[Seite 88↓]


1. Abbassi, O., T. K. Kishimoto, L. V. McIntire, D. C. Anderson, and C. W. Smith. E-selectin supports neutrophil rolling in vitro under conditions of flow. J Clin.Invest 92: 2719-2730, 1993.

2. Adamson, R. H., F. E. Curry, G. Adamson, B. Liu, Y. Jiang, K. Aktories, H. Barth, A. Daigeler, N. Golenhofen, W. Ness, D. Drenckhahn. Rho and Rho kinase modulation of barrier properties: cultured endothelial cells and intact microvessels of rats and mice. J Physiol. 15: 295-308, 2002.

3. Airenne, S., H. M. Surcel, J. Tuukkanen, M. Leinonen, and P. Saikku. Chlamydia pneumoniae inhibits apoptosis in human epithelial and monocyte cell lines. Scand.J Immunol 55: 390-398, 2002.

4. Akira, S., K. Takeda, and T. Kaisho. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat.Immunol. 2: 675-680, 2001.

5. Aktories, K. Bacterial toxins that target Rho proteins. J Clin.Invest 99: 827-829, 1997.

6. Aktories, K., G. Schmidt, and I. Just. Rho GTPases as targets of bacterial protein toxins. Biol.Chem. 381: 421-426, 2000.

7. Alexander, J. S. and J. W. Elrod. Extracellular matrix, junctional integrity and matrix metalloproteinase interactions in endothelial permeability regulation. J Anat. 200: 561-574, 2002.

8. Andor, A., K. Trulzsch, M. Essler, A. Roggenkamp, A. Wiedemann, J. Heesemann, and M. Aepfelbacher. YopE of Yersinia, a GAP for Rho GTPases, selectively modulates Rac-dependent actin structures in endothelial cells. Cell Microbiol. 3: 301-310, 2001.

9. Arbibe, L., J. P. Mira, N. Teusch, L. Kline, M. Guha, N. Mackman, P. J. Godowski, R. J. Ulevitch, and U. G. Knaus. Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway. Nat.Immunol. 1: 533-540, 2000.

10. Auer, J., R. Berent, T. Weber, and B. Eber. Clinical significance of pleiotropic effects of statins: lipid reduction and beyond. Curr.Med.Chem. 9: 1831-1850, 2002.

[Seite 89↓]

11. Baldwin, A. L. and G. Thurston. Mechanics of endothelial cell architecture and vascular permeability. Crit Rev.Biomed.Eng 29: 247-278, 2001.

12. Barbieri, J. T., M. J. Riese, and K. Aktories. Bacterial toxins that modify the actin cytoskeleton. Annu.Rev.Cell Dev.Biol. 18: 315-344, 2002.

13. Bates, D. O. and F. E. Curry. Vascular endothelial growth factor increases hydraulic conductivity of isolated perfused microvessels. Am J Physiol 271: H2520-H2528, 1996.

14. Bates, D. O., N. J. Hillman, B. Williams, C. R. Neal, and T. M. Pocock. Regulation of microvascular permeability by vascular endothelial growth factors. J Anat. 200: 581-597, 2002.

15. Bevilacqua, M. P., S. Stengelin, M. A. Gimbrone, Jr., and B. Seed. Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science 243: 1160-1165, 1989.

16. Beyaert, R., K. Heyninck, and S. Van Huffel. A20 and A20-binding proteins as cellular inhibitors of nuclear factor-kappa B-dependent gene expression and apoptosis. Biochem.Pharmacol. 60: 1143-1151, 2000.

17. Bhakdi, S., H. Bayley, A. Valeva, I. Walev, B. Walker, M. Kehoe, and M. Palmer. Staphylococcal alpha-toxin, streptolysin-O, and Escherichia coli hemolysin: prototypes of pore-forming bacterial cytolysins. Arch.Microbiol. 165: 73-79, 1996.

18. Bhakdi, S., F. Grimminger, N. Suttorp, D. Walmrath, and W. Seeger. Proteinaceous bacterial toxins and pathogenesis of sepsis syndrome and septic shock: the unknown connection. Med.Microbiol.Immunol.(Berl) 183: 119-144, 1994.

19. Bhakdi, S., I. Walev, D. Jonas, M. Palmer, U. Weller, N. Suttorp, F. Grimminger, and W. Seeger. Pathogenesis of sepsis syndrome: possible relevance of pore-forming bacterial toxins. Curr.Top.Microbiol.Immunol. 216: 101-118, 1996.

20. Bloemen, P. G., M. C. van den Tweel, P. A. Henricks, F. Engels, S. S. Wagenaar, A. A. Rutten, and F. P. Nijkamp. Expression and modulation of adhesion molecules on human bronchial epithelial cells. Am J Respir.Cell Mol Biol. 9: 586-593, 1993.

21. Boettner, B. and L. Van Aelst. The role of Rho GTPases in disease development. Gene 286: 155-174, 2002.

[Seite 90↓]

22. Bogatcheva, N. V., J. G. Garcia, and A. D. Verin. Molecular mechanisms of thrombin-induced endothelial cell permeability. Biochemistry (Mosc.) 67: 75-84, 2002.

23. Bonfanti, R., B. C. Furie, B. Furie, and D. D. Wagner. PADGEM (GMP140) is a component of Weibel-Palade bodies of human endothelial cells. Blood 73: 1109-1112, 1989.

24. Boquet, P. Small GTP binding proteins and bacterial virulence. Microbes.Infect. 2: 837-843, 2000.

25. Branger, J., B. B. van den, S. Weijer, J. Madwed, C. L. Bos, A. Gupta, C. L. Yong, S. H. Polmar, D. P. Olszyna, C. E. Hack, S. J. van Deventer, M. P. Peppelenbosch, and P. T. van der. Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia. J Immunol 168: 4070-4077, 2002.

26. Brekken, R. A. and P. E. Thorpe. Vascular endothelial growth factor and vascular targeting of solid tumors. Anticancer Res 21: 4221-4229, 2001.

27. Bryant, A. E. and D. L. Stevens. Phospholipase C and perfringolysin O from Clostridium perfringens upregulate endothelial cell-leukocyte adherence molecule 1 and intercellular leukocyte adherence molecule 1 expression and induce interleukin-8 synthesis in cultured human umbilical vein endothelial cells. Infect.Immun. 64: 358-362, 1996.

28. Buerke, M., U. Sibelius, U. Grandel, U. Buerke, F. Grimminger, W. Seeger, J. Meyer, and H. Darius. Staphylococcus aureus alpha toxin mediates polymorphonuclear leukocyte-induced vasocontraction and endothelial dysfunction. Shock 17: 30-35, 2002.

29. Bullard, D. C. Adhesion molecules in inflammatory diseases: insights from knockout mice. Immunol Res 26: 27-33, 2002.

30. Bullard, D. C., E. J. Kunkel, H. Kubo, M. J. Hicks, I. Lorenzo, N. A. Doyle, C. M. Doerschuk, K. Ley, and A. L. Beaudet. Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice. J Exp.Med. 183: 2329-2336, 1996.

31. Bullard, D. C., L. Qin, I. Lorenzo, W. M. Quinlin, N. A. Doyle, R. Bosse, D. Vestweber, C. M. Doerschuk, and A. L. Beaudet. P-selectin/ICAM-1 double mutant mice: acute emigration of neutrophils into the peritoneum is completely absent but is normal into pulmonary alveoli. J Clin.Invest 95: 1782-1788, 1995.

[Seite 91↓]

32. Bulut, Y., E. Faure, L. Thomas, H. Karahashi, K. S. Michelsen, O. Equils, S. G. Morrison, R. P. Morrison, and M. Arditi. Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway. J Immunol 168: 1435-1440, 2002.

33. Burgess, A. W. and B. E. Anderson. Outer membrane proteins of Bartonella henselae and their interaction with human endothelial cells. Microb.Pathog. 25: 157-164, 1998.

34. Cameron, L. A., P. A. Giardini, F. S. Soo, and J. A. Theriot. Secrets of actin-based motility revealed by a bacterial pathogen. Nat.Rev.Mol Cell Biol. 1: 110-119, 2000.

35. Carbajal, J. M., M. L. Gratrix, C. H. Yu, and R. C. Schaeffer, Jr. ROCK mediates thrombin's endothelial barrier dysfunction. Am.J.Physiol Cell Physiol 279: C195-C204, 2000.

36. Carlos, T. M. and J. M. Harlan. Leukocyte-endothelial adhesion molecules. Blood 84: 2068-2101, 1994.

37. Caron, K. M. and O. Smithies. Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene. Proc.Natl.Acad.Sci.U.S.A 98: 615-619, 2001.

38. Carratelli, C. R., A. Rizzo, M. R. Catania, F. Galle, E. Losi, D. L. Hasty, and F. Rossano. Chlamydia pneumoniae infections prevent the programmed cell death on THP-1 cell line. FEMS Microbiol.Lett. 215: 69, 2002.

39. Chang, L. and M. Karin. Mammalian MAP kinase signalling cascades. Nature 410: 37-40, 2001.

40. Chavakis, T., M. Hussain, S. M. Kanse, G. Peters, R. G. Bretzel, J. I. Flock, M. Herrmann, and K. T. Preissner. Staphylococcus aureus extracellular adherence protein serves as anti-inflammatory factor by inhibiting the recruitment of host leukocytes. Nat.Med. 8: 687-693, 2002.

41. Clauss, M., M. Grell, C. Fangmann, W. Fiers, P. Scheurich, and W. Risau. Synergistic induction of endothelial tissue factor by tumor necrosis factor and vascular endothelial growth factor: functional analysis of the tumor necrosis factor receptors. FEBS Lett. 390: 334-338, 1996.

42. Coghlan, M. P., M. M. Chou, and C. L. Carpenter. Atypical protein kinases C -lambda and -zeta associate with the GTP-binding protein Cdc42 and mediate stress fiber loss. Mol Cell Biol. 20: 2880-2889, 2000.

[Seite 92↓]

43. Cornelis, G. R. The Yersinia Ysc-Yop 'Type III' weaponry. Nat.Rev.Mol Cell Biol. 3: 742-754, 2002.

44. Cossart, P. Met, the HGF-SF receptor: another receptor for Listeria monocytogenes. Trends Microbiol. 9: 105-107, 2001.

45. Cossart, P. Molecular and cellular basis of the infection by Listeria monocytogenes: an overview. Int.J Med.Microbiol. 291: 401-409, 2002.

46. Cossart, P. and H. Bierne. The use of host cell machinery in the pathogenesis of Listeria monocytogenes. Curr.Opin.Immunol 13: 96-103, 2001.

47. Coughlin, S. R. Protease-activated receptors in vascular biology. Thromb.Haemost. 86: 298-307, 2001.

48. Cundell, D. R., N. P. Gerard, C. Gerard, I. Idanpaan-Heikkila, and E. I. Tuomanen. Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor. Nature 377: Eur.Respir.J

49. Darveau, R. P., S. Arbabi, I. Garcia, B. Bainbridge, and R. V. Maier. Porphyromonas gingivalis lipopolysaccharide is both agonist and antagonist for p38 mitogen-activated protein kinase activation. Infect.Immun. 70: 1867-1873, 2002.

50. de Fougerolles, A. R., S. A. Stacker, R. Schwarting, and T. A. Springer. Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1. J Exp.Med. 174: 253-267, 1991.

51. De Martin, R., M. Hoeth, R. Hofer-Warbinek, and J. A. Schmid. The transcription factor NF-kappa B and the regulation of vascular cell function. Arterioscler.Thromb.Vasc.Biol. 20: E83-E88, 2000.

52. Dehio, C. Interactions of Bartonella henselae with vascular endothelial cells. Curr.Opin.Microbiol. 2: 78-82, 1999.

53. Dehio, C. Bartonella interactions with endothelial cells and erythrocytes. Trends Microbiol. 9: 279-285, 2001.

54. Dehio, C., M. Meyer, J. Berger, H. Schwarz, and C. Lanz. Interaction of Bartonella henselae with endothelial cells results in bacterial aggregation on the cell surface and the subsequent engulfment and internalisation of the bacterial aggregate by a unique structure, the invasome. J Cell Sci 110: 2141-2154, 1997.

[Seite 93↓]

55. Dejana, E., R. Spagnuolo, and G. Bazzoni. Interendothelial junctions and their role in the control of angiogenesis, vascular permeability and leukocyte transmigration. Thromb.Haemost. 86: 308-315, 2001.

56. Desagher, S. and J. C. Martinou. Mitochondria as the central control point of apoptosis. Trends Cell Biol. 10: 369-377, 2000.

57. Dong, C., R. J. Davis, and R. A. Flavell. MAP kinases in the immune response. Annu.Rev.Immunol 20: 55-72, 2002.

58. Drevets, D. A. Listeria monocytogenes virulence factors that stimulate endothelial cells. Infect.Immun. 66: 232-238, 1998.

59. Drevets, D. A., R. T. Sawyer, T. A. Potter, and P. A. Campbell. Listeria monocytogenes infects human endothelial cells by two distinct mechanisms. Infect.Immun. 63: 4268-4276, 1995.

60. Drier, E. A., L. H. Huang, and R. Steward. Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation. Genes Dev. 13: 556-568, 1999.

61. Dugan, J. P., R. R. Feuge, and D. S. Burgess. Review of evidence for a connection between Chlamydia pneumoniae and atherosclerotic disease. Clin.Ther. 24: 719-735, 2002.

62. Dvorak, A. M. and D. Feng. The vesiculo-vacuolar organelle (VVO). A new endothelial cell permeability organelle. J Histochem.Cytochem. 49: 419-432, 2001.

63. Dvorak, A. M., S. Kohn, E. S. Morgan, P. Fox, J. A. Nagy, and H. F. Dvorak. The vesiculo-vacuolar organelle (VVO): a distinct endothelial cell structure that provides a transcellular pathway for macromolecular extravasation. J Leukoc.Biol. 59: 100-115, 1996.

64. Earnshaw, W. C., L. M. Martins, and S. H. Kaufmann. Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu.Rev.Biochem. 68: 383-424, 1999.

65. Edfeldt, K., J. Swedenborg, G. K. Hansson, and Z. Q. Yan. Expression of toll-like receptors in human atherosclerotic lesions: a possible pathway for plaque activation. Circulation 105: 1158-1161, 2002.

[Seite 94↓]

66. Elices, M. J., L. Osborn, Y. Takada, C. Crouse, S. Luhowskyj, M. E. Hemler, and R. R. Lobb. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell 60: 577-584, 1990.

67. Ermert, L., H. Bruckner, D. Walmrath, F. Grimminger, K. Aktories, N. Suttorp, H. R. Duncker, and W. Seeger. Role of endothelial cytoskeleton in high-permeability edema due to botulinum C2 toxin in perfused rabbit lungs. Am.J.Physiol 268: L753-L761, 1995.

68. Essayan, D. M. Cyclic nucleotide phosphodiesterases. J Allergy Clin.Immunol 108: 671-680, 2001.

69. Essler, M., J. M. Staddon, P. C. Weber, and M. Aepfelbacher. Cyclic AMP blocks bacterial lipopolysaccharide-induced myosin light chain phosphorylation in endothelial cells through inhibition of Rho/Rho kinase signaling. J.Immunol. 164: 6543-6549, 2000.

70. Fein, A. M. and M. G. Calalang-Colucci. Acute lung injury and acute respiratory distress syndrome in sepsis and septic shock. Crit Care Clin. 16: 289-317, 2000.

71. Feng, D., J. A. Nagy, J. Hipp, H. F. Dvorak, and A. M. Dvorak. Vesiculo-vacuolar organelles and the regulation of venule permeability to macromolecules by vascular permeability factor, histamine, and serotonin. J Exp.Med. 183: 1981-1986, 1996.

72. Feng, D., J. A. Nagy, K. Pyne, I. Hammel, H. F. Dvorak, and A. M. Dvorak. Pathways of macromolecular extravasation across microvascular endothelium in response to VPF/VEGF and other vasoactive mediators. Microcirculation. 6: 23-44, 1999.

73. Ferrara, N. Molecular and biological properties of vascular endothelial growth factor. J Mol.Med. 77: 527-543, 1999.

74. Ferrara, N., K. Houck, L. Jakeman, and D. W. Leung. Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocr.Rev. 13: 18-32, 1992.

75. Fischer, S. F., C. Schwarz, J. Vier, and G. Hacker. Characterization of antiapoptotic activities of Chlamydia pneumoniae in human cells. Infect.Immun. 69: 7121-7129, 2001.

[Seite 95↓]

76. Flusberg, D. A., Y. Numaguchi, and D. E. Ingber. Cooperative control of Akt phosphorylation, bcl-2 expression, and apoptosis by cytoskeletal microfilaments and microtubules in capillary endothelial cells. Mol Biol.Cell 12: 3087-3094, 2001.

77. Folkman, J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat.Med. 1: 27-31, 1995.

78. Garcia, J. G., P. Wang, K. L. Schaphorst, P. M. Becker, T. Borbiev, F. Liu, A. Birukova, K. Jacobs, N. Bogatcheva, and A. D. Verin. Critical involvement of p38 MAP kinase in pertussis toxin-induced cytoskeletal reorganization and lung permeability. FASEB J 16: 1064-1076, 2002.

79. Geyer, M. and A. Wittinghofer. GEFs, GAPs, GDIs and effectors: taking a closer (3D) look at the regulation of Ras-related GTP-binding proteins. Curr.Opin.Struct.Biol. 7: 786-792, 1997.

80. Ghannoum, M. A. Potential role of phospholipases in virulence and fungal pathogenesis. Clin.Microbiol.Rev. 13: 122-43, table, 2000.

81. Ghersa, P., V. H. Hooft, J. Whelan, and J. F. DeLamarter. Labile proteins play a dual role in the control of endothelial leukocyte adhesion molecule-1 (ELAM-1) gene regulation. J Biol.Chem. 267: 19226-19232, 1992.

82. Ghosh, S., M. J. May, and E. B. Kopp. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu.Rev.Immunol 16: 225-260, 1998.

83. Gonzalez-Amaro, R., F. Diaz-Gonzalez, and F. Sanchez-Madrid. Adhesion molecules in inflammatory diseases. Drugs 56: 977-988, 1998.

84. Goth, S. R. and R. S. Stephens. Rapid, transient phosphatidylserine externalization induced in host cells by infection with Chlamydia spp. Infect.Immun. 69: 1109-1119, 2001.

85. Grandel, U., M. Reutemann, L. Kiss, M. Buerke, L. Fink, E. Bournelis, M. Heep, W. Seeger, F. Grimminger, and U. Sibelius. Staphylococcal alpha-toxin provokes neutrophil-dependent cardiac dysfunction: role of ICAM-1 and cys-leukotrienes. Am J Physiol Heart Circ Physiol 282: H1157-H1165, 2002.

[Seite 96↓]

86. Grandel, U., U. Sibelius, J. Schrickel, D. Schmidt, M. Buerke, L. Fink, E. Bournelis, M. Heep, K. Mayer, R. M. Bohle, W. Seeger, and F. Grimminger. Biosynthesis of constitutive nitric oxide synthase-derived nitric oxide attenuates coronary vasoconstriction and myocardial depression in a model of septic heart failure induced by Staphylococcus aureus alpha-toxin. Crit Care Med. 29: 1-7, 2001.

87. Grimminger, F., F. Rose, U. Sibelius, M. Meinhardt, B. Potzsch, R. Spriestersbach, S. Bhakdi, N. Suttorp, and W. Seeger. Human endothelial cell activation and mediator release in response to the bacterial exotoxins Escherichia coli hemolysin and staphylococcal alpha-toxin. J Immunol 159: 1909-1916, 1997.

88. Grimminger, F., U. Sibelius, S. Bhakdi, N. Suttorp, and W. Seeger. Escherichia coli hemolysin is a potent inductor of phosphoinositide hydrolysis and related metabolic responses in human neutrophils. J Clin.Invest 88: 1531-1539, 1991.

89. Hack, C. E. and S. Zeerleder. The endothelium in sepsis: source of and a target for inflammation. Crit Care Med. 29: S21-S27, 2001.

90. Hammerschlag, M. R. Chlamydia pneumoniae and the lung. Eur.Respir.J 16: 1001-1007, 2000.

91. Harlan, J. M. and R. K. Winn. Leukocyte-endothelial interactions: clinical trials of anti-adhesion therapy. Crit Care Med. 30: S214-S219, 2002.

92. Haynes, L. M., D. D. Moore, E. A. Kurt-Jones, R. W. Finberg, L. J. Anderson, and R. A. Tripp. Involvement of toll-like receptor 4 in innate immunity to respiratory syncytial virus. J Virol. 75: 10730-10737, 2001.

93. Henneke, P. and D. T. Golenbock. Innate immune recognition of lipopolysaccharide by endothelial cells. Crit Care Med. 30: S207-S213, 2002.

94. Hinson, J. P., S. Kapas, and D. M. Smith. Adrenomedullin, a multifunctional regulatory peptide. Endocr.Rev. 21: 138-167, 2000.

95. Hommes, D., B. B. van den, T. Plasse, J. Bartelsman, C. Xu, B. Macpherson, G. Tytgat, M. Peppelenbosch, and S. Van Deventer. Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn's disease. Gastroenterology 122: 7-14, 2002.

96. Huang, S. H., T. Triche, and A. Y. Jong. Infectomics: genomics and proteomics of microbial infections. Funct.Integr.Genomics 1: 331-344, 2002.

[Seite 97↓]

97. Hubbard, A. K. and R. Rothlein. Intercellular adhesion molecule-1 (ICAM-1) expression and cell signaling cascades. Free Radic.Biol.Med. 28: 1379-1386, 2000.

98. Hynes, R. Integrins: bidirectional, allosteric signaling machines. Cell 110: 673-687, 2002.

99. Ishida, I., H. Kubo, S. Suzuki, T. Suzuki, S. Akashi, K. Inoue, S. Maeda, H. Kikuchi, H. Sasaki, and T. Kondo. Hypoxia diminishes toll-like receptor 4 expression through reactive oxygen species generated by mitochondria in endothelial cells. J Immunol 169: 2069-2075, 2002.

100. Ishimitsu, T., A. Miyata, H. Matsuoka, and K. Kangawa. Transcriptional regulation of human adrenomedullin gene in vascular endothelial cells. Biochem.Biophys.Res.Commun. 243: 463-470, 1998.

101. Israel, A. The IKK complex: an integrator of all signals that activate NF-kappaB? Trends Cell Biol. 10: 129-133, 2000.

102. Issekutz, A. C., D. Rowter, and T. A. Springer. Role of ICAM-1 and ICAM-2 and alternate CD11/CD18 ligands in neutrophil transendothelial migration. J Leukoc.Biol. 65: 117-126, 1999.

103. Just, I. and P. Boquet. Large clostridial cytotoxins as tools in cell biology. Curr.Top.Microbiol.Immunol. 250:97-107.: 97-107, 2000.

104. Just, I., F. Hofmann, and K. Aktories. Molecular mode of action of the large clostridial cytotoxins. Curr.Top.Microbiol.Immunol. 250:55-83.: 55-83, 2000.

105. Just, I., F. Hofmann, H. Genth, and R. Gerhard. Bacterial protein toxins inhibiting low-molecular-mass GTP-binding proteins. Int.J Med.Microbiol. 291: 243-250, 2001.

106. Kansas, G. S. Selectins and their ligands: current concepts and controversies. Blood 88: 3259-3287, 1996.

107. Karch, H. The role of virulence factors in enterohemorrhagic Escherichia coli (EHEC)--associated hemolytic-uremic syndrome. Semin.Thromb.Hemost. 27: 207-213, 2001.

[Seite 98↓]

108. Kayyali, U. S., C. M. Pennella, C. Trujillo, O. Villa, M. Gaestel, and P. M. Hassoun. Cytoskeletal changes in hypoxic pulmonary endothelial cells are dependent on MAPK-activated protein kinase MK2. J Biol.Chem. 277: 42596-42602, 2002.

109. Kempf, V. A., N. Hitziger, T. Riess, and I. B. Autenrieth. Do plant and human pathogens have a common pathogenicity strategy? Trends Microbiol. 10: 269-275, 2002.

110. Kempf, V. A., M. Schaller, S. Behrendt, B. Volkmann, M. Aepfelbacher, I. Cakman, and I. B. Autenrieth. Interaction of Bartonella henselae with endothelial cells results in rapid bacterial rRNA synthesis and replication. Cell Microbiol. 2: 431-441, 2000.

111. Kern, D. F. and A. B. Malik. Microvascular albumin permeability in isolated perfused lung: effects of EDTA. J Appl.Physiol 58: 372-375, 1985.

112. Kibbe, M., T. Billiar, and E. Tzeng. Inducible nitric oxide synthase and vascular injury. Cardiovasc.Res 43: 650-657, 1999.

113. Kiemer, A. K., N. C. Weber, R. Furst, N. Bildner, S. Kulhanek-Heinze, and A. M. Vollmar. Inhibition of p38 MAPK activation via induction of MKP-1: atrial natriuretic peptide reduces TNF-alpha-induced actin polymerization and endothelial permeability. Circ Res 90: 874-881, 2002.

114. Kjoller, L. and A. Hall. Signaling to Rho GTPases. Exp.Cell Res. 253: 166-179, 1999.

115. Koehler, J. E., C. A. Glaser, and J. W. Tappero. Rochalimaea henselae infection. A new zoonosis with the domestic cat as reservoir. JAMA 271: 531-535, 1994.

116. Koehler, J. E., M. A. Sanchez, C. S. Garrido, M. J. Whitfeld, F. M. Chen, T. G. Berger, M. C. Rodriguez-Barradas, P. E. LeBoit, and J. W. Tappero. Molecular epidemiology of Bartonella infections in patients with bacillary angiomatosis-peliosis. N.Engl.J Med. 337: 1876-1883, 1997.

117. Koo, D. J., M. Zhou, I. H. Chaudry, and P. Wang. The role of adrenomedullin in producing differential hemodynamic responses during sepsis. J Surg.Res. 95: 207-218, 2001.

118. Kotlyarov, A., A. Neininger, C. Schubert, R. Eckert, C. Birchmeier, H. D. Volk, and M. Gaestel. MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis. Nat.Cell Biol. 1: 94-97, 1999.

[Seite 99↓]

119. Krendel, M., F. T. Zenke, and G. M. Bokoch. Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton. Nat.Cell Biol. 4: 294-301, 2002.

120. Kyriakis, J. M. and J. Avruch. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev. 81: 807-869, 2001.

121. Laufs, U. and J. K. Liao. Direct vascular effects of HMG-CoA reductase inhibitors. Trends Cardiovasc.Med. 10: 143-148, 2000.

122. Laufs, U. and J. K. Liao. Targeting Rho in cardiovascular disease. Circ.Res. 87: 526-528, 2000.

123. Lawrence, M. B. and T. A. Springer. Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins. Cell 65: 859-873, 1991.

124. Lawrence, M. B. and T. A. Springer. Neutrophils roll on E-selectin. J Immunol 151: 6338-6346, 1993.

125. Ledebur, H. C. and T. P. Parks. Transcriptional regulation of the intercellular adhesion molecule-1 gene by inflammatory cytokines in human endothelial cells. Essential roles of a variant NF-kappa B site and p65 homodimers. J Biol.Chem. 270: 933-943, 1995.

126. Lee, J. S. and A. I. Gotlieb. Microtubule-actin interactions may regulate endothelial integrity and repair. Cardiovasc.Pathol 11: 135-140, 2002.

127. Lehner, M. D., F. Schwoebel, A. Kotlyarov, M. Leist, M. Gaestel, and T. Hartung. Mitogen-activated protein kinase-activated protein kinase 2-deficient mice show increased susceptibility to Listeria monocytogenes infection. J Immunol 168: 4667-4673, 2002.

128. Leinonen, M. and P. Saikku. Evidence for infectious agents in cardiovascular disease and atherosclerosis. Lancet Infect.Dis. 2: 11-17, 2002.

129. Lentsch, A. B. and P. A. Ward. Regulation of inflammatory vascular damage. J Pathol 190: 343-348, 2000.

130. Levi, M., H. ten Cate, and P. T. van der. Endothelium: interface between coagulation and inflammation. Crit Care Med. 30: S220-S224, 2002.

[Seite 100↓]

131. Ley, K. Integration of inflammatory signals by rolling neutrophils. Immunol Rev. 186: 8-18, 2002.

132. Ley, K. and T. F. Tedder. Leukocyte interactions with vascular endothelium. New insights into selectin-mediated attachment and rolling. J Immunol 155: 525-528, 1995.

133. Li, Q. and I. M. Verma. NF-kappaB regulation in the immune system. Nat.Rev.Immunol 2: 725-734, 2002.

134. Lush, C. W. and P. R. Kvietys. Microvascular dysfunction in sepsis. Microcirculation. 7: 83-101, 2000.

135. Mansell, A., N. Khelef, P. Cossart, and L. A. O'Neill. Internalin B activates nuclear factor-kappa B via Ras, phosphoinositide 3-kinase, and Akt. J Biol.Chem. 276: 43597-43603, 2001.

136. Mantovani, A., S. Sozzani, A. Vecchi, M. Introna, and P. Allavena. Cytokine activation of endothelial cells: new molecules for an old paradigm. Thromb.Haemost. 78: 406-414, 1997.

137. Marti, H. H. and W. Risau. Systemic hypoxia changes the organ-specific distribution of vascular endothelial growth factor and its receptors. Proc.Natl.Acad.Sci U.S.A 95: 15809-15814, 1998.

138. Massey, R. C., M. N. Kantzanou, T. Fowler, N. P. Day, K. Schofield, E. R. Wann, A. R. Berendt, M. Hook, and S. J. Peacock. Fibronectin-binding protein A of Staphylococcus aureus has multiple, substituting, binding regions that mediate adherence to fibronectin and invasion of endothelial cells. Cell Microbiol. 3: 839-851, 2001.

139. Matsumoto, T., I. Turesson, M. Book, P. Gerwins, and L. Claesson-Welsh. p38 MAP kinase negatively regulates endothelial cell survival, proliferation, and differentiation in FGF-2-stimulated angiogenesis. J Cell Biol. 156: 149-160, 2002.

140. May, M. J. and S. Ghosh. Rel/NF-kappa B and I kappa B proteins: an overview. Semin.Cancer Biol. 8: 63-73, 1997.

141. Mayer, K., B. Temmesfeld-Wollbruck, A. Friedland, H. Olschewski, M. Reich, W. Seeger, and A. F. Grimminger. Severe microcirculatory abnormalities elicited by E. coli hemolysin in the rabbit ileum mucosa. Am J Respir.Crit Care Med. 160: 1171-1178, 1999.

[Seite 101↓]

142. McEver, R. P. Adhesive interactions of leukocytes, platelets, and the vessel wall during hemostasis and inflammation. Thromb.Haemost. 86: 746-756, 2001.

143. McEver, R. P., K. L. Moore, and R. D. Cummings. Leukocyte trafficking mediated by selectin-carbohydrate interactions. J Biol.Chem. 270: 11025-11028, 1995.

144. Molestina, R. E., J. B. Klein, R. D. Miller, W. H. Pierce, J. A. Ramirez, and J. T. Summersgill. Proteomic analysis of differentially expressed Chlamydia pneumoniae genes during persistent infection of HEp-2 cells. Infect.Immun. 70: 2976-2981, 2002.

145. Montaner, S., R. Perona, L. Saniger, and J. C. Lacal. Multiple signalling pathways lead to the activation of the nuclear factor kappaB by the Rho family of GTPases. J.Biol.Chem. 273: 12779-12785, 1998.

146. Montaner, S., R. Perona, L. Saniger, and J. C. Lacal. Activation of serum response factor by RhoA is mediated by the nuclear factor-kappaB and C/EBP transcription factors. J Biol.Chem. 274: 8506-8515, 1999.

147. Moore, K. L., N. L. Stults, S. Diaz, D. F. Smith, R. D. Cummings, A. Varki, and R. P. McEver. Identification of a specific glycoprotein ligand for P-selectin (CD62) on myeloid cells. J Cell Biol. 118: 445-456, 1992.

148. Muller, W. A. Leukocyte-endothelial cell interactions in the inflammatory response. Lab Invest 82: 521-533, 2002.

149. Nassif, X., S. Bourdoulous, E. Eugene, and P. O. Couraud. How do extracellular pathogens cross the blood-brain barrier? Trends Microbiol. 10: 227-232, 2002.

150. Nieuw Amerongen, G. P., S. van Delft, M. A. Vermeer, J. G. Collard, and V. W. van Hinsbergh. Activation of RhoA by thrombin in endothelial hyperpermeability: role of Rho kinase and protein tyrosine kinases. Circ.Res. 87: 335-340, 2000.

151. Nieuw Amerongen, G. P. and V. W. van Hinsbergh. Cytoskeletal effects of Rho-like small guanine nucleotide-binding proteins in the vascular system. Arterioscler.Thromb.Vasc.Biol. 21: 300-311, 2001.

[Seite 102↓]

152. Niwa, K., O. Inanami, T. Ohta, S. Ito, T. Karino, and M. Kuwabara. p38 MAPK and Ca2+ contribute to hydrogen peroxide-induced increase of permeability in vascular endothelial cells but ERK does not. Free Radic.Res 35: 519-527, 2001.

153. Noll, G. Pathogenesis of atherosclerosis: a possible relation to infection. Atherosclerosis 140 Suppl 1: S3-S9, 1998.

154. Nwariaku, F. E., J. Chang, X. Zhu, Z. Liu, S. L. Duffy, N. H. Halaihel, L. Terada, and R. H. Turnage. The role of p38 map kinase in tumor necrosis factor-induced redistribution of vascular endothelial cadherin and increased endothelial permeability. Shock 18: 82-85, 2002.

155. Ono, Y., I. Okano, M. Kojima, K. Okada, and K. Kangawa. Decreased gene expression of adrenomedullin receptor in mouse lungs during sepsis. Biochem.Biophys.Res.Commun. 271: 197-202, 2000.

156. Ornan, D. A., I. H. Chaudry, and P. Wang. Pulmonary clearance of adrenomedullin is reduced during the late stage of sepsis. Biochim.Biophys.Acta 1427: 315-321, 1999.

157. Ornan, D. A., I. H. Chaudry, and P. Wang. Saturation of adrenomedullin receptors plays an important role in reducing pulmonary clearance of adrenomedullin during the late stage of sepsis. Biochim.Biophys.Acta 1586: 299-306, 2002.

158. Pantaloni, D., C. Le Clainche, and M. F. Carlier. Mechanism of actin-based motility. Science 292: 1502-1506, 2001.

159. Perfettini, J. L., J. C. Reed, N. Israel, J. C. Martinou, A. Dautry-Varsat, and D. M. Ojcius. Role of Bcl-2 family members in caspase-independent apoptosis during Chlamydia infection. Infect.Immun. 70: 55-61, 2002.

160. Perona, R., S. Montaner, L. Saniger, I. Sanchez-Perez, R. Bravo, and J. C. Lacal. Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins. Genes Dev. 11: 463-475, 1997.

161. Peters, C. J. and S. R. Zaki. Role of the endothelium in viral hemorrhagic fevers. Crit Care Med. 30: S268-S273, 2002.

162. Petzelbauer, P., T. Halama, and M. Groger. Endothelial adherens junctions. J Investig.Dermatol.Symp.Proc. 5: 10-13, 2000.

[Seite 103↓]

163. Pio, R., T. H. Elsasser, A. Martinez, and F. Cuttitta. Identification, characterization, and physiological actions of factor H as an adrenomedullin binding protein present in human plasma. Microsc.Res Tech. 57: 23-27, 2002.

164. Poole, L. J., Y. Yu, P. S. Kim, Q. Z. Zheng, J. Pevsner, and G. S. Hayward. Altered patterns of cellular gene expression in dermal microvascular endothelial cells infected with Kaposi's sarcoma-associated herpesvirus. J Virol. 76: 3395-3420, 2002.

165. Poppert, S., R. Marre, and A. Essig. Biology and clinical significance of Chlamydiae. Contrib.Microbiol. 8: 51-71, 2001.

166. Portnoy, D. A., V. Auerbuch, and I. J. Glomski. The cell biology of Listeria monocytogenes infection: the intersection of bacterial pathogenesis and cell-mediated immunity. J Cell Biol. 158: 409-414, 2002.

167. Prasad, A., J. Zhu, J. P. Halcox, M. A. Waclawiw, S. E. Epstein, and A. A. Quyyumi. Predisposition to atherosclerosis by infections: role of endothelial dysfunction. Circulation 106: 184-190, 2002.

168. Prescott, S. M., T. M. McIntyre, and G. A. Zimmerman. The role of platelet-activating factor in endothelial cells. Thromb.Haemost. 64: 99-103, 1990.

169. Probert, L., K. Akassoglou, L. Alexopoulou, E. Douni, S. Haralambous, S. Hill, G. Kassiotis, D. Kontoyiannis, M. Pasparakis, D. Plows, and G. Kollias. Dissection of the pathologies induced by transmembrane and wild-type tumor necrosis factor in transgenic mice. J Leukoc.Biol. 59: 518-525, 1996.

170. Pruefer, D., J. Makowski, M. Schnell, U. Buerke, M. Dahm, H. Oelert, U. Sibelius, U. Grandel, F. Grimminger, W. Seeger, J. Meyer, H. Darius, and M. Buerke. Simvastatin inhibits inflammatory properties of Staphylococcus aureus alpha-toxin. Circulation 106: 2104-2110, 2002.

171. Rice, G. E., J. M. Munro, and M. P. Bevilacqua. Inducible cell adhesion molecule 110 (INCAM-110) is an endothelial receptor for lymphocytes. A CD11/CD18-independent adhesion mechanism. J Exp.Med. 171: 1369-1374, 1990.

172. Ridley, A. J. Rho family proteins: coordinating cell responses. Trends Cell Biol. 11: 471-477, 2001.

173. Ring, A., J. N. Weiser, and E. I. Tuomanen. Pneumococcal trafficking across the blood-brain barrier. Molecular analysis of a novel bidirectional pathway. J Clin.Invest 102: 347-360, 1998.

[Seite 104↓]

174. Rippe, B. and B. Haraldsson. Transport of macromolecules across microvascular walls: the two-pore theory. Physiol Rev. 74: 163-219, 1994.

175. Risau, W. Mechanisms of angiogenesis. Nature 386: 671-674, 1997.

176. Risau, W. and I. Flamme. Vasculogenesis. Annu.Rev.Cell Dev.Biol. 11: 73-91, 1995.

177. Rose, F., L. Kiss, F. Grimminger, K. Mayer, U. Grandel, W. Seeger, E. Bieniek, and U. Sibelius. E. coli hemolysin-induced lipid mediator metabolism in alveolar macrophages: impact of eicosapentaenoic acid. Am J Physiol Lung Cell Mol Physiol 279: L100-L109, 2000.

178. Rosenkranz, A. R. and T. N. Mayadas. Leukocyte-endothelial cell interactions - lessons from knockout mice. Exp.Nephrol. 7: 125-136, 1999.

179. Rossiter, H., R. Alon, and T. S. Kupper. Selectins, T-cell rolling and inflammation. Mol Med.Today 3: 214-222, 1997.

180. Rot, A. Endothelial cell binding of NAP-1/IL-8: role in neutrophil emigration. Immunol Today 13: 291-294, 1992.

181. Sasu, S., D. LaVerda, N. Qureshi, D. T. Golenbock, and D. Beasley. Chlamydia pneumoniae and chlamydial heat shock protein 60 stimulate proliferation of human vascular smooth muscle cells via toll-like receptor 4 and p44/p42 mitogen-activated protein kinase activation. Circ Res 89: 244-250, 2001.

182. Schaphorst, K. L., F. M. Pavalko, C. E. Patterson, and J. G. Garcia. Thrombin-mediated focal adhesion plaque reorganization in endothelium: role of protein phosphorylation. Am J Respir.Cell Mol.Biol. 17: 443-455, 1997.

183. Schenkel, A. R., Z. Mamdouh, X. Chen, R. M. Liebman, and W. A. Muller. CD99 plays a major role in the migration of monocytes through endothelial junctions. Nat.Immunol 3: 143-150, 2002.

184. Schmiel, D. H. and V. L. Miller. Bacterial phospholipases and pathogenesis. Microbes.Infect. 1: 1103-1112, 1999.

185. Schmitz, H. P., A. Lorberg, and J. J. Heinisch. Regulation of yeast protein kinase C activity by interaction with the small GTPase Rho1p through its amino-terminal HR1 domain. Mol Microbiol. 44: 829-840, 2002.

[Seite 105↓]

186. Schnittler, H. J. and H. Feldmann. Molecular pathogenesis of filovirus infections: role of macrophages and endothelial cells. Curr.Top.Microbiol.Immunol 235: 175-204, 1999.

187. Schnittler, H. J., A. Wilke, T. Gress, N. Suttorp, and D. Drenckhahn. Role of actin and myosin in the control of paracellular permeability in pig, rat and human vascular endothelium. J.Physiol 431: 379-401, 1990.

188. Schütte, H., S. Rosseau, R. Czymek, L. Ermert, D. Walmrath, H. J. Krämer, W. Seeger, and F. Grimminger. Synergism between endotoxin priming and exotoxin challenge in provoking severe vascular leakage in rabbit lungs. Am J Respir.Crit Care Med. 156: 819-824, 1997.

189. Seeger, W., R. G. Birkemeyer, L. Ermert, N. Suttorp, S. Bhakdi, and H. R. Duncker. Staphylococcal alpha-toxin-induced vascular leakage in isolated perfused rabbit lungs. Lab Invest 63: 341-349, 1990.

190. Seeger, W., T. Hansen, R. Rossig, T. Schmehl, H. Schütte, H. J. Krämer, D. Walmrath, N. Weissmann, F. Grimminger, and N. Suttorp. Hydrogen peroxide-induced increase in lung endothelial and epithelial permeability--effect of adenylate cyclase stimulation and phosphodiesterase inhibition. Microvasc.Res. 50: 1-17, 1995.

191. Seeger, W., H. Walter, H. Neuhof, N. Suttorp, and S. Bhakdi. Escherichia coli hemolysin causes thromboxane-mediated hypertension and vascular leakage in rabbit lungs. Prog.Clin.Biol.Res. 308: 67-72, 1989.

192. Senftleben, U. and M. Karin. The IKK/NF-kappa B pathway. Crit Care Med. 30: S18-S26, 2002.

193. Shibuya, M. Structure and function of VEGF/VEGF-receptor system involved in angiogenesis. Cell Struct.Funct. 26: 25-35, 2001.

194. Shindo, T., H. Kurihara, K. Maemura, Y. Kurihara, T. Kuwaki, T. Izumida, N. Minamino, K. H. Ju, H. Morita, Y. Oh-hashi, M. Kumada, K. Kangawa, R. Nagai, and Y. Yazaki. Hypotension and resistance to lipopolysaccharide-induced shock in transgenic mice overexpressing adrenomedullin in their vasculature. Circulation 101: 2309-2316, 2000.

195. Singh, R., B. Wang, A. Shirvaikar, S. Khan, S. Kamat, J. R. Schelling, M. Konieczkowski, and J. R. Sedor. The IL-1 receptor and Rho directly associate to drive cell activation in inflammation. J.Clin.Invest 103: 1561-1570, 1999.

[Seite 106↓]

196. Sinha, B., P. Francois, Y. A. Que, M. Hussain, C. Heilmann, P. Moreillon, D. Lew, K. H. Krause, G. Peters, and M. Herrmann. Heterologously expressed Staphylococcus aureus fibronectin-binding proteins are sufficient for invasion of host cells. Infect.Immun. 68: 6871-6878, 2000.

197. Sinha, B., P. P. Francois, O. Nusse, M. Foti, O. M. Hartford, P. Vaudaux, T. J. Foster, D. P. Lew, M. Herrmann, and K. H. Krause. Fibronectin-binding protein acts as Staphylococcus aureus invasin via fibronectin bridging to integrin a 5 b 1. Cell Microbiol. 1: 101-117, 1999.

198. Slater, S. J., J. L. Seiz, B. A. Stagliano, and C. D. Stubbs. Interaction of protein kinase C isozymes with Rho GTPases. Biochemistry 40: 4437-4445, 2001.

199. Soderling, S. H. and J. A. Beavo. Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions. Curr.Opin.Cell Biol. 12: 174-179, 2000.

200. Steele-Mortimer, O., L. A. Knodler, and B. B. Finlay. Poisons, ruffles and rockets: bacterial pathogens and the host cell cytoskeleton. Traffic. 1: 107-118, 2000.

201. Stenner-Liewen, F., H. Liewen, J. M. Zapata, K. Pawlowski, A. Godzik, and J. C. Reed. CADD, a Chlamydia protein that interacts with death receptors. J Biol.Chem. 277: 9633-9636, 2002.

202. Stevens, T., J. G. Garcia, D. M. Shasby, J. Bhattacharya, and A. B. Malik. Mechanisms regulating endothelial cell barrier function. Am.J.Physiol Lung Cell Mol.Physiol 279: L419-L422, 2000.

203. Sukumaran, S. K. and N. V. Prasadarao. Regulation of protein kinase C in Escherichia coli K1 invasion of human brain microvascular endothelial cells. J Biol.Chem. 277: 12253-12262, 2002.

204. Summersgill, J. T., R. E. Molestina, R. D. Miller, and J. A. Ramirez. Interactions of Chlamydia pneumoniae with human endothelial cells. J Infect.Dis. 181: S479-82, 2000.

205. Suttorp, N., B. Floer, H. Schnittler, W. Seeger, and S. Bhakdi. Effects of Escherichia coli hemolysin on endothelial cell function. Infect.Immun. 58: 3796-3801, 1990.

[Seite 107↓]

206. Suttorp, N., M. Fuhrmann, S. Tannert-Otto, F. Grimminger, and S. Bhadki. Pore-forming bacterial toxins potently induce release of nitric oxide in porcine endothelial cells. J.Exp.Med. 178: 337-341, 1993.

207. Suttorp, N., S. Hippenstiel, M. Fuhrmann, M. Krüll, and T. Podzuweit. Role of nitric oxide and phosphodiesterase isoenzyme II for reduction of endothelial hyperpermeability. Am.J.Physiol 270: C778-C785, 1996.

208. Suttorp, N., A. Nolte, A. Wilke, and D. Drenckhahn. Human neutrophil elastase increases permeability of cultured pulmonary endothelial cell monolayers. Int.J.Microcirc.Clin.Exp. 13: 187-203, 1993.

209. Suttorp, N., M. Polley, J. Seybold, H. Schnittler, W. Seeger, F. Grimminger, and K. Aktories. Adenosine diphosphate-ribosylation of G-actin by botulinum C2 toxin increases endothelial permeability in vitro. J.Clin.Invest 87: 1575-1584, 1991.

210. Suttorp, N., W. Seeger, and H. Neuhof. Effects of bacterial exo- and endotoxins on endothelial arachidonate metabolism. Prog.Clin.Biol.Res. 308: 119-25, 1989.

211. Suttorp, N., W. Seeger, J. Zucker-Reimann, L. Roka, and S. Bhakdi. Mechanism of leukotriene generation in polymorphonuclear leukocytes by staphylococcal alpha-toxin. Infect.Immun. 55: 104-110, 1987.

212. Suttorp, N., U. Weber, T. Welsch, and C. Schudt. Role of phosphodiesterases in the regulation of endothelial permeability in vitro. J.Clin.Invest 91: 1421-1428, 1993.

213. Takai, Y., T. Sasaki, and T. Matozaki. Small GTP-binding proteins. Physiol Rev. 81: 153-208, 2001.

214. Tanaka, K., T. Kawakami, K. Tateishi, H. Yashiroda, and T. Chiba. Control of IkappaBalpha proteolysis by the ubiquitin-proteasome pathway. Biochimie 83: 351-356, 2001.

215. Tato, C. M. and C. A. Hunter. Host-pathogen interactions: subversion and utilization of the NF-kappa B pathway during infection. Infect.Immun. 70: 3311-3317, 2002.

216. Tedder, T. F., D. A. Steeber, A. Chen, and P. Engel. The selectins: vascular adhesion molecules. FASEB J 9: 866-873, 1995.

[Seite 108↓]

217. Tiran, A., H. J. Gruber, W. F. Graier, A. H. Wagner, E. B. Van Leeuwen, and B. Tiran. Aspirin inhibits Chlamydia pneumoniae-induced nuclear factor-kappa B activation, cytokine expression, and bacterial development in human endothelial cells. Arterioscler.Thromb.Vasc.Biol. 22: 1075-1080, 2002.

218. Underhill, D. M. and A. Ozinsky. Toll-like receptors: key mediators of microbe detection. Curr.Opin.Immunol 14: 103-110, 2002.

219. Valbuena, G., H. M. Feng, and D. H. Walker. Mechanisms of immunity against Rickettsiae. New perspectives and opportunities offered by unusual intracellular parasites. Microbes.Infect. 4: 625-633, 2002.

220. van Hinsbergh, V. W. and G. P. van Amerongen. Intracellular signalling involved in modulating human endothelial barrier function. J Anat. 200: 549-560, 2002.

221. van Hinsbergh, W. M. Endothelial permeability for macromolecules. Mechanistic aspects of pathophysiological modulation. Arterioscler.Thromb.Vasc.Biol. 17: 1018-1023, 1997.

222. van Ooij, C., L. Kalman, I. van, M. Nishijima, K. Hanada, K. Mostov, and J. N. Engel. Host cell-derived sphingolipids are required for the intracellular growth of Chlamydia trachomatis. Cell Microbiol. 2: 627-637, 2000.

223. Vandahl, B. B., S. Birkelund, H. Demol, B. Hoorelbeke, G. Christiansen, J. Vandekerckhove, and K. Gevaert. Proteome analysis of the Chlamydia pneumoniae elementary body. Electrophoresis 22: 1204-1223, 2001.

224. Vazquez-Boland, J. A., M. Kuhn, P. Berche, T. Chakraborty, G. Dominguez-Bernal, W. Goebel, B. Gonzalez-Zorn, J. Wehland, and J. Kreft. Listeria pathogenesis and molecular virulence determinants. Clin.Microbiol.Rev. 14: 584-640, 2001.

225. Verin, A. D., A. Birukova, P. Wang, F. Liu, P. Becker, K. Birukov, and J. G. Garcia. Microtubule disassembly increases endothelial cell barrier dysfunction: role of MLC phosphorylation. Am J Physiol Lung Cell Mol.Physiol 281: L565-L574, 2001.

226. Verma, I. M., J. K. Stevenson, E. M. Schwarz, D. Van Antwerp, and S. Miyamoto. Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev. 9: 2723-2735, 1995.

227. Vestweber, D. Regulation of endothelial cell contacts during leukocyte extravasation. Curr.Opin.Cell Biol. 14: 587, 2002.

[Seite 109↓]

228. Volk, T. and W. J. Kox. Endothelium function in sepsis. Inflamm.Res. 49: 185-198, 2000.

229. Wagner, H. Toll meets bacterial CpG-DNA. Immunity 14: 499-502, 2001.

230. Wang, C. Y., M. W. Mayo, R. G. Korneluk, D. V. Goeddel, and A. S. Baldwin. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281: 1680-1683, 1998.

231. Wang, P. Adrenomedullin in sepsis and septic shock. Shock 10: 383-384, 1998.

232. Wang, P., M. Zhou, Z. F. Ba, W. G. Cioffi, and I. H. Chaudry. Up-regulation of a novel potent vasodilatory peptide adrenomedullin during polymicrobial sepsis. Shock 10: 118-122, 1998.

233. Wang, T., X. Zhang, and J. J. Li. The role of NF-kappaB in the regulation of cell stress responses. Int.Immunopharmacol. 2: 1509-1520, 2002.

234. Wang, Y. The function of OmpA in Escherichia coli. Biochem.Biophys.Res Commun. 292: 396-401, 2002.

235. Weber, C. and W. Erl. Modulation of vascular cell activation, function, and apoptosis: role of antioxidants and nuclear factor-kappa B. Curr.Top.Cell Regul. 36: 217-235, 2000.

236. Willuweit, A., G. Sass, A. Schoneberg, U. Eisel, G. Tiegs, and M. Clauss. Chronic inflammation and protection from acute hepatitis in transgenic mice expressing TNF in endothelial cells. J Immunol 167: 3944-3952, 2001.

237. Wojciak-Stothard, B., S. Potempa, T. Eichholtz, and A. J. Ridley. Rho and Rac but not Cdc42 regulate endothelial cell permeability. J Cell Sci 114: 1343-1355, 2001.

238. Wolf, K. and T. Hackstadt. Sphingomyelin trafficking in Chlamydia pneumoniae-infected cells. Cell Microbiol. 3: 145-152, 2001.

239. Wooten, R. M., V. R. Modur, T. M. McIntyre, and J. J. Weis. Borrelia burgdorferi outer membrane protein A induces nuclear translocation of nuclear factor-kappa B and inflammatory activation in human endothelial cells. J Immunol 157: 4584-4590, 1996.

[Seite 110↓]

240. Worthylake, R. A. and K. Burridge. Leukocyte transendothelial migration: orchestrating the underlying molecular machinery. Curr.Opin.Cell Biol. 13: 569-577, 2001.

241. Yang, Y. L. and X. M. Li. The IAP family: endogenous caspase inhibitors with multiple biological activities. Cell Res 10: 169-177, 2000.

242. Yashima, R., M. Abe, K. Tanaka, H. Ueno, K. Shitara, S. Takenoshita, and Y. Sato. Heterogeneity of the signal transduction pathways for VEGF-induced MAPKs activation in human vascular endothelial cells. J Cell Physiol 188: 201-210, 2001.

243. Zhang, G. and S. Ghosh. Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity. J.Clin.Invest 107: 13-19, 2001.

244. Zhou, M., Z. F. Ba, I. H. Chaudry, and P. Wang. Adrenomedullin binding protein-1 modulates vascular responsiveness to adrenomedullin in late sepsis. Am J Physiol Regul.Integr.Comp Physiol 283: R553-R560, 2002.

245. Zimmerman, G. A., M. R. Elstad, D. E. Lorant, T. M. Mclntyre, S. M. Prescott, M. K. Topham, A. S. Weyrich, and R. E. Whatley. Platelet-activating factor (PAF): signalling and adhesion in cell-cell interactions. Adv.Exp.Med.Biol. 416: 297-304, 1996.

246. Zimmerman, G. A., T. M. McIntyre, and S. M. Prescott. Adhesion and signaling in vascular cell-cell interactions. J Clin.Invest 100: S3-S5, 1997.

247. Zuany-Amorim, C., J. Hastewell, and C. Walker. Toll-like receptors as potential therapeutic targets for multiple diseases. Nat.Rev.Drug Discov. 1: 797-807, 2002.

248. Zysk, G., B. K. Schneider-Wald, J. H. Hwang, L. Bejo, K. S. Kim, T. J. Mitchell, R. Hakenbeck, and H. P. Heinz. Pneumolysin is the main inducer of cytotoxicity to brain microvascular endothelial cells caused by Streptococcus pneumoniae. Infect.Immun. 69: 845-852, 2001.

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