[Seite 32↓]

Zitierte Fremdliteratur:

Akbar, A.N., Salmon, M. Cellular environments and apoptosis: tissue microenvironments control activated T-cell death. Immunology Today 18: 72-76, 1997.

Bach, F.H., Ferran, C., Hechenleitner, P., Mark, W., Koyamada, N., Miyatake, T., Winkler, H., Badrichani, A., Candinas, D., Hancock, W.W. Accommodation of vascularized xenografts: expression of "protective genes" by donor endothelial cells in a host Th2 cytokine environment. Nat Med. 3: 196-204, 1997.

Bemelman, F., Honey, K., Adams, E., Cobbold, S., Waldmann, H. Bone marrow transplantation induces either clonal deletion or infectious tolerance depending on the dose. J Immunol. 160: 2645-2658, 1998.

Bilbao, G., Contreras, J.L., Gomez-Navarro, J., Eckhoff, D.E., Mikheeva, G., Krasnykh, V., Hynes, T., Thomas, F.T., Thomas, J.M., Curiel, D.T. Genetic modification of liver grafts with an adenoviral vector encoding the Bcl-2 gene improves organ preservation. Transplantation 67: 846-854, 1999.

Blaese, R.M., Culver, K.W., Miller, D., Carter, C., Fleischer, T., Clerici, M., Shearer, G., Chang, L., Chiang, Y., Tolsthev, P., Grennblatt, J.J., Rosenberg, S.A., Klein, H., Berger, M., Mullen, C.A., Ramsey, W.J., Muul, L., Morgan, R.A., Anderson, W.F. T-lymphocyte-directed gene therapy for ADA- SCID: Initial trial results after 4 years. Science 270: 475-477, 1995.

Brenner, M. Gene transfer by adenovectors. Blood. 94: 3965-3967, 1999.

Bromberg, J.S., Debruyne, L.A., Qin, L. Interactions between the immune system and gene therapy vectors: bidirectional regulation of response and expression. Adv Immunol. 1998; 69: 353-409. Review.

Campos, L., Naji, A., Deli, B.C., Kern, J.H., Kim, J.I., Barker, C.F., Markmann, J.F. Survival of MHC-deficient mouse heterotopic cardiac allografts. Transplantation 59: 187-191, 1995.

[Seite innerhalb Literaturhinweis 33↓]

Cassatella, M.A., Meda, L., Bonora, S., Ceska, M., Constantin, G. Interleukin-10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leucocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1 beta in mediating the production of IL-8 triggered by lipopolysaccharide. J Exp Med 178: 2207-2211, 1993.

Chen, Z., Cobbold, S., Metcalfe, S., Waldmann, H. Tolerance in the mouse to major histocompatibility complex-mismatched heart allografts, and to rat heart xenografts, using monoclonal antibodies to CD4 and CD8. Eur J Immunol 22: 805-180, 1992.

Cobbold, S., Waldmann, H. How do monoclonal antibodies induce tolerance? A role for Infectious Tolerance? Annual Reviews Immunology 16: 619-644, 1998.

Cory, S. Regulation of lymphocyte survival by the bcl-2 gene family. Annual Reviews Immunology 13: 513-543, 1995.

David, A., Chetritt, J., Guillot, C., Tesson, L., Heslan, J.M., Cuturi, M.C., Soulillou, J.P., Anegon, I. Interleukin-10 produced by recombinant adenovirus prolongs survival of cardiac allografts in rats. Gene Ther. 7: 505-510, 2000.

Davies, J.D., Martin, G., Phillips, J., Marshall, S.E., Cobbold, S.P., Waldmann, H. T cell regulation in adult transplantation tolerance. J Immunol 157: 529-533, 1996.

De Waal Malefyt, R., Abrams, J., Bennett, B., Figdor, C.G., De Fries, J.E. Interleukin-10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 174: 1209-1220, 1991a.

De Waal Malefyt, R., Haanen, J., Spits, H., Roncarolo, M.G., Te Felde, A., Figdor, C., Johnson, C., Kastelein, R., Yssel, H., De Fries, J.E. Interleukin-10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J Exp Med 174: 915-924, 1991b.

Fowell, D., Mason, D. Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential. J Exp Med. 177: 627-636, 1993.

Flügel, A., Willem, M., Berkowicz, T., Wekerle, H. Gene transfer into CD4+ T lymphocytes: Green fluorescent protein-engineered, encephalitogenic T cells illuminate brain autoimmune responses. Nature Med 7: 843-847, 1999.

[Seite innerhalb Literaturhinweis 34↓]

Germann, T., Gately, M.K., Schoenhaut, D.S., Lohoff, M., Mattner, F., Fischer, S., Jin, S.C., Schmitt, E., Rude, E. Interleukin-12/Tcell stimulating factor, a cytokine with multiple effects on T helper type1 (Th1) but not on Th2 cells. Eur J Immunol 23: 1762-1768, 1993.

Gershon, R.K. A disquisition on suppressor T cells. Transplant Rev. 26: 170-185, 1975.

Goode, H.F., Webster, N.R., Howdle, P.D., Leek, J.P., Lodge, J.P., Sadek, S.A., Walker, B.E. Reperfusion injury, antioxidants and hemodynamics during orthotopic liver transplantation. Hepatology 19: 354-359, 1994.

Groux, H., O'Garra, A., Bigler, M., Rouleau, M., Antonenko, S., de Vries, J.E., Roncarolo, M.G. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389: 737-742, 1997.

Groux, H., Powrie, F. Regulatory T cells and inflammatory bowel disease. Immunol Today 20: 442-445, 1999.

Hara, M., Kingsley, C.I., Niimi, M., Read, S., Turvey, S.E., Bushell, A.R., Morris, P.J., Powrie, F., Wood, K.J. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J Immunol. 166: 3789-96, 2001.

Hayry, P., Isoniemi, H., Yilmaz, S., Mennander, A., Lemstrom, K., Raisanen-Sokolowski, A., Koskinen, P., Ustinov, J., Lautenschlager, I., Taskinen, E., et al. Chronic allograft rejection. Immunol Rev. 134: 33-81, 1993.

Hsieh, C.S., Macatonia, S.E., Tripp, C.S., Wolf, S.F., O'Garra, A., Murphy, K.M. Listeria-induced Th1 development in aß-TCR transgenic CD4+ T cells occurs through macrophage production of IL-12. Science 260: 547-551, 1993.

Isobe, M., Suzuki, J., Yamazaki, S., Yazaki, Y., Horie, S., Okubo, Y., Maemura, K., Yazaki, Y., Sekiguchi, M. Regulation by differential development of Th1 and Th2 cells in peripheral tolerance to cardiac allograft induced by blocking ICAM-1/LFA-1 adhesion. Circulation. 96: 2247-2253, 1997.

Joo, C., Cho, K., Kim, H., Choi, J.S., Oh, Y.J. Protective role for bcl-2 in experimentally induced cell death of bovine corneal endothelial cells. Ophthalmic Res. 31: 287-296, 1999.

Kay, M.A., Glorioso, J.C., Naldini, L. Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics. Nat Med. 7: 33-40, 2001.

Kennedy, M.K., Picha, K.S., Shanebeck, K.D., Anderson, D.M., Grabstein, K.H. Interleukin-12 regulates the proliferation of Th1, but not Th2 or Th0, clones. Eur J Immunol 24: 2271-2278, 1994.

[Seite innerhalb Literaturhinweis 35↓]

Khoury, S., Sayegh, M.H., Turka, L.A. Blocking costimulatory signals to induce transplantation tolerance and prevent autoimmune disease. Int Rev Immunol 18: 185-199, 1999.

King, C., Mueller Hoenger, R., Malo Cleary, M., Murali-Krishna, K., Ahmed, R., King, E., Sarvetnick, N.. Interleukin-4 acts at the locus of the antigen-presenting dendritic cell to counter-regulate cytotoxic CD8+ T-cell responses. Nat Med. 7: 206-214, 2001.

Klebe, S., Sykes, P.J., Coster, D.J., Krishnan, R., Williams, K.A. Prolongation of sheep corneal allograft survival by ex vivo transfer of the gene encoding interleukin-10. Transplantation. 71: 1214-1220, 2001.

Knorr, D. Serious adverse event on NIH human gene transfer protocol #9512-139. A phase I study of adenovector mediated gene transfer to liver in adults with partial ornithine transcarbamylase deficiency. Memorandum of 21 September 1999, office of recombinant DNA activities at NIH, 1999.

Kroemer, G., Zamzami, N., Susin, S.A. Mitochondrial control of apoptosis. Immunology Today 18: 44-51, 1995.

Lehmann, M., Kuttler, B., Siegling, A., Gordalla, A., Riedel, H., Lacha, J., Hahn, H.J., Brock, J., Volk, H.D. Characterization of the anti-CD4-induced permanent acceptance of rat renal allografts. Transplant Proc. 25: 2859-2860, 1993.

Lehmann, M., Graser, E., Risch, K., Hancock, W.W., Müller, A., Kuttler, B., Hahn, H.J., Kupiec-Weglinski, J.W., Brock, J., Volk, H.D. Anti-CD4 monoclonal antibody-induced allograft tolerance in rats despite persistence of donor-reactive T cells. Transplantation 64: 1181-1187, 1997

Mattner, F., Fischer, S., Guckes, S., Jin, S., Kaulen, H., Schmitt, E., Rude, E., Germann, T. The interleukin-12 subunit p40 specifically inhibits effects of interleukin-12 heterodimer. Eur J Immunol 23: 2202-2207, 1993.

Mosmann, T.R. and Coffmann, R.L. Th1 and Th2 cells: different patterns of lymphokine secretion lead to a different functional properties. Annual Reviews Immunology 7: 145-173, 1989.

Mottram, P.L., Mirisklavos, A., Dumble, L.J., Clunie, G.J. T suppressor cells induced by transfusions and cyclosporine. Studies in the murine cardiac allograft model. Transplantation 50: 1033-1037, 1990.

[Seite innerhalb Literaturhinweis 36↓]

Mueller, R., Davies, J.D., Krahl, T., Sarvetnick, N. IL-4 expression by grafts from transgenic mice fails to prevent allograft rejection. J. Immunol. 159: 1599-1603, 1997.

Nagata, S. Apoptosis by death factor. Cell 88: 355-365, 1997.

Onodera, K., Lehmann, M., Akalin, E., Volk, H.D., Sayegh, M.H., Kupiec-Weglinski, J.W. Induction of „infectious“ tolerance to MHC-incompatible cardiac allografts in CD4 monoclonal antibody-treated sensitized rat recipients. J. Immunol. 157: 1944-1950, 1996.

Otterbein, L.E., Kolls, J.K., Mantell, L.L., Cook, J.L., Alam, J., Choi, A.M. Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury. J Clin Invest. 103: 1047-1054, 1999.

Pearson, T.C., Madsen, J.C., Larsen, C.P., Morris, P.J., Wood, K.J. Induction of transplantation tolerance in adults using donor antigen and anti-CD4 monoclonal antibody. Transplantation 54: 475-483, 1992.

Pileggi, A., Molano, R.D., Berney, T., Cattan, P., Vizzardelli, C., Oliver, R., Fraker, C., Ricordi, C., Pastori, R.L., Bach, F.H., Inverardi, L. Heme oxygenase-1 induction in islet cells results in protection from apoptosis and improved in vivo function after transplantation. Diabetes. 50: 1983-1991, 2001.

Qin, S., Cobbold, S.P., Pope, H., Elliott, J., Kioussis, D., Davies, J., Waldmann, H. „Infectious“ transplantation tolerance. Science 259: 974-977 , 1993.

Qin, L., Ding, Y., Pahud D.R., Robson, N.D., Shaked, A., Bromberg, J.S. Adenovirus-mediated gene transfer of viral interleukin-10 inhibits the immune response to both alloantigen and adenoviral antigen. Hum Gene Ther 8: 1365-1374, 1997.

Quinn, E.R., Lum, L.G., Trevor, K.T. T cell activation modulates retrovirus-mediated gene expression. Hum Gene Ther 9: 1457-1467, 1998.

Rabinovitch, A., Suarez-Pinzon, W.L., Sorensen, O., Rajotte, R.V., Power, R.F. Combination therapy with cyclosporine and interleukin-4 or interleukin-10 prolongs survival of syngeneic pancreatic islet grafts in nonobese diabetic mice: islet graft survival does not correlate with mRNA levels of type 1 or type 2 cytokines, or transforming growth factor-beta in the islet grafts. Transplantation. 64: 1525-1531, 1997.

[Seite innerhalb Literaturhinweis 37↓]

Ralph, P., Nakoinz, I., Sampson, J.A., Fong, S., Lowe, D., Min, HY., Lin, L. IL-10, T lymphocyte inhibitor human blood cell production of IL-1 and tumor necrosis factor. J Immunol 148: 808-814, 1992.

Rosenberg, S.A. et al. Human gene marker/therapy clinical protocols. Hum Gene Ther. 11: 919-979, 2000.

Siegling, A., Lehmann, M., Riedel, H., Platzer, C., Brock, J., Emmrich, F., Volk, H.D. A nondepleting anti-rat CD4 monoclonal antibody that suppresses T helper 1-like but not T helper 2-like intragraft lymphokine secretion induces long-term survival of renal allografts. Transplantation 57: 464-467, 1994a.

Siegling, A., Lehmann, M., Platze,r C., Emmrich, F., Volk, H.D. A novel multispecific competitor fragment for quantitative PCR analysis of cytokine expression in rats. J Immunol Methods 177: 23-, 1994b.

Smith, D.K., Korbutt, G.S., Suarez-Pinzon, W.L., Kao, D., Rajotte, R.V., Elliott, J.F. Interleukin-4 or interleukin-10 expressed from adenovirus-transduced syngeneic islets grafts fails to prevent beta cell destruction in diabetic NOD mice. Transplantation 64: 1040-1049, 1997.

Soares, M.P., Lin, Y., Anrather, J., Csizmadia, E., Takigami, K., Sato, K., Grey, S.T., Colvin, R.B., Choi, A.M., Poss, K.D., Bach, F.H. Expression of heme oxygenase-1 can determine cardiac xenograft survival. Nat Med 4: 1073-1077, 1998.

Steller, H. Mechanisms and genes of cellular suicide. Science 267: 1445-1449, 1995.

Sterman, D.H., Treat, J., Litzky, L.A., Amin, K.M., Coonrod, L., Molnar-Kimber, K., Recio, A., Knox, L., Wilson, J.M., Albelda, S.M., Kaiser, L.R. Adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir gene therapy in patients with localized malignancy: results of a phase I clinical trial in malignant mesothelioma. Hum Gene Ther. 9: 1083-1092, 1998.

Susin, S.A., Zamzami, N., Castedo, M., Hirsch, T., Marchetti, P., Macho, A., Daugas, E., Geuskens, M., Kroemer, G. Bcl-2 inhibits the mitochondrial release of an apoptogenic protease. J Exp Med 184: 1331-1341, 1996.

Takahashi, M., Miyoshi, H., Verma, I.M., Gage, F.H. Rescue from photoreceptor degeneration in the rd mouse by human immunodeficiency virus vector-mediated gene transfer. J Virol. 73: 7812-7816, 1999.

[Seite innerhalb Literaturhinweis 38↓]

Takayama, S., Sato, T., Krajewski, S., Kochel, K., Irie, S., Millan, J.A., Reed, J.C. Cloning and funcional analysis of bag-1 a novel bcl-2 binding protein with anti-cell death activity. Cell 80: 279-384, 1995.

Takeuchi, T., Ueki, T., Sunaga, S., Ikuta, K., Sasaki, Y., Li, B., Moriyama, N., Miyazaki, J-I., Kawabe, K. Murine interleukin-4 heart allograft survival prolonged with down-regulation of the Th1 cytokine mRNA in grafts. Transplantation 64: 152-157, 1997.

Thompson, C.B. Apoptosis in the pathogenesis and treatment of disease. Science 267: 1456-1462, 1995.

Tullius, S.G., Reutzel-Selke, A., Egermann, F., Nieminen-Kelha, M., Jonas, S., Bechstein, W.O., Volk, H.D., Neuhaus, P. Contribution of prolonged ischemia and donor age to chronic renal allograft dysfunction. J Am Soc Nephrol. 11: 1317-1324, 2000.

Tullius, S.G., Nieminen-Kelha, M., Reutzel-Selke, A., Bachmann, U., Jonas, S., Pratschke, J., Bechstein, W.O., Volk, H., Buelow, R., Neuhaus, P., Reinke, P. Improvement of long-term function in renal allografts from 'marginal donors' following the induction of heme-oxygenase-1. Transplant Proc. 33: 1160-1161, 2001.

Volk, H.D., Reinke, P. Transplantation immunology Z Arztl Fortbild Qualitatssich. 93: 84-91, 1999.

Wang, X., Appukuttan, B., Ott, S., Patel, R., Irvine, J., Song, J., Park, J.H., Smith, R., Stout, J.T. Efficient and sustained transgene expression in human corneal cells mediated by a lentiviral vector. Gene Ther. 7: 196-200, 2000.

Wilson, S.E. and Kim, W.J. Keratocyte apoptosis: Implications on corneal wound healing, tissue organization, and disease. Invest Ophthalmol Vis Sci 39: 220-226, 1998.

Woo, J., Iyer, S., Cornejo, M.C., Mori, N., Gao, L., Sipos, I., Maines, M., Buelow, R. Stress protein-induced immunosuppression: inhibition of cellular immune effector functions following overexpression of haem oxygenase (HSP 32). Transpl Immunol. 6: 84-93, 1998.

Yang, Y., Li, Q., Ertl, H.C., Wilson, J.M. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J Virol. 69: 2004-2015, 1995.

[Seite innerhalb Literaturhinweis 39↓]

Zhai, Y., Shen, X.D., Lehmann, M., Busuttil, R., Volk, H.D., Kupiec-Weglinski, J.W. T Cell Subsets and In Vitro Immune Regulation in "Infectious" Transplantation Tolerance. J Immunol. 167: 4814-4820, 2001.

© Die inhaltliche Zusammenstellung und Aufmachung dieser Publikation sowie die elektronische Verarbeitung sind urheberrechtlich geschützt. Jede Verwertung, die nicht ausdrücklich vom Urheberrechtsgesetz zugelassen ist, bedarf der vorherigen Zustimmung. Das gilt insbesondere für die Vervielfältigung, die Bearbeitung und Einspeicherung und Verarbeitung in elektronische Systeme.
XDiML DTD Version 4.0Zertifizierter Dokumentenserver
der Humboldt-Universität zu Berlin
HTML-Version erstellt am: