Lage, Hermann: Atypische pleiotrope Zytostatikaresistenz (Multidrug-Resistenz) humaner Tumorzellen



Biedler, J.L., and Riehm, H. (1970) "Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross resistance radioautographic and cytogenetic studies" . Cancer Res . 30 , 1174-1184.

Diatchenko, L., Lau, Y.F., Campbell, A.P., Chenchik, A., Moqadam, F., Huang, B., Lukyanov, S., Lukyanov, K., Gurskaya, N., Sverdlov, E.D. and Siebert, P.D. (1996) "Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries" . Proc. Natl. Acad. Sci. USA 93 , 6025-6030.

Dietel, M., Arps, H., Lage, H., and Niendorf, A. (1990) "Membrane vesicle formation due to acquired mitoxantrone resistance in human gastric carcinoma cell line EPG85-257" . Cancer Res. 50 , 6100-6106 .

Doyle, L.A., Yang, W., Abruzzo, L.V., Krogmann, T., Gao, Y., Rishi, A.K., and Ross, D.D. (1998) "A multidrug resistance transporter from human MCF-7 breast cancer cells" . Proc. Natl. Acad. Sci. U.S.A. 95 , 15665-15670.

Falk, M.H., and Issels, R.D. (2001) "Hyperthermia in oncology" . Int. J. Hyperthermia 17 , 1-18.

Grottke, C., Mantwill, K., Dietel, M., Schadendorf, D., and Lage, H. (2000) "Identification of differentially expressed genes in human melanoma cells with acquired resistance to various antineoplastic drugs" . Int. J. Cancer 88 , 535-546.

Hedrick, S.M., Cohen, D.I., Nielsen, E.A., and Davis, M.M. (1984) "Isolation of cDNA clones encoding T cell-specific membrane-associated proteins" . Nature 308 , 149-153.

Kellner, U., Hutchinson, L., Seidel, A., Lage, H., Danks, M.K., Dietel, M., and Kaufmann, S.C. (1997) "Decreased drug accumulation in a mitoxantrone-resistant gastric carcinoma cell line in the absence of P-glycoprotein" . Int. J. Cancer 71 , 817-824.

Kitazono, M., Sumizawa, T., Takebayashi, Y., Chen, Z.S., Furukawa, T., Nagayama, S., Tani, A., Takao, S., Aikou, T., and Akiyama, S. (1999) "Multidrug resistance and the lung resistance-related protein in human colon carcinoma SW-620 cells" . J. Natl. Cancer Inst. 91 , 1647-1653.

Kowalski, P., Wichert, A., Holm, P.S., Dietel, M., and Lage, H. (2001) "Selection and characterization of a high activity ribozyme directed against the antineoplastic drug resistance-associated ABC-transporter BCRP/MXR/ABCG2." Cancer Gene Ther. 8, 185-192.

Lage, H., and Dietel, M. (1996) "Cloning of a human cDNA encoding a protein with high homology to yeast methionyl-tRNA synthetase" . Gene 178 , 187-189.

Lage, H., and Dietel, M. (1997) "Cloning and characterization of cDNAs encoding a protein with high homology to rat intestinal development protein OCI-5" . Gene 188 , 151-156.

Lage, H. (1999) "Atypische Multidrug-Resistenz" . Arzneimitteltherapie 17. , 39-44.


Lage, H., Christmann, M., Kern, M.A., Dietel, M., Pick, M., Kaina, B., and Schadendorf, D. (1999) "Expression of DNA repair proteins hMSH2, hMSH6, hMLH1, O6-methylguanine-DNA metyltransfease and N-methylpurine-DNA glycosylase in melanoma cells with aquired drug resistance" . Int. J. Cancer 80 , 744-750.

Lage, H., and Dietel, M. (1999) "Involvement of the DNA mismatch repair system in antineoplastic dug resistance. " J. Cancer Res. Clin. Oncol. 125 , 156-165.

Lage, H., and Dietel, M. (2000) "Effect of the breast cancer resistance protein on atypical multidrug resistance. " Lancet Oncol. 1 , 169-175.

Lage, H., Helmbach, H., Dietel, M., and Schadendorf, D. (2000a) "Modulation of DNA topoisomerase II activity and expression in melanoma cells with acquired drug resistance. " Br. J. Cancer 82 , 488-491.

Lage, H., Jordan, A., Scholz, R., and Dietel, M. (2000b) "Thermosensitivity of multidrug-resistant human gastric and pancreatic carcinoma cells. " Int. J. Hyperthermia 16 , 291-303.

Lage, H., Helmbach, H., Grottke, C., Dietel, M., and Schadendorf, D. (2001) "DFNA5 (ICERE-1) contributes to acquired etoposide resistance in melanoma cells." FEBS Lett. 494 , 54-59.

Lage, H., Perlitz, C., Abele, R., Tampé, R., Dietel, M., Schadendorf, D., and Sinha, P. : "Enhanced expression of human ABC-transporter TAP is associated with cellular resistance to mitoxantrone. " FEBS Lett. " " 503, " " 179-184.

Liang, P. and Pardee, A.B. (1992) , "Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. " Science 257 , 967-971.

Marshall, A. and Hodgson, J. (1998) "DNA chips: an array of possibilities. " Nat. Biotechnol. 16 , 27-31.

Materna, V., Holm, P.S., Dietel, M., and Lage, H. (2001) " Kinetic characterization of ribozymes directed against the cisplatin resistance-associated ABC-transporter cMOAT/MRP2/ABCC3. Cancer Gene Ther." Cancer Gene Ther. 8, 176-184.

Ross, D.D., Yang, W., Abruzzo, L.V., Dalton, W.S., Schneider, E., Lage. H., Dietel, M., Greenberger, L., Cole, S.P.C., and Doyle. L.A. (1999) "Atypical multidrug resistance: breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell lines. " J. Natl. Cancer Inst. 91 , 429-433.

Scheffer, G.L., Wijngaard, P.L., Flens, M.J., Izquierdo, M.A., Slovak, M.L., Pinedo, H.M., Meijer, C.J., Clevers, H.C., and Scheper, R.J. (1995) "The drug resistance-related protein LRP is the human major vault protein. " Nat. Med . 1 , 578-582.

Sinha, P., Hütter, G., Köttgen, E., Dietel, M., Schadendorf, D., and Lage, H. (1998) "Increased expression of annexin I and thioredoxin detected by two-dimensional gel electrophoresis of drug resistant human stomach cancer cells. " J. Biochem. Biophys. Methods 18 , 105-116.


Sinha, P., Hütter, G., Köttgen, E., Dietel, M., Schadendorf, D., and Lage, H. (1999a) "Increased expression of epidermal fatty acid binding protein, cofilin, and 14-3-3-sigma (stratifin) detected by two-dimensional gel electrophoresis, mass spectrometry and micosequencing of drug-resistant human adenocarcinoma of the pancreas. " Electrophoresis 20 , 2952-2960.

Sinha, P., Hütter, G., Köttgen, E., Dietel, M., Schadendorf, D., and Lage, H. (1999b) "Search for novel proteins involved in the development of chemoresistance in colorectal cancer and fibrosarcoma cells in vitro using two-dimensional electrophoresis, mass spectrometry and microsequencing. " Electrophoresis 20 , 2961-2969.

Sinha, P., Kohl, S., Fischer, J., Hütter, G., Kern, M., Köttgen, E., Dietel, M., Lage, H., Schnölzer, M., and Schadendorf, D. (2000) " Identification of novel proteins associated with the development of chemoresistance in malignant melanoma using two-dimensional electrophoresis. " Electrophoresis 21 , 3048-3057.

Wichert, A., Holm, P.S., Dietel, M., and Lage, H. (1999) "Selection of a high activity ribozyme against the cytostatic drug resistance associated glypican-3 using an in vitro assay containing total tumor RNA. " Cancer Gene Ther . 6 , 263-270.

Wichert, A., Holm, P.S., Dietel, M., and Lage, H. : "Glypican-3 is involved in cellular protection against mitoxantrone" . submitted for publication ,

© Die inhaltliche Zusammenstellung und Aufmachung dieser Publikation sowie die elektronische Verarbeitung sind urheberrechtlich geschützt. Jede Verwertung, die nicht ausdrücklich vom Urheberrechtsgesetz zugelassen ist, bedarf der vorherigen Zustimmung. Das gilt insbesondere für die Vervielfältigung, die Bearbeitung und Einspeicherung und Verarbeitung in elektronische Systeme.

DiML DTD Version 2.0
Zertifizierter Dokumentenserver
der Humboldt-Universität zu Berlin
HTML - Version erstellt am:
Mon Sep 9 13:36:15 2002