Lage, Hermann: Atypische pleiotrope Zytostatikaresistenz (Multidrug-Resistenz) humaner Tumorzellen

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Anhang A. Publikationsliste

  1. Dietel, M., Arps, H., Lage, H., and Niendorf, A. (1990) Membrane vesicle formation due to acquired mitoxantrone resistance in human gastric carcinoma cell line EPG85-257. Cancer Res. 50, 6100-6106.
  2. Lage, H., and Dietel, M. (1996) Cloning of a human cDNA encoding a protein with high homology to yeast methionyl-tRNA synthetase. Gene 178, 187-189.
  3. Kellner, U., Hutchinson, L., Seidel, A., Lage, H., Danks, M.K., Dietel, M., and Kaufmann, S.C. (1997) Decreased drug accumulation in a mitoxantrone-resistant gastric carcinoma cell line in the absence of P-glycoprotein. Int. J. Cancer 71, 817-824.
  4. Lage, H., and Dietel, M. (1997) Cloning and characterization of cDNAs encoding a protein with high homology to rat intestinal development protein OCI-5. Gene 188, 151-156.
  5. Lage, H., Dietel, M., Fröschle, G., and Reymann, A. (1998) Expression of the novel mitoxantrone resistance associated gene MXR7 in colorectal malignancies. Int. J. Clin. Pharmacol. Ther. 36, 58-60.
  6. Reymann, A., Woermann, C., Fröschle, G., Schneider, C., Bräsen, J.H., Lage, H., and Dietel, M. (1998) Sensitive assessment of cytostatic drug resistance-mediating factors MDR1 and MRP in tumors of the gastrointestinal tract by RT-PCR. Int. J. Clin. Pharmacol. Ther. 36, 55-57.
  7. Schwendel, A., Richard, F., Langreck, H., Kaufmann, O., Lage, H., Winzer, K.J., Petersen, I., and Dietel, M. (1998) Chromosome alterations in breast carcinomas: frequent involvement of DNA losses including chromosomes 4q and 21q. Br. J. Cancer 78, 806-811.
  8. Sinha, P., Hütter, G., Köttgen, E., Dietel, M., Schadendorf, D., and Lage, H. (1998) Increased expression of annexin I and thioredoxin detected by two-dimensional gel electrophoresis of drug resistant human stomach cancer cells. J. Biochem. Biophys. Methods 18, 105-116.
  9. Lage, H. (1999) Atypische Multidrug-Resistenz. Arzneimitteltherapie 17, 39-44.
  10. Lage, H., Christmann, M., Kern, M.A., Dietel, M., Pick, M., Kaina, B., and Schadendorf, D. (1999) Expression of DNA repair proteins hMSH2, hMSH6, hMLH1, O6-methylguanine-DNA metyltransfease and N-methylpurine-DNA glycosylase in melanoma cells with aquired drug resistance. Int. J. Cancer 80, 744-750.
  11. Lage, H., and Dietel, M. (1999) Involvement of the DNA mismatch repair system in antineoplastic dug resistance. J. Cancer Res. Clin. Oncol. 125, 156-165.

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  1. Ross, D.D., Yang, W., Abruzzo, L.V., Dalton, W.S., Schneider, E., Lage. H., Dietel, M., Greenberger, L., Cole, S.P.C., and Doyle. L.A. (1999) Atypical multidrug resistance: breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell lines. J. Natl. Cancer Inst. 91, 429-433.
  2. Sinha, P., Hütter, G., Köttgen, E., Dietel, M., Schadendorf, D., and Lage, H. (1999) Increased expression of epidermal fatty acid binding protein, cofilin, and 14-3-3-sigma (stratifin) detected by two-dimensional gel electrophoresis, mass spectrometry and micosequencing of drug-resistant human adenocarcinoma of the pancreas. Electrophoresis 20, 2952-2960.
  3. Sinha, P., Hütter, G., Köttgen, E., Dietel, M., Schadendorf, D., and Lage, H. (1999) Search for novel proteins involved in the development of chemoresistance in colorectal cancer and fibrosarcoma cells in vitro using two-dimensional electrophoresis, mass spectrometry and microsequencing. Electrophoresis 20, 2961-2969.
  4. Wichert, A., Holm, P.S., Dietel, M., and Lage, H. (1999) Selection of a high activity ribozyme against the cytostatic drug resistance associated glypican-3 using an in vitro assay containing total tumor RNA. Cancer Gene Ther. 6, 263-270.
  5. Grottke, C., Mantwill, K., Dietel, M., Schadendorf, D., and Lage, H. (2000) Identification of differentially expressed genes in human melanoma cells with acquired resistance to various antineoplastic drugs. Int. J. Cancer 88, 535-546.
  6. Lage, H., and Dietel, M. (2000) Effect of the breast cancer resistance protein on atypical multidrug resistance. Lancet Oncol. 1, 169-175.
  7. Lage, H., Helmbach, H., Dietel, M., and Schadendorf, D. (2000) Modulation of DNA topoisomerase II activity and expression in melanoma cells with acquired drug resistance. Br. J. Cancer 82, 488-491.
  8. Lage, H., Jordan, A., Scholz, R., and Dietel, M. (2000) Thermosensitivity of multidrug-resistant human gastric and pancreatic carcinoma cells. Int. J. Hyperthermia 16, 291-303.
  9. Sinha, P., Kohl, S., Fischer, J., Hütter, G., Kern, M., Köttgen, E., Dietel, M., Lage, H., Schnölzer, M., and Schadendorf, D. (2000) Identification of novel proteins associated with the development of chemoresistance in malignant melanoma using two-dimensional electrophoresis. Electrophoresis 21, 3048-3057.
  10. Christmann, M., Pick, M., Lage, H., Schadendorf, D., and Kaina, B. (2001) Resistance of melanoma cells to the antineoplastic agent fotemustine is caused by reactivation of the DNA repair gene MGMT. Int. J. Cancer 92, 123-129.
  11. Kowalski, P., Wichert, A., Holm, P.S., Dietel, M., and Lage, H. (2001) Selection and characterization of a high activity ribozyme directed against the antineoplastic drug resistance-associated ABC-transporter BCRP/MXR/ABCG2. Cancer Gene Ther. 8, 185-192.

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  1. Lage, H., Helmbach, H., Grottke, C., Dietel, M., and Schadendorf, D. (2001) DFNA5 (ICERE-1) contributes to acquired etoposide resistance in melanoma cells. FEBS Lett. 494, 54-59.
  2. Lage, H., Kellner, U., Tannapfel, A., and Dietel, M. (2001) Expression of a glypican-related 62-kDa antigen is decreased in hepatocellular carcinoma in correspondence to the grade of tumor differentiation. Virchows Arch. 438, 567-573.
  3. Lage, H., Perlitz, C., Abele, R., Tampé, R., Dietel, M., Schadendorf, D., and Sinha, P. (2001) Enhanced expression of human ABC-transporter TAP is associated with cellular resistance to mitoxantrone. FEBS Lett. 503, 179-184.
  4. Materna, V., Holm, P.S., Dietel, M., and Lage, H. (2001) Kinetic characterization of ribozymes directed against the cisplatin resistance-associated ABC-transporter cMOAT/MRP2/ABCC3. Cancer Gene Ther. 8, 176-184.
  5. Sinha, P., Poland, J., Schnölzer, M., Celis, J.E., and Lage, H. (2001) Characterization of the differential protein expression associated with thermoresistance in human gastric carcinoma cell lines. Electrophoresis 22, 2990-3000.


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