Gräfe, Michael: Die Bedeutung entzündlicher Reaktionen für die Pathogenese der Arteriosklerose - Untersuchungen an einem in vitro Modell menschlicher kardialer Endothelzellen



1. Abdullah KM, Udoh EA, Shewen PE, Mellors A : "A neutral glycoprotease of Pasteurella haemolytica A1 specifically cleaves O-sialoglycoproteins." Infect Immun. 1992 ;60 :56-62

2. Abe Y, El-Masri B, Kimball KT, Pownall H, Reilly CF, Osmundsen K, Smith CW, Ballantyne CM : "Soluble cell adhesion molecules in hypertriglyceridemia and potential significance on monocyte adhesion" . Arterioscler Thromb Vasc Biol 1998 ;18 :723-731

3. AIRE-Study-Investigators : "Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure" . Lancet 1993 ;342 :821-828

4. Allen HJ, Johnson EA : "A simple procedure for the isolation of L-fucose-binding lectins from Ulex europaeus and Lotus tetragonolobus" . Carbohydr Res 1977 ;58 :253-265

5. Allen S, Khan S, Al-Mohanna F, Batten P, Yacoub M : "Native low density lipoprotein-induced calcium transients trigger VCAM- 1 and E-selectin expression in cultured human vascular endothelial cells" . J Clin Invest 1998 ;101 :1064-1075

6. Alon R, Feizi T, Yuen C-T, Fuhlbrigge RC, Springer TA : "Glycolipid ligands for selectins support leukocyte tethering and rolling under physiological flow conditions" . J Immunol 1995 ;154 :5356-5366

7. Armitage P, Berry G: Statistical Inference, in Armitage P, Berry G (eds) : "Statistical interference" in: Statistical Methods in Medical Research . Oxford London Edinburgh Boston Palo Alto Melbourne , Blackwell , 1987 , pp 104-112

8. Asakura T, Karino T : "Flow patterns and spatial distribution of atherosclerotic lesions in human coronary arteries" . Circ Res 1990 ;66 :1045-1066

9. Auch-Schwelk W, Duske E, Hink U, Betz M, Unkelbach M, Fleck E : "Vasomotor responses in cyclosporin A-treated rats after chronic angiotensin blockade" . Hypertension 1994 ;23 :832-837

10. Auch-Schwelk W, Kuchenbuch C, Claus M, Walter B, Bossaller C, Friedel N, Graf K, Gräfe M, Fleck E : "Local regulation of vascular tone by bradykinin and converting enzyme inhibitors" . Eur Heart J 1993 ;14 (Suppl I) :154-160

11. Auerbach R., Alby L, Morrissey LW, Tu M, Joseph J : "Expression of organ-specific "


"antigens on capillary endothelial cells" . Microvasc Res 1985 ;29 :401-411

12. Aukrust P, Muller F, Ueland T, Berget T, Aaser E, Brunsvig A, Solum NO, Forfang K, Froland SS, Gullestad L : "Enhanced levels of soluble and membrane-bound CD40 ligand in patients with unstable angina. Possible reflection of T lymphocyte and platelet involvement in the pathogenesis of acute coronary syndromes" . Circulation 1999 ;100 :614-620

13. Barath P, Fishbein MC, Cao J, Berenson J, Helfant RH, Forrester JS : "Detection and localization of tumor necrosis factor in human atheroma" . Am J Cardiol 1990 ;65 :297-302

14. Barger AC, Beeuwkes R, Lainey LL, Silverman KJ : "Hypothesis: vasa vasorum and neovascularization of human coronary arteries. A possible role in the pathophysiology of atherosclerosis" . N Engl J Med 1984 ;310 :175-177

15. Bassingthwaighte JB, Yipintsoi T, Harvey RB : "Microvasculature of the dog left ventricular myocardium" . Microvasc Res 1974 ;7 :229-249

16. Baumhueter S, Singer MS, Henzel W, Hemmerich S, Renz M, Rosen SD, Lasky LA : "Binding of L-Selectin to the vascular sialomucin CD34" . Science 1993 ;262 :436-438

17. Bazzoni F, Beutler B : "Seminars in Medicine of the Beth Israel Hospital, Boston: The Tumor Necrosis Factor Ligand and Receptor Families" . N Engl J Med 1996 ;334 :1717-1725

18. Berg EL, Mullowney AT, Andrew DP, Goldberg JE, Butcher EC : "Complexity and differential expression of carbohydrate epitopes associated with L-selectin recognition of high endothelial venules" . Am J Pathol 1998 ;152 :469-477

19. Berk BC, Corson MA : "Angiotensin II signal transduction in vascular smooth muscle: role of tyrosine kinases" . Circ Res 1997 ;80 :607-616

20. Beutler B, Van Huffel C : "An evolutionary and functional approach to the TNF receptor/ligand family" . Ann N Y Acad Sci 1994 ;730 : 118-133

21. Beutler B, Van Huffel C : "Unraveling function in the TNF ligand and receptor families" . Science 1994 ;264 :667-668

22. Bevilacqua MP : "Endothelial-leukozyte adhesion molecules" . Annu Rev Immunol 1993 ;11 :767-804

23. Bevilacqua MP, Pober JS, Majeau GR, Fiers W, Cotran RS, Gimbrone MA, Jr. : "Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1" . Proc Natl Acad Sci USA 1986 ;83 :4533-4537


24. Bevilacqua MP, Pober JS, Wheeler ME, Cotran RS, Gimbrone MA, Jr. : "Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines" . J Clin Invest 1985 ;76 :2003-2011

25. Bevilacqua MP, Stengelin S, Gimbrone MA, Jr., Seed B : "Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins" . Science 1989 ;243 :1160-1165

26. Biancone L, Cantaluppi V, Camussi G : "CD40-CD154 interaction in experimental and human disease (review)." Int J Mol Med 1999 ;3 :343-353

27. Bochner BS, Luscinskas FW, Gimbrone MAJ, Newman W, Sterbinsky SA, Derse-Anthony CP, Klunk D, Schleimer RP : "Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules" . J Exp Med 1991 ;173 :1553-1557

28. Bowman PD, Betz AL, Ar D, Wollinsky JS, Penney JB, Shivers RR, Goldstein GW : "Primary cultures of capillary endothelium from rat brain" . In Vitro 1981 ;17 :353-362

29. Breslow JL, Plump A, Dammerman M : "New models of lipoprotein disorder and atherosclrosis" , in Fuster V, Ross R, Topol EJ (eds): Atherosclerosis and coronary heart disease . Philadelphia , Lipincott-Raven Publishers , 1996 , pp 363-378

30. Brighton CT, Lorich DG, Kupcha R, Reilly TM, Jones AR, Woodbury RA 2nd : "The pericyte as a possible osteoblast progenitor cell" . Clin Orthop 1992 ;275 :287-299

31. Briscoe DM, Yeung AC, Schoen EL, Allred EN, Stavrakis G, Ganz P, Cotran RS, Pober JS : "Predicitve value of inducible endothelial cell adhesion molecule expression for acute rejection of human cardiac allografts" . Transplantation 1995 ;59 :204-211

32. Brunner HR, Laragh RH, Baer L, Newton MA, Goodwin FT, Krakoff LR, Bard RH, Buhler FR : "Essential hypertension: renin and aldosterone, heart attack and stroke" . N Engl J Med 1972 ;286 :441-449

33. Buege JA, Aust SD : "Microsomal lipid peroxidation" . Methods Enzymol 1976 ;52 :302-310

34. Buerke M, Weyrich AS, Murohara T, Queen C, Klingbeil CK, Co MS, Lefer AM : "Humanized monoclonal antibody DREG-200 directed against I-selectin protects in feline myocardial reperfusion injury" . J Pharmacol Exp Ther 1994 ;271 :134-142

35. Butcher EC, Picker LJ : "Lymphocyte homing and homeostasis" . Science 1996 ;272 :60-66

36. Bührer C, Berlin C, Thiele HG, Hamann A : "Lymphocyte activation and expression of the human leucocyte-endothelial cell adhesion molecule 1 (Leu-8/TQ1 antigen)."


Immunol 1990 ;71 :442-448

37. Cai JP, Falanga V, Taylor JR, Chin YH : "Transforming growth factor-beta differentially regulates the adhesiveness of normal and psoriatic dermal microvascular endothelial cells for peripheral blood mononuclear cells" . J Invest Dermatol 1992 ;98 :405-409

38. Cambien F, Poirier O, Lecerf L, Evans A, Cambou JP, Arveiler D, Luc G, Bard JM, Bara L, Ricard S, Tiret L, Amouyel P, Alhenc-Gelas F, Soubrier.F. : "Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction" . Nature 1992 ;359 :641-644

39. Camera M, Giesen PL, Fallon J, Aufiero BM, Taubman M, Tremoli E, Nemerson Y : "Cooperation between VEGF and TNF-alpha is necessary for exposure of active tissue factor on the surface of human endothelial cells" . Arterioscler Thromb Vasc Biol 1999 ;19 :531-537

40. Campbell SM, Taha MM, Medina D, Rosen JM : "A clonal derivative of mammary epithelial cell line COMMA-D retains stem cell characteristics of unique morphological and functional heterogeneity" . Exp Cell Res 1988 ;177 :109-121

41. Carson MP, Haudenschild CC : "Microvascular endothelium and pericytes: high yield, low passage cultures" . In Vitro Cell Dev Biol 1986 ;22 :344-354

42. Cathcart MK, Morel DW, Chisolm GM : "Monocytes and neutrophils oxidize low density lipoprotein making it cytotoxic" . J Leukoc Biol 1985 ;38 :341-350

43. Chang MY, Sasahara M, Chait A, Raines EW, Ross R : "Inhibition of hypercholesterolemia-induced atherosclerosis in the nonhuman primate by probucol. II. Cellular composition and proliferation" . Arterioscler Thromb Vasc Biol 1995 ;15 :1631-1640

44. Chaudhari A, Kirschenbaum MA: "Decreased renal preglomerular microvascular PGI2 and PGE2 biosynthesis in cholesterol-fed rabbits" . Prostaglandins Leukot Essent Fatty Acids 1989 ;36 :81-84

45. Chen XL, Tummala PE, Olbrych MT, Alexander RW, Medford RM : "Angiotensin II induces monocyte chemoattractant protein-1 gene expression in rat vascular smooth muscle cells" . Circ Res 1998 ;83 :952-959

46. Cheng G, Cleary AM, Ye ZS, Hong DI, Lederman S, Baltimore D : "Involvement of CRAF1, a relative of TRAF, in CD40 signaling" . Science 1995 ;267 :1494-1498

47. Chobanian AV, Haudenschild CC, Nickerson C, Hope S : "Trandolapril inhibits atherosclerosis in the watanabe heritable hyperlipidemic rabbit" . Hypertension 1992 ;20 :473-477


48. Chomczynski P, Sacchi N : "Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction" . Anal Biochem 1987 ;162 :156-159

49. Clark EA, Ledbetter JA : "Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50" . Proc Natl Acad Sci USA 1986 ;83 :4494-4498

50. Clark RA, Fuhlbrigge RC, Springer TA : "L-Selectin ligands that are O-glycoprotease resistant and distinct from MECA-79 antigen are sufficient for tethering and rolling of lymphocytes on human high endothelial venules" . J Cell Biol 1998 ;140 :721-731

51. Collins T, Palmer HJ, Whitley MZ, Neish AS, Williams.A.J .: "A common theme in endothelial activation" . Trends in Cardiovasc Med 1993 ;3 :92-97

52. Collins T, Read MA, Neish AS, Whitley MZ, Thanos D, Maniatis T : "Transkriptional regulation of endothelial cell adhesion molecules: NF-kB and cytokine-inducible enhancers" . FASEB Journal 1995 ;9 :899-909

53. Colombo MP, Pierotti MA, Ballinari D, Parmiani G : "Expression of H-2 and viral antigens and resistance to the antitumor lysis of tunicamycin-treated MBL-2 lymphoma cells" . Immunobiology 1983 ;165 :186-199

54. Cordell JL, Falini B, Erber WN, Ghosh AK, Abdulaziz Z, MacDonald S, Pulford KA, Stein H, Mason DY : "Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes)" . J Histochem Cytochem 1984 ;32 :219-229

55. Craxton A, Shu G, Graves JD, Saklatvala J, Krebs EG, Clark EA : "p38 MAPK is required for CD40-induced gene expression and proliferation in B lymphocytes" . J Immunol 1998 ;161 :3225-3236

56. Crutchley DJ, McPhee GV, Terris MF, Canossa-Terris MA : "Levels of three hemostatic factors in relation to serum lipids. Monocyte procoagulant activity, tissue plasminogen activator, and type- 1 plasminogen activator inhibitor" . Arterioscler Thromb Vasc Biol 1989 ;9 :934-939

57. Cushing SD, Berliner JA, Valente AJ, Territo MC, Navab M, Parhami F, Gerrity R, Schwartz CJ, Fogelman AM : "Minimally modified low density lipoprotein induces monocyte chemotactic protein1in human endothelial cells and smooth muscle cells" . Proc Natl Acad Sci USA 1990 ;87 :5134-5138

58. Cybulsky MI, Gimbrone MA, Jr. : "Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis" . Science 1991 ;251 :788-791

59. Cyrus T, Witztum JL, Rader DJ, Tangirala R, Fazio S, Linton MF, Funk CD : "Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice" . J Clin Invest 1999 ;103 :1597-1604


60. Dousset V, Delalande C, Ballarino L, Quesson B, Seilhan D, Coussemacq M, Thiaudiere E, Brochet B, Canioni P, Caille JM : "In vivo macrophage activity imaging in the central nervous system detected by magnetic resonance" . Magn Reson Med. 1999 ;41 :329-333

61. Drake TA, Hannani K, Fei HH, Lavi S, Berliner JA : "Minimally oxidized low-density lipoprotein induces tissue factor expression in cultured human endothelial cells" . Am J Pathol 1991 ;138 :601-607

62. Drexler H : "Endothelial dysfunction: clinical implications" . Prog Cardiovasc Dis 1997 ;39 :287-324

63. Dunn OJ : "Multiple comparisons among means" . Journal of the American Statistical Association 1961 ;56 :52-64

64. Duplaa C, Couffinhal T, Labat L, Moreau C, Petit-Jean ME, Doutre MS, Lamaziere JM, Bonnet J : "Monocyte/macrophage recruitment and expression of endothelial adhesion proteins in human atherosclerotic lesions" . Atherosclerosis 1996 ;121 :253-266

65. Falk E, Fernandez-Ortiz A : "Role of thrombosis in atherosclerosis and its complications" . Am J Cardiol 1995 ;75 :5B-11B

66. Fei H, Berliner JA, Parhami F, Drake TA : "Regulation of endothelial cell tissue factor expression by minimally oxidized LDL and lipopolysaccharide" . Arterioscler Thromb 1993 ;13 :1711-1717

67. Feletou M, Teisseire B : "Converting enzyme inhibition in isolated porcine resistance artery potentiates bradykinin relaxation" . Eur J Pharmacol 1990 ;190 :159-166

68. Franke RP, Gräfe M, Schnittler H, Seiffge D, Mittermayer C, Drenckhahn D : "Induction of human vascular endothelial stress fibres by fluid shear stress" . Nature 1984 ;307 :648-649

69. Friedland J, Silverstein E : "A sensitive fluorimetric assay for serum angiotensin-converting enzyme" . Am J Clin Pathol 1976 ;66 :416-424

70. Fries KM, Sempowski GD, Gaspari AA, Blieden T, Looney RJ, Phipps RP : "CD40 expression by human fibroblasts" . Clin Immunol Immunopathol 1995 ;77 :42-51

71. Fuster V, Badimon L, Badimon JJ, Chesebro JH : "The pathogenesis of coronary artery disease and the acute coronary syndromes" . N Engl J Med 1992 ;326 :242-250

72. Fuster V, Poon M, Willerson JT : "Learning from the transgenic mouse: endothelium, adhesive molecules, and neointimal formation" . Circulation 1998 ;97 :16-18

73. Galle J, Bassenge E, Busse R : "Oxidized low density lipoproteins potentiate "


"vasoconstrictions to various agonists by direct interaction with vascular smooth muscle" . Circ Res 1990 ;66 :1287-1293

74. Galle J, Mülsch A, Busse R, Bassenge E : "Effects of native and oxidized low density lipoproteins on formation and inactivation of endothelium-derived relaxing factor" . Arterioscler Thromb 1991 ;11 :198-203

75. Gallery EDM, Rowe J, Schrieber L, Jackson CJ : "Isolation and purification of microvascular endothelium from human decidual tissue in the late phase of pregancy" . Am J Obstet Gynecol 1991 ;165 :191-196

76. Geisterfer AAT, Peach MJ, Ownes.G.K .: "Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells" . Circ Res 1988 ;62 :749-756

77. Ghaleh B, Hittinger L, Kim SJ, Kudej RK, Iwase M, Uechi M, Berdeaux A, Bishop SP, Vatner SF : "Selective large coronary endothelial dysfunction in conscious dogs with chronic coronary pressure overload" . Am J Physiol 1998 ;274 :H539-H551

78. Gibbons GH, Dzau VJ : "Molecular therapies for vascular diseases" . Science 1996 ;272 :689-693

79. Giuffre L, Cordey AS, Monai N, Tardy Y, Schapira M, Spertini O : "Monocyte adhesion to activated aortic endothelium: role of L-selectin and heparan sulfate proteoglycans" . J Cell Biol 1997 ;136 :945-956

80. Glaser BM, D`Amore PA, Michels RG, Patz A, Fenselau A : "Demonstration of vasoproliferative activity from mammalian retina" . J Cell Biol 1980 ;84 :298-304

81. Goetz DJ, Greif DM, Ding H, Camphausen RT, Howes S, Comess KM, Snapp KR, Kansas GS, Luscinskas FW : "Isolated P-selectin glycoprotein ligand-1 dynamic adhesion to P- and E- selectin" . J Cell Biol 1997 ;137 :509-519

82. Goetze S, Xi XP, Kawano Y, Kawano H, Fleck E, Hsueh WA, Law RE : "TNF-alpha-induced migration of vascular smooth muscle cells is MAPK dependent" . Hypertension 1999 ;33 :183-189

83. Gospodarowicz D, Ill C : "Extracellular matrix and control of proliferation of vascular endothelial cells" . J Clin Invest 1980; 65 :1351-1364

84. Graf D, Korthauer U, Mages HW, Senger G, Kroczek RA : "Cloning of TRAP, a ligand for CD40 on human T cells" . Eur J Immunol 1992 ;22 :3191-3194

85. Graf D, Muller S, Korthauer U, van Kooten C, Weise C, Kroczek RA : "A soluble form of TRAP (CD40 ligand) is rapidly released after T cell activation" . Eur J Immunol 1995 ;25 :1749-1754

86. Gräfe M, Auch-Schwelk W, Graf K, Hertel H, Hoffmann R, Bartsch P, Regitz-


Zagrosek V, Friedel N, Hetzer R, Fleck E : "E-selectin expression is induced by angiotensin II in human cardiac endothelial cells" . Eur Heart J 1994 ;15 (suppl) :493-493(Abstract)

87. Gräfe M, Auch-Schwelk W, Graf K, Terbeek D, Hertel H, Unkelbach M, Hildebrandt AG, Fleck E : "Isolation and characterization of macrovascular and microvascular endothelial cells from human hearts" . Am J Physiol 1994 ;267 :H2138-H2148

88. Gräfe M, Auch-Schwelk W, Hertel H, Terbeek D, Steinheider G, Loebe M, Fleck E : "Human cardiac microvascular and macrovascular endothelial cells respond differently to oxidatively modified LDL" . Atherosclerosis 1998 ;137 :87-95

89. Gräfe M, Auch-Schwelk W, Zakrzewicz A, Regitz-Zagrosek V, Bartsch P, Graf K, Loebe M, Gaehtgens P, Fleck E : "Angiotensin II induced leukocyte adhesion on human coronary endothelial cells is mediated by E-selectin" . Circ Res 1997 ;81 :804-811

90. Gräfe M, Graf K, Auch-Schwelk W, Hertel H, Hoffmann R, Bartsch P, Fleck E : "Modulation of adhesion molercule expression in human coronary endothelial cells" . Eur Heart J 1993 ;14 :58-58(Abstract)

91. Gräfe M, Steinheider G, Desaga U, Warnecke C, Lehmkuhl HB, Regitz-Zagrosek V, Hildebrandt AG, Fleck E : "Characterization of two distinct mechanisms for induction of apoptosis in human vascular endothelial cells" . Clin Chem Lab Med 1999 ;37 :505-510

92. Greenburg G, Vlodavsky I, Foidart JM, Gospodarowicz D : "Conditioned medium from endothelial cell cultures can restore the normal phenotypic expression of vascular endothelium maintained in vitro in the absence of fibroblast growth factor" . J Cell Physiol. 1980 ;103 :333-347

93. Griendling KK, Minieri CA, Ollerenshaw JD, Alexander RW : "Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells" . Circ Res 1994 ;74 :1141-1148

94. Groenen MA, Dijkhof RJ, van der Poel JJ : "Characterization of a GlyCAM1-like gene (glycosylation-dependent cell adhesion molecule 1) which is highly and specifically expressed in the lactating bovine mammary gland" . Gene 1995 ;158 :189-195

95. Hamsten A, d.Faire U, Walldius G, Dahlen G, Szamosi A, Landou C, Blombäck M, Wiman B : "Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction" . Lancet 1987 ;2 :3-9

96. Han Y, Runge MS, Brasier AR : "Angiotensin II induces interleukin-6 transcription in vascular smooth muscle cells through pleiotropic activation of nuclear factor-kappa B transcription factors" . Circ Res 1999 ;84 :695-703

97. Hansson GC, Zopf D : "Biosynthesis of the cancer-associated sialyl-Lea antigen" . J Biol


Chem 1985 ;260 :9388-9392

98. Hansson GK : "Immune and inflammatory mechanisms in the development of atherosclerosis" . Br Heart J 1993 ;69 (Suppl) :S38-S41

99. Harker LA, Ross R, Glomset J : "Role of the platelet in atherogenesis" . Ann N Y Acad Sci 1976 ;275 :321-329

100. Harrison DG : "Endothelial function and oxidant stress" . Clin Cardiol 1997 ;20 ;(Suppl) 2 :1-7

101. Havel RJ, Eder HA, Bragdon JH : "The distribution and chemical composition of ultracentrifugally seperated lipoproteins in human serum" . J Clin Invest 1955 ;43 :1345-1353

102. Heinhold J, Gaede K-W : "Einige parameterfreie Methoden" , in Heinhold J, Gaede K-W (eds): Ingenieur-Statistik . München Wien , R.Oldenburg Verlag , 1972 , pp 300-305

103. Hemmerich S, Butcher EC, Rosen SD : "Sulfation-dependent recognition of high endothelial venules (HEV)- ligands by L-selectin and MECA 79, and adhesion-blocking monoclonal antibody" . J Exp Med 1994 ;180 :2219-2226

104. Henn V, Slupsky JR, Gräfe M, Anagnostopoulos I, Forster R, Muller-Berghaus G, Kroczek RA : "CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells" . Nature 1998 ;391 :591-594

105. Hennekens CH, Buring JE, Manson JE, Stampfer M, Rosner B, Cook NR, Belanger C, LaMotte F, Gaziano JM, Ridker PM, Willett W, Peto R : "Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease" . N Engl J Med 1996 ;334 :1145-1149

106. Hess S, Rensing-Ehl A, Schwabe R, Bufler P, Engelmann H : "CD40 function in nonhematopoietic cells. Nuclear factor kappa B mobilization and induction of IL-6 production" . J Immunol 1995 ;155 :4588-4595

107. Hoffman R, Brook GJ, Aviram M : "Hypolipidemic drugs reduce lipoprotein susceptibilizy to undergo lipid peroxidation: in vitro and ex vivo studies" . Atherosclerosis 1992 ;93 :105-113

108. Hollander W, Colombo M, Paddock J : "Lipoproteins in human atherosclerotic vessels" . Exp Mol Pathol 1979 ;30 :172-189

109. Hollenbaugh D, Mischel-Petty N, Edwards CP, Simon JC, Denfeld RW, Kiener PA, Aruffo A : "Expression of functional CD40 by vascular endothelial cells" . J Exp.Med 1995 ;182 :33-40

110. Holzmeister J, Ludewig B, Kroczek RA, Frei U, Brause M, Fleck E, Regitz-Zagrosek V : "Functional expression of CD40 on human coronary vascular smooth muscle cells" .


Hypertension 1996 ;28 :509(Abstract)

111. Howard LM, Miga AJ, Vanderlugt CL, Dal CM, Laman JD, Noelle RJ, Miller SD : "Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis" . J Clin Invest 1999 ;103 :281-290

112. Imai Y, Lasky LA, Rosen SD : "Sulphation requirement for Glycam-1, an endothelial ligand for L-selectin" . Nature 1993 ;361 :555-557

113. Imai Y, Singer MS, Fennie C, Lasky LA, Rosen SD : "Identification of a carbohydrate-based endothelial ligand for a lymphocyte homing receptor" . J Cell Biol 1991 ;113 :1213-1221

114. Ishibashi S, Brown MS, Goldstein JL, Gerard RD, Hammer RE, Herz J : "Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery" . J Clin Invest 1993 ;92 :883-893

115. Jaffe EA, Nachman RL, Becker CG, Minick CR : "Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria" . J Clin Invest 1973 ;52 :2745-2756

116. Jaffe EA, Ross R : "Synthesis of von willebrand factor by endothelial cells" , in U.S.Ryan (ed): Endothelial cells . CRC Press, Inc. , Boca Raton, Florida , 1988 , pp 119-126

117. Johansson BB, Fredriksson K : "Cerebral arteries in hypertension: structural and hemodynamic aspects" . J Cardiovasc Pharmacol 1985 ;7 :S90-S93

118. Kanda T, Yamawaki M, Ariga T, Yu RK : "Interleukin 1 beta up-regulates the expression of sulfoglucuronosyl paragloboside, a ligand for L-selectin, in brain microvascular endothelial cells" . Proc Natl Acad Sci USA 1995 ;92 :7897-7901

119. Kane JP : "Apolipoprotein B: structural and metabolic heterogeneity" . Annu Rev Physiol 1983 ;45 :637-650

120. Kansas GS, Spertini O, Stoolman LM, Tedder TF : "Molecular mapping of functional domains of the leukocyte receptor for endothelium, LAM-1" . J Cell Biol 1991 ;114 :351-358

121. Kapiloff MS, Strittmatter SM, Fricker LD, Snyder SH : "A fluorometric assay for angiotensin-converting enzyme activity" . Anal Biochem 1984 ;140 :293-302

122. Karmann K, Hughes CC, Schechner J, Fanslow WC, Pober JS : "CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression" . Proc Natl Acad Sci USA 1995 ;92 :4342-4346

123. Katsuda S, Boyd HC, Fligner C, Ross R, Gown AM : "Human atherosclerosis. III. Immunocytochemical analysis of the cell composition of lesions of young adults" . Am


J Pathol 1992 ;140 :907-914

124. Katz ED, Haff LA : "Rapid separation, quantitation and purification of products of polymerase chain reaction by liquid chromatography" . J Chromatography 1990 ;512 :433-444

125. Kawabe T, Naka T, Yoshida K, Tanaka T, Fujiwara H, Suematsu S, Yoshida N, Kishimoto T, Kikutani H : "The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation" . Immunity 1994 ;1 :167-178

126. Kelm M, Preik M, Hafner DJ, Strauer BE : "Evidence for a multifactorial process involved in the impaired flow response to nitric oxide in hypertensive patients with endothelial dysfunction" . Hypertension 1996 ;27 :346-353

127. Kerins DM, Hao Q, Vaughan DE : "Angiotensin induction of PAI-1 expression in endothelial cells is mediated by the hexapeptide angiotensin IV" . J Clin Invest 1995; 96 :2515-2520

128. Khan BV, Parthasarathy SS, Alexander RW, Medford RM : "Modified low density lipoprotein and its constituents augment cytokine- activated vascular cell adhesion molecule-1 gene expression in human vascular endothelial cells" . J Clin Invest 1995 ;95 :1262-1270

129. Koenig A, Norgard-Sumnicht K, Linhardt R, Varki A : "Differential interactions of heparin and heparan sulfate glycosaminoglycans with the selectins. Implications for the use of unfractionated and low molecular weight heparins as therapeutic agents" . J Clin Invest 1998 ;101 :877-889

130. Kugiyama K, Sakamoto T, Misumi I, Sugiyama S, Ohgushi M, Ogawa H, Horiguchi M, Yasue H : "Transferable Lipids in Oxidized Low-Density Lipoprotein Stimulate Plasminogen Activator Inhibitor-1 and Inhibit Tissue- Type Plasminogen Activator Release From Endothelial Cells" . Circ Res 1993 ;73 :335-343

131. Kuhn H, Belkner J, Suzuki H, Yamamoto S : "Oxidative modification of human lipoproteins by lipoxygenases of different positional specificities" . J Lipid Res 1994 ;35 :1749-1759

132. Kume N, Murase T, Moriwaki H, Aoyama T, Sawamura T, Masaki T, Kita T : "Inducible expression of lectin-like oxidized LDL receptor-1 in vascular endothelial cells" . Circ Res 1998 ;83 :322-327

133. Laemmli UK : "Cleavage of structural proteins during the assembly of the head of bacteriophage T4" . Nature 1970 ;227 :680-685

134. Larsen CP, Elwood ET, Alexander DZ, Ritchie SC, Hendrix R, Tucker-Burden C, Cho HR, Aruffo A, Hollenbaugh D, Linsley PS, Winn KJ, Pearson TC : "Long-term "


"acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways" . Nature 1996 ;381 :434-438

135. Lasky LA, Singer MS, Dowbenko D, Imai Y, Henzel WJ, Grimley C, Fennie C, Gillett N, Watson SR, Rosen SD : "An endothelial ligand for L-selectin is a novel mucin-like molecule" . Cell 1992 ;69 :927-938

136. Latron Y, Chautan M, Anfosso F, Alessi MC, Nalbone G, Lafont H, Juhan-Vague I : "Stimulating effect of oxidized low density lipoproteins on plasminogen activator inhibitor-1 synthesis by endothelial cells" . Arterioscler Thromb 1991 ;11 :1821-1829

137. Leeuwenberg JF, Jeunhomme TM, Buurman WA : "Role of ELAM-1 in adhesion of monocytes to activated human endothelial cell" s. Scand J Immunol 1992 ;35 :335-341

138. Leeuwenberg JF, Smeets EF, Neefjes JJ, Shaffer MA, Cinek T, Jeunhomme, TM, Ahern TJ, Buurman WA : "E-selectin and intercellular adhesion molecule-1 are released by activated human endothelial cells in vitro" . Immunol 1992 ;77 :543-549

139. Leeuwenberg JF, von AE, Jeunhomme TM, Buurman WA : "IFN-gamma regulates the expression of the adhesion molecule ELAM-1 and IL-6 production by human endothelial cells in vitro" . J Immunol 1990 ;145 :2110-2114

140. Levin EG, Miles LA, Fless GM, Scanu AM, Baynham P, Curtiss LK, Plow EF : "Lipoproteins inhibit the secretion of tissue plasminogen activator from human endothelial cells" . Arterioscler Thromb 1994 ;14 :438-442

141. Levin J, Bang FB : "Clottable Protein in Limulus: Its Location and Kinetics of Its Coagulation by Endotoxin" . Thromb Diath Haemorrh 1968 ;19 :186-197

142. Levinovitz A, Muhlhoff J, Isenmann S, Vestweber D : "Identification of a glycoprotein ligand for E-selectin on mouse myeloid cells" . J Cell Biol 1993 ;121 :449-459

143. Ley K, Tedder TF, Kansas GS : "L-selectin can mediate leukocyte rolling in untreated mesenteric venules in vivo independent of E- or P-selectin" . Blood 1993 ;82 :1632-1638

144. Ley K, Zakrzewicz A, Hanski C, Stoolman LM, Kansas GS : "Sialylated O-glycans and L-selectin sequentially mediate myeloid cell rolling in vivo" . Blood 1995 ;85 :3727-3735

145. Li D, Yang B, Philips MI, Mehta JL : "Proapoptotic effects of ANG II in human coronary artery endothelial cells: role of AT1 receptor and PKC activation" . Am J Physiol 1999 ;276 :H786-H792

146. Lowe JB, Stoulman LM, Nair RP, Larsen RD, Berhend PL, Marks RM : "ELAM-1 depedent cell adhesion to vascular endothelium determined by a transfected human fucosyl transferase cDNA" . Cell 1990 ;63 :475-484


147. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ : "Protein measurement with the folin phenol reagent" . J Biol Chem 1951 ;193 :265-275

148. Luscinskas FW, Cybulsky MI, Kiely JM, Peckins CS, Davis VM, Gimbrone MA Jr. : "Cytokine-activated human endothelial monolayers support enhanced neutrophil transmigration via a mechanism involving both endothelial- leukocyte adhesion molecule-1 and intercellular adhesion molecule-1" . J Immunol 1991 ;146 :1617-1625

149. Luscinskas FW, Kansas GS, Ding H, Pizcueta P, Schleiffenbaum BE, Tedder TF, Gimbrone MA, Jr. : "Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrins" . J Cell Biol 1994 ;125 :1417-1427

150. Mach F, Schönbeck U, Libby P : "CD40 signaling in vascular cells: a key role in atherosclerosis?" Atherosclerosis 1998 ;137 (Suppl) :S89-95

151. Mach F, Schönbeck U, Sukhova GK, Atkinson E, Libby P : "Reduction of atherosclerosis in mice by inhibition of CD40 signalling" . Nature 1998 ;394 :200-203

152. Maisel AS, Harris T, Rearden CA, Michel MC : "Beta-adrenergic receptors in lymphocyte subsets after exercise. Alterations in normal individuals and patients with congestive heart failure" . Circulation 1990 ;82 :2003-2010

153. Malden LT, Chait A, Raines EW, Ross R : "The influence of oxidatively modified low density lipoproteins on expression of platelet-derived growth factor by human monocyte- derived macrophages" . J Biol Chem 1991 ;266 :13901-13907

154. Masuda J, Ross R : "Atherogenesis during low level hypercholesterolemia in the nonhuman primate. I. Fatty streak formation" . Arterioscler Thromb 1990 ;10 :164-177

155. Masuda J, Ross R : "Atherogenesis during low level hypercholesterolemia in the nonhuman primate. II. Fatty streak conversion to fibrous plaque" . Arterioscler Thromb 1990 ;10 :178-187

156. McEvoy LM, Sun H, Tsao PS, Cooke JP, Berliner JA, Butcher EC : "Novel vascular molecule involved in monocyte adhesion to aortic endothelium in models of atherogenesis" . J Exp Med 1997 ;185 :2069-2077

157. Meininger CJ, Granger HJ : "Mechanisms leading to adenosine-stimulated proliferation of microvascular endothelial cells" . Am J Physiol 1990 ;27 :H198-H206

158. Michie SA, Streeter PR, Bolt PA, Butcher EC, Picker LJ : "The human peripheral lymph node vascular addressin. An inducible endothelial antigen involved in lymphocyte homing" . Am J Pathol 1993 ;143 :1688-1698


159. Mitsuoka C, kawakami-Kimura N, Kasugai-Sawada M, Hiraiwa N, Toda K, Ishida H, Kiso M, Hasegawa A, Kannagi R : "Sulfated sialyl lewis x, the putative l-selectin ligand, detected on endothelial cells of high endothelial venules by a distinct set of anti-sialyl lewis x antibodies" . Biochem Biophys Res Commun 1997 ;230 :546-551

160. Montoya MC, Holtmann K, Snapp KR, Borges E, Sanchez-Madrid F, Luscinskas FW, Kansas GS, Vestweber D, de Landazuri MO : "Memory B lymphocytes from secondary lymphoid organs interact with E- selectin through a novel glycoprotein ligand" . J Clin Invest 1999 ;103 :1317-1327

161. Morawietz H, Rueckschloss U, Niemann B, Duerrschmidt N, Galle J, Hakim K, Zerkowski HR, Sawamura T, Holtz J : "Angiotensin II induces LOX-1, the human endothelial receptor for oxidized low-density lipoprotein" . Circulation 1999 ;100 :899-902

162. Moriwaki H, Kume N, Sawamura T, Aoyama T, Hoshikawa H, Ochi H, Nishi E, Masaki T, Kita T : "Ligand specificity of LOX-1, a novel endothelial receptor for oxidized low density lipoprotein" . Arterioscler Thromb Vasc Biol 1998 ;18 :1541-1547

163. Mulligan MS, Watson SR, Fennie C, Ward PA : "Protective effects of selectin chimeras in neutrophil-mediated lung injury" . J Immunol 1993 ;151 :6410-6417

164. Munro JM, Cotran RS : "Biology of disease. The pathogenesis of atherosclerosis: Atherogenesis and inflammation" . Lab Invest 1988 ;58 :249-261

165. Nationale Heart, Lung and Blood Institute : Morbidity and mortality chartbook on cardiovascular, lung, and blood disease 1990 . Washington , U.S. Department of Health und Human Services

166. Nebert DW, Gelboin HV : "The role of ribonucleic acid and protein synthesis in microsomal aryl hydrocarbon hydroxylase induction in cell culture. The independence of transcription and translation" . J Biol Chem 1970 ;245 :160-168

167. Nees S, Gerbes AL, Gerlach E : "Isolation, identification, and continuous culture of coronary endothelial cells from guinea pig hearts" . Eur J Cell Biol 1981 ;24 (Suppl) :287-297

168. Nelson RM, Cecconi O, Roberts WG, Aruffo A, Linhardt RJ, Bevilacqua MP : "Heparin oligosaccharides bind L- and P-selectin and inhibit acute inflammation" . Blood 1993 ;82 :3253-3258

169. Nelson RM, Dolich S, Aruffo A, Cecconi O, Bevilacqua MP : "Higher-affinity oligosaccharide ligands for E-selectin" . J Clin Invest 1993 ;91 :1157-1166

170. Neuss M, Regitz-Zagrosek V, Hildebrandt AG, Fleck E : "Human cardiac fibroblasts express an angiotensin receptor with unusual binding characteristics which is coupled to cellular proliferation" . Biochem Biophys Res Commun 1994 ;204 :1334-



171. Newman PJ : "The biology of PECAM-1" . J Clin Invest 1997 ;99 :3-8

172. Newman PJ, Berndt MC, Gorski J, White GC, Lyman S, Paddock C, Muller WA : "PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily" . Science 1990 ;247 :1219-1222

173. Nishida M, Carley WW, Gerritsen ME, Ellingsen O, Kelly RA, Smith.T.W .: "Isolation and characterization of human and rat cardiac microvascular endothelial cells" . Am J Physiol 1993 ;264 :H639-H652

174. Noble RP : "Electrophoretic separation of plasma lipoproteins in agarose gel" . J Lipid Res 1968 ;9 :693-700

175. Norgard-Sumnicht K, Varki A : "Endothelial heparan sulfate proteoglycans that bind to L-selectin have glucosamine residues with unsubstituted amino groups" . J Biol Chem 1995 ;270 :12012-12024

176. Norgard-Sumnicht K, Varki NM, Varki A : "Calcium-dependent heparin-like ligands for L-selectin in nonlymphoid endothelial cells" . Science 1993 ;261 :480-483

177. Norgard KE, Moore KL, Diaz S, Stults NL, Ushiyama S, McEver RP, Cummings RD, Varki A : "Characterization of a specific ligand for P-selection on myeloid cells. A minor glycoprotein with sialylated O-linked oligosaccharides" . J Biol Chem 1993 ;268 :12764-12774

178. O`Brian KD, Allen MD, McDonald TO, Chait A, Harlan JM, Fishbein D, McCarty J, Ferguson M, Hudkins K, Benjamin CD : "Vascular adhesion molecule-1 is expressed in human coronary atherosclerotic plaques: implication for the mode of progression of advanced atherosclerosis" . J Clin Invest 1993 ;92 :945-951

179. O`Brian KD, McDonald TO, Chait A, Allen MD, Alpers CE : "Neovascular expression of E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in human atherosclerosis and their relation to intimal leukocyte content" . Circulation 1996 ;93 :672-682

180. Olofsson BO, Dahlen G, Nilsson TK : "Evidence for increased levels of plasminogen activator inhibitor and tissue plasminogen activator in plasma of patients with angiographically verified coronary artery disease" . Eur Heart J 1989 ;10 :77-82

181. Osborn L, Hession C, Tizard R, Vassallo C, Luhowskyj S, Chi-Rosso G, Lobb R : "Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes" . Cell 1989 ;59 :1203-1211

182. Palmer-Crocker RL, Pober JS : "IL-4 induction of VCAM-1 on endothelial cells "


"involves activation of a protein tyrosine kinase" . J Immunol 1995 ;154 :2838-2845

183. Pfeffer MA, Braunwald E, on behalf of the SAVE investigators : "Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction" . N Engl J Med 1993 ;327 :669-677

184. Pfeiffer A, Schatz H : "Diabetic microvascular complications and growth factors" . Exp Clin Endocrinol Diabetes 1995 ;103 :7-14

185. Piedrahita JA, Zhang SH, Hagaman JR, Oliver PM, Maeda N : "Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells" . Proc Natl Acad Sci USA 1992 ;89 :4471-4475

186. Pietinen P, Ascherio A, Korhonen P, Hartman AM, Willett WC, Albanes D, Virtamo J : "Intake of fatty acids and risk of coronary heart disease in a cohort of Finnish men. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study" . Am J Epidemiol 1997 ;145 :876-887

187. Piper HM, Spahr R, Mertens S, Krützfeldt A, Watanabe H : "Microvascular endothelial cells from heart" , in H.M.Piper (ed): Cell culture techniques in heart and vessel research . Springer-Verlag , Berlin , 1990 , pp 158-177

188. Pitt B : "Angiotensin-converting enzyme inhibitors in patients with coronary atherosclerosis" . Am Heart J 1994 ;128 :1328-1332

189. Pitt B, Segal R, Martinez FA, Meurers G, Cowley AJ, Thomas I, Deedwania PC, Ney DE, Snavely DB, Chang PI : "Randomised trial of losartan versus captopril in patients over 65 with heart failure (Evaluation of Losartan in the Elderly Study, ELITE)" . Lancet 1997 ;349 :747-752

190. Pober JS, Cotran RS : "The role of endothelial cells in inflammation" . Transplantation 1990 ;50 :537-544

191. Pober JS, Lapierre LA, Stolpen AH, Brock TA, Springer TA, Fiers W, Bevilacqua MP, Mendrick DL, Gimbrone MA, Jr. : "Activation of cultured human endothelial cells by recombinant lymphotoxin: comparison with tumor necrosis factor and interleukin 1 species" . J Immunol 1987 ;138 :3319-3324

192. Powell JS, Clozel J, Müller RK, Kuhn H, Hefti F, Hosang M, Baumgartner HR : "Inhibitors of angiotensin-converting enzyme prevent myointimal proliferation after vascular injury" . Science 1989 ;245 :186-188

193. Pörsti I, Bara AT, Busse R, Hecker M : "Release of nitric oxide by angiotensin-(1-7) from porcine coronary endothelium: implications for a novel angiotensin receptor" . Br J Pharmacol 1994 ;111 :652-654

194. Prydz H, Allison C : "Tissue thromboplastin activity of isolated human monocytes" .


Thromb Haemost 1978 ;39 :582-582

195. Pueyo ME, Gonzalez W, Nicoletti A, Savoie F, Arnal JF, Michel JB : "Angiotensin II Stimulates Endothelial Vascular Cell Adhesion Molecule-1 via Nuclear Factor-kappaB Activation Induced by Intracellular Oxidative Stress" . Arterioscler Thromb Vasc Biol 2000 ;20 :645-651

196. Rajavashisth TB, Andalibi A, Territo MC, Berliner JA, Navab M, Fogelman AM, Lusis AJ : "Induction of endothelial cell expression of granulocyte and macrophage colony- stimulating factors by modified low-density lipoproteins" . Nature 1990 ;344 :254-257

197. Regitz-Zagrosek V, Friedel N, Heymann A, Bauer P, Neuss M, Rolfs A, Steffen C, Hildebrandt AG, Hetzer R, Fleck E : "Regulation, chamber localization and subtype distribution of angiotensin II receptors in human hearts" . Circulation 1995 ;91 :1461-1471

198. Rijken DC, Juhan-Vague I, De Cock F, Collen D : "Measurement of human tissue-type plasminogen activator by a two- site immunoreactive assay" . J Lab Clin Med 1983 ;101 :274-284

199. Rodes J, Cote G, Lesperance J, Bourassa MG, Doucet S, Bilodeau L, Bertrand OF, Harel F, Gallo R, Tardif JC : "Prevention of restenosis after angioplasty in small coronary arteries with probucol" . Circulation 1998 ;97 :429-436

200. Ross R : "The pathogenesis of atherosclerosis: a perspective for the 1990s" . Nature 1993 ;362 :801-809

201. Ross R : "Atherosclerosis--an inflammatory disease" . N Engl J Med 1999 ;340 :115-126

202. Ross R, Glomset J, Harker L : "Response to injury and atherogenesis" . Am J Pathol 1977 ;86 :675-684

203. Ross R, Glomset JA : "Atherosclerosis and the arterial smooth muscle cell: Proliferation of smooth muscle is a key event in the genesis of the lesions of atherosclerosis" . Science 1973 ;180 :1332-1339

204. Ross R, Raines E, Bowen-Pope D : "Growth factors from platelets, monocytes, and endothelium: their role in cell proliferation" . Ann N Y Acad Sci 1982 ;397 :18-24

205. Sackstein R, Fu L, Allen KL : "A hematopoietic cell L-selectin ligand exhibits sulfate-independent binding activity" . Blood 1997 ;89 :2773-2781

206. Sadoshima J, Izumo S : "Molecular characterization of angiotensin II-induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts" . Circ Res 1993 ;73 :413-423


207. Salmi M, Granfors K, MacDermott R, Jalkanen S : "Aberrant binding of lamina propria lymphocytes to vascular endothelium in inflammatory bowel diseases" . Gastroenterology 1994 ;106 :596-605

208. Sassetti C, Tangemann K, Singer MS, Kershaw DB, Rosen SD : "Identification of podocalyxin-like protein as a high endothelial venule ligand for L-selectin: parallels to CD34" . J Exp Med 1998 ;187 :1965-1975

209. Sawamura T, Kume N, Aoyama T, Moriwaki H, Hoshikawa H, Aiba Y, Tanaka T, Miwa S, Katsura Y, Kita T, Masaki T : "An endothelial receptor for oxidized low-density lipoprotein" . Nature 1997 ;386 :73-77

210. Schreck R, Rieber P, Baeuerle PA : "Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kB transcription factor and HIV-1" . EMBO J 1991 ;10 :2247-2258

211. Schultz Hector S, Balz K : "Radiation-induced loss of endothelial alkaline phosphatase activity and development of myocardial degeneration. An ultrastructural study" . Lab Invest 1994 ;71 :252-260

212. Shih PT, Elices MJ, Fang ZT, Ugarova TP, Strahl D, Territo MC, Frank JS, Kovach NL, Cabanas C, Berliner JA, Vora DK : "Minimally modified low-density lipoprotein induces monocyte adhesion to endothelial connecting segment-1 by activating beta1 integrin" . J Clin Invest 1999 ;103 :613-625

213. Shimizu Y, Shaw S : "Mucins in the mainstream" . Nature 1993 ;366 :630-631

214. Siedel J, Hägele O, Ziegenhorn J, Wahlefeld AW : "Reagent for the Enzymatic Determination of Serum Total Cholesterol with Improved Lipolytic Efficiency" . Clin Chem 1983 ;29 :1075-1080

215. Simionescu M, Simionescu N : "Proatherosclerotic events: pathobiochemical changes occurring in the arterial wall before monocyte migration" . FASEB J 1993 ;7 :1359-1366

216. Simionescu M, Simionescu N : "Isolation and characterization of endothelial cells from the heart microvasculature" . Microvasc Res 1978 ;16 :426-452

217. Slupsky JR, Kalbas M, Willuweit A, Henn V, Kroczek RA, Muller-Berghaus G : "Activated platelets induce tissue factor expression on human umbilical vein endothelial cells by ligation of CD40" . Thromb Haemost 1998 ;80 :1008-1014

218. Spanel-Borowski K, van der Bosch J : "Different phenotypes of cultured microvessel endothelial cells obtained from bovine corpus luteum" . Cell Tissue Res 1990 ;261 :35-47

219. Spillmann D, Witt D, Lindahl U, Webb LM, Ehrengruber MU, Clark-Lewis I, Baggiolini M, Rot A : "Defining the interleukin-8-binding domain of heparan sulfate."


"Binding to heparan sulfate or heparin enhances neutrophil responses to interleukin 8" . J Biol Chem 1998 ;273 :15487-15493

220. Springer TA : "Adhesion receptors of the immune system" . Nature 1990 ;346 :425-434

221. Springer TA : "The sensation of interactions with the extracellular environment: The cell biology of lymphocyte adhesion receptors" . Annu Rev Cell Biol 1990 ;6 :359-402

222. Steegmaier M, Levinovitz A, Isenmann S, Borges E, Lenter M, Kocher HP, Kleuser B, Vestweber D : "The E-selectin-ligand ESL-1 is a variant of a receptor for fibroblast growth factor" . Nature 1995 ;373 :615-620

223. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL : "Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity" . N Engl J Med 1989 ;320 :915-924

224. Steinbrecher UP, Witztum JL, Parthasarathy S, Steinberg D : "Decrease in reactive amino groups during oxidation or endothelial cell modification of LDL: correlation with changes in receptor-mediated catabolism" . Arterioscler Thromb 1987 ;7 :135-143

225. Steininger CN, Eddy CA, Leimgruber RM, Mellors A, Welply JK : "The glycoprotease of Pasteurella haemolytica A1 eliminates binding of myeloid cells to P-selectin but not to E-selectin" . Biochem Biophys Res Commun 1992 ;188 :760-766

226. Stephens NG, Parsons A, Schofield PM, Kelly F, Cheeseman K, Mitchinson MJ : "Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)" . Lancet 1996 ;347 :781-786

227. Stevens RL, Schwartz LB, Austen KF, Lohmander LS, Kimura JH : "Effect of tunicamycin on insulin binding and on proteoglycan synthesis and distribution in Swarm rat chondrosarcoma cell cultures" . J Biol Chem 1982 ;257 :5745-5750

228. Stoll M, Steckelings UM, Paul M, Bottari SP, Metzger R, Unger T : "The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells" . J Clin Invest 1995 ;95 :651-657

229. Streeter PR, Berg EL, Rouse BT, Bargatze RF, Butcher EC : "A tissue-specific endothelial cell molecule involved in lymphocyte homing" . Nature 1988 ;331 :41-46

230. Sutherland CL, Heath AW, Pelech SL, Young PR, Gold MR : "Differential activation of the ERK, JNK, and p38 mitogen-activated protein kinases by CD40 and the B cell antigen receptor" . J Immunol 1996 ;157 :3381-3390

231. Tanner FC, Noll G, Boulanger CM, Lüscher TF : "Oxidized low density lipoproteins inhibit relaxations of porcine coronary arteries. Role of scavenger receptor and endothelium- derived nitric oxide" . Circulation 1991 ;83 :2012-2020


232. Tardif J-C, Cote G, Lesperance J, Bourassa M, Lambert J, Doucet S, Bilodeau L, Nattel S, de Guise P : "Probucol and multivitamins in the prevention of restenosis after coronary angioplasty" . N Engl J Med 1997 ;337 :365-372

233. Tedder TF, Penta AC, Levine HB, Freedman AS : "Expression of the human leukocyte adhesion molecule, LAM1. Identity with the TQ1 and Leu-8 differentiation antigens" . J Immunol 1990 ;144 :532-540

234. Tedder TF, Steeber DA, Pizcueta P : "L-selectin-deficient mice have impaired leukocyte recruitment into inflammatory sites" . J Exp Med 1995 ;181 :2259-2264

235. Thornton SC, Mueller SN, Levine EM : "Human endothelial cells: Use of heparin in cloning and long-term serial cultivation" . Science 1983 ;222 :623-625

236. Toppila S, Lauronen J, Mattila P, Turunen JP, Penttila L, Paavonen T, Renkonen O, Renkonen R : "L-selectin ligands in rat high endothelium: multivalent sialyl Lewis x glycans are high-affinity inhibitors of lymphocyte adhesion" . Eur J Immunol 1997 ;27 :1360-1365

237. Traub O, Berk BC : "Laminar shear stress: mechanisms by which endothelial cells transduce an atheroprotective force" . Arterioscler Thromb Vasc Biol 1998 ;18 :677-685

238. Tremoli E, Camera M, Maderna P, Sironi L, Prati L, Colli S, Piovella F, Bernini F, Corsini A, Mussoni L : "Increased synthesis of plasminogen activator inhibitor-1 by cultured human endothelial cells exposed to native and modified LDLs" . Arterioscler Thromb 1993 ;13 :338-346

239. True DD, Singer MS, Lasky LA, Rosen SD : "Requirement for sialic acid on the endothelial ligand of a lymphocyte homing receptor" . J Cell Biol 1990 ;111 :2757-2764

240. Tu L, Delahunty MD, Ding H, Luscinskas FW, Tedder TF : "The cutaneous lymphocyte antigen is an essential component of the L- selectin ligand induced on human vascular endothelial cells" . J Exp Med 1999 ;189 :241-252

241. Tummala PE, Chen XL, Sundell CL, Laursen JB, Hammes CP, Alexander RW, Harrison DG, Medford RM : "Angiotensin II induces vascular cell adhesion molecule-1 expression in rat vasculature: A potential link between the renin-angiotensin system and atherosclerosis" . Circulation 1999 ;100 :1223-1229

242. Turunen JP, Majuri ML, Seppo A, Tiisala S, Paavonen T, Miyasaka M, Lemström K, Penttila L, Renkonen O, Renkonen R : "De novo expression of endothelial sialyl Lewis(a) and sialyl Lewis(x) during cardiac transplant rejection: superior capacity of a tetravalent sialyl Lewis(x) oligosaccharide in inhibiting L-selectin-dependent lymphocyte adhesion" . J Exp Med 1995 ;182 :1133-1141

243. Urata H, Nishimura H, Ganten D : "Chymase-dependent angiotensin II forming systems in humans" . Am J Hypertens 1996 ;9 :277-284


244. Urata H, Nishimura H, Ganten D, Arakawa K : "Angiotensin-converting enzyme-independent pathways of angiotensin II formation in human tissues and cardiovascular diseases" . Blood Press Suppl 1996 ;2 :22-28

245. Van der Wal AC, Das PK, Tigges AJ, Becker AE : "Adhesion molecules on the endothelium and mononuclear cells in human atherosclerotic lesions" . Am J Pathol 1992 ;141 :1427-1433

246. van Hinsbergh VWM, Havekes L, Emeis JJ, van Corven E, Scheffer MA : "Low density lipoprotein metabolism by endothelial cells from human umbilical cord arteries and veins" . Arterioscler Thromb 1983 ;3 :547-559

247. Vartdal F, Kvalheim G, Lea TE, Bosnes V, Gaudernack G, Ugelstad J, Albrechtsen D : "Depletion of T lymphocytes from human bone marrow. Use of magnetic monosized polymer microspheres coated with T lymphocyte- specific monoclonal antibodies" . Transplantation 1987 ;43 :366-371

248. Vestweber D : "The selectins and their ligands" . Curr Top Microbiol Immunol 1993 ;184 :65-75

249. Vlodavsky I, Johnson LK, Gospodarowicz D : "Appearance in confluent vascular endothelial cell monolayers of a specific cell surface protein (CSP-60) not detected in actively growing endothelial cells or in cell types growing in multiple layers" . Proc Natl Acad Sci USA 1979 ;76 :2306-2310

250. von Andrian UH, Chambers JD, McEvoy LM, Bargatze RF, Arfors KE, Butcher EC : "Two-step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte beta 2 integrins in vivo" . Proc Natl Acad Sci USA 1991 ;88 :7538-7542

251. Voyta JC, Via DP, Butterfield CE, Zetter BR : "Identification and isolation of endothelial cells based on their increased uptake of acetylated-low density lipoprotein" . J Cell Biol 1984 ;99 :2034-2040

252. Wagner JD, St.Clair RW, Schwenke DC, Shively CA, Adams MR, Clarkson TB : "Regional differences in arterial low density lipoprotein metabolism in surgically postmenopausal cynomolgus monkeys. Effects of estrogen and progesterone replacement therapy" . Arterioscler Thromb 1992 ;12 :717-726

253. Wahlefeld AW: Bergmeyer HU (ed): Methoden der enzymatischen Analyse . Weinheim , Verlag Chemie , 1974 , pp 1878-1878

254. Watanabe K, Sekiya M, Ikeda S, Miyagawa M, Hashida K : "Preventive effects of probucol on restenosis after percutaneous transluminal coronary angioplasty" . Am Heart J 1996 ;132 :23-29

255. Watanabe M, Hirohashi S, Shimosato Y, Ino Y, Yamada T, Teshima S, Sekine T, Abe


O : "Carbohydrate antigen defined by a monoclonal antibody raised against a gastric cancer xenograft" . Jpn J Cancer Res 1985 ;76 :43-52

256. Watanabe Y, Ito T, Shiomi M : "The effect of selective breeding on the development of coronary atherosclerosis in WHHL rabbits. An animal model for familial hypercholesterolemia" . Atherosclerosis 1985 ;56 :71-79

257. Watson SR, Imai Y, Fennie C, Geoffroy JS, Rosen SD, Lasky LA : "A homing receptor-IgG chimera as a probe for adhesive ligands of lymph node high endothelial venules" . J Cell Biol 1990 ;110 :2221-2229

258. Webb LM, Ehrengruber MU, Clark-Lewis I, Baggiolini M, Rot A : "Binding to heparan sulfate or heparin enhances neutrophil responses to interleukin 8" . Proc Natl Acad Sci USA 1993 ;90 :7158-7162

259. Weber C, Erl W, Pietsch A, Strobel M, Ziegler-Heitbrock HW, Weber PC : "Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-kappa B mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicals" . Arterioscler Thromb 1994 ;14 :1665-1673

260. Weis JR, Pitas RE, Wilson BD, Rodgers GM : "Oxidized low-density lipoprotein increases cultured human endothelial cell tissue factor activity and reduces protein C activation" . FASEB Journal 1991 ;5 :2459-2465

261. Wray W, Boulikas T, Wray VP, Hancock R : "Silver staining of proteins in polyacrylamide gels" . Anal Biochem 1981 ;118 :197-203

262. Xi XP, Graf K, Goetze S, Fleck E, Hsueh WA, Law RE : "Central role of the MAPK pathway in ang II-mediated DNA synthesis and migration in rat vascular smooth muscle cells" . Arterioscler Thromb Vasc Biol 1999 ;19 :73-82

263. Yanagishita M : "Tunicamycin inhibits proteoglycan synthesis in rat ovarian granulosa cells in culture" . Arch Biochem Biophys 1986 ;251 :287-298

264. Yeh TC, Zhang W, Ildstad ST, Ho C : "In vivo dynamic MRI tracking of rat T-cells labeled with superparamagnetic iron-oxide particles" . Magn Reson Med 1995 ;33 :200-208

265. Ylä-Herttuala S, Palinski W, Butler SW, Picard S, Steinberg D, Witztum JL : "Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL" . Arterioscler Thromb 1994 ;14 :32-40

266. Ylä-Herttuala S, Palinski W, Rosenfeld ME, Parthasarathy S, Carew TE, Butler SW, Witztum JL, Steinberg D : "Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man" . J Clin Invest 1989 ;84 :1086-1095


267. Yuan C, Petty C, O'Brien KD, Hatsukami TS, Eary JF, Brown BG : "In vitro and in situ magnetic resonance imaging signal features of atherosclerotic plaque-associated lipids" . Arterioscler Thromb Vasc Biol 1997 ;17 :1496-1503

268. Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G : "Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators" . N Engl J Med 2000 ;342 :145-153

269. Zakrzewicz A, Gräfe M, Terbeek D, Bongrazio M, Auch-Schwelk W, Walzog B, Graf K, Fleck E, Ley K, Gaehtgens P : "L-selectin-dependent leukocyte adhesion to microvascular but not to macrovascular endothelial cells of the human coronary system" . Blood 1997 ;89 :3228-3235

270. Zakrzewicz A, Walzog B, Kansas GS, Tedder TF, Gaehtgens P, Ley K : "L-Selectin promotes neutrophil adhesion to fibronectin and fibrinogen under condition of flow" . J Cell Biochem Suppl 1994 ;18A :301-301(Abstract)

271. Zhang Y, Cliff WJ, Schoefl GI, Higgins G : "Immunohistological study of intimal microvessels in coronary atherosclerosis" . Am J Pathol 1993 ;143 :164-172

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