[Seite 33↓]


(1) Stallmach, A. und Zeitz, M. (1999): Immunologie des Intestinaltraktes, Caspary, W. F. und Stein, J., Darmkrankheiten , Seite 55-61, Springer Verlag, Berlin-Heidelberg.

(2) Strobel, S. und Mowat, A. M. (1998): Immune Response to dietary antigens: oral tolerance, Immunol.Today (Band 19), Seite 173-181.

(3) Bailey, M.; Plunkett, F. J.; Rothkotter, H. J.; Vega-Lopez, M. A.; Haverson, K. und Stokes, C. R. (2001): Regulation of mucosal immune responses in effector sites, Proc.Nutr.Soc. (Band 60), Nr. 4, Seite 427-435.

(4) Kamradt, T und Mitchison, N. A. (2001): Tolerance and Autoimmunity, N.Engl.J.Med. (Band 344), Nr. 9, Seite 655-664.

(5) Mackay, I. R. und Rosen, F. S (2001): Tolerance and Autoimmunity, N.Engl.J.Med. (Band 344), Seite 655-664.

(6) Mowat, A. M. (2003): Anatomical basis of tolerance and immunity to intestinal antigens, Nat.Rev.Immunol. (Band 3), Nr. 4, Seite 331-341.

(7) Farhadi, A.; Banan, A.; Fields, J. und Keshavarzian, A. (2003): Intestinal barrier: an interface between health and disease, J.Gastroenterol.Hepatol. (Band 18), Nr. 5, Seite 479-497.

(8) Nagler-Anderson, C. (2001): Man the barrier! Strategic defences in the intestinal mucosa, Nat.Rev.Immunol. (Band 1), Nr. 1, Seite 59-67.

(9) Dignass, A. U. (2001): Mechanisms and modulation of intestinal epithelial repair, Inflamm.Bowel.Dis. (Band 7), Nr. 1, Seite 68-77.

(10) Dignass, A.; Sturm, A. und Podolsky, D. J. (1999): Epithel injury and restitution, Domschke, W.; Stoll, R.; Brasitius, T. A. und Kagnoff, M. F., Intestinal Mucosa and its Diseases , Seite 2943-300, Kluwer Academic Publisher, London.

(11) Mackay, I. R. und Rosen, F. S (2000): The Immune System - First of Two Parts, N.Engl.J.Med. (Band 341), Seite 37-49.

(12) Goldsby, R. A.; Kindt, T. J. und Osborne, B. A. (2000): Overview of the Immune Systemw, Goldsby, R. A.; Kindt, T. J. und Osborne, B. A., Immunology , Seite 3-26, Freemann, New York.

[Seite 34↓]

(13) Delves, P. J. und Roitt, I. M. (2000): The Immune System; Second of Two Parts, N.Engl.J.Med. (Band 343), Seite 108-117.

(14) Wittig, B. M. und Zeitz, M. (2003): The gut as an organ of immunology, Int.J.Colorectal Dis. (Band 18), Nr. 3, Seite 181-187.

(15) Reinhardt, R. L.; Khoruts, A.; Merica, R.; Zell, T. und Jenkins, M. K. (2001): Visualizing the generation of memory CD4 T cells in the whole body, Nature (Band 410), Seite 101-105.

(16) Sturm, A.; Itoh, J.; Jacobberger, J. W. und Fiocchi, C. (2002): p53 negatively regulates intestinal immunity by delaying mucosal T cell cycling, J.Clin.Invest (Band 109), Seite 1481-1492.

(17) Sturm, A.; Mohr, S. und Fiocchi, C. (2002): Critical role of caspases in the regulation of apoptosis and proliferation of mucosal T cells, Gastroenterology (Band 122), Seite 1334-1345.

(18) Schieferdecker, H. L.; Ullrich, R.; Hirseland, H. und Zeitz, M. (1992): T cell differentiation antigens on lymphocytes in the human intestinal lamina propria, J.Immunol. (Band 149), Nr. 8, Seite 2816-2822.

(19) Dailey, M. O. (1998): Expression of T lymphocyte adhesion molecules: regulation during antigen-induced T cell activation and differentiation, Crit Rev.Immunol. (Band 18), Nr. 3, Seite 153-184.

(20) Dalton, S. L.; Scharf, E.; Briesewitz, R.; Marcantonio, E. E. und Assoian, R. K. (1995): Cell adhesion to extracellular matrix regulates the life cycle of integrins, Mol.Biol.Cell (Band 6), Nr. 12, Seite 1781-1791.

(21) Ochieng, J.; Leite-Browning, M. L. und Warfield, P. (1998): Regulation of cellular adhesion to extracellular matrix proteins by galectin-3, Biochem.Biophys.Res.Commun. (Band 246), Nr. 3, Seite 788-791.

(22) Schwartz, M. A. und Ingber, D. E. (1994): Integrating with integrins, Mol.Biol.Cell (Band 5), Nr. 4, Seite 389-393.

(23) Krivacic, K. A. und Levine, A. D. (2003): Extracellular matrix conditions T cells for adhesion to tissue interstitium, J.Immunol. (Band 170), Nr. 10, Seite 5034-5044.

[Seite 35↓]

(24) Fiocchi, C. (1989): Lymphokines and the intestinal immune response. Role in inflammatory bowel disease, Immunol.Invest (Band 18), Nr. 1-4, Seite 91-102.

(25) Qiao, L.; Schurmann, G.; Betzler, M. und Meuer, S. C. (1991): Activation and signaling status of human lamina propria T lymphocytes, Gastroenterology (Band 101), Nr. 6, Seite 1529-1536.

(26) Carol, M.; Lambrechts, A.; Van Gossum, A.; Libin, M.; Goldman, M. und Mascart-Lemone, F. (1998): Spontaneous secretion of interferon gamma and interleukin 4 by human intraepithelial and lamina propria gut lymphocytes, Gut (Band 42), Nr. 5, Seite 643-649.

(27) MacDonald, T. T. (1999): Effector and regulatory lymphoid cells and cytokines in mucosal sites, Curr.Top.Microbiol.Immunol. (Band 236:113-35.), Seite 113-135.

(28) Targan, S. R.; Deem, R. L.; Liu, M.; Wang, S. und Nel, A. (1995): Definition of a lamina propria T cell responsive state. Enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway, J.Immunol. (Band 154), Nr. 2, Seite 664-675.

(29) Mowat, A. M. und Viney, J. L. (1997): The anatomical basis of intestinal immunity, Immunol.Rev. (Band 156), Seite 145-166.

(30) Garside, P. und Mowat, A. M. (2001): Oral tolerance, Semin.Immunol. (Band 13), Nr. 3, Seite 177-185.

(31) Duchmann, R.; Kaiser, I.; Hermann, E.; Mayet, W.; Ewe, K. und Meyer zum Buschenfelde, K. H. (1995): Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD), Clin.Exp.Immunol. (Band 102), Nr. 3, Seite 448-455.

(32) Duchmann, R.; Neurath, M.; Marker-Hermann, E. und Meyer zum Buschenfelde, K. H. (1997): Immune responses towards intestinal bacteria--current concepts and future perspectives, Z.Gastroenterol. (Band 35), Nr. 5, Seite 337-346.

(33) Duchmann, R.; Neurath, M. F. und Meyer zum Buschenfelde, K. H. (1997): Responses to self and non-self intestinal microflora in health and inflammatory bowel disease, Res.Immunol. (Band 148), Nr. 8-9, Seite 589-594.

[Seite 36↓]

(34) Ciacci, C.; Lind, S. E. und Podolsky, D. J. (1993): Transforming growth factor b regulation of migration in wounded rat intestinal epithelial monolayers, Gastroenterology (Band 105), Seite 93-101.

(35) Dignass, A. U. und Podolsky, D. K. (1993): Cytokine modulation of intestinal epithelial cell restitution: central role of transforming growth factor beta, Gastroenterology (Band 105), Nr. 5, Seite 1323-1332.

(36) Dignass, A. U.; Stow, J. L. und Babyatsky, M. W. (1996): Acute epithelial injury in the rat small intestine in vivo is associated with expanded expression of transforming growth factor alpha and beta, Gut (Band 38), Nr. 5, Seite 687-693.

(37) Mayer, L. (1997): Review article: Local and systemic regulation of mucosal immunity, Aliment.Pharmacol.Ther. (Band Suppl 3), Seite 81-85.

(38) Monteleone, G.; Kumberova, A.; Croft, N. M.; McKenzie, C.; Steer, H. W. und MacDonald, T. T. (2001): Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease, J.Clin.Invest (Band 108), Nr. 4, Seite 601-609.

(39) Wakefield, L. M.; Roberts, A. B.; Assoian, R. K.; Fanger, B. O.; Masui, T.; Lechner, J. F.; Harris, C. C. und Sporn, M. B. (1986): Structure and function of transforming growth factor-beta, Proc.West Pharmacol.Soc. (Band 29:475-7.), Seite 475-477.

(40) Dignass, A. U. und Sturm, A. (2001): Peptide growth factors in the intestine, Eur.J.Gastroenterol.Hepatol. (Band 13), Nr. 7, Seite 763-770.

(41) Sturm, A. und Dignass, A. U. (2002): Modulation of gastrointestinal wound repair and inflammation by phospholipids, Biochim.Biophys.Acta (Band 1582), Nr. 1-3, Seite 282-288.

(42) Daaka, Y. (2002): Mitogenic action of LPA in prostate, Biochim.Biophys.Acta (Band 1582), Nr. 1-3, Seite 265-269.

(43) Huang, M. C.; Graeler, M.; Shankar, G.; Spencer, J. und Goetzl, E. J. (2002): Lysophospholipid mediators of immunity and neoplasia, Biochim.Biophys.Acta (Band 1582), Nr. 1-3, Seite 161-167.

(44) Fukushima, N.; Ishii, I.; Contos, J. J.; Weiner, J. A. und Chun, J. (2001): Lysophospholipid receptors, Annu.Rev.Pharmacol.Toxicol. (Band 41:507-34.), Seite 507-534.

[Seite 37↓]

(45) Guidot, D. M.; Bursten, S. L.; Rice, G. C.; Chaney, R. B.; Singer, J. W.; Repine, A. J.; Hybertson, B. M. und Repine, J. E. (1997): Modulating phosphatidic acid metabolism decreases oxidative injury in rat lungs, Am.J.Physiol (Band 273), Nr. 5 Pt 1, Seite L957-L966.

(46) Rice, G. C.; Brown, P. A.; Nelson, R. J.; Bianco, J. A.; Singer, J. W. und Bursten, S. (1994): Protection from endotoxic shock in mice by pharmacologic inhibition of phosphatidic acid, Proc.Natl.Acad.Sci.U.S.A (Band 91), Nr. 9, Seite 3857-3861.

(47) Fabia, R.; Ar'Rajab, A.; Willen, R.; Andersson, R. und Bengmark, S. (1993): Effect of putative phospholipase A2 inhibitors on acetic acid-induced acute colitis in the rat, Br.J.Surg. (Band 80), Nr. 9, Seite 1199-1204.

(48) Bone, R. C. (1992): Phospholipids and their inhibitors: a critical evaluation of their role in the treatment of sepsis, Crit Care Med. (Band 20), Nr. 6, Seite 884-890.

(49) Stack, W. A.; Jenkins, D.; Vivet, P. und Hawkey, C. J. (1998): Lack of effectiveness of the platelet-activating factor antagonist SR27417A in patients with active ulcerative colitis: a randomized controlled trial. The Platelet Activating Factor Antagonist Study Group in Ulcerative Colitis, Gastroenterology (Band 115), Seite 1340-1345.

(50) Moolenaar, W. H. (1995): Lysophosphatidic acid signalling, Curr.Opin.Cell Biol. (Band 7), Nr. 2, Seite 203-210.

(51) Hasegawa, N.; Oka, Y.; Nakayama, M.; Berry, G. J.; Bursten, S.; Rice, G. und Raffin, T. A. (1997): The effects of post-treatment with lisofylline, a phosphatidic acid generation inhibitor, on sepsis-induced acute lung injury in pigs, Am.J.Respir.Crit Care Med. (Band 155), Nr. 3, Seite 928-936.

(52) Waxman, K.; Daughters, K.; Aswani, S. und Rice, G. (1996): Lisofylline decreases white cell adhesiveness and improves survival after experimental hemorrhagic shock, Crit Care Med. (Band 24), Nr. 10, Seite 1724-1728.

(53) van Furth, A. M.; Verhard-Seijmonsbergen, E. M.; van Furth, R. und Langermans, J. A. (1997): Effect of lisofylline and pentoxifylline on the bacterial-stimulated production of TNF-alpha, IL-1 beta IL-10 by human leucocytes, Immunology (Band 91), Nr. 2, Seite 193-196.

[Seite 38↓]

(54) Bauditz, J.; Haemling, J.; Ortner, M.; Lochs, H. und Schreiber, S. (1997): Treatment with tumour necrosis factor inhibitor oxpentifylline does not improve corticosteroid dependent chronic active Crohn's disease, Gut (Band 40), Seite 470-474.

(55) Sturm, A.; Zeeh, J.; Sudermann, T.; Rath, H.; Gerken, G. und Dignass, A. U. (2002): Lisofylline and lysophospholipids ameliorate experimental colitis in rats, Digestion (Band 66), Nr. 1, Seite 23-29.

(56) Fiocchi, C. (1997): The immune system in inflammatory bowel disease, Acta Gastroenterol.Belg. (Band 60), Nr. 2, Seite 156-162.

(57) Pallone, F.; Fais, S.; Squarcia, O.; Biancone, L.; Pozzilli, P. und Boirivant, M. (1987): Activation of peripheral blood and intestinal lamina propria lymphocytes in Crohn's disease. In vivo state of activation and in vitro response to stimulation as defined by the expression of early activation antigens, Gut (Band 28), Nr. 6, Seite 745-753.

(58) Kugathasan, S.; Willis, J.; Dahms, B. B.; O'Riordan, M. A.; Hupertz, V.; Binion, D. G.; Boyle, J. T. und Fiocchi, C. (1998): Intrinsic hyperreactivity of mucosal T cells to interleukin-2 in pediatric Crohn's disease, J.Pediatr. (Band 133), Nr. 5, Seite 675-681.

(59) Boirivant, M.; Marini, M.; Di Felice, G.; Pronio, A. M.; Montesani, C.; Tersigni, R. und Strober, W. (1999): Lamina propria T cells in Crohn's disease and other gastrointestinal inflammation show defective CD2 pathway-induced apoptosis, Gastroenterology (Band 116), Nr. 3, Seite 557-565.

(60) Ina, K.; Itoh, J.; Fukushima, K.; Kusugami, K.; Yamaguchi, T.; Kyokane, K.; Imada, A.; Binion, D. G.; Musso, A.; West, G. A.; Dobrea, G. M.; McCormick, T. S.; Lapetina, E. G.; Levine, A. D.; Ottaway, C. A. und Fiocchi, C. (1999): Resistance of Crohn's disease T cells to multiple apoptotic signals is associated with a Bcl-2/Bax mucosal imbalance, J.Immunol. (Band 163), Nr. 2, Seite 1081-1090.

(61) Itoh, J.; de La, Motte C.; Strong, S. A.; Levine, A. D. und Fiocchi, C. (2001): Decreased Bax expression by mucosal T cells favours resistance to apoptosis in Crohn's disease, Gut (Band 49), Nr. 1, Seite 35-41.

[Seite 39↓]

(62) Sturm, A.; Leite, A. Z.; Jacobberger, J. W. und Fiocchi, C. (2002): Distinct cell cycle kinetics, clonal expansion and caspase activity differentiate the replicative potential of lamina propria T-cells (LPT) in Crohn's disease (CD) and ulcerative colitis (UC), Gastroenterology (Band 122), Seite A1049.

(63) Moolenaar, W. H. (1991): Mitogenic action of lysophosphatidic acid, Adv.Cancer Res. (Band 57:87-102.), Seite 87-102.

(64) Sturm, A.; Becker, A.; Schulte, K. M.; Goebell, H. und Dignass, A. U. (1998): Lysophosphatidic acid modulates intestinal epithelial cell function in vitro, Ann.N.Y.Acad.Sci. (Band 859:223-6.), Seite 223-226.

(65) Sturm, A.; Sudermann, T.; Schulte, K. M.; Goebell, H. und Dignass, A. U. (1999): Modulation of intestinal epithelial wound healing in vitro and in vivo by lysophosphatidic acid, Gastroenterology (Band 117), Nr. 2, Seite 368-377.

(66) Elson, C. O.; Sartor, R. B.; Tennyson, G. S. und Riddell, R. H. (1995): Experimental models of inflammatory bowel disease, Gastroenterology (Band 109), Nr. 4, Seite 1344-1367.

(67) Cario, E.; Becker, A.; Sturm, A.; Goebell, H. und Dignass, A. U. (1999): Peripheral blood mononuclear cells promote intestinal epithelial restitution in vitro through an interleukin-2/interferon-gamma-dependent pathway, Scand.J.Gastroenterol. (Band 34), Nr. 11, Seite 1132-1138.

(68) Godaly, G.; Hang, L.; Frendeus, B. und Svanborg, C. (2000): Transepithelial neutrophil migration is CXCR1 dependent in vitro and is defective in IL-8 receptor knockout mice, J.Immunol. (Band 165), Nr. 9, Seite 5287-5294.

(69) Lenardo, M. J. (1997): The molecular regulation of lymphocyte apoptosis, Semin.Immunol. (Band 9), Nr. 1, Seite 1-5.

(70) De Maria, R.; Boirivant, M.; Cifone, M. G.; Roncaioli, P.; Hahne, M.; Tschopp, J.; Pallone, F.; Santoni, A. und Testi, R. (1996): Functional expression of Fas and Fas ligand on human gut lamina propria T lymphocytes. A potential role for the acidic sphingomyelinase pathway in normal immunoregulation, J.Clin.Invest (Band 97), Nr. 2, Seite 316-322.

(71) Hengartner, M. O. (2000): The biochemistry of apoptosis, Nature (Band 407), Nr. 6805, Seite 770-776.

[Seite 40↓]

(72) Kennedy, N. J.; Kataoka, T.; Tschopp, J. und Budd, R. C. (1999): Caspase activation is required for T cell proliferation, J.Exp.Med. (Band 190), Seite 1891-1896.

(73) Sturm, A.; Schulte, C.; Schatton, R.; Becker, A.; Cario, E.; Goebell, H. und Dignass, A. U. (2000): Transforming growth factor-beta and hepatocyte growth factor plasma levels in patients with inflammatory bowel disease, Eur.J.Gastroenterol.Hepatol. (Band 12), Nr. 4, Seite 445-450.

(74) Hauser, H. und Lipka, G. (1994): Lipid Dynamics in Brush Border Membrane, Hoekstra, D., Lipid Dynamics in Brush Border Membrane , Seite 167-195, Academic Press, San Diego.

(75) Angel, I.; Bar, A. und Haring, R. (2002): Bioactive lipids and their receptors, Curr.Opin.Drug Discov.Devel. (Band 5), Nr. 5, Seite 728-740.

(76) Chapman, D. (1974): Biological membranes, Biomembranes. (Band 4A), Nr. 0, Seite 123-158.

(77) Kemeny, L. und Ruzicka, T. (1994): Lipidmediatoren, Hautarzt (Band 45), Seite 582-591.

(78) Moolenaar, W. H.; van der Bend, R. L.; van Corven, E. J.; Jalink, K.; Eichholtz, T. und van Blitterswijk, W. J. (1992): Lysophosphatidic acid: a novel phospholipid with hormone- and growth factor-like activities, Cold Spring Harb.Symp.Quant.Biol. (Band 57:163-7.), Seite 163-167.

(79) van Corven, E. J.; van Rijswijk, A.; Jalink, K.; van der Bend, R. L.; van Blitterswijk, W. J. und Moolenaar, W. (1992): mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts, Biochem J (Band 181), Seite 163-169.

(80) Durieux, M. E. und Lynch, K. R. (1993): Signalling properties of lysophosphatidic acid, Trends Pharmacol.Sci. (Band 14), Nr. 6, Seite 249-254.

(81) Bursten, S.; Weeks, R.; West, J.; Le, T.; Wilson, T.; Porubek, D.; Bianco, J. A.; Singer, J. W. und Rice, G. C. (1994): Potential role for phosphatidic acid in mediating the inflammatory responses to TNF alpha and IL-1 beta, Circ.Shock (Band 44), Nr. 1, Seite 14-29.

[Seite 41↓]

(82) Coon, M. E.; Diegel, M.; Leshinsky, N. und Klaus, S. J. (1999): Selective pharmacologic inhibition of murine and human IL-12-dependent Th1 differentiation and IL-12 signaling, J.Immunol. (Band 163), Nr. 12, Seite 6567-6574.

(83) Clarke, E.; Rice, G. C.; Weeks, R. S.; Jenkins, N.; Nelson, R.; Bianco, J. A. und Singer, J. W. (1996): Lisofylline inhibits transforming growth factor beta release and enhances trilineage hematopoietic recovery after 5-fluorouracil treatment in mice, Cancer Res. (Band 56), Nr. 1, Seite 105-112.

(84) Willerford, D. M.; Chen, J.; Ferry, J. A.; Davidson, L.; Ma, A. und Alt, F. W. (1995): Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment, Immunity. (Band 3), Nr. 4, Seite 521-530.

(85) Beverly, B.; Kang, S. M.; Lenardo, M. J. und Schwartz, R. H. (1992): Reversal of in vitro T cell clonal anergy by IL-2 stimulation, Int.Immunol. (Band 4), Nr. 6, Seite 661-671.

(86) Baum, L. G.; Pang, M.; Perillo, N. L.; Wu, T.; Delegeane, A.; Uittenbogaart, C. H.; Fukuda, M. und Seilhamer, J. J. (1995): Human thymic epithelial cells express an endogenous lectin, galectin-1, which binds to core 2 O-glycans on thymocytes and T lymphoblastoid cells, J.Exp.Med. (Band 181), Nr. 3, Seite 877-887.

(87) Deem, R. L.; Shanahan, F. und Targan, S. R. (1991): Triggered human mucosal T cells release tumour necrosis factor-alpha and interferon-gamma which kill human colonic epithelial cells, Clin.Exp.Immunol. (Band 83), Nr. 1, Seite 79-84.

(88) Elson, C. O. (1989): Specialized receptors for antigens on gut epithelial T cells, Gastroenterology (Band 97), Nr. 5, Seite 1341-1342.

(89) Joseph, N. E.; Fiocchi, C. und Levine, A. D. (1997): Crohn's disease and ulcerative colitis mucosal T cells are stimulated by intestinal epithelial cells: implications for immunosuppressive therapy, Surgery (Band 122), Nr. 4, Seite 809-814.

(90) Mahida, Y. R.; Galvin, A. M.; Gray, T.; Makh, S.; McAlindon, M. E.; Sewell, H. F. und Podolsky, D. K. (1997): Migration of human intestinal lamina propria lymphocytes, macrophages and eosinophils following the loss of surface epithelial cells, Clin.Exp.Immunol. (Band 109), Nr. 2, Seite 377-386.

[Seite 42↓]

(91) Mennechet, F. J.; Kasper, L. H.; Rachinel, N.; Li, W.; Vandewalle, A. und Buzoni-Gatel, D. (2002): Lamina propria CD4+ T lymphocytes synergize with murine intestinal epithelial cells to enhance proinflammatory response against an intracellular pathogen, J.Immunol. (Band 168), Nr. 6, Seite 2988-2996.

(92) Amundson, S. A.; Myers, T. G. und Fornace, A. J., Jr. (1998): Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress, Oncogene (Band 17), Nr. 25, Seite 3287-3299.

(93) Fridman, J. S. und Lowe, S. W. (2003): Control of apoptosis by p53, Oncogene (Band 22), Nr. 56, Seite 9030-9040.

(94) Boirivant, M.; Pica, R.; DeMaria, R.; Testi, R.; Pallone, F. und Strober, W. (1996): Stimulated human lamina propria T cells manifest enhanced Fas-mediated apoptosis, J.Clin.Invest (Band 98), Nr. 11, Seite 2616-2622.

(95) Scaffidi, C.; Medema, J. P.; Krammer, P. H. und Peter, M. E. (1997): FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b, J.Biol.Chem. (Band 272), Nr. 43, Seite 26953-26958.

(96) Levine, A. D. und Fiocchi, C. (2001): Regulation of life and death in lamina propria T cells, Semin.Immunol. (Band 13), Nr. 3, Seite 195-199.

(97) Fiocchi, C. (1998): Inflammatory bowel disease: etiology and pathogenesis, Gastroenterology (Band 115), Nr. 1, Seite 182-205.

(98) Duchmann, R.; Schmitt, E.; Knolle, P.; Meyer zum Buschenfelde, K. H. und Neurath, M. (1996): Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies to interleukin-12, Eur.J.Immunol. (Band 26), Nr. 4, Seite 934-938.

(99) Ueyama, H.; Kiyohara, T.; Sawada, N.; Isozaki, K.; Kitamura, S.; Kondo, S.; Miyagawa, J.; Kanayama, S.; Shinomura, Y.; Ishikawa, H.; Ohtani, T.; Nezu, R.; Nagata, S. und Matsuzawa, Y. (1998): High Fas ligand expression on lymphocytes in lesions of ulcerative colitis, Gut (Band 43), Nr. 1, Seite 48-55.

(100) Gett, A. V. und Hodgkin, P. D. (1998): Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation, Proc.Natl.Acad.Sci.U.S.A (Band 95), Nr. 16, Seite 9488-9493. URL: PM:9689107

(101) Richter, A.; Lohning, M. und Radbruch, A. (1999): Instruction for cytokine expression in T helper lymphocytes in relation to proliferation and cell cycle progression, J.Exp.Med. (Band 190), Nr. 10, Seite 1439-1450.

[Seite 43↓]

(102) Jonuleit, H.; Schmitt, E.; Stassen, M.; Tuettenberg, A.; Knop, J. und Enk, A. H. (2001): Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood, J.Exp.Med. (Band 193), Nr. 11, Seite 1285-1294.

(103) Fiocchi, C. (1991): Production of inflammatory cytokines in the intestinal lamina propria, Immunol.Res. (Band 10), Nr. 3-4, Seite 239-246.

(104) Hodes, R. J. (1999): Telomere length, aging, and somatic cell turnover, J.Exp.Med. (Band 190), Nr. 2, Seite 153-156.

(105) Hodes, R. J.; Hathcock, K. S. und Weng, N. P. (2002): Telomeres in T and B cells, Nat.Rev.Immunol. (Band 2), Nr. 9, Seite 699-706.

(106) Blasco, M. A.; Funk, W.; Villeponteau, B. und Greider, C. W. (1995): Functional characterization and developmental regulation of mouse telomerase RNA, Science (Band 269), Nr. 5228, Seite 1267-1270.

(107) Buys, C. H. (2000): Telomeres, telomerase, and cancer, N.Engl.J.Med. (Band 342), Nr. 17, Seite 1282-1283.

(108) Appay, V. und Rowland-Jones, S. L. (2002): Premature ageing of the immune system: the cause of AIDS?, Trends Immunol. (Band 23), Nr. 12, Seite 580-585.

(109) Cottliar, A.; Fundia, A.; Boerr, L.; Sambuelli, A.; Negreira, S.; Gil, A.; Gomez, J. C.; Chopita, N.; Bernedo, A. und Slavutsky, I. (2000): High frequencies of telomeric associations, chromosome aberrations, and sister chromatid exchanges in ulcerative colitis, Am.J.Gastroenterol. (Band 95), Nr. 9, Seite 2301-2307.

(110) Fiocchi, C. (1997): Intestinal inflammation: a complex interplay of immune and nonimmune cell interactions, Am.J.Physiol (Band 273), Nr. 4 Pt 1, Seite G769-G775.

(111) Schonbeck, U. und Libby, P. (2001): The CD40/CD154 receptor/ligand dyad, Cell Mol.Life Sci. (Band 58), Seite 4-43.

(112) Danese, S.; de La, Motte C.; Sturm, A.; Vogel, J. D.; West, G. A.; Strong, S. A.; Katz, J. A. und Fiocchi, C. (2003): Platelets trigger a CD40-dependent inflammatory response in the microvasculature of inflammatory bowel disease patients, Gastroenterology (Band 124), Nr. 5, Seite 1249-1264.

[Seite 44↓]

(113) Heits, F.; Stahl, M.; Ludwig, D.; Stange, E. F. und Jelkmann, W. (1999): Elevatet serum thrombopoetin and interleukin-6 concentrations in thombocytosis associated with inflammatory bowel disease, J.Interferon Cytokine Res. (Band 19), Seite 757-760.

(114) Morowitz, D. A.; Allen, L. W. und Kirsner, J. B (1968): Thrombocytosis in chronic inflammatory bowel disease, Ann.Intern.Med. (Band 68), Seite 1013-1021.

(115) Binion, D. G.; West, G. A.; Ina, K.; Ziats, N. P.; Emancipator, S. N. und Fiocchi, C. (1997): Enhanced leukocyte binding by intestinal microvascular endothelial cells in inflammatory bowel disease, Gastroenterology (Band 112), Nr. 6, Seite 1895-1907.

(116) Laroux, F. S. und Grisham, M. B. (2001): Immunological basis of inflammatory bowel disease: role of the microcirculation, Microcirculation (Band 8), Seite 283-301.

(117) Vogel, J. D.; West, G. A.; Danese, S.; de La, Motte C.; Phillips, M. H.; Strong, S. A.; Willis, J. und Fiocchi, C. (2004): CD40-mediated immune-nonimmune cell interactions induce mucosal fibroblast chemokines leading to T-cell transmigration, Gastroenterology (Band 126), Nr. 1, Seite 63-80.

(118) Nicholson, D. W. (2000): From bench to clinic with apoptosis-based therapeutic agents, Nature (Band 407), Seite 810-816.

(119) Thames, H. D.; Petersen, C.; Petersen, S.; Nieder, C. und Baumann, M. (2002): Immunohistochemically detected p53 mutations in epithelial tumors and results of treatment with chemotherapy and radiotherapy. A treatment-specific overview of the clinical data, Strahlenther.Onkol. (Band 178), Nr. 8, Seite 411-421.

(120) Hupp, T. R.; lane, D. P. und Ball, K. L. (2000): Strategies for manipulating the p53 pathway in the treatment of human cancer, Biochem.J. (Band 352 Pt 1:1-17.), Seite 1-17.

(121) Shimada, H.; Matsubara, H. und Ochiai, T. (2002): p53 gene therapy for esophageal cancer, J.Gastroenterol. (Band 37 Suppl 14:87-91.), Seite 87-91.

(122) Gudkov, A. V. und Komarova, E. A. (2003): The role of p53 in determining sensitivity to radiotherapy, Nat.Rev.Cancer (Band 3), Nr. 2, Seite 117-129.

[Seite 45↓]

(123) Swisher, S. G. und Roth, J. A. (2002): Clinical update of Ad-p53 gene therapy for lung cancer, Surg.Oncol.Clin.N.Am. (Band 11), Nr. 3, Seite 521-535.

(124) Jerry, D. J.; Minter, L. M.; Becker, K. A. und Blackburn, A. C. (2002): Hormonal control of p53 and chemoprevention, Breast Cancer Res. (Band 4), Nr. 3, Seite 91-94.

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