[Seite 39↓]

Literaturverzeichnis

Alger BE, Teyler TJ (1976) Long-term and short-term plasticity in CA1, CA3 and dentate region of the rat hippocampal slice. Brain Res 110: 463-480.

Amaral DG (1993) Emerging principles of intrinsic hippocampal organization. Curr Opin Neurobiol 3: 225-229.

Amaral DG, Witter MP (1989) The three-dimensional organization of the hippocampal formation: A review of anatomical data. Neuroscience 31: 571-591.

Amaral DG, Witter MP (1995) The hippocampal formation. In: The rat nervous system (Paxinos G, ed), pp 443-494. New York: Academic Press.

Andersen P, Bliss TVP, Skrede KK (1971 ) Lamellar organization of hippocampal excitatory pathways. Exp Brain Res 13: 222-238.

Annegers JF (1997) The epidemiology of epilepsy. In: The Treatment of Epilepsy: Principles and Practic, Second Edition (Wyllie E, ed), pp 165-172 . Baltimore: Williams & Wilkins.

Babb TL, Brown WJ (1987) Pathological findings in epilepsy. In: Surgical Treatment of the Epilepsies (Engel J, Jr., ed), pp 511-540 . New York: Raven Press.

Babb TL, Brown WJ, Pretorius JK, Davenport CJ, Lieb JP, Crandall PH (1984) Temporal lobe volumetric cell densities in temporal lobe epilepsy. Epilepsia 25(6): 729-740.

Babb TL, Kupfer WR, Pretorius JK, Crandall PH, Lévesque MF (1991) Synaptic reorganization by mossy fibers in human epileptic fascia dentata. Neuroscience 42: 351-363.

Babb TL, Mathern GW, Leite JP, Pretorius JK, Yeoman KM, Kuhlman PA (1996) Glutamate AMPA receptors in the fascia dentata of human and kainate rat hippocampal epilepsy. Epilepsy Res 26: 193-205.

Babb TL, Pretorius JK (1993 ) Pathologic substrates of epilepsy. In: The treatment of epilepsy: principles and practice (Wylie E, ed), pp 55-70. Philadelphia: Lea and Wibiger.


[Seite 40↓]

Behr J, Empson RM, Schmitz D, Gloveli T, Heinemann U (1997) Effects of serotonin on synaptic and intrinsic properties of rat subicular neurons in vitro. Brain Res 773: 217-222.

Behr J, Heinemann U (1996) Effects of serotonin on different patterns of low Mg2+-induced epileptiform activity in the subiculum of rats studied in vitro. Brain Res 737: 331-334.

Ben-Ari Y (1985 ) Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Neuroscience 14: 375-403.

Ben-Ari Y, Represa A, Tremblay E, Nitecka L (1986) Selective and non-selective seizure related brain damage produced by kainic acid. In: Excitatory amino acids and epilepsy (Schwarcz R, Ben-Ari Y, eds), pp 647-657. New York and London: Plenum Press.

Benardo LS, Prince DA (1982 ) Dopamine action on hippocampal pyramidal cells. J Neurosci 2: 415-423.

Bengzon J, Okabe S, Lindvall O, McKay RD (1999) Suppression of epileptogenesis by modification of N-methyl-D-aspartate receptor subunit composition. Eur J Neurosci 11: 916-922.

Bernard A, Ferhat L, Dessi F, Charton G, Represa A, Ben Ari Y, Khrestchatisky M (1999) Q/R editing of the rat GluR5 and GluR6 kainate receptors in vivo and in vitro: evidence for independent developmental, pathological and cellular regulation. Eur J Neurosci 11: 604-616.

Bernasconi N, Bernasconi A, Andermann F, Dubeau F, Feindel W, Reutens DC (1999) Entorhinal cortex in temporal lobe epilepsy: a quantitative MRI study. Neurology 52 : 1870-1876.

Bernasconi N, Bernasconi A, Caramanos Z, Dubeau F, Richardson J, Andermann F, Arnold DL (2001) Entorhinal cortex atrophy in epilepsy patients exhibiting normal hippocampal volumes. Neurology 56: 1335-1339.

Berretta N, Berton F, Bianchi R, Capogna M, Francesconi W, Brunelli M (1990 ) Effects of dopamine, D-1 and D-2 dopaminergic agonists on the excitability of hippocampal CA1 pyramidal cells in guinea pig. Exp Brain Res 83: 124-130.


[Seite 41↓]

Bertram EH, Zhang DX, Mangan P, Fountain N, Rempe D (1998) Functional anatomy of limbic epilepsy: a proposal for central synchronization of a diffusely hyperexcitable network. Epilepsy Res 32: 194-205.

Boulton CL, von Haebler D, Heinemann U (1992) Tracing of axonal connections by rhodamine-dextran-amine in the rat hippocampal-entorhinal cortex slice preparation . Hippocampus 2: 99-106.

Bragin A, Engel J, Jr., Wilson CL, Fried I, Buzsaki G (1999b ) High-frequency oscillations in human brain . Hippocampus 9: 137-142.

Bragin A, Engel J, Jr., Wilson CL, Fried I, Mathern GW (1999a) Hippocampal and entorhinal cortex high-frequency oscillations (100--500 Hz) in human epileptic brain and in kainic acid-treated rats with chronic seizures. Epilepsia 40: 127-137.

Bruinink A, Bischoff S (1993 ) Dopamine D2 receptors are unevenly distributed in the rat hippocampus and are modulated differently than in striatum. Eur J Pharmacol 245: 157-164.

Buckmaster PS, Dudek FE (1997) Neuron loss, granule cell axon reorganization, and functional changes in the dentate gyrus of epileptic kainate-treated rats. J Comp Neurol 385: 385-404.

Buhl EH, Otis TS, Mody I (1996) Zinc-induced collapse of augmented inhibition by GABA in a temporal lobe epilepsy model. Science 271: 369-373.

Cantallops I, Routtenberg A (1996 ) Rapid induction by kainic acid of both axonal growth and F1/GAP- 43 protein in the adult rat hippocampal granule cells. J Comp Neurol 366: 303-319.

Canteras NS, Swanson LW (1992 ) Projections of the ventral subiculum to the amygdala, septum, and hypothalamus: a PHAL anterograde tract-tracing study in the rat. J Comp Neurol 324: 180-194.

Collingridge GL, Watkins JC (1994) The NMDA Receptor. Oxford, UK: Oxford University Press.

Collins RC, Tearse RG, Lothman EW (1983) Functional anatomy of limbic seizures: focal discharges from medial entorhinal cortex in rat. Brain Res 280: 25-40.

Cronin J, Dudek FE (1988) Chronic seizures and collateral sprouting of dentate mossy fibers after kainic acid treatment in rats. Brain Res 474: 181-184.


[Seite 42↓]

Cutting GR, Lu L, O'Hara BF, Kasch LM, Montrose-Rafizadeh C, Donovan DM, Shimada S, Antonarakis SE, Guggino WB, Uhl GR, Kazazian HH, Jr. (1991) Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina. Proc Natl Acad Sci U S A 88: 2673-2677.

Dasheiff RM, McNamara JO (1982 ) Electrolytic entorhinal lesions cause seizures. Brain Res 231: 444-450.

De Lanerolle NC, Kim JH, Robbins RJ, Spencer DD (1989 ) Hippocampal interneuron loss and plasticity in human temporal lobe epilepsy. Brain Res 495: 387-395.

Delgado JMR, Sevillano M (1961) Evolution of repeated hippocampal seizures in the cat. Electroencephalogr Clin Neurophysiol 13: 722-727.

Deller T, Martínez A, Nitsch R, Frotscher M (1996 ) A novel entorhinal projection to the rat dentate gyrus: Direct innervation of proximal dendrites and cell bodies of granule cells and GABAergic neurons. J Neurosci 16: 3322-3333.

Descarries L, Lemay B, Doucet G, Berger B (1987) Regional and laminar density of the dopamine innervation in adult rat cerebral cortex. Neuroscience 21: 807-824.

Dreier JP, Heinemann U (1990 ) Late low magnesium-induced epileptiform activity in rat entorhinal cortex slices becomes insensitive to the anticonvulsant valproic acid. Neurosci Lett 119: 68-70.

Dreier JP, Heinemann U (1991) Regional and time dependent variations of low magnesium induced epileptiform activity in rat temporal cortex. Exp Brain Res 87: 581-596.

Du F, Eid T, Lothman EW, Köhler C, Schwarcz R (1995 ) Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy. J Neurosci 15: 6301-6313.

Du F, Whetsell WO, Jr., Abou-Khalil B, Blumenkopf B, Lothman EW, Schwarcz R (1993 ) Preferential neuronal loss in layer III of the entorhinal cortex in patients with temporal lobe epilepsy. Epilepsy Res 16: 223-233.


[Seite 43↓]

Dudek FE, Spitz M (1997 ) Hypothetical mechanisms for the cellular and neurophysiologic basis of secondary epileptogenesis: proposed role of synaptic reorganization. J Clin Neurophysiol 14 : 90-101.

Eichenbaum H, Otto T, Cohen NJ (1994) Two functional components of the hippocampal memory system. Behav Brain Sci 17: 449-518.

Empson RM, Heinemann U (1995) The perforant path projection to hippocampal area CA1 in the rat hippocampal-entorhinal cortex combined slice. J Physiol (Lond ) 484: 707-729.

Engel J, Jr.(1996 ) Introduction to temporal lobe epilepsy . Epilepsy Res 26: 141-150.

Engel J, Jr., Pedley TA (1997) Epilepsy: a comprehensive textbook. Philadelphia, New York: Lippincott-Raven Publishers.

Engel J, Jr.(2001) Mesial temporal lobe epilepsy: what have we learned? Neuroscientist 7: 340-352.

Finnerty GT, Whittington MA, Jefferys JG (2001) Altered dentate filtering during the transition to seizure in the rat tetanus toxin model of epilepsy. J Neurophysiol 86: 2748-2753.

Fremeau RT, Jr., Duncan GE, Fornaretto MG, Dearry A, Gingrich JA, Breese GR, Caron MG (1991) Localization of D1 dopamine receptor mRNA in brain supports a role in cognitive, affective, and neuroendocrine aspects of dopaminergic neurotransmission. Proc Natl Acad Sci U S A 88: 3772-3776.

Galarreta M, Hestrin S (1998) Frequency-dependent synaptic depression and the balance of excitation and inhibition in the neocortex. Nature Neurosci 1: 587-594.

Gao WJ, Krimer LS, Goldman-Rakic PS (2001) Presynaptic regulation of recurrent excitation by D1 receptors in prefrontal circuits. Proc Natl Acad Sci U S A 98: 295-300.

Gasbarri A, Verney C, Innocenzi R, Campana E, Pacitti C (1994) Mesolimbic dopaminergic neurons innervating the hippocampal formation in the rat: a combined retrograde tracing and immunohistochemical study. Brain Res 668: 71-79.

Gloveli T, Dugladze T, Schmitz D, Heinemann U (2001) Properties of entorhinal cortex deep layer neurons projecting to the rat dentate gyrus . Eur J Neurosci 13: 413-420.


[Seite 44↓]

Gloveli T, Egorov AV, Schmitz D, Heinemann U, Müller W (1999) Carbachol-induced changes in excitability and [Ca2+]i signalling in projection cells of medial entorhinal cortex layers II and III. Eur J Neurosci 11: 3626-3636.

Gloveli T, Schmitz D, Heinemann U (1997 ) Prolonged inhibitory potentials in layer III projection cells of the rat medial entorhinal cortex induced by synaptic stimulation in vitro. Neuroscience 80: 119-131.

Goddard GV (1967) Development of epileptic seizures through brain stimulation at low intensity. Nature 214: 1020-1021.

Goddard GV, McIntyre DC, Leech CK (1969) A permanent change in brain function resulting from daily electical stimulation. Exp Neurol 25: 295-330.

Golarai G, Sutula TP (1996) Functional alterations in the dentate gyrus after induction of long-term potentiation, kindling, and mossy fiber sprouting. J Neurophysiol 75: 343-353.

Gribkoff VK, Ashe JH (1984 ) Modulation by dopamine of population responses and cell membrane properties of hippocampal CA1 neurons in vitro. Brain Res 292: 327-338.

Hamon B, Stanton PK, Heinemann U (1987) An N-methyl-D-aspartate receptor-independent excitatory action of partial reduction of extracellular [Mg2+] in CA1-region of rat hippocampal slices. Neurosci Lett 75: 240-245.

Hampson RE, Hedberg T, Deadwyler SA (2000) Differential information processing by hippocampal and subicular neurons. Ann N Y Acad Sci 911: 151-165.

Hauser WA (1997 ) Incidence and prevalence. In: Epilepsy: A Comprehensive Textbook (Engel J, Jr., Pedley TA, eds), pp 47-57. Philadelphia : Lippincott-Raven Publishers.

Heinemann U (1987) Basic mechanisms of the epilepsies. In: A textbook of clinical neurophysiology (Halliday AM, Butler SR, Paul R, eds), pp 497-534. Chichester, New York, Brisbane, Toronto, Singapore: John Wiley & Sons.

Heinemann U, Beck H, Dreier JP, Ficker E, Stabel J, Zhang CL (1992) The dentate gyrus as a regulated gate for the propagation of epileptiform activity. In: The dentate gyrus and its role in seizures (Ribak CE, Gall CM, Mody I, eds), pp 273-280 . Amsterdam: Elsevier Science Publishers BV.


[Seite 45↓]

Heinemann U, Eder C (1997) Control of neuronal excitability. In: Epilpesy: A Comprehensive Textbook (Engel J, Jr., Pedley TA, eds), pp 237-250 . Philadelphia, New York: Lippincott-Raven.

Heinemann U, Jones RSG (1990 ) Neurophysiology . In: Comprehensive Epileptology (Dam M, Gram L, eds), pp 17-42. New York: Raven Press.

Heinemann U, Zhang CL, Eder C (1993) Entorhinal cortex-hippocampal interactions in normal and epileptic temporal lobe. Hippocampus 3 Suppl.: 89-98.

Herman JP, Cullinan WE, Young EA, Akil H, Watson SJ (1992 ) Selective forebrain fiber tract lesions implicate ventral hippocampal structures in tonic regulation of paraventricular nucleus corticotropin- releasing hormone (CRH) and arginine vasopressin (AVP) mRNA expression. Brain Res 592: 228-238.

Houser CR, Miyashiro JE, Swartz BE, Walsh GO, Rich JR, Delgado-Escueta AV (1990 ) Altered patterns of dynorphin immunoreactivity suggest mossy fiber reorganization in human hippocampal epilepsy . J Neurosci 10 : 267-282.

Hsu KS (1996 ) Characterization of dopamine receptors mediating inhibition of excitatory synaptic transmission in the rat hippocampal slice . J Neurophysiol 76: 1887-1895.

Ishizuka N, Weber J, Amaral DG (1990 ) Organization of intrahippocampal projections originating from CA3 pyramidal cells in the rat. J Comp Neurol 295: 580-623.

Isokawa M, Avanzini G, Finch DM, Babb TL, Lévesque MF (1991) Physiologic properties of human dentate granule cells in slices prepared from epileptic patients. Epilepsy Res 9: 242-250.

Isokawa M, Lévesque MF, Babb TL, Engel J, Jr. (1993) Single mossy fiber axonal systems of human dentate granule cells studied in hippocampal slices from patients with temporal lobe epilepsy . J Neurosci 13: 1511-1522.

Jay TM, Witter MP (1991 ) Distribution of hippocampal CA1 and subicular efferents in the prefrontal cortex of the rat studied by means of anterograde transport of Phaseolus vulgaris-leucoagglutinin. J Comp Neurol 313: 574-586.

Jensen MS, Yaari Y (1997) Role of intrinsic burst firing, potassium accumulation, and electrical coupling in the elevated potassium model of hippocampal epilepsy. J Neurophysiol 77: 1224-1233.


[Seite 46↓]

Jones RSG, Heinemann U (1988) Synaptic and intrinsic responses of medial entorhinal cortical cells in normal and magnesium-free medium in vitro. J Neurophysiol 59: 1476-1497.

Jones RSG, Heinemann U, Lambert JDC (1992) The entorhinal cortex and generation of seizures activity: studies of normal synaptic transmission and epileptogenesis in vitro . In: Neurotransmitters in Epilepsy (Avanzini G, Engel J, Fariello R, Heinemann U, eds ), pp 173-180 . Amsterdam: Elsevier.

Jones RSG, Lambert JDC (1990b) Synchronous discharges in the rat entorhinal cortex in vitro: Site of initiation and the role of excitatory amino acid receptors. Neuroscience 34: 657-670.

Jones RSG, Lambert JDC (1990a) The role of excitatory amino acid receptors in the propagation of epileptiform discharges from the entorhinal cortex to the dentate gyrus in vitro . Exp Brain Res 80: 310-322.

Jung HY, Staff NP, Spruston N (2001) Action potential bursting in subicular pyramidal neurons is driven by a calcium tail current. J Neurosci 21: 3312-3321.

Kamphuis W, De Rijk TC, Talamini LM, Lopes da Silva FH (1994 ) Rat hippocampal kindling induces changes in the glutamate receptor mRNA expression patterns in dentate granule neurons. Eur J Neurosci 6: 1119-1127.

Kamphuis W, Gorter JA, Wadman WJ, Lopes da Silva FH (1992) Hippocampal kindling leads to different changes in paired- pulse depression of local evoked field potentials in CA1 area and in fascia dentata. Neurosci Lett 141: 101-105.

Kamphuis W, Hendriksen H, Diegenbach PC, Lopes da Silva FH (1995) N-methyl-D-aspartate and kainate receptor gene expression in hippocampal pyramidal and granular neurons in the kindling model of epileptogenesis. Neuroscience 67: 551-559.

Kebabian JW, Calne DB (1979) Multiple receptors for dopamine. Nature 277: 93-96.

Kim JH, Guimaraes PO, Shen MY, Masukawa LM, Spencer DD (1990) Hippocampal neuronal density in temporal lobe epilepsy with and without gliomas. Acta Neuropathol Berl 80: 41-45.

Köhler C (1986 ) Intrinsic connections of the retrohippocampal region in the rat brain. II. The medial entorhinal area. J Comp Neurol 246: 149-169.


[Seite 47↓]

Köhler C (1988 ) Intrinsic connections of the retrohippocampal region in the rat brain: III. The lateral entorhinal area. J Comp Neurol 271: 208-228.

Köhr G, De Koninck Y, Mody I (1993 ) Properties of NMDA receptor channels in neurons acutely isolated from epileptic (kindled) rats . J Neurosci 13: 3612-3627.

Köhr G, Mody I (1994) Kindling increases N-methyl-D-aspartate potency at single N-methyl-D-aspartate channels in dentate gyrus granule cells. Neuroscience 62: 975-981.

Lacaille J-C, Schwartzkroin PA (1988) Stratum lacunosum-moleculare interneurons of hippocampal CA1 region. I. intracellular response characteristics, synaptic responses, and morphology. J Neurosci 8: 1400-1410.

Law-Tho D, Hirsch JC, Crepel F (1994 ) Dopamine modulation of synaptic transmission in rat prefrontal cortex: an in vitro electrophysiological study. Neurosci Res 21: 151-160.

Lehmann T-N, Gabriel S, Eilers A, Njunting M, Kovacs R, Schulze K, Lanksch WR, Heinemann U (2001) Fluorescent tracer in pilocarpine-treated rats shows widespread aberrant hippocampal neuronal activity. Eur J Neurosci 14: 83-95.

Lerma J, Paternain AV, Rodriguez-Moreno A, Lopez-Garcia JC (2001) Molecular physiology of kainate receptors. Physiol Rev 81: 971-998.

Lewis PR, Shute CCD (1967 ) The cholinergic limbic system: projections to hippocampal formation, medial cortex, nuclei of the ascending cholinergic reticular system, and the subfornical organ and supra-optic crest. Brain 90: 521-540.

Lévesque MF, Nakasato N, Vinters HV, Babb TL (1991) Surgical treatment of limbic epilepsy associated with extrahippocampal lesions: the problem of dual pathology . J Neurosurg 75: 364-370.

Lieberman DN, Mody I (2000) Properties of single NMDA receptor channels in human dentate gyrus granule cells. J Physiol (Lond ) 518: 55-70.

Lindvall O, Bjorklund A (1974) The organization of the ascending catecholamine neuron systems in the rat brain as revealed by the glyoxylic acid fluorescence method. Acta Physiol Scand Suppl 412: 1-48.

Liu G, Tsien RW (1995) Properties of synaptic transmission at single hippocampal synaptic boutons. Nature 375: 404-408.


[Seite 48↓]

Longo BM, Mello LE (1998) Supragranular mossy fiber sprouting is not necessary for spontaneous seizures in the intrahippocampal kainate model of epilepsy in the rat. Epilepsy Res 32: 172-182.

Longo BM, Mello LEAM (1997 ) Blockade of pilocarpine- or kainate-induced mossy fiber sprouting by cycloheximide does not prevent subsequent epileptogenesis in rats. Neurosci Lett 226 : 163-166.

Lothman EW (1994 ) Seizure circuits in the hippocampus and associated structures. Hippocampus 4: 286-290.

Lothman EW, Stringer JL, Bertram EH (1992) The dentate gyrus as a control point for seizures in the hippocampus and beyond. In: The dentate gyrus and its role in seizures (Ribak CE, Gall CM, Mody I, eds), pp 273-280. Amsterdam: Elsevier Science Publishers BV.

Lynch M, Sayin U, Golarai G, Sutula T (2000) NMDA receptor-dependent plasticity of granule cell spiking in the dentate gyrus of normal and epileptic rats. J Neurophysiol 84 : 2868-2879.

Lynch M, Sutula T (2000 ) Recurrent excitatory connectivity in the dentate gyrus of kindled and kainic acid-treated rats . J Neurophysiol 83: 693-704.

Martres MP, Bouthenet ML, Sales N, Sokoloff P, Schwartz J-C (1985) Widespread distribution of brain dopamine receptors evidenced with [125I]iodosulpride, a highly selective ligand. Science 228: 752-755.

Masukawa LM, Uruno K, Sperling MR, O'Connor MJ, Burdette LJ (1992) The functional relationship between antidromically evoked field responses of the dentate gyrus and mossy fiber reorganization in temporal lobe epileptic patients. Brain Res 579: 119-127.

Mathern GW, Cifuentes F, Leite JP, Pretorius JK, Babb TL (1993) Hippocampal EEG excitability and chronic spontaneous seizures are associated with aberrant synaptic reorganization in the rat intrahippocampal kainate model. Electroencephalogr Clin Neurophysiol 87: 326-339.


[Seite 49↓]

Mathern GW, Kupfer WR, Pretorius JK, Babb TL, Lévesque MF (1992) Onset and patterns of hippocampal sprouting in the rat kainate seizure model: evidence for progressive cell loss and neo- innervation in regio inferior and superior. Dendron 1: 69-84.

Mattia D, Kawasaki H, Avoli M (1997 ) Repetitive firing and oscillatory activity of pyramidal-like bursting neurons in the rat subiculum. Exp Brain Res 114: 507-517.

McBain CJ, Mayer ML (1994 ) N-methyl-D-aspartic acid receptor structure and function . Physiol Rev 74: 723-760.

McNamara JO (1994 ) Cellular and molecular basis of epilepsy . J Neurosci 14: 3413-3425.

McNamara JO (1995) Analyses of the molecular basis of kindling development. Psychiatry Clin Neurosci 49: S175-S178.

McNamara RK, Routtenberg A (1995) NMDA receptor blockade prevents kainate induction of protein F1/GAP-43 mRNA in hippocampal granule cells and subsequent mossy fiber sprouting in the rat. Mol Brain Res 33: 22-28.

McNaughton BL, Barnes CA, Andersen P (1981) Synaptic efficacy and EPSP summation in granule cells of rat fascia dentata studied in vitro. J Neurophysiol 46: 952-966.

Meador-Woodruff JH, Grandy DK, Van-Tol HH, Damask SP, Little KY, Civelli O, Watson SJ (1994 ) Dopamine receptor gene expression in the human medial temporal lobe. Neuropsychopharmacology 10: 239-248.

Misgeld U, Bijak M, Jarolimek W (1995) A physiological role for GABAB receptors and the effects of baclofen in the mammalian central nervous system. Prog Neurobiol 46: 423-462.

Mody I (1998 ) Ion channels in epilepsy. Int Rev Neurobiol 42: 199-226.

Mody I, Heinemann U (1987) NMDA receptors of dentate gyrus granule cells participate in synaptic transmission following kindling. Nature 326: 701-704.

Mody I, Lieberman DN (1998) Lasting prolongation of NMDA channel openings after kindling. In: Kindling 5 (Corcoran ME, Moshé SL, eds), pp 65-73. New York: Plenum Press.

Mody I, Stanton PK, Heinemann U (1988) Activation of N-methyl-D-aspartate receptors parallels changes in cellular and synaptic properties of dentate gyrus granule cells after kindling. J Neurophysiol 59: 1033-1054.


[Seite 50↓]

Molnar P, Nadler JV (1999) Mossy fiber-granule cell synapses in the normal and epileptic rat dentate gyrus studied with minimal laser photostimulation . J Neurophysiol 82: 1883-1894.

Momiyama T, Sim JA, Brown DA (1996 ) Dopamine D1-like receptor-mediated presynaptic inhibition of excitatory transmission onto rat magnocellular basal forebrain neurones . J Physiol (Lond ) 495: 97-106.

Moore RY, Halaris AE (1975) Hippocampal innervation by seretonin neurons of the midbrain raphe in the rat. J Comp Neurol 164: 171-183.

Mulle C, Sailer A, Perez-Otano I, Dickinson-Anson H, Castillo PE, Bureau I, Maron C, Gage FH, Mann JR, Bettler B, Heinemann SF (1998) Altered synaptic physiology and reduced suspectibility to kainate-induced seizures in GluR6-deficient mice. Nature 392: 601-605.

Nadler JV, Perry BW, Cotman CW (1978) Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells . Nature 271: 676-677.

Nadler JV, Perry BW, Cotman CW (1980) Selective reinnervation of hippocampal area CA1 and the fascia dentata after destruction of CA3-CA4 afferents with kainic acid. Brain Res 182: 1-9.

Nicola SM, Kombian SB, Malenka RC (1996 ) Psychostimulants depress excitatory synaptic transmission in the nucleus accumbens via presynaptic D1-like dopamine receptors. J Neurosci 16: 1591-1604.

Nusser Z, Hájos N, Somogyi P, Mody I (1998 ) Increased number of synaptic GABA(A) receptors underlies potentiation at hippocampal inhibitory synapses. Nature 395: 172-177.

O'Mara SM, Commins S, Anderson M, Gigg J (2001 ) The subiculum: a review of form, physiology and function . Prog Neurobiol 64: 129-155.

Okazaki MM, Evenson DA, Nadler JV (1995 ) Hippocampal mossy fiber sprouting and synapse formation after status epilepticus in rats: Visualization after retrograde transport of biocytin. J Comp Neurol 352: 515-534.

Olafsson E, Hauser WA (1999) Prevalence of epilepsy in rural Iceland: a population-based study. Epilepsia 40: 1529-1534.


[Seite 51↓]

Oliver MW, Miller JJ (1985) Alterations of inhibitory processes in the dentate gyrus following kindling-induced epilepsy . Exp Brain Res 57: 443-447.

Otis TS, De Koninck Y, Mody I (1994) Lasting potentiation of inhibition is associated with an increased number of t -aminobutyric acid type A receptors activated during miniature inhibitory postsynaptic currents. Proc Natl Acad Sci U S A 91: 7698-7702.

Otis TS, Mody I (1993) Three mechanisms for increased GABAergic inhibition after kindling-induced epilepsy. Soc Neurosci Abstr 19: 1267-1267.

Otmakhova NA, Lisman JE (1999) Dopamine selectively inhibits the direct cortical pathway to the CA1 hippocampal region. J Neurosci 19: 1437-1445.

Paré D, DeCurtis M, Llinás RR (1992 ) Role of the hippocampal-entorhinal loop in temporal lobe epilepsy: Extra- and intracellular study in the isolated guinea pig brain in vitro. J Neurosci 12: 1867-1881.

Patrylo PR, Dudek FE (1998 ) Physiological unmasking of new glutamatergic pathways in the dentate gyrus of hippocampal slices from kainate-induced epileptic rats. J Neurophysiol 79 : 418-429.

Pennartz CM, Dolleman-Van der Weel MJ, Kitai ST, Lopes da Silva FH (1992) Presynaptic dopamine D1 receptors attenuate excitatory and inhibitory limbic inputs to the shell region of the rat nucleus accumbens studied in vitro. J Neurophysiol 67: 1325-1334.

Pitkänen A, Tuunanen J, Halonen T (1995) Subiculum, presubiculum and parasubiculum have different sensitivities to seizure-induced neuronal damage in the rat. Neurosci Lett 192: 65-68.

Pollard H, Héron A, Moreau J, Ben-Ari Y, Khrestchatisky M (1993) Alterations of the GluR-B AMPA receptor subunit flip/flop expression in kainate-induced epilepsy and ischemia. Neuroscience 57: 545-554.

Pralong E, Jones RSG (1993) Interactions of dopamine with glutamate- and GABA-mediated synaptic transmission in the rat entorhinal cortex in vitro. Eur J Neurosci 5: 760-767.

Racine R (1972 ) Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol 32: 281-294.


[Seite 52↓]

Ribak CE, Peterson GM (1991) Intragranular mossy fibers in rats and gerbils form synapses with the somata and proximal dendrites of basket cells in the dentate gyrus. Hippocampus 1: 355-364.

Ribak CE, Seress L, Amaral DG (1985) The development, ultrastructure and synaptic connections of the mossy cells of the dentate gyrus. J Neurocytol 14: 835-857.

Rutecki PA, Grossman RG, Armstrong D, Irish-Loewen S (1989) Electrophysiological connections between the hippocampus and entorhinal cortex in patients with complex partial seizures . J Neurosurg 70: 667-675.

Ribak CE, Gall CM, Mody I (1992) The dentate gyrus and its role in seizures. Amsterdam, London, New York, Tokyo: Elsevier.

Ryan TA, Smith SJ (1995) Vesicle pool mobilization during action potential firing at hippocampal synapses. Neuron 14: 983-989.

Scharfman HE (1996) Hyperexcitability of entorhinal cortex and hippocampus after application of aminooxyacetic acid (AOAA) to layer III of the rat medial entorhinal cortex in vitro. J Neurophysiol 76: 2986-3001.

Schmitz D, Gloveli T, Behr J, Dugladze T, Heinemann U (1998) Subtreshold membrane potential oscillations in neurones of deep layers of the entorhinal cortex. Neuroscience 85: 999-1004.

Schwartzkroin PA (1993) Epilepsy: models, mechanisms, and concepts. Cambridge, UK: Cambridge University Press.

Schweitzer JS, Patrylo PR, Dudek FE (1992) Prolonged field bursts in the dentate gyrus: Dependence on low calcium, high potassium, and nonsynaptic mechanisms. J Neurophysiol 68 : 2016-2025.

Seress L, Ribak CE (1983) GABAergic cells in the dentate gyrus appear to be local circuit and projection neurons. Exp Brain Res 50: 173-182.

Shin C, Pedersen HB, McNamara JO (1985 ) gamma-aminobutyric acid and benzidiazepine receptors in the kindling model of epilepsy: a quantitative radiohistochemical study . J Neurosci 5 : 2696-2701.

Silver RA, Momiyama A, Cull-Candy SG (1998 ) Locus of frequency-dependent depression identified with multiple- probability fluctuation analysis at rat climbing fibre-Purkinje cell synapses . J Physiol (Lond ) 510: 881-902.


[Seite 53↓]

Sloviter RS (1992 ) Possible functional consequences of synaptic reorganization in the dentate gyrus of kainate-treated rats . Neurosci Lett 137 : 91-96.

Sloviter RS (1994 ) On the relationship between neuropathology and pathophysiology in the epileptic hippocampus of humans and experimental animals . Hippocampus 4: 250-253.

Spencer DD (1994) Classifying the epilepsies by substrate. Clin Neurosci 2: 104-109.

Spencer DD, Spencer SS (1994) Hippocampal resections and the use of human tissue in defining temporal lobe epilepsy syndromes. Hippocampus 4: 243-249.

Sperk G (1994) Kainic acid seizures in the rat. Prog Neurobiol 42: 1-32.

Sprengel R, Suchanek B, Amico C, Brusa R, Burnashev N, Rozov A, Hvalby O, Jensen V, Paulsen O, Andersen P, Kim JJ, Thompson RF, Sun W, Webster LC, Grant SGN, Eilers J, Konnerth A, Li J, McNamara JO, Seeburg PH (1998) Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. Cell 92: 279-289.

Stanton PK, Jones RSG, Mody I, Heinemann U (1987) Epileptiform activity induced by lowering extracellular [Mg2+] in combined hippocampal-entorhinal cortex slices: modulation by receptors for norepinephrine and N-methyl-D-aspartate. Epilepsy Res 1: 53-62.

Starr MS (1996) The role of dopamine in epilepsy. Synapse 22: 159-194.

Stenkamp K, Heinemann U, Schmitz D (1998) Dopamine suppresses stimulus-induced field potentials in layer III of rat medial entorhinal cortex. Neurosci Lett 255: 119-121.

Surmeier DJ, Bargas J, Hemmings HC, Jr., Nairn AC, Greengard P (1995) Modulation of calcium currents by a D1 dopaminergic protein kinase/phosphatase cascade in rat neostriatal neurons. Neuron 14: 385-397.

Sutula T, Koch J, Golarai G, Watanabe Y, McNamara JO (1996 ) NMDA receptor dependence of kindling and mossy fiber sprouting: Evidence that the NMDA receptor regulates patterning of hippocampal circuits in the adult brain. J Neurosci 16: 7398-7406.


[Seite 54↓]

Sutula TP, Cascino G, Cavazos JE, Parada I, Ramirez L (1989) Mossy fiber synaptic reorganization in the epileptic human temporal lobe. Ann Neurol 26: 321-330.

Suzuki WA (1999) The long and the short of it: memory signals in the medial temporal lobe. Neuron 24: 295-298.

Tamamaki N, Nojyo Y (1995) Preservation of topography in the connections between the subiculum, field CA1, and the entorhinal cortex in rats . J Comp Neurol 353: 379-390.

Tauck DL, Nadler JV (1985 ) Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats . J Neurosci 5, No.4: 1016-1022.

Titulaer MNG, Ghijsen WEJM, Kamphuis W, De Rijk TC, Lopes da Silva FH (1995) Opposite changes in GABAA receptor function in the CA1- 3 area and fascia dentata of kindled rat hippocampus . J Neurochem 64: 2615-2621.

Tong G, Shepherd D, Jahr CE (1995) Synaptic desensitization of NMDA receptors by calcineurin. Science 267: 1510-1512.

Tuff LP, Racine RJ, Adamec R (1983a) The effects of kindling on GABA-mediated inhibition in the dentate gyrus of the rat - I. paired-pulse depression. Brain Res 277: 79-90.

Tuff LP, Racine RJ, Mishra RK (1983b) The effects of kindling on GABA-mediated inhibition in the dentate gyrus of the rat - II. receptor binding . Brain Res 277: 91-98.

Valdes F, Dasheiff RM, Birmingham F, Crutcher KA, McNamara JO (1982) Benzodiazepine receptor increases after repeated seizures: evidence for localization to dentate granule cells. Proc Natl Acad Sci U S A 79: 193-197.

Van Groen T, Lopes da Silva FH, Wadman WJ (1987) Synaptic organization of olfactory inputs and local circuits in the entorhinal cortex: a current source density analysis in the cat. Exp Brain Res 67: 615-622.

Verney C, Baulac M, Berger B, Alvarez C, Vigny A, Helle KB (1985) Morphological evidence for a dopaminergic terminal field in the hippocampal formation of young and adult rat. Neuroscience 14: 1039-1052.


[Seite 55↓]

Vissel B, Royle GA, Christie BR, Schiffer HH, Ghetti A, Tritto T, Perez-Otano I, Radcliffe RA, Seamans J, Sejnowski T, Wehner JM, Collins AC, O'Gorman S, Heinemann SF (2001) The role of RNA editing of kainate receptors in synaptic plasticity and seizures. Neuron 29: 217-227.

Walther H, Lambert JDC, Jones RSG, Heinemann U, Hamon B (1986) Epileptiform activity in combined slices of the hippocampus, subiculum and entorhinal cortex during perfusion with low magnesium medium . Neurosci Lett 69: 156-161.

White TD, Tan AM, Finch DM (1990) Functional reciprocal connections of the rat entorhinal cortex and subicular complex with the medial frontal cortex: An in vivo intracellular study. Brain Res 533 : 95-106.

Wieser H-G, Engel J, Jr., Williamson PD, Babb TL, Gloor P (1993) Surgically remediable temporal lobe syndrome. In: Surgical Treatment of the Epilepsies, Second Edition (Engel J, Jr., ed), pp 49-63. New York : Raven Press.

Williams GV, Goldman-Rakic PS (1995) Modulation of memory fields by dopamine D1 receptors in prefrontal cortex . Nature 376: 572-575.

Wilson CL, Isokawa M, Babb TL, Crandall PH (1990) Functional connections in the human temporal lobe I. Analysis of limbic system pathways using neuronal responses evoked by electrical stimulation. Exp Brain Res 82 : 279-292.

Wisden W, Seeburg PH (1993 ) A complex mosaic of high-affinity kainate receptors in rat brain. J Neurosci 13: 3582-3598.

Witter MP (1993) Organization of the entorhinal-hippocampal system: A review of current anatomical data. Hippocampus 3 Suppl.: 33-44.

Witter MP, Groenewegen HJ, Da Silva FHL, Lohman AHM (1989) Functional organization of the extrinsic and intrinsic circuitry of the parahippocampal region . Prog Neurobiol 33: 161-253.

Wozny, C., Heinemann, U., and Behr, J. Cell-specific synaptic plasticity in the rat subiculum in vitro. Proceedings of the 28th Göttingen Neurobiology Conference 2001 , 630. 2001.

Wuarin J-P, Dudek FE (1996 ) Electrographic seizures and new recurrent excitatory circuits in the dentate gyrus of hippocampal slices from kainate- treated epileptic rats. J Neurosci 16: 4438-4448.


[Seite 56↓]

Wyss JM (1981 ) An autoradiographic study of the efferent connections of the entorhinal cortex in the rat. J Comp Neurol 199: 495-512.

Wyss JM, Swanson LW, Cowan WM (1979 ) A study of subcortical afferents to the hippocampal formation in the rat. Neuroscience 4: 463-476.

Zhang CL, Dreier JP, Heinemann U (1995) Paroxysmal epileptiform discharges in temporal lobe slices after prolonged exposure to low magnesium are resistant to clinically used anticonvulsants. Epilepsy Res 20: 105-111.

Zucker RS (1989) Short-term synaptic plasticity. Annu Rev Neurosci 12 : 13-31 .


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