The work for this thesis was performed in the Experimental Oncology Laboratory of the Virchow Hospital of the Charité, Medical Faculty of the Humboldt University, Berlin.

I would like to express my gratitude to all those who gave me the possibility to complete this thesis. Special thanks go to my supervisor PD. Holger N. Lode who has played a pivotal role throughout this project, providing his confidence and enthusiasm. His advice and friendship will always be appreciated and remembered lifelong. My sincere thanks also go to Professor G. Gaedicke, the head of the Department of general Pediatric, for providing me constant encouragement.

Many thanks go to my colleagues, all members of Experimental Oncology Laboratory headed by Dr. Lode. These include Prof. J.K. Jiang; Dip.biol. N. Huebener; Dr. J. Wenkel; Dr. S. Fest; Dr. S. Weixler; U. Schroeder; B. Lange; A. Strandsby; K. Hilt; A. Wöhler. I am deeply thankful for their support and valuable friendship. This work would not have been compeleted without their help and I would not have had such an unforgettable life in Germany without their friendship.

I would like to pay tribute to Assistant Professor Dr. R. Xiang, who kindly offered many important suggestion on this work, and with whom I had many discussion on the realm of science.

Lastly, I want to give my special appreciation to my dearest grandparents who formed part of my view and taught me all the good things that really matter in life. I am grateful to my parents, my brother and all my family for their support and understanding.

Many more persons participated in various ways to ensure my work to succeed than I have mentioned and I am thankful to all of them.

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