2 Orginalarbeiten zum Habilitationsthema

2.1 Apoptose und Zellzyklus bei malignen Zellen

Bargou, R.C., Wagener, C., Bommert, K., Arnold, W., Daniel, P.T., Mapara, M.Y., Grinstein, E., Royer, H.D. and Dörken, B. (1996). Blocking the transcription factor E2F/DP by dominant-negative mutants in a normal breast epithelial cell line efficiently inhibits apoptosis and induces tumor growth in SCID mice. J. Exp. Med. 183, 1205-1213.

2.2 Die Rolle von Apoptoseresistenzmechanismen bei der Pathogenese maligner Lymphome

Bar­gou, R.C., Mapara, M.Y., Zugck, C., Daniel, P.T., Pawlita, M., Döhner, H., and Dörken, B. (1993). Characterization of a novel Hodgkin cell line HD-MyZ with myelo-monocytoid features mi­micking Hodgkin´s disease in SCID mice. J. Exp. med. 177, 1257- 1268.

Bargou, R.C., Leng, C., Krappmann, D., Mapara, M.Y., Daniel, P.T., Bommert, K., Scheidereit, C., and Dörken, B. (1996). High level nuclear NF-kB and Oct-2 are a common feature of cultured Hodgkin/Reed-Sternberg cells. Blood 87, 4340-4347.

Bargou, R.C., Emmerich, F., Mapara, M.Y., Bommert, K., Greiner, A., Royer, H.-D., Krappmann, D., Scheidereit, C., and Dörken, B. (1997). Constitutive NF-κB-RelA activation is required for proliferation and survival of Hodgkin`s disease tumor cells. J. Clin. Inv. 100, 2961-2969.

2.3 Apoptose und Therapieresistenz bei malignen Lymphomen

Bargou, R.C., Jurchott, K., Wagener, C., Bergmann, S., Metzner, S., Bommert, K., Mapara, M.Y., Winzer, K. J., Dietel, M., Dörken, B., and Royer, H.D. (1997). Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression. Nat. Med.3, 447-450.

Wagener, C., Bargou, R.C., Daniel, P.T., Bommert, K., Mapara, M.Y., Royer, H.D., and Dörken, B. (1996). Induction of the death-promoting gene bax-alpha sensitizes cultured breast-cancer cells to drug-induced apoptosis. Int. J. Cancer67, 138-141.

Mapara, M.Y., Bargou, R.C., Zugck, C., Döhner, H., Ustaoglu, F., Jonker, R. R., Krammer, P. H., and Dörken, B. (1993). APO-1 mediated apoptosis or proliferation in human chronic B lymphocytic leukemia: correlation with bcl-2 oncogene expression. Eur. J. Immunol. 23, 702-708.

Daniel, P.T., Kroidl, A., Cayeux, S., Bargou, R.C., Blankenstein, T., and Dörken, B. (1997). Costimulatory signals through B7.1/CD28 prevent T cell apoptosis during target cell lysis. J. Immunol. 159, 3808-3815.

Bargou, R.C., Bommert, K., Weinmann, P., Daniel, P.T., Wagener, C., Mapara, M.Y., and Dörken, B. (1995). Induction of Bax-alpha precedes apoptosis in a human B lymphoma cell line: potential role of the bcl-2 gene family in surface IgM-mediated apoptosis. Eur. J. Immunol. 25, 770-775.

Mapara, M.Y., Weinmann, P., Bommert, K., Daniel, P.T., Bargou, R.C, and Dörken, B. (1995). Involvement of NAK-1, the human nur77 homologue, in surface IgM-mediated apoptosis in Burkitt lymphoma cell line BL41. Eur. J. Immunol. 25, 2506-2510.

Weinmann, P., Bommert, K., Mapara, M.Y., Dörken, B., and Bargou, R.C. (1997). Overexpression of the death-promoting gene bax-alpha sensitizes human BL-41 Burkitt lymphoma cells for surface IgM-mediated apoptosis. Eur. J. Immunol. 27, 2466-2468.

Daniel, P.T., Oettinger, U., Mapara, M.Y, Bommert, K., Bargou, R.C., and Dörken, B. (1997). Activation and activation-induced death of human tonsilar B cells and Burkitt lymphoma cells. Lack of CD95 (fas/APO-1) ligand expression and function. Eur. J. Immunol. 27, 1029-1034.

Löffler, A., Kufer, P., Lutterbüse, R., Zettl, F., Daniel, P., Schwenkenbecher, J., Riethmüller, G., Dörken, B., and Bargou, R.C. (2000). A recombinant bispecific single chain antibody, CD19xCD3 induces rapid and high lymphoma directed cytotoxicity by unstimulated T lymphocytes. Blood 95, 2098-2103.


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