitle>Coupling of a signal response domain in I</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B</articletitle>
               <articletitle>&#945;</articletitle>
               <articletitle> to multiple pathways for NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B activation.</articletitle> Mol Cell Biol, <volume>15</volume>, <pages>2809-2818.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Brown, K., Gerstberger, S., Carlson, L., Franzoso, G. and Siebenlist, U</workauthor>
               <pubdate>. (1995)</pubdate>
               <articletitle>Control of I</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B</articletitle>
               <articletitle>&#945;</articletitle>
               <articletitle> proteolysis by site-specific, signal-induced phosphorylation.</articletitle> Science, <volume>267</volume>, <pages>1485-1488.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Bryant, P. and Ploegh, H</workauthor>
               <pubdate>. (2004)</pubdate>
               <articletitle>Class II MHC peptide loading by the professionals.</articletitle> Curr Opin Immunol, <volume>16</volume>, <pages>96-102.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Bull, P., Morley, K.L., Hoekstra, M.F., Hunter, T. and Verma, I.M.</workauthor>
               <pubdate>(1990)</pubdate>
               <articletitle>The</articletitle>
               <articletitle> mouse c-rel protein has an N-terminal regulatory domain and a C-terminal transcriptional transactivation domain.</articletitle> Mol Cell Biol, <volume>10</volume>, <pages>5473-5485.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Burr, J.S., Savage, N.D., Messah, G.E., Kimzey, S.L., Shaw, A.S., Arch, R.H. and Green, J.M.</workauthor>
               <pubdate>(2001)</pubdate>
               <articletitle>Cutting edge: distinct motifs within CD28 regulate T cell proliferation and induction of Bcl-XL.</articletitle> J Immunol, <volume>166,</volume>
               <pages>5331-5335.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Call, M.E. and Wucherpfennig, K.W</workauthor>. <pubdate>(2005)</pubdate>
               <articletitle>The T cell receptor: critical role of the membrane environment in receptor assembly and function.</articletitle> Annu Rev Immunol, <volume>23</volume>, <pages>101-125.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Cenciarelli, C., Hou, D., Hsu, K.C., Rellahan, B.L., Wiest, D.L., Smith, H.T., Fried, V.A. and Weissman, A.M.</workauthor>
               <pubdate>(1992)</pubdate>
               <articletitle>Activation-induced ubiquitination of the T cell antigen receptor. </articletitle>Science, <volume>257</volume>, <pages>795-797.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Che, T., You, Y., Wang, D., Tanner, M.J., Dixit, V.M. and Lin, X</workauthor>
               <pubdate>. (2004)</pubdate>
               <articletitle>MALT1/paracaspase is a signaling component downstream of CARMA1 and mediates T cell receptor-induced NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B activation.</articletitle> J Biol Chem, <volume>279,</volume>
               <pages>15870-15876.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Chen, H.I. and Sudol, M.</workauthor>
               <pubdate>(1995)</pubdate>
               <articletitle>The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules. </articletitle>Proc Natl Acad Sci U S A<volume>, 92</volume>, <pages>7819-7823.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Chiang, Y.J., Kole, H.K., Brown, K., Naramura, M., Fukuhara, S., Hu, R.J., Jang, I.K., Gutkind, J.S., Shevach, E. and </workauthor>
               <workauthor>Gu</workauthor>
               <workauthor>, H.</workauthor>
               <pubdate>(2000)</pubdate>
               <articletitle>Cbl-b regulates the CD28 dependence of T-cell activation. </articletitle>Nature, <volume>403</volume>, <pages>216-220.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Chin,</workauthor>
               <workauthor> A.I., Dempsey, P.W., Bruhn, K., Miller, J.F., Xu, Y. and Cheng, G</workauthor>. <pubdate>(2002</pubdate>
               <articletitle>) Involvement of receptor-interacting protein 2 in innate and adaptive immune responses.</articletitle> Nature, <volume>416</volume>, <pages>190-194.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Chuang, E., Fisher, T.S., Morgan, R.W., Robbins, M.D., Duerr, J.M., Vander Heiden, M.G., Gardner, J.P., Hambor, J.E., Neveu, M.J. and Thompson, C.B.</workauthor>
               <pubdate>(2000)</pubdate>
               <articletitle>The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A.</articletitle> Immunity, <volume>13</volume>, <pages>313-322.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Coudronniere, N., Villalba, M., Englund, N. and Altman, A.</workauthor>
               <pubdate>(2000) </pubdate>
               <articletitle>NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C q.</articletitle> Proc Natl Acad Sci U S A, <volume>97</volume>, <pages>3394-3399.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Cross, S.L., Halden, N.F., Lenardo, M.J. and Leonard, W.J.</workauthor>
               <pubdate>(1989)</pubdate>
               <articletitle>Functionally</articletitle>
               <articletitle> distinct </articletitle>
               <articletitle><br/>NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B binding sites in the immunoglobulin </articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle> and IL-2 receptor a chain genes.</articletitle> Science, <volume>244</volume>, <pages>466-469.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Davis, M.M., Boniface, J.J., Reich, Z., Lyons, D., Hampl, J., Arden, B. and Chien, Y.</workauthor>
               <pubdate>(1998)</pubdate>
               <articletitle>Ligand recognition by </articletitle>
               <articletitle>&#945;</articletitle>
               <articletitle>/</articletitle>
               <articletitle>&#946;</articletitle>
               <articletitle> T cell receptors.</articletitle> Annu Rev Immunol, <volume>16</volume>, <pages>523-544.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Deng, L., Wang, C., Spencer, E., Yang, L., Braun, A., You, J., Slaughter, C., Pickart, C. and Chen, Z.J.</workauthor>
               <pubdate>(2000)</pubdate>
               <articletitle>Activation of the I</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain.</articletitle> Cell, <volume>103,</volume>
               <pages>351-361.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Delhase, M., Hayakawa, M., Chen, Y. and Karin, M</workauthor>
               <pubdate>. (1999)</pubdate>
               <articletitle>Positive and negative regulation of I</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B kinase activity through IKK</articletitle>
               <articletitle>&#946;</articletitle>
               <articletitle> subunit phosphorylation.</articletitle> Science, <volume>284</volume>, <pages>309-313.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>DiDonato, J.A., Hayakawa, M., Rothwarf, D.M., Zandi, E. and Karin, M.</workauthor>
               <pubdate>(1997)</pubdate>
               <articletitle>A cytokine-responsive I</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B kinase that activates the transcription factor NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B. </articletitle>Nature, <volume>388</volume>, <pages>548-554.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Dierlamm, J., Baens, M., Wlodarska, I., Stefanova-Ouzounova, M., Hernandez, J.M., Hossfeld, D.K., De Wolf-Peeters, C., Hagemeijer, A., Van den Berghe, H. and Marynen, P.</workauthor>
               <pubdate>(1999)</pubdate>
               <articletitle>The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas.</articletitle> Blood, <volume>93,</volume>
               <pages>3601-3609.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Dimitratos, S.D., Woods, D.F., Stathakis, D.G. and Bryant, P.J</workauthor>
               <pubdate>. (1999)</pubdate>
               <articletitle>Signaling pathways are focused at specialized regions of the plasma membrane by scaffolding proteins of the MAGUK family. </articletitle>Bioessays, <volume>21</volume>, <pages>912-921.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Dong, C., Yang, D.D., Tournier, C., Whitmarsh, A.J., Xu, J., Davis, R.J. and Flavell, R.A.</workauthor>
               <pubdate>(2000)</pubdate>
               <articletitle>JNK is required for effector T-cell function but not for T-cell activation</articletitle>. Nature, <volume>405</volume>, <pages>91-94.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Dong, C., Yang, D.D., Wysk, M., Whitmarsh, A.J., Davis, R.J. and Flavell, R.A</workauthor>
               <pubdate>. (1998)</pubdate>
               <articletitle>Defective T cell differentiation in the absence of Jnk1.</articletitle> Science, <volume>282</volume>, <pages>2092-2095.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Douglass, A.D. and Vale, R.D</workauthor>. <pubdate>(2005)</pubdate>
               <articletitle>Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells. </articletitle>Cell, <volume>121</volume>, <pages>937-950.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Duan, L., Reddi, A.L., Ghosh, A., Dimri, M. and Band, H</workauthor>
               <pubdate>. (2004)</pubdate>
               <articletitle>The Cbl family and other ubiquitin ligases: destructive forces in control of antigen receptor signaling</articletitle>. Immunity, <volume>21</volume>, <pages>7-17.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Dunn, R. and Hicke, L.</workauthor>
               <pubdate>(2001)</pubdate>
               <articletitle>Multiple</articletitle>
               <articletitle> roles for Rsp5p-dependent ubiquitination at the internalization step of endocytosis.</articletitle> J Biol Chem, <volume>276</volume>, <pages>25974-25981.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Dunne, A. and O'Neill, L.A</workauthor>
               <pubdate>. (2003)</pubdate>
               <articletitle>The</articletitle>
               <articletitle> interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense.</articletitle> Sci STKE, <volume>171</volume>, <pages>re3</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Egawa, T., Albrecht, B., Favier, B., Sunshine, M.J., Mirchandani, K., O'Brien, W., Thome, M. and Littman, D.R.</workauthor>
               <pubdate>(2003)</pubdate>
               <articletitle>Requirement for CARMA1 in antigen receptor-induced </articletitle>
               <articletitle><br/>NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B activation and lymphocyte proliferation.</articletitle> Curr Biol, <volume>13</volume>, <pages>1252-1258.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Fan, C.M. and Maniatis, T.</workauthor>
               <pubdate>(1991)</pubdate>
               <articletitle>Generation of p50 subunit of NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B by processing of p105 through an ATP-dependent pathway.</articletitle> Nature, <volume>354</volume>, <pages>395-398.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Fang, D., Elly, C., Gao, B., Fang, N., Altman, Y., Joazeiro, C., Hunter, T., Copeland, N., Jenkins, N. and Liu, Y.C.</workauthor>
               <pubdate>(2002</pubdate>) <articletitle>Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation.</articletitle> Nat Immunol, <volume>3</volume>, <pages>281-287.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Fanning, A.S. and Anderson, J.M.</workauthor>
               <pubdate>(1999)</pubdate>
               <articletitle>Protein modules as organizers of membrane structure.</articletitle>Curr Opin Cell Biol, <volume>11</volume>, <pages>432-439.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Fisk, H.A. and Yaffe, M.P. </workauthor>
               <pubdate>(1999)</pubdate>
               <articletitle>A role for ubiquitination in mitochondrial inheritance in Saccharomyces cerevisiae.</articletitle> J Cell Biol, <volume>145</volume>, <pages>1199-1208.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Gaide, O., Favier, B., Legler, D.F., Bonnet, D., Brissoni, B., Valitutti, S., Bron, C., Tschopp, J. and Thome, M</workauthor>
               <pubdate>. (2002)</pubdate>
               <articletitle>CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B activation.</articletitle> Nat Immunol, <volume>3</volume>, <pages>836-843.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Gaide, O., Martinon, F., Micheau, O., Bonnet, D., Thome, M. and Tschopp, J</workauthor>
               <pubdate>. (2001)</pubdate>
               <articletitle>Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and </articletitle>
               <articletitle><br/>NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B activation.</articletitle> FEBS Lett, <volume>496</volume>, <pages>121-127.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Galan, J.M. and Haguenauer-Tsapis, R.</workauthor> (<pubdate>1997) </pubdate>
               <articletitle>Ubiquitin lys63 is involved in ubiquitination of a yeast plasma membrane protein. </articletitle>Embo J, <volume>16</volume>, <pages>5847-5854.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Gao</workauthor>
               <workauthor>, M., Labuda, T., Xia, Y., Gallagher, E., Fang, D., Liu, Y.C. and Karin, M.</workauthor>
               <pubdate>(2004)</pubdate>
               <articletitle>Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch.</articletitle> Science, <volume>306</volume>, <pages>271-275.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Garcia, K.C., Degano, M., Stanfield, R.L., Brunmark, A., Jackson, M.R., Peterson, P.A., Teyton, L. and Wilson, I.A.</workauthor>
               <pubdate>(1996)</pubdate>
               <articletitle>An</articletitle>
               <articletitle>&#945;</articletitle>
               <articletitle>/</articletitle>
               <articletitle>&#946;</articletitle>
               <articletitle> T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex</articletitle>. Science, <volume>274</volume>, <pages>209-219.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Gay, N.J. and Keith, F.J.</workauthor>
               <pubdate>(1991)</pubdate>
               <articletitle>Drosophila Toll and IL-1 receptor.</articletitle> Nature, <volume>351</volume>, <pages>355-356.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Ghosh, S. and Karin, M.</workauthor>
               <pubdate>(2002)</pubdate>
               <articletitle>Missing pieces in the NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B puzzle.</articletitle> Cell, <volume>109</volume>, <pages>81-96.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Ghosh, S., May, M.J. and Kopp, E.B</workauthor>
               <pubdate>. (1998)</pubdate>
               <articletitle>NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B and Rel proteins: evolutionarily conserved mediators of immune responses.</articletitle> Annu Rev Immunol, <volume>16</volume>, <pages>225-260.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Green, J.M., Noel, P.J., Sperling, A.I., Walunas, T.L., Gray, G.S., Bluestone, J.A. and Thompson, C.B.</workauthor>
               <pubdate>(1994)</pubdate>
               <articletitle>Absence of B7-dependent responses in CD28-deficient mice.</articletitle> Immunity, <volume>1</volume>, <pages>501-508</pages>.</citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Greenwald, R.J., Freeman, G.J. and Sharpe, A.H</workauthor>
               <pubdate>. (2005)</pubdate>
               <articletitle>The B7 family revisited.</articletitle> Annu Rev Immunol, <volume>23</volume>, <pages>515-548.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Greenwald, R.J., Latchman, Y.E. and Sharpe, A.H.</workauthor>
               <pubdate>(2002)</pubdate>
               <articletitle>Negative co-receptors on lymphocytes.</articletitle>Curr Opin Immunol, <volume>14</volume>, <pages>391-396.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Griffin, G.E., Leung, K., Folks, T.M., Kunkel, S. and Nabel, G.J.</workauthor>
               <pubdate>(1989)</pubdate>
               <articletitle>Activation of HIV gene expression during monocyte differentiation by induction of NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B.</articletitle> Nature, <volume>339</volume>, <pages>70-73.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Griffiths, G.M.</workauthor>
               <pubdate>(1995)</pubdate>
               <articletitle>The</articletitle>
               <articletitle> cell biology of CTL killing.</articletitle> Curr Opin Immunol, <volume>7</volume>, <pages>343-348.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Hannink, M. and Temin, H.M.</workauthor>
               <pubdate>(1989)</pubdate>
               <articletitle>Transactivation of gene expression by nuclear and cytoplasmic rel proteins.</articletitle>Mol Cell Biol, <volume>9</volume>, <pages>4323-4336.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Hara, H., Wada, T., Bakal, C., Kozieradzki, I., Suzuki, S., Suzuki, N., Nghiem, M., Griffiths, E.K., Krawczyk, C., Bauer, B., D'Acquisto, F., Ghosh, S., Yeh, W.C., Baier, G., Rottapel, R. and Penninger, J.M.</workauthor>
               <pubdate>(2003)</pubdate>
               <articletitle>The MAGUK family protein CARD11 is essential for lymphocyte activation.</articletitle> Immunity, <volume>18</volume>, <pages>763-775.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Haskill, S., Beg, A.A., Tompkins, S.M., Morris, J.S., Yurochko, A.D., Sampson-Johannes, A., Mondal, K., Ralph, P. and Baldwin, A.S., Jr.</workauthor>
               <pubdate>(1991)</pubdate>
               <articletitle>Characterization of an immediate-early gene induced in adherent monocytes that encodes I</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B-like activity.</articletitle> Cell, <volume>65</volume>, <pages>1281-1289.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Hatada, E.N., Krappmann, D. and Scheidereit, C.</workauthor>
               <pubdate>(2000)</pubdate>
               <articletitle>NF-kB and the innate immune response.</articletitle>Curr Opin Immunol, <volume>12</volume>
               <pages>, 52-58.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Hatada, E.N., Naumann, M. and Scheidereit, C.</workauthor>
               <pubdate>(1993)</pubdate>
               <articletitle>Common structural constituents confer I</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B activity to NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B p105 and IkB/MAD-3.</articletitle> Embo J, <volume>12</volume>, <pages>2781-2788.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Hayden, M.S. and Ghosh, S.</workauthor>
               <pubdate>(2004)</pubdate>
               <articletitle>Signaling to NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B.</articletitle> Genes Dev, <volume>18,</volume>
               <pages>2195-2224.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>He, H.T., Lellouch, A. and Marguet, D.</workauthor>
               <pubdate>(2005)</pubdate>
               <articletitle>Lipid rafts and the initiation of T cell receptor signaling.</articletitle>Semin Immunol, <volume>17</volume>, <pages>23-33.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Hehner, S.P., Li-Weber, M., Giaisi, M., Droge, W., Krammer, P.H. and Schmitz, M.L.</workauthor>
               <pubdate>(2000)</pubdate>
               <articletitle>Vav synergizes with protein kinase C </articletitle>
               <articletitle>&#952;</articletitle>
               <articletitle> to mediate IL-4 gene expression in response to CD28 costimulation in T cells. </articletitle>J Immunol, <volume>164,</volume>
               <pages>3829-3836.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Heissmeyer, V., Macian, F., Im, S.H., Varma, R., Feske, S., Venuprasad, K., Gu, H., Liu, Y.C., Dustin, M.L. and Rao, A.</workauthor>
               <pubdate>(2004)</pubdate>
               <articletitle>Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins.</articletitle> Nat Immunol, <volume>5</volume>, <pages>255-265.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Hicke, L.</workauthor>
               <pubdate>(2001)</pubdate>
               <articletitle>Protein regulation by monoubiquitin.</articletitle>Nat Rev Mol Cell Biol, <volume>2</volume>, <pages>195-201.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Hicke, L. and Dunn, R</workauthor>
               <pubdate>. (2003)</pubdate>
               <articletitle>Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins.</articletitle> Annu Rev Cell Dev Biol, <volume>19,</volume>
               <pages>141-172.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Hicke, L. and Riezman, H</workauthor>
               <pubdate>. (1996)</pubdate>
               <articletitle>Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis.</articletitle> Cell<volume>, 84</volume>, <pages>277-287.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Ho, L., Davis, R.E., Conne, B., Chappuis, R., Berczy, M., Mhawech, P., Staudt, L.M. and Schwaller, J.</workauthor>
               <pubdate>(2005) </pubdate>
               <articletitle>MALT1 and the API2-MALT1 fusion act between CD40 and IKK and confer NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B-dependent proliferative advantage and resistance against FAS-induced cell death in B cells. </articletitle>Blood, <volume>105,</volume>
               <pages>2891-2899.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Horejsi, V.</workauthor>
               <pubdate>(2005)</pubdate>
               <articletitle>Lipid rafts and their roles in T-cell activation.</articletitle> Microbes Infect, <volume>7</volume>, <pages>310-316.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Hoshino, K., Takeushi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K. and Akira, S.</workauthor>
               <pubdate>(1999)</pubdate>
               <articletitle>Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product</articletitle>. J Immunol, <volume>162</volume>, <pages>3749 - 3752.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Hsu, H., Huang, J., Shu, H.B., Baichwal, V. and Goeddel, D.V.</workauthor>
               <pubdate>(1996)</pubdate>
               <articletitle>TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex.</articletitle> Immunity, <volume>4</volume>, <pages>387-396.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Hsu, H., Shu, H.B., Pan, M.G. and Goeddel, D.V</workauthor>
               <pubdate>. (1996)</pubdate>
               <articletitle>TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways.</articletitle> Cell, <volume>84</volume>, <pages>299-308.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Hsu, H., Xiong, J. and Goeddel, D.V.</workauthor>
               <pubdate>(1995)</pubdate>
               <articletitle>The TNF receptor 1-associated protein TRADD signals cell death and NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B activation.</articletitle> Cell, <volume>81</volume>, <pages>495-504.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Hu, Y., Baud, V., Delhase, M., Zhang, P., Deerinck, T., Ellisman, M., Johnson, R. and Karin, M.</workauthor>
               <pubdate>(1999)</pubdate>
               <articletitle>Abnormal morphogenesis but intact IKK activation in mice lacking the IKK</articletitle>
               <articletitle>&#945;</articletitle>
               <articletitle> subunit of I</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B kinase.</articletitle> Science, <volume>284</volume>, <pages>316-320.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Hustad, C.M., Perry, W.L., Siracusa, L.D., Rasberry, C., Cobb, L., Cattanach, B.M., Kovatch, R., Copeland, N.G. and Jenkins, N.A.</workauthor>
               <pubdate>(1995)</pubdate>
               <articletitle>Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus.</articletitle> Genetics, <volume>140</volume>, <pages>255-265.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Iezzi, G., Karjalainen, K. and Lanzavecchia, A.</workauthor>
               <pubdate>(1998) </pubdate>
               <articletitle>The</articletitle>
               <articletitle> duration of antigenic stimulation determines the fate of naïve and effector T cells.</articletitle> Immunity, <volume>8</volume>, <pages>89-95.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Ingham, R.J., Colwill, K., Howard, C., Dettwiler, S., Lim, C.S., Yu, J., Hersi, K., Raaijmakers, J., Gish, G., Mbamalu, G., Taylor, L., Yeung, B., Vassilovski, G., Amin, M., Chen, F., Matskova, L., Winberg, G., Ernberg, I., Linding, R., O'Donnell, P., Starostine, A., Keller, W., Metalnikov, P., Stark, C. and Pawson, T.</workauthor>
               <pubdate>(2005)</pubdate>
               <articletitle>WW domains provide a platform for the assembly of multiprotein networks</articletitle>. Mol Cell Biol, <volume>25</volume>, <pages>7092-7106.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Ingham, R.J., Gish, G. and Pawson, T.</workauthor>
               <pubdate>(2004)</pubdate>
               <articletitle>The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture.</articletitle> Oncogene, <volume>23,</volume>
               <pages>1972-1984.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Irvine, D.J., Purbhoo, M.A., Krogsgaard, M. and Davis, M.M.</workauthor>
               <pubdate>(2002)</pubdate>
               <articletitle>Direct observation of ligand recognition by T cells.</articletitle>Nature, <volume>419</volume>, <pages>845-849.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Isakov, N. and Altman, A.</workauthor>
               <pubdate>(1985)</pubdate>
               <articletitle>Tumor promoters in conjunction with calcium ionophores mimic antigenic stimulation by reactivation of alloantigen-primed murine T lymphocytes.</articletitle> J Immunol, <volume>135,</volume>
               <pages>3674-3680.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Iwashima, M., Irving, B.A., van Oers, N.S., Chan, A.C. and Weiss, A. </workauthor>
               <pubdate>(1994)</pubdate>
               <articletitle>Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases.</articletitle> Science, <volume>263</volume>, <pages>1136-1139.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Jain, J., Loh, C. and Rao, A.</workauthor>
               <pubdate>(1995)</pubdate>
               <articletitle>Transcriptional regulation of the IL-2 gene.</articletitle> Curr Opin Immunol, <volume>7</volume>, <pages>333-342.</pages>
            </citation>
         
         
            <citation published="yes" workType="Book">
               <workauthor>Janeway, C. A. Jr., Travers, P., Walport, M. und Shlomchik, M.</workauthor>
               <pubdate> (2002) </pubdate>
               <articletitle>Immunologie,</articletitle> Spektrum Akademischer Verlag, <version>5. </version>
               <version>Auflage</version>.</citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Janeway, C.A. Jr. and Medzhitov, R.</workauthor>
               <pubdate>(2002)</pubdate>
               <articletitle>Innate</articletitle>
               <articletitle> immune recognition.</articletitle> Annu Rev Immunol, <volume>20</volume>, <pages>197-216.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Jun, J.E., Wilson, L.E., Vinuesa, C.G., Lesage, S., Blery, M., Miosge, L.A., Cook, M.C., Kucharska, E.M., Hara, H., Penninger, J.M., Domashenz, H., Hong, N.A., Glynne, R.J., Nelms, K.A. and Goodnow, C.C.</workauthor>
               <pubdate>(2003)</pubdate>
               <articletitle>Identifying the MAGUK protein Carma1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. </articletitle>Immunity, <volume>18</volume>, <pages>751-762.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Kaibuchi, K., Takai, Y. and Nishizuka, Y.</workauthor>
               <pubdate>(1985)</pubdate>
               <articletitle>Protein kinase C and calcium ion in mitogenic response of macrophage-depleted human peripheral lymphocytes.</articletitle> J Biol Chem, <volume>260</volume>, <pages>1366-1369.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Kawai, T., Adachi, O., Ogawa, T., Takeda, K. and Akira, S.</workauthor>
               <pubdate>(1999)</pubdate>
               <articletitle>Unresponsiveness of MyD88-deficient mice to endotoxin.</articletitle> Immunity, <volume>11</volume>, <pages>115-122.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Khoshnan, A., Bae, D., Tindell, C.A. and Nel, A.E</workauthor>
               <pubdate>. (2000b</pubdate>
               <articletitle>) The physical association of protein kinase C </articletitle>
               <articletitle>&#952;</articletitle>
               <articletitle> with a lipid raft-associated inhibitor of </articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B factor kinase (IKK) complex plays a role in the activation of the NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B cascade by TCR and CD28</articletitle>. J Immunol, <volume>165</volume>, <pages>6933-6940.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Khoshnan, A., Tindell, C., Laux, I., Bae, D., Bennett, B. and Nel, A.E.</workauthor>
               <pubdate>(2000a)</pubdate>
               <articletitle>The NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B cascade is important in Bcl-XL expression and for the anti-apoptotic effects of the CD28 receptor in primary human CD4+ lymphocytes.</articletitle> J Immunol, <volume>165</volume>, <pages>1743-1754.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Kitamura, H., Kanehira, K., Okita, K., Morimatsu, M. and Saito, M.</workauthor>
               <pubdate>(2000)</pubdate>
               <articletitle>MAIL, a novel nuclear I</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B protein that potentiates LPS-induced IL-6 production.</articletitle> FEBS Lett, <volume>485</volume>, <pages>53-56.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Kobayashi, K., Inohara, N., Hernandez, L.D., Galan, J.E., Nunez, G., Janeway, C.A., Medzhitov, R. and Flavell, R.A.</workauthor>
               <pubdate>(2002)</pubdate>
               <articletitle>RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems.</articletitle> Nature, <volume>416</volume>, <pages>194-199.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Kopp, E. and Medzhitov, R.</workauthor>
               <pubdate>(2003)</pubdate>
               <articletitle>Recognition of microbial infection by Toll-like receptors.</articletitle> Curr Opin Immunol, <volume>15</volume>, <pages>396-401.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Koseki, T., Inohara, N., Chen, S., Carrio, R., Merino, J., Hottiger, M.O., Nabel, G.J. and Nunez, G</workauthor>.<pubdate> (1999) </pubdate>
               <articletitle>CIPER, a novel NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10.</articletitle> J Biol Chem, <volume>274,</volume>
               <pages>9955-9961.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Krappmann, D., Hatada, E.N., Tegethoff, S., Li, J., Klippel, A., Giese, K., Baeuerle, P.A. and Scheidereit, C</workauthor>
               <pubdate>. (2000)</pubdate>
               <articletitle>The I</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B kinase (IKK) complex is tripartite and contains IKK</articletitle>
               <articletitle>&#947;</articletitle>
               <articletitle/>
               <articletitle>but not IKAP as a regular component. </articletitle>J Biol Chem, <volume>275</volume>, <pages>29779-29787.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Kucharczak, J., Simmons, M.J., Fan, Y. and Gelinas, C.</workauthor>
               <pubdate>(2003)</pubdate>
               <articletitle>To</articletitle>
               <articletitle> be, or not to be: NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B is the answer--role of Rel/NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B in the regulation of apoptosis</articletitle>. Oncogene<volume>, 22</volume>, <pages>8961-8982.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Kupfer, H., Monks, C.R. and Kupfer, A</workauthor>
               <pubdate>. (1994)</pubdate>
               <articletitle>Small splenic B cells that bind to antigen-specific T helper (Th) cells and face the site of cytokine production in the Th cells selectively proliferate: immunofluorescence microscopic studies of Th-B antigen-presenting cell interactions.</articletitle> J Exp Med, <volume>179</volume>, <pages>1507-1515.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Le Good, J.A., Ziegler, W.H., Parekh, D.B., Alessi, D.R., Cohen, P. and Parker, P.J.</workauthor>
               <pubdate>(1998)</pubdate>
               <articletitle>Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.</articletitle> Science, <volume>281</volume>, <pages>2042-2045.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Lee, K.H., Holdorf, A.D., Dustin, M.L., Chan, A.C., Allen, P.M. and Shaw, A.S</workauthor>
               <pubdate>. (2002)</pubdate>
               <articletitle>T cell receptor signaling precedes immunological synapse formation. </articletitle>Science<volume>, 295,</volume>
               <pages>1539-1542.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Lee, K.Y., D'Acquisto, F., Hayden, M.S., Shim, J.H. and Ghosh, S.</workauthor>
               <pubdate>(2005)</pubdate>
               <articletitle>PDK1 nucleates T cell receptor-induced signaling complex for NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B activation. </articletitle>Science, <volume>308</volume>, <pages>114-118.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Lenschow, D.J., Walunas, T.L. and Bluestone, J.A.</workauthor>
               <pubdate>(1996)</pubdate>
               <articletitle>CD28/B7 system of T cell costimulation.</articletitle> Annu Rev Immunol, <volume>14</volume>, <pages>233-258.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Li-Weber, M., Giasi, M. and Krammer, P.H.</workauthor>
               <pubdate>(1998)</pubdate>
               <articletitle>Involvement of Jun and Rel proteins in up-regulation of interleukin-4 gene activity by the T cell accessory molecule CD28.</articletitle> J Biol Chem, <volume>273</volume>, <pages>32460-32466.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Li, Q., Lu, Q., Hwang, J.Y., Buscher, D., Lee, K.F., Izpisua-Belmonte, J.C. and Verma, I.M.</workauthor>
               <pubdate>(1999a)</pubdate>
               <articletitle>IKK1-deficient mice exhibit abnormal development of skin and skeleton.</articletitle> Genes Dev, <volume>13</volume>, <pages>1322-1328.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Li, Q., Van Antwerp, D., Mercurio, F., Lee, K.F. and Verma, I.M</workauthor>
               <pubdate>. (1999b)</pubdate>
               <articletitle>Severe liver degeneration in mice lacking </articletitle>
               <articletitle>the I</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B kinase 2 gene. </articletitle>Science, <volume>284</volume>, <pages>321-325.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Li, Z.W., Chu, W., Hu, Y., Delhase, M., Deerinck, T., Ellisman, M., Johnson, R. and Karin, M.</workauthor>
               <pubdate>(1999c)</pubdate>
               <articletitle>The IKK</articletitle>
               <articletitle>&#946;</articletitle>
               <articletitle> subunit of IkB kinase (IKK) is essential for nuclear factor </articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B activation and prevention of apoptosis.</articletitle> J Exp Med, <volume>189</volume>, <pages>1839-1845.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Lin, J., Miller, M.J. and Shaw, A.S.</workauthor>
               <pubdate>(2005) </pubdate>
               <articletitle>The</articletitle>
               <articletitle> c-SMAC: sorting it all out (or in).</articletitle> J Cell Biol, <volume>170</volume>, <pages>177-182.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Lin, J. and Weiss, A.</workauthor>
               <pubdate>(2001)</pubdate>
               <articletitle>T cell receptor signalling.</articletitle> J Cell Sci, <volume>114</volume>, <pages>243-244.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Lin, X., O'Mahony, A., Mu, Y., Geleziunas, R. and Greene, W.C.</workauthor>
               <pubdate>(2000)</pubdate>
               <articletitle>Protein kinase C </articletitle>
               <articletitle>&#952;</articletitle>
               <articletitle> participates in NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B activation induced by CD3-CD28 costimulation through selective activation of IkB kinase </articletitle>
               <articletitle>&#946;</articletitle>
               <articletitle>. </articletitle>Mol Cell Biol, <volume>20</volume>, <pages>2933-2940.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Liu, S.K., Fang, N., Koretzky, G.A. and McGlade, C.J.</workauthor>
               <pubdate>(1999)</pubdate>
               <articletitle>The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors. </articletitle>Curr Biol, <volume>9</volume>
               <pages>, 67-75.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Liu, Y.C.</workauthor>
               <pubdate>(2004)</pubdate>
               <articletitle>Ubiquitin ligases and the immune response.</articletitle> Annu Rev Immunol, <volume>22</volume>, <pages>81-127.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Lomaga, M.A., Yeh, W.C., Sarosi, I., Duncan, G.S., Furlonger, C., Ho, A., Morony, S., Capparelli, C., Van, G., Kaufman, S., van der Heiden, A., Itie, A., Wakeham, A., Khoo, W., Sasaki, T., Cao, Z., Penninger, J.M., Paige, C.J., Lacey, D.L., Dunstan, C.R., Boyle, W.J., Goeddel, D.V. and Mak, T.W</workauthor>. <pubdate>(1999)</pubdate>
               <articletitle>TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.</articletitle> Genes Dev, <volume>13</volume>, <pages>1015-1024.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Lucas, P.C., Yonezumi, M., Inohara, N., McAllister-Lucas, L.M., Abazeed, M.E., Chen, F.F., Yamaoka, S., Seto, M. and Nunez, G.</workauthor>
               <pubdate>(2001)</pubdate>
               <articletitle>Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B signaling pathway. </articletitle>J Biol Chem, <volume>276</volume>, <pages>19012-19019.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Marengere, L.E., Waterhouse, P., Duncan, G.S., Mittrucker, H.W., Feng, G.S. and Mak, T.W.</workauthor>
               <pubdate>(1996)</pubdate>
               <articletitle>Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4.</articletitle> Science, <volume>272</volume>, <pages>1170-1173.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Mastrandrea, L.D., You, J., Niles, E.G. and Pickart, C.M.</workauthor>
               <pubdate>(1999)</pubdate>
               <articletitle>E2/E3-mediated assembly of lysine 29-linked polyubiquitin chains.</articletitle>J Biol Chem, <volume>274,</volume>
               <pages>27299-27306.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Matsumoto, R., Wang, D., Blonska, M., Li, H., Kobayashi, M., Pappu, B., Chen, Y., Wang, D. and Lin, X</workauthor>
               <pubdate>. (2005)</pubdate>
               <articletitle>Phosphorylation of CARMA1 Plays a Critical Role in T </articletitle>
               <articletitle>Cell</articletitle>
               <articletitle> Receptor-Mediated NF-kB Activation.</articletitle> Immunity, <volume>23</volume>, <pages>575-585.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>May, M.J., D'Acquisto, F., Madge, L.A., Glockner, J., Pober, J.S. and Ghosh, S.</workauthor>
               <pubdate>(2000)</pubdate>
               <articletitle>Selective inhibition of NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B activation by a peptide that blocks the interaction of NEMO with the IkB kinase complex. </articletitle>Science, <volume>289,</volume>
               <pages>1550-1554.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>May, M.J. and Ghosh, S</workauthor>. <pubdate>(1998)</pubdate>
               <articletitle>Signal transduction through NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B.</articletitle> Immunol Today<volume>, 19</volume>, <pages>80-88.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Mellman, I. and Steinman, R.M.</workauthor>
               <pubdate>(2001)</pubdate>
               <articletitle>Dendritic</articletitle>
               <articletitle> cells: specialized and regulated antigen processing machines. </articletitle>Cell, <volume>106,</volume>
               <pages>255-258.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Mercurio, F., Zhu, H., Murray, B.W., Shevchenko, A., Bennett, B.L., Li, J., Young, D.B., Barbosa, M., Mann, M., Manning, A. and Rao, A.</workauthor>
               <pubdate>(1997)</pubdate>
               <articletitle>IKK-1 and IKK-2: cytokine-activated IkB kinases essential for NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B activation.</articletitle> Science, <volume>278</volume>, <pages>860-866.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Miller, B.S. and Zandi, E.</workauthor>
               <pubdate>(2001)</pubdate>
               <articletitle>Complete reconstitution of human I</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B kinase (IKK) complex in yeast.</articletitle>
               <articletitle>Assessment of its stoichiometry and the role of IKK</articletitle>
               <articletitle>&#947;</articletitle>
               <articletitle> on the complex activity in the absence of stimulation.</articletitle> J Biol Chem, <volume>276</volume>, <pages>36320-36326.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Monks, C.R., Freiberg, B.A., Kupfer, H., Sciaky, N. and Kupfer, A.</workauthor>
               <pubdate>(1998)</pubdate>
               <articletitle>Three-dimensional segregation of supramolecular activation clusters in T cells. </articletitle>Nature, <volume>395</volume>, <pages>82-86</pages>.</citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Monks, C.R., Kupfer, H., Tamir, I., Barlow, A. and Kupfer, A.</workauthor>
               <pubdate>(1997)</pubdate>
               <articletitle>Selective modulation of protein kinase C </articletitle>
               <articletitle>&#952;</articletitle>
               <articletitle> during T-cell activation.</articletitle> Nature, <volume>385</volume>
               <pages>, 83-86.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Mordmuller, B., Krappmann, D., Esen, M., Wegener, E. and Scheidereit, C.</workauthor>
               <pubdate>(2003)</pubdate>
               <articletitle>Lymphotoxin and lipopolysaccharide induce NF-kB-p52 generation by a co-translational mechanism.</articletitle> EMBO Rep, <volume>4</volume>
               <pages>, 82-87.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Moren, A., Imamura, T., Miyazono, K., Heldin, C.H. and Moustakas, A.</workauthor>
               <pubdate>(2005</pubdate>) <articletitle>Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases.</articletitle> J Biol Chem, <volume>280</volume>, 22115-22123.</citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Mueller, D.L.</workauthor>
               <pubdate>(2004)</pubdate>
               <articletitle>E3 ubiquitin ligases as T cell anergy factors</articletitle>. Nat Immunol, <volume>5</volume>, <pages>883-890.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Murillas, R., Simms, K.S., Hatakeyama, S., Weissman, A.M. and Kuehn, M.R.</workauthor>
               <pubdate>(2002)</pubdate>
               <articletitle>Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase</articletitle>. J Biol Chem<volume>, 277</volume>, <pages>2897-2907.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Naramura, M., Jang, I.K., Kole, H., Huang, F., Haines, D. and </workauthor>
               <workauthor>Gu</workauthor>
               <workauthor>, H.</workauthor>
               <pubdate>(2002)</pubdate>
               <articletitle>c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation.</articletitle> Nat Immunol, <volume>3</volume>, <pages>1192-1199.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Okkenhaug, K., Bilancio, A., Emery, J.L. and Vanhaesebroeck, B.</workauthor>
               <pubdate>(2004)</pubdate>
               <articletitle>Phosphoinositide 3-kinase in T cell activation and survival. </articletitle>Biochem Soc Trans, <volume>32</volume>, <pages>332-335.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Palombella, V.J., Rando, O.J., Goldberg, A.L. and Maniatis, T.</workauthor>
               <pubdate>(1994)</pubdate>
               <articletitle>The</articletitle>
               <articletitle> ubiquitin-proteasome pathway is required for processing the NF-kB1 precursor protein and the activation of NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B. </articletitle>Cell, <volume>78</volume>, <pages>773-785.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Pfeifhofer, C., Kofler, K., Gruber, T., Tabrizi, N.G., Lutz, C., Maly, K., Leitges, M. and Baier, G.</workauthor>
               <pubdate>(2003)</pubdate>
               <articletitle>Protein kinase C </articletitle>
               <articletitle>&#952;</articletitle>
               <articletitle> affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells.</articletitle> J Exp Med, <volume>197</volume>, <pages>1525-1535.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Pickart, C.M.</workauthor>
               <pubdate>(2000)</pubdate>
               <articletitle>Ubiquitin in chains.</articletitle> Trends Biochem Sci, <volume>25</volume>, <pages>544-548.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Pickart, C.M</workauthor>
               <pubdate>. (2001)</pubdate>
               <articletitle>Mechanisms underlying ubiquitination.</articletitle> Annu Rev Biochem, <volume>70</volume>, <pages>503-533.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Pitcher, L.A. and van Oers, N.S.</workauthor>
               <pubdate>(2003)</pubdate>
               <articletitle>T-cell receptor signal transmission: who gives an ITAM? </articletitle>Trends Immunol, <volume>24</volume>, <pages>554-560.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Plaksin, D., Baeuerle, P.A. and Eisenbach, L.</workauthor>
               <pubdate> (1993) </pubdate>
               <articletitle>KBF1 (p50 NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B homodimer) acts as a repressor of H-2Kb gene expression in metastatic tumor cells</articletitle>. J Exp Med, <volume>177,</volume>
               <pages>1651-1662.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Poltorak, A., He, X., Liu, M. Y., Van Huffel, C., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., Freudenberg, M., Ricciardi-Castagnoli, P., Layton, B. and Beutler, B.</workauthor>
               <pubdate>(1998)</pubdate>
               <articletitle>Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in TLR4 gene.</articletitle> Science, <volume>11</volume>, <pages>2085 - 2088.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Reiner, S.L. and Seder, R.A.</workauthor>
               <pubdate>(1995)</pubdate>
               <articletitle>T helper cell differentiation in immune response.</articletitle> Curr Opin Immunol, <volume>7</volume>, <pages>360-366.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Reynolds, L.F., Smyth, L.A., Norton, T., Freshney, N., Downward, J., Kioussis, D. and Tybulewicz, V.L.</workauthor>
               <pubdate>(2002)</pubdate>
               <articletitle>Vav1 transduces T cell receptor signals to the activation of phospholipase C</articletitle>
               <articletitle>&#947;</articletitle>
               <articletitle>1 via phosphoinositide 3-kinase-dependent and -independent pathways.</articletitle> J Exp Med<volume>, 195</volume>, <pages>1103-1114.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Rocha, B. and Tanchot, C.</workauthor>
               <pubdate>(2004)</pubdate>
               <articletitle>CD8 T cell memory</articletitle>. Semin Immunol, <volume>16</volume>, <pages>305-314.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Rodriguez, M.S., Wright, J., Thompson, J., Thomas, D., Baleux, F., Virelizier, J.L., Hay, R.T. and Arenzana-Seisdedos, F</workauthor>
               <pubdate>. (1996)</pubdate>
               <articletitle>Identification of lysine residues required for signal-induced ubiquitination and degradation of I</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B</articletitle>
               <articletitle>&#945;</articletitle>
               <articletitle> in vivo.</articletitle> Oncogene, <volume>12</volume>, <pages>2425-2435.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Rothwarf, D.M., Zandi, E., Natoli, G. and Karin, M.</workauthor>
               <pubdate>(1998)</pubdate>
               <articletitle>IKK</articletitle>
               <articletitle>&#947;</articletitle>
               <articletitle> is an essential regulatory subunit of </articletitle>
               <articletitle>the I</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B kinase complex.</articletitle> Nature, <volume>395</volume>, <pages>297-300.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Rotin, D., Staub, O. and Haguenauer-Tsapis, R.</workauthor>
               <pubdate>(2000)</pubdate>
               <articletitle>Ubiquitination and endocytosis of plasma membrane proteins: role of Nedd4/Rsp5p family of ubiquitin-protein ligases. </articletitle>J Membr Biol, <volume>176</volume>, <pages>1-17.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Rueda, D. and Thome, M.</workauthor>
               <pubdate>(2005</pubdate>) <articletitle>Phosphorylation of CARMA1: The Link(er) to NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B Activation.</articletitle> Immunity, <volume>23</volume>, <pages>551-553.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Ruefli-Brasse, A.A., French, D.M. and Dixit, V.M.</workauthor>
               <pubdate>(2003)</pubdate>
               <articletitle>Regulation of NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B-dependent lymphocyte activation and development by paracaspase</articletitle>. Science, <volume>302</volume>, <pages>1581-1584.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Ruefli-Brasse, A.A., Lee, W.P., Hurst, S. and Dixit, V.M.</workauthor>
               <pubdate>(2004)</pubdate>
               <articletitle>Rip2 participates in Bcl10 signaling and T-cell receptor-mediated NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B activation. </articletitle>J Biol Chem, <volume>279,</volume>
               <pages>1570-1574.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Ruland, J., Duncan, G.S., Elia, A., </workauthor>
               <workauthor>del</workauthor>
               <workauthor> Barco Barrantes, I., Nguyen, L., Plyte, S., Millar, D.G., Bouchard, D., Wakeham, A., Ohashi, P.S. and Mak, T.W.</workauthor>
               <pubdate>(2001)</pubdate>
               <articletitle>Bcl10 is a positive regulator of antigen receptor-induced activation of NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B and neural tube closure.</articletitle> Cell, <volume>104</volume>, <pages>33-42.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Ruland, J., Duncan, G.S., Wakeham, A. and Mak, T.W.</workauthor>
               <pubdate>(2003)</pubdate>
               <articletitle>Differential requirement for Malt1 in T and B cell antigen receptor signaling. </articletitle>Immunity, <volume>19,</volume>
               <pages>749-758.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Russell, N.S. and Wilkinson, K.D.</workauthor>
               <pubdate>(2004)</pubdate>
               <articletitle>Identification of a novel 29-linked polyubiquitin binding protein, Ufd3, using polyubiquitin chain analogues</articletitle>. Biochemistry, <volume>43</volume>
               <pages>, 4844-4854.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Sancho, D., Vicente-Manzanares, M., Mittelbrunn, M., Montoya, M.C., Gordon-Alonso, M., Serrador, J.M. and Sanchez-Madrid, F.</workauthor>
               <pubdate>(2002)</pubdate>
               <articletitle>Regulation of microtubule-organizing center orientation and actomyosin cytoskeleton rearrangement during immune interactions.</articletitle>Immunol Rev, <volume>189</volume>, <pages>84-97.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Scharschmidt, E., Wegener, E., Heissmeyer, V., Rao, A. and Krappmann, D.</workauthor>
               <pubdate>(2004)</pubdate>
               <articletitle>Degradation of Bcl10 induced by T-cell activation negatively regulates NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B signaling. </articletitle>Mol Cell Biol, <volume>24</volume>, <pages>3860-3873.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Schlienger, K., Craighead, N., Lee, K.P., Levine, B.L. and June, C.H.</workauthor>
               <pubdate>(2000)</pubdate>
               <articletitle>Efficient priming of protein antigen-specific human </articletitle>
               <articletitle>CD4(</articletitle>
               <articletitle>+) T cells by monocyte-derived dendritic cells.</articletitle> Blood, <volume>96</volume>, <pages>3490-3498.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Schmidt-Supprian, M., Courtois, G., Tian, J., Coyle, A.J., Israel, A., Rajewsky, K. and Pasparakis, M.</workauthor>
               <pubdate>(2003)</pubdate>
               <articletitle>Mature T cells depend on signaling through the IKK complex.</articletitle> Immunity, <volume>19</volume>, <pages>377-389.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Schmitz, M.L., Bacher, S. and Dienz, O.</workauthor>
               <pubdate>(2003)</pubdate>
               <articletitle>NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B activation pathways induced by T cell costimulation.</articletitle>Faseb J<volume>, 17,</volume>
               <pages>2187-2193.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Schmitz, M.L., dos Santos Silva, M.A., Altmann, H., Czisch, M., Holak, T.A. and Baeuerle, P.A. </workauthor>
               <pubdate>(1994)</pubdate>
               <articletitle>Structural and functional analysis of the NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B p65 C terminus.</articletitle>
               <articletitle> An acidic and modular transactivation domain with the potential to adopt </articletitle>
               <articletitle>an a</articletitle>
               <articletitle>-helical conformation.</articletitle> J Biol Chem, <volume>269,</volume>
               <pages>25613-25620.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Schwandner, R., Dziarski, R., Wesche, H., Rothe, M. and Kirschning, C. J.</workauthor>
               <pubdate>(1999)</pubdate>
               <articletitle>Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor2</articletitle>. J Biol Chem, <volume>274,</volume>
               <pages>17406-17409. </pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Schwartz, R.H.</workauthor>
               <pubdate>(2003)</pubdate>
               <articletitle>T cell anergy</articletitle>. Annu Rev Immunol, <volume>21</volume>, <pages>305-334.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Sen, R. and Baltimore, D.</workauthor>
               <pubdate>(1986) </pubdate>
               <articletitle>Inducibility of k immunoglobulin enhancer-binding protein NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B by a posttranslational mechanism.</articletitle> Cell, <volume>47</volume>, <pages>921-928.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Sen, R. and Baltimore, D.</workauthor>
               <pubdate>(1986)</pubdate>
               <articletitle>Multiple</articletitle>
               <articletitle> nuclear factors interact with the immunoglobulin enhancer sequences. </articletitle>Cell, <volume>46</volume>, <pages>705-716.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Senftleben, U., Cao, Y., Xiao, G., Greten, F.R., Krahn, G., Bonizzi, G., Chen, Y., Hu, Y., Fong, A., Sun, S.C. and Karin, M.</workauthor>
               <pubdate>(2001)</pubdate>
               <articletitle>Activation by IKK</articletitle>
               <articletitle>&#945;</articletitle>
               <articletitle> of a second, evolutionary conserved, NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B signaling pathway.</articletitle> Science, <volume>293</volume>, <pages>1495-1499.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Shapiro, V.S., Truitt, K.E., Imboden, J.B. and Weiss, A.</workauthor>
               <pubdate>(1997)</pubdate>
               <articletitle>CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites. </articletitle>Mol Cell Biol, <volume>17</volume>, <pages>4051-4058.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Shi, C.S. and Kehrl, J.H.</workauthor>
               <pubdate>(2003)</pubdate>
               <articletitle>Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2</articletitle>). J Biol Chem, <volume>278</volume>, <pages>15429-15434.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Siebenlist, U., Franzoso, G. and Brown, K.</workauthor>
               <pubdate>(1994)</pubdate>
               <articletitle>Structure, regulation and function of </articletitle>
               <articletitle><br/>NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B.</articletitle> Annu Rev Cell Biol, <volume>10</volume>, <pages>405-455.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Singer, A.L. and Koretzky, G.A.</workauthor>
               <pubdate>(2002)</pubdate>
               <articletitle>Control of T cell function by positive and negative regulators.</articletitle> Science, <volume>296</volume>, <pages>1639-1640.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Sommer, K., Guo, B., Pomerantz, J.L., Bandaranayake, A.D., Moreno-Garcia, M.E., Ovechkina, Y.L. and Rawlings, D.J.</workauthor>
               <pubdate>(2005)</pubdate>
               <articletitle>Phosphorylation of the CARMA1 Linker Controls NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B Activation.</articletitle> Immunity, <volume>23</volume>, <pages>561-574.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Spencer E., Jiang J. and Chen, Z.J.</workauthor>
               <pubdate>(1999)</pubdate>
               <articletitle>Signal-induced ubiquitination of </articletitle>
               <articletitle>I</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B</articletitle>
               <articletitle>&#945;</articletitle>
               <articletitle> by the F-box protein Slimb/b-TrCP</articletitle>. Genes and Dev, <volume>13</volume>, <pages>284 - 294.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Springael, J.Y., De Craene, J.O. and Andre, B.</workauthor>
               <pubdate>(1999)</pubdate>
               <articletitle>The</articletitle>
               <articletitle> yeast Npi1/Rsp5 ubiquitin ligase lacking its N-terminal C2 domain is competent for ubiquitination but not for subsequent endocytosis of the gap1 permease.</articletitle> Biochem Biophys Res Commun, <volume>257</volume>, <pages>561-566.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Srinivasula, S.M., Ahmad, M., Lin, J.H., Poyet, J.L., Fernandes-Alnemri, T., Tsichlis, P.N. and Alnemri, E.S</workauthor>
               <pubdate>. (1999)</pubdate>
               <articletitle>CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B activation and apoptosis.</articletitle> J Biol Chem, <volume>274</volume>, <pages>17946-17954.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Stern, L.J. and Wiley, D.C.</workauthor>
               <pubdate>(1994)</pubdate>
               <articletitle>Antigenic peptide binding by class I and class II histocompatibility proteins.</articletitle> Structure, <volume>2</volume>, <pages>245-251.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Stockinger, B., Kassiotis, G. and Bourgeois, C</workauthor>
               <pubdate>. (2004)</pubdate>
               <articletitle>CD4 T-cell memory.</articletitle> Semin Immunol, <volume>16</volume>, <pages>295-303.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Streubel, B., Lamprecht, A., Dierlamm, J., Cerroni, L., Stolte, M., Ott, G., Raderer, M. and Chott, A.</workauthor>
               <pubdate>(2003) </pubdate>
               <articletitle>T(</articletitle>
               <articletitle>14;18)(q32;q21) involving IGH and MALT1 is a frequent chromosomal aberration in MALT lymphoma.</articletitle> Blood, <volume>101</volume>, <pages>2335-2339.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Su, H., Bidere, N., Zheng, L., Cubre, A., Sakai, K., Dale, J., Salmena, L., Hakem, R., Straus, S. and Lenardo, M.</workauthor>
               <pubdate>(2005)</pubdate>
               <articletitle>Requirement for caspase-8 in NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B activation by antigen receptor.</articletitle> Science, <volume>307</volume>, <pages>1465-1468.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Sudol, M., Chen, H.I., Bougeret, C., Einbond, A. and Bork, P.</workauthor>
               <pubdate>(1995)</pubdate>
               <articletitle>Characterization of a novel protein-binding module--the WW domain.</articletitle>FEBS Lett, <volume>369,</volume>
               <pages>67-71.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Sudol, M. and Hunter, T.</workauthor>
               <pubdate>(2000)</pubdate>
               <articletitle>NeW wrinkles for an old domain.</articletitle> Cell, <volume>103</volume>, <pages>1001-1004.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Sun, L. and Chen, Z.J.</workauthor>
               <pubdate>(2004</pubdate>
               <articletitle>) </articletitle>
               <articletitle>The</articletitle>
               <articletitle> novel functions of ubiquitination in signaling.</articletitle> Curr Opin Cell Biol, <volume>16</volume>, <pages>119-126.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Sun, L., Deng, L., Ea, C.K., Xia, Z.P. and Chen, Z.J.</workauthor>
               <pubdate>(2004)</pubdate>
               <articletitle>The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes.</articletitle> Mol Cell, <volume>14</volume>, <pages>289-301.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Sun, Z., Arendt, C.W., Ellmeier, W., Schaeffer, E.M., Sunshine, M.J., Gandhi, L., Annes, J., Petrzilka, D., Kupfer, A., Schwartzberg, P.L. and Littman, D.R.</workauthor>
               <pubdate> (2000) </pubdate>
               <articletitle>PKC</articletitle>
               <articletitle>&#952;</articletitle>
               <articletitle> is required for TCR-induced NF-kB activation in mature but not immature T lymphocytes</articletitle>. Nature, <volume>404</volume>, <pages>402-407.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Suzuki, N., Suzuki, S., Duncan, G.S., Millar, D.G., Wada, T., Mirtsos, C., Takada, H., Wakeham, A., Itie, A., Li, S., Penninger, J.M., Wesche, H., Ohashi, P.S., Mak, T.W. and Yeh, W.C.</workauthor>
               <pubdate>(2002)</pubdate>
               <articletitle>Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4.</articletitle> Nature, <volume>416,</volume>
               <pages>750-756.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Takeda, K., Kaisho, T. and Akira, S.</workauthor>
               <pubdate>(2003)</pubdate>
               <articletitle>Toll-like receptors.</articletitle> Annu Rev Immunol, <volume>21</volume>, <pages>335-376.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Takeda, K., Takeuchi, O., Tsujimura, T., Itami, S., Adachi, O., Kawai, T., Sanjo, H., Yoshikawa, K., Terada, N. and Akira, S.</workauthor>
               <pubdate>(1999) </pubdate>
               <articletitle>Limb and skin abnormalities in mice lacking IKK</articletitle>
               <articletitle>&#945;</articletitle>
               <articletitle>.</articletitle> Science, <volume>284</volume>, <pages>313-316.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Takeushi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., Takeda, K. and Akira, S.</workauthor>
               <pubdate>(1999)</pubdate>
               <articletitle>Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.</articletitle> Immunity, <volume>11</volume>, <pages>443 - 451.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Tanaka, M., Fuentes, M. E., Yamaguchi, K., Durnin, M. H., Dalrymple, D. A., Hardy, K. L. and Goeddel, D. V.</workauthor>
               <pubdate>(1999)</pubdate>
               <articletitle>Embyonic lethality, liver degeneration, and impaired NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B activation in IKK</articletitle>
               <articletitle>&#946;</articletitle>
               <articletitle>-deficient mice.</articletitle> Immunity, <volume>10</volume>, <pages>421-429.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Tegethoff, S., Behlke, J. and Scheidereit, C.</workauthor>
               <pubdate>(2003)</pubdate>
               <articletitle>Tetrameric oligomerization of IKK</articletitle>
               <articletitle>&#947;</articletitle>
               <articletitle> is obligatory for IKK complex activity and NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B activation.</articletitle> Mol Cell Biol, <volume>23,</volume>
               <pages>2029 - 2041.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Thery, C. and Amigorena, S.</workauthor>
               <pubdate>(2001)</pubdate>
               <articletitle>The</articletitle>
               <articletitle> cell biology of antigen presentation in dendritic cells.</articletitle> Curr Opin Immunol, <volume>13</volume>, <pages>45-51.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Thomas, J.A., Allen, J.L., Tsen, M., Dubnicoff, T., Danao, J., Liao, X.C., Cao, Z. and Wasserman, S.A. </workauthor>
               <pubdate>(1999) </pubdate>
               <articletitle>Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase.</articletitle> J Immunol<volume>, 163</volume>, <pages>978-984.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Thome, M., Gaide, O., Micheau, O., Martinon, F., Bonnet, D., Gonzalez, M. and Tschopp, J.</workauthor>
               <pubdate>(2001)</pubdate>
               <articletitle>Equine herpesvirus protein E10 induces membrane recruitment and phosphorylation of its cellular homologue, Bcl-10.</articletitle> J Cell Biol, <volume>152</volume>, <pages>1115-1122.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Thome, M., Martinon, F., Hofmann, K., Rubio, V., Steiner, V., Schneider, P., Mattmann, C. and Tschopp, J.</workauthor>
               <pubdate>(1999)</pubdate>
               <articletitle>Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B transcription factor and c-Jun N-terminal kinase.</articletitle> J Biol Chem, <volume>274</volume>, <pages>9962-9968.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Thompson, J.E., Phillips, R.J., Erdjument-Bromage, H., Tempst, P. and Ghosh, S.</workauthor>
               <pubdate>(1995)</pubdate>
               <articletitle>I</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B-</articletitle>
               <articletitle>&#946;</articletitle>
               <articletitle> regulates the persistent response in a biphasic activation of NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B. </articletitle>Cell, <volume>80</volume>, <pages>573-582.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Tivol, E.A., Borriello, F., Schweitzer, A.N., Lynch, W.P., Bluestone, J.A. and Sharpe, A.H.</workauthor>
               <pubdate>(1995)</pubdate>
               <articletitle>Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4.</articletitle> Immunity, <volume>3</volume>, <pages>541-547.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Truneh, A., Albert, F., Golstein, P. and Schmitt-Verhulst, A.M</workauthor>. <pubdate>(1985)</pubdate>
               <articletitle>Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester. </articletitle>Nature, <volume>313,</volume>
               <pages>318-320</pages>.</citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Ullman, K.S., Northrop, J.P., Verweij, C.L. and Crabtree, G.R.</workauthor>
               <pubdate> (1990) </pubdate>
               <articletitle>Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: the missing link</articletitle>. Annu Rev Immunol, <volume>8</volume>, <pages>421-452.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Uren, A.G., O'Rourke, K., Aravind, L.A., Pisabarro, M.T., Seshagiri, S., Koonin, E.V. and Dixit, V.M</workauthor>. <pubdate>(2000)</pubdate>
               <articletitle>Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma.</articletitle> Mol Cell, <volume>6</volume>, <pages>961-967.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Valitutti, S., Muller, S., Salio, M. and Lanzavecchia, A. </workauthor>
               <pubdate>(1997)</pubdate>
               <articletitle>Degradation of T cell receptor (TCR)-CD3-z complexes after antigenic stimulation. </articletitle>J Exp Med, <volume>185,</volume>
               <pages>1859-1864.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>van</workauthor>
               <workauthor> der Merwe, P.A. and Davis, S.J.</workauthor>
               <pubdate>(2002)</pubdate>
               <articletitle>Immunology. </articletitle>
               <articletitle>The immunological synapse - a multitasking system.</articletitle>Science, <volume>295,</volume>
               <pages>1479-1480.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Verma, I.M., Stevenson, J.K., Schwarz, E.M., Van Antwerp, D. and Miyamoto, S.</workauthor>
               <pubdate>(1995) </pubdate>
               <articletitle>Rel/NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B/I</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B family: intimate tales of association and dissociation.</articletitle> Genes Dev, <volume>9,</volume>
               <pages>2723-2735.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Villalba, M., Bi, K., Hu, J., Altman, Y., Bushway, P., Reits, E., Neefjes, J., Baier, G., Abraham, R.T. and Altman, A.</workauthor>
               <pubdate>(2002) </pubdate>
               <articletitle>Translocation of PKC</articletitle>
               <articletitle>&#952;</articletitle>
               <articletitle> in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C.</articletitle> J Cell Biol, <volume>157</volume>, <pages>253-263.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Viola, A. and Lanzavecchia, A.</workauthor>
               <pubdate>(1996)</pubdate>
               <articletitle>T cell activation determined by T cell receptor number and tunable thresholds</articletitle>. Science, <volume>273</volume>, <pages>104-106.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Walunas, T.L., Lenschow, D.J., Bakker, C.Y., Linsley, P.S., Freeman, G.J., Green, J.M., Thompson, C.B. and Bluestone, J.A.</workauthor>
               <pubdate>(1994)</pubdate>
               <articletitle>CTLA-4 can function as a negative regulator of T cell activation. </articletitle>Immunity<volume>, 1</volume>
               <pages>, 405-413.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Wang, C., Deng, L., Hong, M., Akkaraju, G.R., Inoue, J. and Chen, Z.J.</workauthor>
               <pubdate>(2001) </pubdate>
               <articletitle>TAK1 is </articletitle>
               <articletitle>a</articletitle>
               <articletitle> ubiquitin-dependent kinase of MKK and IKK.</articletitle> Nature, <volume>412</volume>, <pages>346-351.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Wang, M. and Pickart, C.M.</workauthor>
               <pubdate>(2005)</pubdate>
               <articletitle>Different HECT domain ubiquitin ligases employ distinct mechanisms of polyubiquitin chain synthesis.</articletitle> Embo J, <volume>24</volume>, <pages>4324-4333.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Waterhouse, P., Marengere, L.E., Mittrucker, H.W. and Mak, T.W.</workauthor>
               <pubdate>(1996)</pubdate>
               <articletitle>CTLA-4, a negative regulator of T-lymphocyte activation.</articletitle>Immunol Rev, <volume>153</volume>, <pages>183-207.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Waterhouse, P., Penninger, J.M., Timms, E., Wakeham, A., Shahinian, A., Lee, K.P., Thompson, C.B., Griesser, H. and Mak, T.W.</workauthor>
               <pubdate>(1995)</pubdate>
               <articletitle>Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. </articletitle>Science, <volume>270</volume>, <pages>985-988.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Whiteside, S.T., Epinat, J.C., Rice, N.R. and Israel, A.</workauthor>
               <pubdate>(1997)</pubdate>
               <articletitle>IkBe, a novel member of </articletitle>
               <articletitle>the I</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B family, controls RelA and cRel NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B activity. </articletitle>Embo J, <volume>16,</volume>
               <pages>1413-1426.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Wilkinson, K.D.</workauthor>
               <pubdate>(2000)</pubdate>
               <articletitle>Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome.</articletitle> Semin Cell Dev Biol, <volume>11,</volume>
               <pages>141-148.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Willis, T.G., Jadayel, D.M., Du, M.Q., Peng, H., Perry, A.R., Abdul-Rauf, M., Price, H., Karran, L., Majekodunmi, O., Wlodarska, I., Pan, L., Crook, T., Hamoudi, R., Isaacson, P.G. and Dyer, M.J.</workauthor>
               <pubdate>(1999)</pubdate>
               <articletitle>Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types.</articletitle> Cell, <volume>96</volume>, <pages>35-45.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Wulczyn, F.G., Naumann, M. and Scheidereit, C.</workauthor>
               <pubdate>(1992)</pubdate>
               <articletitle>Candidate proto-oncogene Bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B.</articletitle> Nature, <volume>358</volume>, <pages>597-599.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Xiao, G., Harhaj, E.W. and Sun, S.C.</workauthor>
               <pubdate>(2001)</pubdate>
               <articletitle>NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B-inducing kinase regulates the processing of NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B2 p100.</articletitle> Mol Cell, <volume>7,</volume>
               <pages>401-409.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Yablonski, D., Kadlecek, T. and Weiss, A.</workauthor>
               <pubdate>(2001)</pubdate>
               <articletitle>Identification of a phospholipase C</articletitle>
               <articletitle>&#947;</articletitle>
               <articletitle>1 (PLC</articletitle>
               <articletitle>&#947;</articletitle>
               <articletitle>1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC</articletitle>
               <articletitle>&#947;</articletitle>
               <articletitle>1 and NFAT. </articletitle>Mol Cell Biol, <volume>21</volume>, <pages>4208-4218.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Yamaoka, S., Courtois, G., Bessia, C., Whiteside, S.T., Weil, R., Agou, F., Kirk, H.E., Kay, R.J. and Israel, A.</workauthor>
               <pubdate>(1998)</pubdate>
               <articletitle>Complementation cloning of NEMO, a component of </articletitle>
               <articletitle>the I</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B kinase complex essential for NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B activation.</articletitle> Cell, <volume>93</volume>, <pages>1231-1240</pages>.</citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Yang, D.D., Conze, D., Whitmarsh, A.J., Barrett, T., Davis, R.J., Rincon, M. and Flavell, R.A.</workauthor>
               <pubdate>(1998)</pubdate>
               <articletitle>Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2.</articletitle> Immunity, <volume>9</volume>, <pages>575-585.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Yaron, A., Hatzubai, A., Davis, M., Lavon, I., Amit, S., Manning, A.M., Andersen, J.S., Mann, M., Mercurio, F. and Ben-Neriah, Y.</workauthor>
               <pubdate>(1998) </pubdate>
               <articletitle>Identification of the receptor component of the </articletitle>
               <articletitle>&#921;</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B</articletitle>
               <articletitle>&#945;</articletitle>
               <articletitle>-ubiquitin ligase.</articletitle>Nature, <volume>396</volume>, <pages>590-594.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Zandi, E., Chen, Y. and Karin, M.</workauthor>
               <pubdate>(1998)</pubdate>
               <articletitle>Direct phosphorylation of I</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B by IKK</articletitle>
               <articletitle>&#945;</articletitle>
               <articletitle> and IKK</articletitle>
               <articletitle>&#946;</articletitle>
               <articletitle>: discrimination between free and NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B-bound substrate.</articletitle> Science, <volume>281,</volume>
               <pages>1360-1363.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Zandi, E., Rothwarf, D.M., Delhase, M., Hayakawa, M. and Karin, M</workauthor>
               <pubdate>. (1997)</pubdate>
               <articletitle>The</articletitle>
               <articletitle> I</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B kinase complex (IKK) contains two kinase subunits, IKK</articletitle>
               <articletitle>&#945;</articletitle>
               <articletitle> and IKK</articletitle>
               <articletitle>&#946;</articletitle>
               <articletitle>, necessary for I</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B phosphorylation and NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B activation. </articletitle>Cell, <volume>91</volume>, <pages>243-252.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Zhang, Q., Didonato, J.A., Karin, M. and McKeithan, T.W.</workauthor>
               <pubdate>(1994)</pubdate>
               <articletitle>Bcl3 encodes a nuclear protein which can alter the subcellular location of NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B proteins.</articletitle> Mol Cell Biol, <volume>14,</volume>
               <pages>3915-3926</pages>.</citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Zhang, Q., Siebert, R., Yan, M., Hinzmann, B., Cui, X., Xue, L., Rakestraw, K.M., Naeve, C.W., Beckmann, G., Weisenburger, D.D., Sanger, W.G., Nowotny, H., Vesely, M., Callet-Bauchu, E., Salles, G., Dixit, V.M., Rosenthal, A., Schlegelberger, B. and Morris, S.W.</workauthor>
               <pubdate>(1999)</pubdate>
               <articletitle>Inactivating mutations and overexpression of Bcl10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32</articletitle>). Nat Genet<volume>, 22</volume>, <pages>63-68.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Zhang, W., Sloan-Lancaster, J., Kitchen, J., Trible, R.P. and Samelson, L.E.</workauthor>
               <pubdate>(1998a) </pubdate>
               <articletitle>LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.</articletitle> Cell, <volume>92</volume>, <pages>83-92.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Zhang, W., Trible, R.P. and Samelson, L.E.</workauthor>
               <pubdate>(1998b) </pubdate>
               <articletitle>LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. </articletitle>Immunity, <volume>9</volume>, <pages>239-246.</pages>
            </citation>
         
         
            <citation published="yes" workType="Journal">
               <workauthor>Zhou, H., Wertz, I., O'Rourke, K., Ultsch, M., Seshagiri, S., Eby, M., Xiao, W. and Dixit, V.M.</workauthor>
               <pubdate>(2004)</pubdate>
               <articletitle>Bcl10 activates the NF-</articletitle>
               <articletitle>&#954;</articletitle>
               <articletitle>B pathway through ubiquitination of NEMO.</articletitle> Nature, <volume>427</volume>, <pages>167-171.</pages>
            </citation>
         
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