<?xml version="1.0" encoding="ISO-8859-1"?><cms:container xmlns:cms="http://edoc.hu-berlin.de/diml/module/cms"><cms:document><cms:meta><cms:entry id="front" part="front" ref="front" type="front"/><cms:entry type="title">T-cell mediated suppression of neuroblastoma following fractalkine gene therapy is amplified by targeted IL-2</cms:entry><cms:entry type="author">Yan Zeng, aus Chongqing, V.R.China</cms:entry><cms:entry id="N10072" part="N10072" ref="N10072" type="preface">Preface</cms:entry><cms:entry id="N10079" part="N10072" ref="N10079" type="citenumber">1</cms:entry><cms:entry id="I_Ref124344199" part="N10072" ref="I_Ref124344199" type="link"/><cms:entry id="I_Ref124344202" part="N10072" ref="I_Ref124344202" type="link"/><cms:entry id="I_Ref124344203" part="N10072" ref="I_Ref124344203" type="link"/><cms:entry id="I_Ref124344204" part="N10072" ref="I_Ref124344204" type="link"/><cms:entry id="chapter1" part="chapter1" ref="chapter1" type="chapter">1</cms:entry><cms:entry id="N1009B" part="chapter1" ref="N1009B" type="helpercitenumber">1</cms:entry><cms:entry id="N100A3" part="chapter1" ref="N100A3" type="citenumber">2</cms:entry><cms:entry id="N100AF" part="chapter1" ref="N100AF" type="citenumber">3</cms:entry><cms:entry id="N100B2" part="chapter1" ref="N100B2" type="mm">605#112</cms:entry><cms:entry id="N10102" part="chapter1" ref="N10102" type="citenumber">4</cms:entry><cms:entry id="N10114" part="chapter1" ref="N10114" type="citenumber">5</cms:entry><cms:entry id="chapter2" part="chapter2" ref="chapter2" type="chapter">2</cms:entry><cms:entry id="N10127" part="chapter2" ref="N10127" type="helpercitenumber">5</cms:entry><cms:entry id="N1012A" part="chapter2" ref="N1012A" type="section">2.1</cms:entry><cms:entry id="N10133" part="chapter2" ref="N10133" type="section">2.2</cms:entry><cms:entry id="N1013A" part="chapter2" ref="N1013A" type="citenumber">6</cms:entry><cms:entry id="N1014B" part="chapter2" ref="N1014B" type="section">2.3</cms:entry><cms:entry id="N10150" part="chapter2" ref="N10150" type="subsection">2.3.1</cms:entry><cms:entry id="N1015F" part="chapter2" ref="N1015F" type="subsection">2.3.2</cms:entry><cms:entry id="N10166" part="chapter2" ref="N10166" type="citenumber">7</cms:entry><cms:entry id="N10178" part="chapter2" ref="N10178" type="section">2.4</cms:entry><cms:entry id="N10193" part="chapter2" ref="N10193" type="section">2.5</cms:entry><cms:entry id="N101AC" part="chapter2" ref="N101AC" type="citenumber">8</cms:entry><cms:entry id="N101AF" part="chapter2" ref="N101AF" type="mm">439#45</cms:entry><cms:entry id="N101B5" part="chapter2" ref="N101B5" type="section">2.6</cms:entry><cms:entry id="N101C7" part="chapter2" ref="N101C7" type="section">2.7</cms:entry><cms:entry id="chapter3" part="chapter3" ref="chapter3" type="chapter">3</cms:entry><cms:entry id="N101D8" part="chapter3" ref="N101D8" type="citenumber">9</cms:entry><cms:entry id="N101DE" part="chapter3" ref="N101DE" type="mm">605#178</cms:entry><cms:entry id="N101EA" part="chapter3" ref="N101EA" type="section">3.1</cms:entry><cms:entry id="N101F9" part="chapter3" ref="N101F9" type="section">3.2</cms:entry><cms:entry id="N10200" part="chapter3" ref="N10200" type="citenumber">10</cms:entry><cms:entry id="N10206" part="chapter3" ref="N10206" type="mm">377#209</cms:entry><cms:entry id="N10217" part="chapter3" ref="N10217" type="citenumber">11</cms:entry><cms:entry id="N1021A" part="chapter3" ref="N1021A" type="mm">604#242</cms:entry><cms:entry id="N1022A" part="chapter3" ref="N1022A" type="section">3.3</cms:entry><cms:entry id="N10234" part="chapter3" ref="N10234" type="mm">423#248</cms:entry><cms:entry id="N10248" part="chapter3" ref="N10248" type="citenumber">12</cms:entry><cms:entry id="N10254" part="chapter3" ref="N10254" type="mm">587#364</cms:entry><cms:entry id="N10261" part="chapter3" ref="N10261" type="section">3.4</cms:entry><cms:entry id="N10271" part="chapter3" ref="N10271" type="citenumber">13</cms:entry><cms:entry id="N10274" part="chapter3" ref="N10274" type="mm">605#324</cms:entry><cms:entry id="N1028E" part="chapter3" ref="N1028E" type="mm">605#226</cms:entry><cms:entry id="N1029E" part="chapter3" ref="N1029E" type="section">3.5</cms:entry><cms:entry id="N102A5" part="chapter3" ref="N102A5" type="citenumber">14</cms:entry><cms:entry id="N102B1" part="chapter3" ref="N102B1" type="mm">564#600</cms:entry><cms:entry id="N102C4" part="chapter3" ref="N102C4" type="section">3.6</cms:entry><cms:entry id="N102CE" part="chapter3" ref="N102CE" type="citenumber">15</cms:entry><cms:entry id="N102DA" part="chapter3" ref="N102DA" type="mm">604#328</cms:entry><cms:entry id="N102E7" part="chapter3" ref="N102E7" type="section">3.7</cms:entry><cms:entry id="N1030F" part="chapter3" ref="N1030F" type="citenumber">16</cms:entry><cms:entry id="N10312" part="chapter3" ref="N10312" type="mm">600#247</cms:entry><cms:entry id="N10347" part="chapter3" ref="N10347" type="mm">432#307</cms:entry><cms:entry id="chapter4" part="chapter4" ref="chapter4" type="chapter">4</cms:entry><cms:entry id="N1036E" part="chapter4" ref="N1036E" type="citenumber">17</cms:entry><cms:entry id="N10386" part="chapter4" ref="N10386" type="citenumber">18</cms:entry><cms:entry id="N103B6" part="chapter4" ref="N103B6" type="citenumber">19</cms:entry><cms:entry ref="N103D1" type="back"/><cms:entry id="N103D3" part="N103D3" ref="N103D3" type="abbreviation">Abkürzungsverzeichnis</cms:entry><cms:entry id="N103DA" part="N103D3" ref="N103DA" type="table"/><cms:entry ref="N1066E" type="bibliography">Literaturverzeichnis</cms:entry><cms:entry id="N10AA2" part="N10AA2" ref="N10AA2" type="declaration">Anteilserklärung</cms:entry><cms:entry id="N10B62" part="N10B62" ref="N10B62" type="acknowledgement">Acknowledgment</cms:entry><cms:entry id="N10B7A" part="N10B7A" ref="N10B7A" type="declaration">Eidestattliche Erklärung</cms:entry><cms:entry part="N1066E" type=":current"/><cms:entry type=":lang">de</cms:entry><cms:entry id=":contents" part="front" ref=":contents" type=":contents">Inhaltsverzeichnis</cms:entry><cms:entry type=":help"><url href="http://...">Hilfe</url></cms:entry></cms:meta><cms:content><bibliography id="N1066E">
         <head>Literaturverzeichnis</head>
         <freehead>5.1 Own Publications</freehead>
         
            <citation published="yes" workType="Journal">
               <cut>[1]</cut>
               <workauthor>Zeng Y; Fest S; Kunert R; Katinger H; Pistoia V; Michon J; Lewis G; Ladenstein R; Lode HN.: </workauthor>
               <articletitle>Anti-neuroblastoma effect of ch14.18 antibody produced in CHO cells is mediated by NK-cells in mice</articletitle>. Mol Immunol. <pubdate>2005</pubdate>
               <number> Jul;42(11)</number>
               <number>,</number>
               <pages>1311-9</pages>.</citation>
         
         
            <citation published="yes" workType="Journal">
               <cut>[2]</cut>. <workauthor>Huebener,N.; Lange,B.; Lemmel,C.; Rammensee,H.G.; Strandsby,A.; Wenkel,J.; Jikai,J.; Zeng,Y.; Gaedicke,G.; Lode,H.N</workauthor>.: <articletitle>Vaccination with minigenes encoding for novel 'self' antigens are effective in DNA-vaccination against neuroblastoma.</articletitle> Cancer Lett.<number/>
               <pubdate>2003</pubdate>
               <number>; Jul 18;197(1-2)</number>
               <number>,</number>
               <pages>211-7</pages>.</citation>
         
         
            <citation published="yes" workType="Journal">
               <cut>[3]</cut>. <workauthor>Lode,H.N.; Huebener,N.; Zeng,Y.; Fest,S.; Weixler,S.; Gaedicke,G</workauthor>.: <articletitle>DNA minigene vaccination for adjuvant neuroblastoma therapy</articletitle>. Ann N Y Acad Sci. <pubdate>2004</pubdate>
               <number> Dec;1028</number>, <pages>113-21</pages>.</citation>
         
         
            <citation published="yes" workType="Journal">
               <cut>[4].</cut>
               <workauthor>Zeng Y; Jiang J</workauthor>
               <workauthor>;</workauthor>
               <workauthor> Huebener N</workauthor>
               <workauthor>;</workauthor>
               <workauthor> Wenkel J</workauthor>
               <workauthor>;</workauthor>
               <workauthor> Gaedicke G</workauthor>
               <workauthor>;</workauthor>
               <workauthor> Xi</workauthor>
               <workauthor>a</workauthor>
               <workauthor>ng R</workauthor>
               <workauthor>; </workauthor>
               <workauthor>Lode</workauthor>
               <workauthor> HN.</workauthor>
               <articletitle>Fractalkine gene therapy for neuroblastoma is more effective in combination with targeted IL-2</articletitle>. Cancer Lett. <pubdate>2005</pubdate>
               <number> Jun 10</number>.</citation>
         
         <freehead>5.2 Publications of other authors</freehead>
         
            <citation published="yes" workType="Journal">
               <cut>(1)</cut>
               <workauthor>Lode HN, Pertl U, Xiang R, Gaedicke G, Reisfeld RA.</workauthor>: <articletitle>Tyrosine hydroxylase-based DNA-vaccination is effective against murine neuroblastoma</articletitle>. Med Pediatr Oncol. <pubdate>2000</pubdate>
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               <cut>(2)</cut>
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               <cut>(3)</cut>
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               <number>; 385(6617)</number>, <pages>640-644</pages>.</citation>
         
         
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               <cut>(4)</cut>
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               <articletitle>Fractalkine in vascular biology: from basic research to clinical disease</articletitle>. Arterioscler Thromb Vasc Biol. <pubdate>2004</pubdate>
               <number>, 24(1)</number>, <pages>34-40</pages>.</citation>
         
         
            <citation published="yes" workType="Journal">
               <cut>(5)</cut>
               <workauthor>Garton KJ, Gough PJ, Blobel CP, Murphy G, Greaves DR, Dempsey PJ et al.</workauthor>: <articletitle>Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1)</articletitle>. J Biol Chem. <pubdate>2001</pubdate>
               <number>; 276(41)</number>, <pages>37993-38001</pages>.</citation>
         
         
            <citation published="yes" workType="Journal">
               <cut>(6)</cut>
               <workauthor>Moser B, Loetscher P.</workauthor>: <articletitle>Lymphocyte traffic control by chemokines</articletitle>, Nat Immunol. <pubdate>2001</pubdate>
               <number>, 2(2)</number>, <pages>123-128</pages>.</citation>
         
         
            <citation published="yes" workType="Journal">
               <cut>(7)</cut>
               <workauthor>Fong AM, Robinson LA, Steeber DA, Tedder TF, Yoshie O, Imai T et al</workauthor>.: <articletitle>Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow</articletitle>. J Exp Med. <pubdate>1998</pubdate>
               <number>, 188(8)</number>, <pages>1413-1419</pages>.</citation>
         
         
            <citation published="yes" workType="Journal">
               <cut>(8)</cut>
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               <number>, 274(15)</number>, <pages>10053-10058</pages>.</citation>
         
         
            <citation published="yes" workType="Journal">
               <cut>(9)</cut>
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               <number>, 97(7)</number>, <pages>1925-1928</pages>.</citation>
         
         
            <citation published="yes" workType="Journal">
               <cut>(10)</cut>
               <workauthor>Imai T, Hieshima K, Haskell C, Baba M, Nagira M, Nishimura M et al</workauthor>.: <articletitle>Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion</articletitle>. Cell. <pubdate>1997</pubdate>
               <number>, 91(4)</number>, <pages>521-530</pages>.</citation>
         
         
            <citation published="yes" workType="Journal">
               <cut>(11)</cut>
               <workauthor>Nishimura M, Umehara H, Nakayama T, Yoneda O, Hieshima K, Kakizaki M et al.:</workauthor>
               <articletitle>Dual functions of fractalkine/CX3C ligand 1 in trafficking of perforin+/granzyme B+ cytotoxic effector lymphocytes that are defined by CX3CR1 expression</articletitle>. J Immunol <pubdate>2002</pubdate>; <number>168(1)</number>
               <number>, </number>
               <pages>6173-6180</pages>.</citation>
         
         
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               <cut>(12)</cut>
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               <workauthor>Yoneda O, Imai T, Nishimura M, Miyaji M, Mimori T, Okazaki T et al</workauthor>.: <articletitle>Membrane-bound form of fractalkine induces IFN-gamma production by NK cells</articletitle>. Eur J Immunol <pubdate>2003</pubdate>, <number>33(1)</number>, <pages>53-58</pages>.</citation>
         
         
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