[Seite 84↓]


Adams, G.M., Falke, S., Goldberg, A.L., Slaughter, C.A., DeMartino, G.N. und Gogol, E.P. (1997) Structural and functional effects of PA700 and modulator protein on proteasomes. J Mol Biol, 273, 646-657.

Bachmair, A. und Varshavsky, A. (1989) The degradation signal in a short-lived protein. Cell, 56, 1019-1032.

Belgareh, N. und Doye, V. (1997) Dynamics of nuclear pore distribution in nucleoporin mutant yeast cells. J Cell Biol, 136, 747- 759

Boeke, J.D., Trueheart, J., Natsoulis, G. und Fink, G.R. (1987) 5-Fluoroorotic acid as a selective agent in yeast molecular genetics. Methods Enzymol, 154, 164-175.

Bradford, M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem, 72, 248-254.

Braun, B.C., Glickman, M., Kraft, R., Dahlmann, B., Kloetzel, P.M., Finley, D. und Schmidt, M. (1999) The base of the proteasome regulatory particle exhibits chaperone-like activity. Nat Cell Biol, 1, 221-226.

Breitschopf, K., Bengal, E., Ziv, T., Admon, A. und Ciechanover, A. (1998) A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein. Embo J, 17, 5964-5973.

Bucci, M. und Wente, S.R. (1998) A novel fluorescence-based genetic strategy identifies mutants of Saccharomyces cerevisiae defective for nuclear pore complex assembly. Mol Biol Cell, 9, 2439-2461.

Chau, V., Tobias, J.W., Bachmair, A., Marriott, D., Ecker, D.J., Gonda, D.K. und Varshavsky, A. (1989) A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein. Science, 243, 1576-1583.

Chaves, S.R. und Blobel, G. (2001) Nuclear import of Spo12p, a protein essential for meiosis. J Biol Chem, 276, 17712-17717.

Chelsky, D., Ralph, R. und Jonak, G. (1989) Sequence requirements for synthetic peptide-mediated translocation to the nucleus. Mol Cell Biol, 9, 2487-2492.

Chen, P. und Hochstrasser, M. (1996) Autocatalytic subunit processing couples active site formation in the 20S proteasome to completion of assembly. Cell, 86, 961-972.

Chook, Y.M. und Blobel, G. (1999) Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp. Nature, 399, 230-237.

Ciechanover, A. (1998) The ubiquitin-proteasome pathway: on protein death and cell life. Embo J, 17, 7151-7160.

Ciechanover, A. und Brundin, P.(2003) The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg. Neuron, 40, 427- 446

Ciechanover, A., Orian, A. und Schwartz, A.L. (2000) Ubiquitin-mediated proteolysis: biological regulation via destruction. Bioessays, 22, 442-451.

Cingolani, G., Petosa, C., Weis, K. und Muller, C.W. (1999) Structure of importin-beta bound to the IBB domain of importin-alpha. Nature, 399, 221-229.

Conti, E., Uy, M., Leighton, L., Blobel, G. und Kuriyan, J. (1998) Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha. Cell, 94, 193-204.

Cope, G.A., Suh, G.S., Aravind, L., Schwarz, S.E., Zipursky, S.L., Koonin, E.V. und Deshaies, R.J. (2002) Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. Science, 298, 608-611.

Delahodde, A., Pandjaitan, R., Corral-Debrinski, M. und Jacq, C. (2001) Pse1/Kap121-dependent nuclear localization of the major yeast multidrug resistance (MDR) transcription factor Pdr1. Mol Microbiol, 39, 304-312.

[Seite 85↓]

DeMarini, D.J., Papa, F.R., Swaminathan, S., Ursic, D., Rasmussen, T.P., Culbertson, M.R. und Hochstrasser, M. (1995) The yeast SEN3 gene encodes a regulatory subunit of the 26S proteasome complex required for ubiquitin-dependent protein degradation in vivo. Mol Cell Biol, 15, 6311-6321.

DeMartino, G.N., Proske, R.J., Moomaw, C.R., Strong, A.A., Song, X., Hisamatsu, H., Tanaka, K. und Slaughter, C.A. (1996) Identification, purification, and characterization of a PA700-dependent activator of the proteasome. J Biol Chem, 271, 3112-3118.

Deveraux, Q., Ustrell, V., Pickart, C., Rechsteiner, M.(1994) A 26S protease subunit that binds ubiquitin conjugates. J Biol Chem, 269, 7059- 7061

Dingwall, C. und Laskey, R.A. (1991) Nuclear targeting sequences--a consensus? Trends Biochem Sci, 16, 478-481.

Dubiel, W., Ferrell, K., Dumdey, R., Standera, S., Prehn, S. und Rechsteiner, M. (1995) Molecular cloning and expression of subunit 12: a non-MCP and non-ATPase subunit of the 26S protease. FEBS Lett, 363 , 97- 100

Dunand-Sauthier, I., Walker, C., Wilkinson, C., Gordon, C., Crane, R., Norbury, C. und Humphrey, T. (2002) Sum1, a Component of the Fission Yeast eIF3 Translation Initiation Complex, Is Rapidly Relocalized During Environmental Stress and Interacts with Components of the 26S Proteasome. Mol. Biol. Cell, 13, 1626-1640.

Egner, R., Mahe, Y., Pandjaitan, R. and Kuchler, K. (1995) Endocytosis and vacuolar degradation of the plasma membrane- localized Pdr5 ATP- binding cassette multidrug transporter in Saccharomyces cerevisiae. Mol Cell Biol, 11, 5879- 5887

Elsasser, S., Gali, R.R., Schwickart, M., Larsen, C.N., Leggett, D.S., Muller, B., Feng, M.T., Tubing, F., Dittmar, G.A. und Finley, D. (2002) Proteasome subunit Rpn1 binds ubiquitin-like protein domains. Nat Cell Biol, 4, 725-730.

Enenkel, C., Blobel, G. und Rexach, M. (1995) Identification of a yeast karyopherin heterodimer that targets import substrate to mammalian nuclear pore complexes. J Biol Chem, 270, 16499-16502.

Enenkel, C., Lehmann, A. und Kloetzel, P.M. (1998) Subcellular distribution of proteasomes implicates a major location of protein degradation in the nuclear envelope-ER network in yeast. Embo J, 17, 6144-6154.

Fatica, A., Oeffinger, M., Dlakic, M. und Tollervey, D. (2003) Nob1p is required for cleavage of the 3' end of 18S rRNA. Mol Cell Biol, 23, 1798-1807.

Fehlker, M., Wendler, P., Lehmann, A. und Enenkel, C. (2003) Blm3 is part of nascent proteasomes and is involved in a late stage of nuclear proteasome assembly. EMBO Rep, 4, 959-963.

Ferdous, A., Gonzalez, F., Sun, L., Kodadek, T. und Johnston, S.A. (2001) The 19S regulatory particle of the proteasome is required for efficient transcription elongation by RNA polymerase II. Mol Cell, 7, 981-991.

Ferdous, A., Kodadek, T. und Johnston, S.A. (2002) A nonproteolytic function of the 19S regulatory subunit of the 26S proteasome is required for efficient activated transcription by human RNA polymerase II. Biochemistry, 41, 12798-12805.

Fischer, U., Huber, J., Boelens, W.C., Mattaj, I.W. und Luhrmann, R. (1995) The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs. Cell, 82, 475-483.

Fontes, M.R., Teh, T., Jans, D., Brinkworth, R.I. und Kobe, B. (2003) Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha. J Biol Chem, 278, 27981-27987.

Fontes, M.R., Teh, T. und Kobe, B. (2000) Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha. J Mol Biol, 297, 1183-1194.

Frentzel, S., Pesold-Hurt, B., Seelig, A. und Kloetzel, P.M. (1994) 20 S proteasomes are assembled via distinct precursor complexes. Processing of LMP2 and LMP7 proproteins takes place in 13-16 S preproteasome complexes. J Mol Biol, 236, 975-981.

[Seite 86↓]

Fu, H., Reis, N., Lee, Y., Glickman, M.H. und Vierstra, R.D. (2001) Subunit interaction maps for the regulatory particle of the 26S proteasome and the COP9 signalosome. Embo J, 20, 7096-7107.

Fu, H., Sadis, S., Rubin, D.M., Glickman, M., van Nocker, S., Finley, D. und Vierstra, R.D. (1998) Multiubiquitin chain binding and protein degradation are mediated by distinct domains within the 26 S proteasome subunit Mcb1. J Biol Chem, 273, 1970-1981.

Fujimuro, M., Tanaka, K., Yokosawa, H. und Toh-e, A. (1998) Son1p is a component of the 26S proteasome of the yeast Saccharomyces cerevisiae. FEBS Lett, 423, 149-154.

Gaczynska, M., Rock, K.L. und Goldberg, A.L.(1993) Gamma-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes. Nature, 365, 264-267.

Gavin, A.C., Bosche, M., Krause, R., Grandi, P., Marzioch, M., Bauer, A., Schultz, J., Rick, J.M., Michon, A.M., Cruciat, C.M., Remor, M., Hofert, C., Schelder, M., Brajenovic, M., Ruffner, H., Merino, A., Klein, K., Hudak, M., Dickson, D., Rudi, T., Gnau, V., Bauch, A., Bastuck, S., Huhse, B., Leutwein, C., Heurtier, M.A., Copley, R.R., Edelmann, A., Querfurth, E., Rybin, V., Drewes, G., Raida, M., Bouwmeester, T., Bork, P., Seraphin, B., Kuster, B., Neubauer, G. und Superti-Furga, G. (2002) Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature, 415, 141-147.

Gerlinger, U.-M., Guckel, R., Hoffmann, M., Wolf, D.H. and Hilt, W. (1997) Yeast Cycloheximide-resistant crl Mutants Are Proteasome Mutants Defective in Protein Degradation. Mol. Biol. Cell, 8, 2487-2499.

Ghislain, M., Udvardy, A. und Mann, C. (1993) S. cerevisiae 26S protease mutants arrest cell division in G2/metaphase. Nature, 366, 358-362.

Gilon, T., Chomsky, O. und Kulka, R.G. (1998) Degradation signals for ubiquitin system proteolysis in Saccharomyces cerevisiae. Embo J, 17, 2759-2766.

Girod, P.A., Fu, H., Zryd, J.P. und Vierstra, R.D. (1999) Multiubiquitin chain binding subunit MCB1 (RPN10) of the 26S proteasome is essential for developmental progression in Physcomitrella patens. Plant Cell, 11, 1457-1472.

Glickman, M.H., Rubin, D.M., Coux, O., Wefes, I., Pfeifer, G., Cjeka, Z., Baumeister, W., Fried, V.A. und Finley, D. (1998a) A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3. Cell, 94, 615-623.

Glickman, M.H., Rubin, D.M., Fried, V.A. und Finley, D. (1998b) The regulatory particle of the Saccharomyces cerevisiae proteasome. Mol Cell Biol, 18, 3149-3162.

Glickman, M.H. und Ciechanover, A. (2002) The ubiquitin- proteasome proteolytic pathway: destruction for the sake of construction Physiol Rev, 82, 373- 428.

Gonzalez, F., Delahodde, A., Kodadek, T. und Johnston, S.A. (2002) Recruitment of a 19S proteasome subcomplex to an activated promoter. Science, 296, 548-550.

Gordon, C. (2002) The intracellular localization of the proteasome. Curr Top Microbiol Immunol, 268, 175-184.

Gorlich, D. (1998) Transport into and out of the cell nucleus. Embo J, 17, 2721-2727.

Gorlich, D., Dabrowski, M., Bischoff, F.R., Kutay, U., Bork, P., Hartmann, E., Prehn, S. und Izaurralde, E. (1997) A novel class of RanGTP binding proteins. J Cell Biol, 138, 65-80.

Gorlich, D., Henklein, P., Laskey, R.A. und Hartmann, E. (1996) A 41 amino acid motif in importin-alpha confers binding to importin-beta and hence transit into the nucleus. Embo J, 15, 1810-1817.

Gorlich, D. und Kutay, U. (1999) Transport between the cell nucleus and the cytoplasm. Annu Rev Cell Dev Biol, 15, 607-660.

Groll, M., Ditzel, L., Lowe, J., Stock, D., Bochtler, M., Bartunik, H.D. und Huber, R. (1997) Structure of 20S proteasome from yeast at 2.4 A resolution. Nature, 386, 463-471.

Groll, M. und Huber, R. (2003) Substrate access and processing by the 20S proteasome core particle. Int J Biochem Cell Biol, 35, 606-616.

[Seite 87↓]

Guo, J. und Sen, G. (2000) Characterization of the interaction between the interferon- induced protein P56 and the Int6 protein encoded by the locus of insertion of the mouse mammary tumor virus. J Virol., 74, 1892- 1899

Guterman, A. und Glickman, M.H. (2004) Complementary roles for rpn11 and ubp6 in deubiquitination and proteolysis by the proteasome. J Biol Chem, 279, 1729-1738.

Haracska, L. und Udvardy, A. (1995) Cloning and sequencing of a non- ATPase subunit of the regulatory complex of the Drosophila 26S protease. Eur J Biochem, 231, 720- 725

Harreman, M.T., Hodel, M.R., Fanara, P., Hodel, A.E. und Corbett, A.H. (2003) The auto-inhibitory function of importin alpha is essential in vivo. J Biol Chem, 278, 5854-5863.

Hartmann-Petersen, R., Tanaka, K. und Hendil, K.B.(2001) Quaternary structure of the ATPase complex of human 26S proteasomes determined by chemical cross- linking. Arch Biochem Biophys, 386, 89- 94

Hartmann-Petersen, R., Seeger, M. und Gordon, C. (2003) Transferring substrates to the 26S proteasome. Trends Biochem Sci, 28, 26-31.

Heath, C.V., Copeland, C.S., Amberg, D.C., Del Priore, V., Snyder, M. und Cole (1995) Nuclear pore complex clustering and nuclear accumulation of poly(A)+ RNA associated with mutation of the Saccharomyces cerevisiae RAT2/NUP120 gene. J Cell Biol, 131, 1677- 1697

Heinemeyer, W., Kleinschmidt, J.A., Saidowsky, J., Escher, C. und Wolf, D.(1991) Proteinase yscE, the yeast proteasome/ multicatalytic- multifunctional proteinase: mutants unravel its function in stress induced proteolysis and uncover its necessity for cell survival. EMBO J., 10, 555- 562

Heinemeyer, W., Trondle, N., Albrecht, G. und Wolf, D.H. (1994) PRE5 and PRE6, the last missing genes encoding 20S proteasome subunits from yeast? Indication for a set of 14 different subunits in the eukaryotic proteasome core. Biochemistry, 33, 12229-12237.

Heinemeyer, W., Fischer, M., Krimmer, T., Stachon, U. und Wolf, D.H. (1997) The active sites of the eukaryotic 20 S proteasome and their involvement in subunit precursor processing. J Biol Chem, 272, 25200-25209.

Henkel, T., Zabel, U., van Zee, K., Muller, J.M., Fanning, E. und Baeuerle, P.A. (1992) Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-kappa B subunit. Cell, 68, 1121-1133.

Hershko, A., Leshinsky, E., Ganoth, D. und Heller, H. (1984) ATP- dependent degradation of ubiquitin- protein conjugates. Proc Natl Acad Sci USA, 81, 1619- 1623

Hershko, A. und Ciechanover, A. (1998) The ubiquitin system. Annu Rev Biochem, 67, 425-479.

Hilt, W. und Wolf, D.H.(2000) Proteasomes: The World of Regulatory Proteolysis. Eurekah.com

Ho, J.H., Kallstrom, G. und Johnson, A.W. (2000) Nmd3p is a Crm1p-dependent adapter protein for nuclear export of the large ribosomal subunit. J Cell Biol, 151, 1057-1066.

Ho, Y., Gruhler, A., Heilbut, A., Bader, G.D., Moore, L., Adams, S.L., Millar, A., Taylor, P., Bennett, K., Boutilier, K., Yang, L., Wolting, C., Donaldson, I., Schandorff, S., Shewnarane, J., Vo, M., Taggart, J., Goudreault, M., Muskat, B., Alfarano, C., Dewar, D., Lin, Z., Michalickova, K., Willems, A.R., Sassi, H., Nielsen, P.A., Rasmussen, K.J., Andersen, J.R., Johansen, L.E., Hansen, L.H., Jespersen, H., Podtelejnikov, A., Nielsen, E., Crawford, J., Poulsen, V., Sorensen, B.D., Matthiesen, J., Hendrickson, R.C., Gleeson, F., Pawson, T., Moran, M.F., Durocher, D., Mann, M., Hogue, C.W., Figeys, D. und Tyers, M. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature, 415, 180-183.

Hofmann, K. und Bucher, P. (1998) The PCI domain: a common theme in three multi- protein complexes. Trends Biochem Sci, 23, 204-205.

Hofmann, K. und Falquet, L. (2001) A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systems. Trends Biochem Sci, 26, 347-350.

[Seite 88↓]

Holzl, H., Kapelari, B., Kellermann, J., Seemuller, E., Sumegi, M., Udvardy, A., Medalia, O., Sperling, J., Muller, S.A., Engel, A. und Baumeister, W. (2000) The regulatory complex of Drosophila melanogaster 26S proteasomes. Subunit composition and localization of a deubiquitylating enzyme. J Cell Biol, 150, 119-130.

Hori, T., Kato, S., Saeki, M., DeMartino, G.N., Slaughter, C.A., Takeuchi, J., Toh-e, A. and Tanaka, K. (1998) cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome. Gene, 216,113-122.

Huh, W.K., Falvo, J.V., Gerke, L.C., Carroll, A.S., Howson, R.W., Weissman, J.S. und O’Shea, E.K. (2003) Global analysis of protein localization in budding yeast. Nature, 425, 686- 691

Iovine, M.K. und Wente, S.R. (1997) A nuclear export signal in Kap95 is required for both recycling the import factor and interaction with the nucleoporin GLFG repeat regions of Nup116p and Nup100p. J Cell Biol, 137, 797- 811

Jakel, S., Albig, W., Kutay, U., Bischoff, F.R., Schwamborn, K., Doenecke, D. und Gorlich, D. (1999) The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1. Embo J, 18, 2411-2423.

Jans, D.A., Xiao, C.Y. und Lam, M.H.C. (2000) Nuclear targeting signal recognition: a key control point in nuclear transport? Bioessays, 22, 532- 544

Kaffman, A., Rank, N.M. und O'Shea, E.K. (1998) Phosphorylation regulates association of the transcription factor Pho4 with its import receptor Pse1/Kap121. Genes Dev, 12, 2673-2683.

Kaiser, P., Moncollin, V., Clarke, D.J., Watson, M.H., Bertolaet, B.L., Reed, S.I. und Bailly, E. (1999) Cyclin-dependent kinase and Cks/Suc1 interact with the proteasome in yeast to control proteolysis of M-phase targets. Genes Dev, 13, 1190-1202.

Kaiser, C., Michaelis, S. und A., Mitchell (1994) Methods in yeast genetics. In. Cold Spring Harbor Laboratory Press, New York.

Kajava, A.V. (2002) What curves alpha-solenoids? Evidence for an alpha-helical toroid structure of Rpn1 and Rpn2 proteins of the 26 S proteasome. J Biol Chem, 277, 49791-49798.

Kalderon, D., Richardson, W.D., Markham, A.F. und Smith, A.E. (1984a) Sequence requirements for nuclear location of simian virus 40 large-T antigen. Nature, 311, 33-38.

Kalderon, D., Roberts, B.L., Richardson, W.D. und Smith, A.E. (1984b) A short amino acid sequence able to specify nuclear location. Cell, 39, 499-509.

Kapelari, B., Bech-Otschir, D., Hegerl, R., Schade, R., Dumdey, R. und Dubiel, W. (2000). Electron microscopy and subunit-subunit interaction studies reveal a first architecture of COP9 signalosome. J Mol Biol, 300,1169-1178.

Kehlenbach, R.H. und Gerace, L. (2000) Phosphorylation of the nuclear transport machinery down-regulates nuclear protein import in vitro. J Biol Chem, 275, 17848-17856.

Kisselev, A.F., Akopian, T.N., Castillo, V. und Goldberg, A.L. (1999) Proteasome active sites allosterically regulate each other, suggesting a cyclical bite-chew mechanism for protein breakdown. Mol Cell, 4, 395-402.

Kleijnen, M.F., Shih, A.H., Zhou, P., Kumar, S., Soccio, R.E., Kedersha, N.L., Gill, G. und Howley, P.M. (2000) The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome. Mol Cell, 6, 409-419.

Kloetzel, P.M. (2001) Antigen processing by the proteasome. Nat Rev Mol Cell Biol, 2, 179-187.

Kobe, B. (1999) Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha. Nat Struct Biol, 6, 388-397.

Kobe, B. und Kemp, B.E. (1999) Active site-directed protein regulation. Nature, 402, 373-376.

Köhler, A., Cascio, P., Leggett, D.S., Woo, K.M., Goldberg, A.L. und Finley, D. (2001) The axial channel of the proteasome core particle is gated by the rpt2 atpase and controls both substrate entry and product release. Mol Cell, 7, 1143-1152.

Köhler, M., Ansieau, S., Prehn, S., Leutz, A., Haller, H. und Hartmann, E. (1997) Cloning of two novel human importin- alpha subunits and analysis of the expression pattern of the importin- alpha protein family. FEBS Lett, 417, 104- 108

[Seite 89↓]

Kominami, K., DeMartino, G. N., Moomaw, C. R., Slaughter, C. A., Shimbara, N., Fujimuro, M., Yokosawa, H., Hisamatsu, H., Tanahashi, N. und Shimizu, Y. (1995). Nin1p, a regulatory subunit of the 26S proteasome, is necessary for activation of Cdc28p kinase of Saccharomyces cerevisiae. Embo J, 14,3105-3115.

LaCasse, E.C. und Lefebvre, Y.A. (1995) Nuclear localization signals overlap DNA- or RNA- binding domains in nucleic acid- binding proteins. Nucleic Acids Res, 23, 1647- 1656

Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227, 680-685.

Lam, Y.A., Lawson, T.G., Velayutham, M., Zweier, J.L. und Pickart, C.M. (2002) A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal. Nature, 416, 763-767.

Lecker, S.H., Solomon, V., Mitch, W.E. und Goldberg, A.L. (1999) Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states. J Nutr, 129, 227S-237S.

Leggett, D.S., Hanna, J., Borodovsky, A., Crosas, B., Schmidt, M., Baker, R.T., Walz, T., Ploegh, H. und Finley, D. (2002) Multiple associated proteins regulate proteasome structure and function. Mol Cell, 10, 495-507.

Lehmann, A., Janek, K., Braun, B., Kloetzel, P.M. und Enenkel, C. (2002) 20 S proteasomes are imported as precursor complexes into the nucleus of yeast. J Mol Biol, 317, 401-413.

Leslie, D.M., Grill, B., Rout, M.P., Wozniak, R.W. und Aitchison, J.D. (2002) Kap121p-mediated nuclear import is required for mating and cellular differentiation in yeast. Mol Cell Biol, 22, 2544-2555.

Loeb, J.D., Schlenstedt, G., Pellman, D., Kornitzer, D., Silver, P.A. und Fink, G.R. (1995) The yeast nuclear import receptor is required for mitosis. Proc Natl Acad Sci U S A, 92, 7647-7651.

Lowe, J., Stock, D., Jap, B., Zwickl, P., Baumeister, W. und Huber, R. (1995) Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution. Science, 268, 533-539.

Lupas, A., Baumeister, W. und Hofmann, K. (1997) A repetitive sequence in subunits of the 26S proteasome and 20S cyclosome (anaphase-promoting complex). Trends Biochem Sci, 22, 195-196.

Mannhaupt, G., Schnall, R., Karpov, V., Vetter, I. und Feldmann, H. (1999) Rpn4p acts as a transcription factor by binding to PACE, a nonamer box found upstream of 26S proteasomal and other genes in yeast. FEBS Lett, 450, 27-34.

Maytal-Kivity, V., Reis, N., Hofmann, K. und Glickman, M.H. (2002) MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function. BMC Biochem, 3, 28.

McBride, W.H., Iwamoto, K.S., Syljuasen, R., Pervan, M. und Pajonk, F. (2003) The role of the ubiquitin/ proteasome system in cellular responses to radiation. Oncogene, 22, 5755- 5773.

McDonald, H.B., Helfant, A.H., Mahony, E.M., Khosla, S.K. und Goetsch, L. (2002) Mutational analysis reveals a role for the C Terminus of the proteasome subunit Rpt4 in spindle pole body. Genetics, 162, 705- 720

Moreland, R.B., Langevin, G.L., Singer, R.H., Garcea, R.L. und Hereford, L.M. (1987) Amino acid sequences that determine the nuclear localization of yeast histone 2B. Mol Cell Biol, 7, 4048-4057.

Mosammaparast, N., Jackson, K.R., Guo, Y., Brame, C.J., Shabanowitz, J., Hunt, D.F. und Pemberton, L.F. (2001) Nuclear import of histone H2A and H2B is mediated by a network of karyopherins. J Cell Biol, 153, 251-262.

Nachury, M.V., Ryder, U.W., Lamond, A.I. und Weis, K. (1998) Cloning and characterization of hSRP1 gamma, a tissue-specific nuclear transport factor. Proc Natl Acad Sci U S A, 95, 582-587.

Nadler, S.G., Tritschler, D., Haffar, O.K., Blake, J., Bruce, A.G. und Cleaveland, J.S. (1997) Differential expression and sequence-specific interaction of karyopherin alpha with nuclear localization sequences. J Biol Chem, 272, 4310-4315.

[Seite 90↓]

Nisogi, H., Kominami, K., Tanaka, K. und Toh-e, A. (1992). A new essential gene of Saccharomyces cerevisiae, a defect in it may result in instability of nucleus. Exp Cell Res, 200,48-57.

Orlowski, M. (1990) The multicatalytic proteinase complex, a major extralysosomal proteolytic system. Biochemistry, 29, 10289-10297.

Özkaynak, E., Finley, D., Varshavsky, A. (1989) The yeast au genes: a family of natural gene fusions. EMBO J, 5, 1429- 1439

Paine, P.L., Moore, L.C. und Horowitz, S.B. (1975) Nuclear envelope permeability. Nature, 254, 109-114.

Palmeri, D. und Malim, M.H. (1999) Importin beta can mediate the nuclear import of an arginine-rich nuclear localization signal in the absence of importin alpha. Mol Cell Biol, 19, 1218-1225.

Pante, N. und Kann, M. (2002) Nuclear pore complex is able to transport macromolecules with diameters of about 39 nm. Mol Biol Cell, 13, 425-434.

Papa, F.R., Amerik, A.Y. und Hochstrasser, M. (1999) Interaction of the Doa4 deubiquitinating enzyme with the yeast 26S proteasome. Mol Biol Cell, 10, 741-756.

Pemberton, L.F., Rosenblum, J.S. und Blobel, G. (1999) Nuclear import of the TATA-binding protein: mediation by the karyopherin Kap114p and a possible mechanism for intranuclear targeting. J Cell Biol, 145, 1407-1417.

Pries, R., Bomeke, K., Draht, O., Kunzler, M. und Braus, G.H. (2003) Nuclear import of yeast Gcn4p requires karyopherins Srp1p and Kap95p. Mol Genet Genomics, 27, 27.

Ramos, P.C., Hockendorff, J., Johnson, E.S., Varshavsky, A. und Dohmen, R.J. (1998) Ump1p is required for proper maturation of the 20S proteasome and becomes its substrate upon completion of the assembly. Cell, 92, 489-499.

Realini, C., Rogers, S.W. undRechsteiner, M. (1994) KEKE motifs. Proposed roles in protein- protein association and presentation of peptides by MHC class I receptors. FEBS Lett, 348, 109-113

Reits, E.A.J., Benham, A.M., Plougastel, B., Neefjes, J. und Trowsdale, J. (1997) Dynamics of proteasome distribution in living cells. Embo J, 16, 6087-6094.

Rexach, M. und Blobel, G. (1995) Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins. Cell, 83, 683-692.

Richmond, C., Gorbea, C. und Rechsteiner, M. (1997) Specific Interactions between ATPase Subunits of the 26 S Protease. J. Biol. Chem., 272, 13403-13411.

Rinaldi, T., Ricci, C., Porro, D., Bolotin-Fukuhara, M. und Frontali, L. (1998) A Mutation in a Novel Yeast Proteasomal Gene, RPN11/MPR1, Produces a Cell Cycle Arrest, Overreplication of Nuclear and Mitochondrial DNA, and an Altered Mitochondrial Morphology. Mol. Biol. Cell, 9, 2917-2931.

Rosenblum, J.S., Pemberton, L.F., Bonifaci, N. und Blobel, G.(1998) Nuclear import and the evolution of a multifunctional RNA- binding protein. J Cell Biol, 143, 887- 899

Rosenblum, J.S., Pemberton, L.F. und Blobel, G. (1997) A nuclear import pathway for a protein involved in tRNA maturation. J Cell Biol, 139, 1655-1661.

Rout, M.P. und Aitchison, J.D. (2000) Pore relations: nuclear pore complexes and nucleocytoplasmic exchange. Essays Biochem, 36, 75-88.

Rout, M.P., Aitchison, J.D., Magnasco, M.O. und Chait, B.T. (2003) Virtual gating and nuclear transport: the hole picture. Trends Cell Biol, 13, 622-628.

Rout, M.P., Aitchison, J.D., Suprapto, A., Hjertaas, K., Zhao, Y. und Chait, B.T. (2000) The yeast nuclear pore complex: composition, architecture, and transport mechanism. J Cell Biol, 148, 635-651.

Rout, M.P., Blobel, G. und Aitchison, J.D. (1997) A distinct nuclear import pathway used by ribosomal proteins. Cell, 89, 715-725.

[Seite 91↓]

Rubin, D.M., Glickman, M.H., Larsen, C.N., Dhruvakumar, S. und Finley, D. (1998) Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasome. Embo J, 17, 4909-4919.

Russell, S.J., Steger, K.A. und Johnston, S.A. (1999) Subcellular localization, stoichiometry, and protein levels of 26 S proteasome subunits in yeast. J Biol Chem, 274, 21943-21952.

Saeki, Y., Toh-e, A. und Yokosawa, H. (2000) Rapid isolation and characterization of the yeast proteasome regulatory complex. Biochem Biophys Res Commun, 273, 509-515.

Sambrook, J., Fritsch, E.F. und Maniatis, T.(1989) Molecular cloning, a laboratory Manual. Cold Spring Harbor Laboratory Press, New York

Santamaria, P.G., Finley, D., Ballesta, J.P.G. und Remacha, M. (2003) Rpn6p, a Proteasome Subunit from Saccharomyces cerevisiae, is Essential for the Assembly and Activity of the 26S Proteasome. J. Biol. Chem., 278, 6687-6695.

Satoh, K., Sasajima, H., Nyoumura, K., Yokosawa, H. und Sawada, H. (2001) Assembly of the 26S Proteasome Is Regulated by Phosphorylation of the p45/Rpt6 ATPase Subunit. Biochemistry, 40, 314-319.

Schafer, T., Strauss, D., Petfalski, E., Tollervey, D. und Hurt, E. (2003) The path from nucleolar 90S to cytoplasmic 40S pre-ribosomes. Embo J, 22, 1370-1380.

Schmidtke, G., Kraft, R., Kostka, S., Henklein, P., Frömmel, C., Lowe, J., Huber, R., Kloetzel, P.M. und Schmidt, M.(1996) Analysis of mammalian 20S proteasome biogenesis: the maturation of beta- subunits is an ordered two- step mechanism involving autocatalysis EMBO J, 15, 6887- 6898

Seedorf, M. und Silver, P.A. (1997) Importin/ karyopherin protein family members required for mRNA export from the nucleus. Proc. Natl. Acad. Sci. USA, 94, 8590- 8595

Senger, B., Simos, G., Bischoff, F.R., Podtelejnikov, A., Mann, M. und Hurt, E. (1998) Mtr10p functions as a nuclear import receptor for the mRNA-binding protein Npl3p. Embo J, 17, 2196-2207.

Shulga, N., Roberts, P., Gu, Z., Spitz, L., Tabb, M.M., Nomura, M. und Goldfarb, D.S. (1996) In vivo nuclear transport kinetics in Saccharomyces cerevisiae: a role for heat shock protein 70 during targeting and translocation. J Cell Biol, 135, 329-339.

Stoffler, D., Feja, B., Fahrenkrog, B., Walz, J., Typke, D. und Aebi, U. (2003) Cryo-electron tomography provides novel insights into nuclear pore architecture: implications for nucleocytoplasmic transport. J Mol Biol, 328, 119-130.

Strom, A.C. und Weis, K. (2001) Importin-beta-like nuclear transport receptors. Genome Biol, 2, REVIEWS3008.

Tabb, M.M., Tongaonkar, P., Vu, L. und Nomura, M. (2000) Evidence for separable functions of Srp1p, the yeast homolog of importin alpha (Karyopherin alpha): role for Srp1p and Sts1p in protein degradation. Mol Cell Biol, 20, 6062-6073.

Takeuchi, J., Fujimuro, M., Yokosawa, H., Tanaka, K. und Toh-e, A. (1999) Rpn9 is required for efficient assembly of the yeast 26S proteasome. Mol Cell Biol, 19, 6575-6584.

Thrower, J.S., Hoffman, L., Rechsteiner, M. und Pickart, C.M. (2000) Recognition of the polyubiquitin proteolytic signal. Embo J, 19, 94-102.

Tone, Y., Tanahashi, N., Tanaka, K., Fujimuro, M., Yokosawa, H. und Toh-e, A. (2000) Nob1p, a new essential protein, associates with the 26S proteasome of growing saccharomyces cerevisiae cells. Gene, 243, 37-45.

Tone, Y. und Toh, E.A. (2002) Nob1p is required for biogenesis of the 26S proteasome and degraded upon its maturation in Saccharomyces cerevisiae. Genes Dev, 16, 3142-3157.

Traencker, E.B., Wilk, S. und Baeuerle, P.A. (1994) A proteasom inhibitor prevents activation of NF- kappa B and stabilzes a newly phosphorylated form of I kappa B- alpha that is still bound to NF- kappa B. EMBO J, 13, 5433- 5441

[Seite 92↓]

Uetz, P., Giot, L., Cagney, G., Mansfield, T.A., Judson, R.S., Knight, J.R., Lockshon, D., Narayan, V., Srinivasan, M., Pochart, P., Qureshi-Emili, A., Li, Y., Godwin, B., Conover, D., Kalbfleisch, T., Vijayadamodar, G., Yang, M., Johnston, M., Fields, S. und Rothberg, J.M.(2000) A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature, 403, 623-627.

Vale, R. D. (2000) AAA Proteins: Lords of the Ring. J Cell Biol, 150, F13- F19

van Nocker, S., Sadis, S., Rubin, D.M., Glickman, M., Fu, H., Coux, O., Wefes, I., Finley, D. and Vierstra, R.D. (1996). The multiubiquitin-chain-binding protein Mcb1 is a component of the 26S proteasome in Saccharomyces cerevisiae and plays a nonessential, substrate-specific role in protein turnover. Mol Cell Biol, 16,6020-6028.

Verma, R., Aravind, L., Oania, R., McDonald, W.H., Yates, J.R., 3rd, Koonin, E.V. und Deshaies, R.J. (2002) Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome. Science, 298, 611-615.

Verma, R., Chen, S., Feldman, R., Schieltz, D., Yates, J., Dohmen, J. und Deshaies, R.J. (2000) Proteasomal proteomics: identification of nucleotide-sensitive proteasome-interacting proteins by mass spectrometric analysis of affinity-purified proteasomes. Mol Biol Cell, 11, 3425-3439.

Voges, D., Zwickl, P. und Baumeister, W. (1999) The 26S proteasome: a molecular machine designed for controlled proteolysis. Annu Rev Biochem, 68, 1015-1068.

von Arnim, A.G. (2001) A hitchhiker's guide to the proteasome. Sci STKE, 2001, PE2.

Walker, J.E., Saraste, M., Runswick, M.J. und Gay, N.J. (1982) Distantly related sequences in the α- and β- subunits of ATP synthase, myosin, kinases and other ATP- requiring enzymes and a common nucleotide binding fold. EMBO J, 1, 945- 951

Walz, J., Erdmann, A., Kania, M., Typke, D., Koster, A.J. und Baumeister, W. (1998) 26S proteasome structure revealed by three-dimensional electron microscopy. J Struct Biol, 121, 19-29.

Warner, J.R. (1999) The economics of ribosome biosynthesis in yeast. Trends Biochem Sci, 24, 437- 440

Weis, K., Ryder, U. und Lamond, A.I. (1996) The conserved amino-terminal domain of hSRP1 alpha is essential for nuclear protein import. Embo J, 15, 1818-1825.

Wen, W., Meinkoth, J.L., Tsien, R.Y. und Taylor, S.S. (1995) Identification of a signal for rapid export of proteins from the nucleus. Cell, 82, 463-473.

Wilkinson, C.R., Ferrell, K., Penney, M., Wallace, M., Dubiel, W. und Gordon, C. (2000) Analysis of a gene encoding Rpn10 of the fission yeast proteasome reveals that the polyubiquitin-binding site of this subunit is essential when Rpn12/Mts3 activity is compromised. J Biol Chem, 275, 15182-15192.

Wilkinson, C.R., Wallace, M., Seeger, M., Dubiel, W. und Gordon, C. (1997) Mts4, a non-ATPase subunit of the 26 S protease in fission yeast is essential for mitosis and interacts directly with the ATPase subunit Mts2. J Biol Chem, 272, 25768-25777.

Wilkinson, C.R., Wallace, M., Morphew, M., Perry, P., Allshire, R., Javerzat, J.P., McIntosh, J.R. und Gordon, C. (1998) Localization of the 26S proteasome during mitosis and meiosis in fission yeast. Embo J, 17, 6465-6476.

Winzeler, E.A., Shoemaker, D.D., Astromoff, A., Liang, H., Anderson, K., Andre, B., Bangham, R., Benito, R., Boeke, J.D., Bussey, H., Chu, A.M., Connelly, C., Davis, K., Dietrich, F., Dow, S.W., El Bakkoury, M., Foury, F., Friend, S.H., Gentalen, E., Giaever, G., Hegemann, J.H., Jones, T., Laub, M., Liao, H., Davis, R.W. (1999) Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science, 285, 901-906.

Witt, E., Zantopf, D., Schmidt, M., Kraft, R., Kloetzel, P.M. und Kruger, E. (2000) Characterisation of the newly identified human Ump1 homologue POMP and analysis of LMP7(beta 5i) incorporation into 20 S proteasomes. J Mol Biol, 301, 1-9.

Wojcik, C. und DeMartino, G.N. (2003) Intracellular localization of proteasomes. Int J Biochem Cell Biol, 35, 579-589.

Wozniak, R.W., Rout, M.P. und Aitchison, J.D. (1998) Karyopherins and kissing cousins. Trends Cell Biol, 8, 184-188.

[Seite 93↓]

Xiao, C.Y., Hubner, S. und Jans, D.A. (1997) SV40 large tumor antigen nuclear import is regulated by the double-stranded DNA-dependent protein kinase site (serine 120) flanking the nuclear localization sequence. J Biol Chem, 272, 22191-22198.

Xiao, C.Y., Jans, P. und Jans, D.A. (1998) Negative charge at the protein kinase CK2 site enhances recognition of the SV40 large T-antigen NLS by importin: effect of conformation. FEBS Lett, 440, 297-301.

Xie, Y. und Varshavsky, A. (2000) Physical association of ubiquitin ligases and the 26S proteasome. Proc Natl Acad Sci U S A, 97, 2497-2502.

Xie, Y. und Varshavsky, A. (2001) RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: A negative feedback circuit. Proc Natl Acad Sci U S A, 98, 3056-3061.

Xie, Y. und Varshavsky, A. (2002) UFD4 lacking the proteasome- binding region catalyses ubiquitination but is impaired in proteolysis. Nat Cell Biol., 4, 1003- 1007

Yaffe, M.P. und Schatz, G. (1984) Two nuclear mutations that block mitochondrial protein import in yeast. Proc Natl Acad Sci U S A, 81, 4819-4823.

Yano, R., Oakes, M., Yamaghishi, M., Dodd, J.A. und Nomura, M. (1992) Cloning and characterization of SRP1, a suppressor of temperature-sensitive RNA polymerase I mutations, in Saccharomyces cerevisiae. Mol Cell Biol, 12,5640-5651.

Yano, R., Oakes, M.L., Tabb, M.M. und Nomura, M. (1994) Yeast Srp1p has homology to armadillo/plakoglobin/beta-catenin and participates in apparently multiple nuclear functions including the maintenance of the nucleolar structure. Proc Natl Acad Sci U S A, 91, 6880-6884.

Yao, T. und Cohen, R.E. (2002) A cryptic protease couples deubiquitination and degradation by the proteasome. Nature, 419, 403-407.

Yen, H.C., Espiritu, C. und Chang, E.C. (2003a) Rpn5 is a conserved proteasome subunit and required for proper proteasome localization and assembly. J Biol Chem, 278, 30669- 30676

Yen, H.C., Gordon, C. und Chang, E.C. (2003b) Schizosaccharomyces pombe Int6 and Ras Homologs Regulate Cell Division and Mitotic Fidelity via the Proteasome. Cell, 112, 207-217.

Yokota, K., Kagawa, S., Shimizu, Y., Akioka, H., Tsurumi, C., Noda, C., Fujimuro, M., Yokosawa, H., Fujiwara, T., Takahashi, E., Ohba, M., Yamasaki, M., DeMartino, G.N., Slaughter, C.A., Toh-e, A. und Tanaka, K. (1996) CDNA cloning of p112, the largest regulatory subunit of the human 26s proteasome, and functional analysis of its yeast homologue, sen3p. Mol Biol Cell, 7, 853-870.

Yoshida, K. und Blobel, G. (2001) The karyopherin Kap142p/Msn5p mediates nuclear import and nuclear export of different cargo proteins. J Cell Biol, 152, 729-740.

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