Ullrich, Oliver: Mechanismen protektiver und destruktiver Funktionen der Poly(ADP-Ribose)-Polymerase-1 (PARP-1) bei Zell- und Gewebeschädigungen

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Anhang A. Publikationsverzeichnis

Originalarbeiten

  1. O.Ullrich, T.Grune, W.Henke, H.Esterbauer, W.G.Siems. Identification of metabolic pathways of the lipid peroxidation product 4-hydroxynonenal by mitochondria isolated from rat kidney cortex. FEBS Lett. 352, 84-86 (1994) IF = 3,581
  2. O.Ullrich, T.Grune, W.Henke, H.Esterbauer, W.G.Siems. The effect of the cytotoxic lipid peroxidation product 4-hydroxynonenal and its metabolite 4-hydroxynonenoic acid on respiration of isolated rat kidney cortex mitochondria. Free Radical Res. 24(6), 421-427 (1996) IF = 2,034
  3. O.Ullrich, T.Grune, K.Lehmann, H.Huser, W.Ehrlich, W.G.Siems. Inhibition of the poly(ADP-ribose) formation by 4-hydroxynonenal in primary cultures of rabbit synovial fibroblasts. Biochem. J. 315(3), 705-708 (1996) IF = 3,855
  4. O.Ullrich, H.Huser, W.Ehrlich, T.Grune. Intracellular metabolism of 4-hydroxynonenal in primary cultures of rabbit synovial fibroblasts. Free Radical Biol. Med. 22(7), 1153-1157 (1997) IF =4,348
  5. O.Ullrich, T.Grune. Detection of 8-hydroxy-deoxyguanosine in K562 human hematopoietic cells by high performance capillary electrophoresis. J. Chrom. B 697, 243-249 (1997) IF = 1,395
  6. O.Sommerburg, O.Ullrich, N.Sitte, W.Siems, T.Grune. Dose- and wavelength-dependent oxidation of crystallins by UV light - Selective recognition and degradation by the 20S proteasome. Free Radical Biol. Med. 24(9), 1369-1374 (1998) IF = 4,348
  7. T.Reinheckel, N.Sitte, O.Ullrich, U.Kuckelkorn, K.J.A.Davies, T.Grune. Resistance of the 20S proteasome to oxidative stress - comparison of the activities of the 20S and 26S proteasome. Biochem. J. 335, 637-642 (1998) IF = 3,855
  8. O.Ullrich, N.Sitte, O.Sommerburg, V.Sandig, T.Grune. Influence of DNA binding on the degradation of oxidized histones by the 20S proteasome. Arch. Biochem. Biophys. 362(2), 21-216 (1999) IF = 2,497

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  9. O.Ullrich, T.Reinheckel, N.Sitte, R.Hass, T.Grune. Poly-ADP-ribose-polymerase activates nuclear proteasome to degrade oxidatively damaged histones. Proc. Natl. Acad. Sci. U.S.A. 96, 6223-6228 (1999) IF = 9,821
  10. P. Meyer-Kuckuk, O.Ullrich, T.Grune, M. Ziegler, M.Schweiger. Functional interaction of poly(ADP-ribose) with the 20S proteasome in vitro. Biochem. Biophys. Res. Comms. 259, 576-581 (1999) IF = 2,780
  11. O.Ullrich, T.Reinheckel, N.Sitte, T.Grune. Degradation of hypochlorite damaged glucose-6-phosphate dehydrogenase by the 20S proteasome. Free Radical Biol. Med. 27, 487-492 (1999) IF = 4,348
  12. T.Reinheckel, O.Ullrich, N.Sitte, T.Grune. Differential impairment of 20S and 26S proteasome activities in human hematopoietic K562 cells during oxidative stress. Arch. Biochem. Biophys. 377(1), 65-68, (2000) IF = 2,497
  13. O.Ullrich*, Ö.Ciftci*, R.Hass. Proteasome activation by poly-ADP-ribose-polymerase in human myelomonocytic cells after oxidative stress. Free Radical Biol. Med. 29(10), 995-1004 (2000) *both authors contributed equally as “first author“ IF = 4,348
  14. J.Mehlhase, J.Gieche, O.Ullrich, N.Sitte, T.Grune. LPS-induced protein oxidation and proteolysis in BV-2 microglial cells. IUBMB Life 50(4-5), 331-335 (2000) IF = 0,418
  15. P.Lasch, T.Petras, O.Ullrich, J.Backmann, D.Naumann, T.Grune. Hydrogen peroxide- induced structural alterations of RNase A J. Biol. Chem. 276, 9492-9502 (2001) IF = 7,199
  16. Ö.Ciftci*, O.Ullrich*, C.A.Schmidt, A.Diestel, R.Hass. Regulation of the nuclear proteasome activity in human leukemia cells after adriamycin-treatment. Blood 97(9), 2830-2838 (2001) *both authors contributed equally as “first author“ IF = 8,372
  17. O.Ullrich, A.Diestel, I.Bechmann, M.Homberg, T.Grune, R.Hass, R.Nitsch. Turnover of oxidatively-damaged proteins in BV-2 microglia cells is linked to their activation state by poly(ADP-ribose) polymerase. FASEB J. 15, 1460-1462 (2001) online: 10.1096/fj.00-0540.fje (April 27, 2001) IF = 13,861
  18. O.Ullrich, T.Grune. Proteasomal degradation of oxidatively-damaged endogenous histones in K562 human leukemic cells. Free Radic. Biol. Med. 31, 887-893 (2001) IF = 4,348

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  19. O.Ullrich*, A.Diestel*, I.Y.Eyüpoglu, R.Nitsch. Regulation of microglial expression of integrins by poly(ADP-ribose)polymerase-1. Nature Cell Biol. 3, 1035-1042 (2001) *both authors contributed equally as “first author“ IF = 11,939
  20. S.Keck, R.Nitsch, T.Grune, O.Ullrich. Proteasome inhibition by paired helical filament-tau (PHF-tau) in the brain of patients with Alzheimers disease. (submitted)

Summe der Impact-Faktoren aller bereits publiziertenoder „in press“ befindlichen Publikationen = 95,844

Summe der Impact-Faktoren aller Erstautorpublikationen = 74,747

Übersichtsartikel

  1. O.Ullrich, T.Grune. Freie Radikale: Angriff auf Neurone (Review und Titelthema). Pharmazeutische Zeitschrift 46 (2001)
  2. O.Ullrich, T.Grune. Oxidative Schäden bei neurodegenerativen Erkrankungen (Review und Titelthema). Pharmazeutische Zeitschrift 47 (2001)

Eingeladene Hauptvorträge auf internationalen Konferenzen

O.Ullrich. A new mechanism to protect neurons from secondary damage by microglial PARP-1 inhibition. 13th International Conference on ADP-Ribosylation reactions, New York, USA (2001), invited plenary lecture

Vorträge

  1. O.Ullrich. Poly-ADP-Ribosylierung: Relevanz von 4-Hydroxynonenal bei Genexpression und DNA-Reparatur. 11.Meeting des Sauerstoffclubs Berlin und Brandenburg, Deutsches Institut für Ernährungsforschung, Bergholz-Rehbrücke, 13.07.1995
  2. O.Ullrich. Biologische Effekte des Lipidperoxidationsproduktes 4-Hydroxynonenal: Wirkung auf die mitochondriale Atmungskette und die nukleäre Poly-ADP-Ribose-Synthese. Universitätsklinikum der Otto-von-Guericke-Universität Magdeburg, Magdeburg, 20.02.1997
  3. O.Ullrich. Aktivierung des nukleären 20S-Proteasoms durch Poly-ADP-Ribosylierung nach oxidativen Stress - Bedeutung für den selektiven Abbau

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    oxidativ geschädigter Histone ? Meeting des Sauerstoffclubs Berlin und Brandenburg, Universitätsklinikum Charité, Berlin, Januar 1998
  4. O.Ullrich. Poly(ADP-Ribose)-Polymerase-gesteuerte Aktivierung des nukleären Proteasoms nach oxidativen Stress in hochmalignen humanen Leukämiezellen. 16. Arbeitstagung der Anatomischen Gesellschaft in Würzburg, Germany (1999)
  5. P.Mayer-Kuckuk, O.Ullrich. Poly(ADP-ribosyl)transferase and nuclear proteolysis. Institut für Veterinärpharmakologie, Universität Zürich (1999)
  6. O.Ullrich. Functional involvement of poly-ADP-ribose-polymerase in activation, migration and survival of microglial cells. 7.Tagung “Mechanismen der Zell- und Gewebeschädigung“, Weinheim, Germany (2000)
  7. W.Siems, O.Ullrich, T.Grune. Apoptose, Proteinoxidation und Proteinturnover in PC12-Zellen. 7.Tagung “Mechanismen der Zell- und Gewebeschädigung“, Weinheim, Germany (2000)
  8. S.Keck, T.Grune, O.Ullrich. Protein turnover and oxidative stress - applications to the tau protein. 1st Meeting “Cellular Mechanisms of Alzheimers disease.“, Eibsee, Germany (2000)
  9. O.Ullrich. Prevention of secondary neuronal damage by targeting microglial PARP-dependent signaling. 96.Versammlung der Anatomischen Gesellschaft, Münster, Germany (2001)
  10. Ö.Ciftci, O.Ullrich, C.A.Schmidt, A.Diestel, R.Hass PARP-associated proteasome activation represents a possible target within chemotherapeutic defense mechanisms developed by leukemia cells. 13th International Conference on ADP-Ribosylation reactions, New York, USA (2001),

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Beiträge auf internationalen und nationalen Konferenzen (Abstracts)

  1. O.Ullrich, T.Grune, W.Henke, K.Jung, W.G.Siems. The effect of the lipid peroxidation product 4-hydroxynonenal on respiratory parameters of isolated rat kidney cortex mitochondria. Critical Aspects of Free radicals in Chemistry, Biochemistry and Medicine, Vienna, Austria, 1993
  2. O.Ullrich, K.Lehmann, T.Grune, W.G.Siems, H.Huser, H.Kröger, W.Ehrlich. Inhibition of the poly(ADP-ribosyl)ation by physiological concentrations of the lipid peroxidation product 4-hydroxynonenal in rabbit synovial fibroblasts. Cellular Oxidants Conference, Queenstown, New Zealand, 1994
  3. O.Ullrich, T.Grune, W.G.Siems. Metabolism of 4-hydroxynonenal in mitochondria. 7th Biennal Scientific Meeting of the International Society for Free Radical Research, Sydney, Australia, 1994
  4. O.Ullrich, W.G.Siems, K.Lehmann, H.Huser, W.Ehrlich, T.Grune. Interactions of 4-hydroxynonenal and poly-ADP-ribose in a cell model of rheumatoid arthritis. 8th Biennal Scientific Meeting of the International Society for Free Radical Research, Barcelona, Spain (1996)
  5. O.Ullrich, T.Grune. Activation of the 20S proteasome by poly-ADP-ribosylation and free ADP-ribose in isolated nuclei of K562 human hematopoietic cells. International Symposium on Free Radicals in Medicine and Biology, Udaipur, India (1997)
  6. O.Ullrich, N.Sitte, T.Grune. Detachment of histones from DNA and increased proteolytic susceptibility by the 20S proteasome after oxidative stress. International Symposium on Free Radicals in Medicine and Biology, Udaipur, India (1997)
  7. O.Ullrich, T.Grune. Detection of 8-hydroxydeoxyguanosine in K562 human hematopoietic cells by high performance capillary electrophoresis. International Symposium on Free Radicals in Medicine and Biology, Udaipur, India (1997)
  8. T. Grune, N.Sitte, O.Ullrich. Stability of histones after oxidative stress. Gorden Research Conference “Oxygen Radicals in Biology“, Ventura, California, USA (1998)
  9. T.Grune, N.Sitte, O.Ullrich. Poly-ADP-ribose mediated regulation of the 20S proteasome. Annual Meeting of the Oxygen Club of California - ´98 World

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    Congress “Oxidants and Antioxidants in Biology“, Santa Barbara, California, USA (1998)
  10. O.Ullrich, T.Grune. Poly(ADP-ribosyl)ation-regulated degradation of histones by the 20S proteasome after oxidative stress. Autumn Meeting of the Society for Biochemistry and Molecular Biology (GBM), Jena, Germany (1998)
  11. O.Ullrich, T.Grune. Proteasomal histone degradation in K562 cells after oxidative stress. 5th Annual Meeting of the Oxygen Society, Washington D.C., USA (1998)
  12. O.Ullrich, N.Sitte, T.Grune. Inhibition of the 20S proteasome by DNA-histone-crosslinks. 5th Annual Meeting of the Oxygen Society, Washington D.C., USA (1998)
  13. P.Meyer-Kuckuk, O.Ullrich, T.Grune, M.Schweiger. Poly(ADP-ribosyl)transferase interacts with the 20S proteasome complex in vitro. 5 th Annual Meeting of the Oxygen Society, Washington D.C., USA (1998)
  14. K.Krämer, P.P.Hoppe, U.Oberfrank, T.Grune, O.Ullrich, N.Sitte, W.G.Siems. Balance between (n-3) PUFA and vitamine E in eggs. Annual Meeting of the Oxygen Club of California - ´98 World Congress, Santa Barbara, California, USA (1999)
  15. O.Ullrich, I.Bechmann, B.Steiner, M.Homberg, R.Hass, R.Nitsch. Enhanced degradation of oxidatively modified proteins by activated microglia in a proteasome- and PARP-dependent pathway. Berlin Neuroscience Forum, Bogensee, Germany (1999)
  16. M.Schrimpf, O.Ullrich, H.Ott. Effect of a 40 hour-sleep deprivation on the EEG and performance during a vigilance task. Berlin Neuroscience Forum, Bogensee, Germany (1999)
  17. R.Hass, O.Ullrich, D. Bächner. Astrocytes induce differentiation and GFAP expression in human promonocytic cells. Berlin Neuroscience Forum, Bogensee, Germany (1999)
  18. O.Ullrich, M.Homberg, I.Bechmann, B.Steiner, R.Nitsch. Antioxidativer Schutz aktivierter BV-2 Mikrogliazellen aufgrund des proteasomalen Abbaus oxidierter Proteine. 16. Arbeitstagung der Deutschen Anatomischen Gesellschaft in Würzburg, Germany (1999)

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  19. Ö.Ciftci, O.Ullrich, R.Hass. High malignancy in human leukemic cells is associated with increased proteasome activity after oxidative stress and requires PARP. Gemeinsame Jahrestagung der Deutschen und Österreichischen Gesellschaften für Hämatologie und Onkologie, Jena, Germany (1999)
  20. O.Ullrich, I.Bechmann, B.Steiner, M.Homberg, R.Hass, R.Nitsch. Turnover of oxidatively-damaged proteins in BV-2 microglia cells is proteasome-dependent and linked to its activation state by poly(ADP-ribose)polymerase. 29th Annual Meeting of the Society for Neuroscience, Miami, USA (1999)
  21. A.Selle, O.Ullrich, R.Hass. Functional active poly(ADP-ribosyl)transferase upregulates nuclear protein turnover during retrodifferentiation of human U937 myelomonocytic leukemia cells. 3th Joint Meeting of the German Signal Transduction Society, Berlin, Germany (1999)
  22. Ö.Ciftci, O.Ullrich, R.Hass. Regulation of protein degradation after oxidative stress in different states of malignancy of human U937 myelomonocytic leukemia cells. 3th Joint Meeting of the German Signal Transduction Society, Berlin, Germany (1999)
  23. O.Ullrich, P.Mayer-Kuckuk, T.Grune, R.Hass. Regulation of the nuclear 20S proteasome after oxidative stress. 3rd Joint Meeting of the German Signal Transduction Society, Berlin, Germany (1999)
  24. O.Ullrich, A.Diestel, I.Eyüpoglu, R.Nitsch. Microglia activation and migration towards sites of excitotoxic neuronal injury requires functional active poly-ADP-ribose polymerase. Anatomy 2000 Tripartite Meeting, Cambridge, UK (2000)
  25. O.Ullrich, A.Diestel, I.Eyüpoglu, R.Nitsch. Functional involvement of poly-ADP-ribose-polymerase in microglia activation, antioxidative defence and migration towards sites of exicitotoxic neuronal injury. 17. Arbeitstagung der Anatomischen Gesellschaft, Würzburg, Berlin, Germany (2000)
  26. O.Ullrich, A.Diestel, R.Nitsch and F.Zipp. Microglia activation by cholesterol oxides in the cerebrospinal fluid of patients with multiple sclerosis. 30th Annual Meeting of the Society for Neuroscience, New Orleans, USA (2000)
  27. A.Diestel, I.Eyüpoglu, R.Nitsch, O.Ullrich. Functional involvement and signalling of poly-ADP-ribose-polymerase in microglia activation and

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    migration towards sites of exicitotoxic neuronal injury. 30th Annual Meeting of the Society for Neuroscience, New Orleans, USA (2000)
  28. Ö.Ciftci, O.Ullrich, R.Hass. PARP-dependent proteasome activation in human leukemic cells after adriamycin treatment. 4th Joint Meeting of the German Signal Transduction Society, Berlin, Germany (2000)
  29. E.Kwidzinski, S.Peter, O.Ullrich, U.Gimsa, F.Zipp, R.Nitsch, I.Bechmann. Expression und Regulation der IDO (Indolamin-2,3-Dioxygenase) im ZNS. 96.Versammlung der Anatomischen Gesellschaft, Münster, Germany (2001)
  30. Ö.Ciftci, O.Ullrich, R.Hass. Proteasome activation by poly-ADP-ribose-polymerase is involved in potential protection mechanisms in oxidatively-stressed human myelomonocytic cells. 13th International Conference on ADP-Ribosylation reactions, New York, USA (2001)
  31. S.Keck, R.Nitsch, T.Grune, O.Ullrich. Proteasome inhibition by paired helical filaments (PHFs) in brains of patients with Alzheimer´s disease. 18th Biennal Meeting of the International Society for Neurochemistry, Buenos Aires, Argentina (2001)
  32. A.Diestel, R.Nitsch, O.Ullrich. Prevention of secondary neuronal damage by microglial PARP-1 inhibition. 31th Annual Meeting of the Society for Neuroscience, San Diego, USA (2001)
  33. S.Keck, R.Nitsch, T.Grune, O.Ullrich. Paired helical filaments (PHFs) interact with the proteasome in brains of patients with Alzheimer´s disease. 31th Annual Meeting of the Society for Neuroscience, San Diego, USA (2001)
  34. O.Ullrich, A.Diestel, R.Nitsch. Cholesteroloxid-vermittelte Aktivierung und Migration von Mikrogliazellen durch exzitotoxisch geschädigte Neurone. 18. Arbeitstagung der Anatomischen Gesellschaft, Würzburg, Germany (2001)
  35. Ö.Ciftci, A.Diestel, C.A.Schmidt, R.Hass, O.Ullrich. PARP-vermittelte Proteasomaktivierung bei Chemotherapie-assoziierten Resistenzmechanismen in Leukämiezellen. 18. Arbeitstagung der Anatomischen Gesellschaft, Würzburg, Germany (2001)
  36. A.Diestel, I.Häke, O.Aktas, R.Nitsch, F.Zipp, O.Ullrich. Mikroglia-Aktivierung durch oxidierte Cholesterole im Liquor cerebrospinalis von Patienten mit Multipler Sklerose. 18. Arbeitstagung der Anatomischen Gesellschaft, Würzburg, Germany (2001)

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  37. S.Keck, R.Nitsch, T.Grune, O.Ullrich. Proteasom-Hemmung durch PHFs im Hirn von Patienten mit Alzheimer-Erkrankung. 18. Arbeitstagung der Anatomischen Gesellschaft, Würzburg, Germany (2001)
  38. A.Selle, O.Ullrich, R.Hass. Retrodifferentiation of human leukemic cells is mediated by poly-ADP-ribose-polymerase. 5th Joint Meeting of the German Signal Transduction Society, Weimar, Germany (2001)
  39. O.Ullrich, A.Diestel, I.Eyüpoglu, R.Nitsch. Neuroprotection by downregulation of microglial PARP-1 and CD11a expression. 5th Joint Meeting of the German Signal Transduction Society, Weimar, Germany (2001)
  40. O.Ullrich, A.Diestel, I.Eyüpoglu, R.Nitsch. A new mechanism to protect neurons from secondary damage by microglial PARP-1 inhibition. Ernst-Schering-Research-Foundation-Workshop, Berlin, Germany (2001)

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