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Armstrong, J.F., Pritchard-Jones, K., Bickmore, W.A., Hastie, N.D., Bard, J.B. The expression of the Wilms´tumor gene, WT1, in the developing mammalian embryo. Mech. Dev. 40:85-97,1993.

Bonetta, L., Kuehn, S.E., Huang, A., Law, D.J., Kalikin, L.M., Koi, M., Reeve, A.E., Brownstein, B.H., Yeger, H., Williams, B.R.G., Feinberg, A.P. Wilms´tumor locus on 11p13 defined by multiple CpG island-associated transcripts. Science 250:994-997,1990.

Call, K.M., Glaser, T., Ito, C.Y., Buckler, A.J., Pelletier, J., Haber, D.A., Rose, E.A., Kral, A., Yeger, H., Lewis, W.H., Jones, C., Housman, D.E. Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms´tumor locus. Cell 60:509-520,1990.

Cook, D.M., Hinkes, M.T., Bernfield, M., Rauscher, F.J. Transcriptional activation of the syndecan-1 promoter by the Wilms´tumor protein WT1. Oncogene 13: 1789-1799,1996.

Drummond, I.A., Madden, S.L., Rohwer-Nutter, P., Bell, G.I., Sukhatme, V.P., Rauscher, F.J. Repression of the insulin-like growth factor II gene by the Wilms´tumor suppressor WT1. Science 257:674-678,1992.

Drummond, I.A., Rupprecht, H.D., Rohwer-Nutter, P., Lopez-Guisa, J.M., Madden, S.L., Rauscher, F.J., Sukhatme, V.P. DNA recognition by splicing variants of the Wilms´tumor suppressor, WT1. Mol. Cell. Biol. 14:3800-3809,1994.

Englert, C., Hou, X., Maheswaran, S., Bennett, P., Ngwu, C., Re, G.G., Garvin, A.J., Rosner, M.R., Haber, D.A. WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis. EMBO J. 14:4662-4675,1995.

Ernstsson, S., Pierrou, S., Hulander, M., Cederberg, A., Hellqvist, M., Carlsson, P., Enerbäck, S. Characterization of the human forkhead gene FREAC-4. J. Biol. Chem. 271:21094-21099,1996.

Gashler, A.L., Bonthron, D.T., Madden, S.L., Rauscher, F.J., Collins, T., Sukhatme, V.P. Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms´tumor suppressor WT1. Proc. Natl. Acad. Sci. USA 89: 10984-10988, 1992.

Gessler, M., Poustka, A., Cavenee, W., Neve, R.L., Orkin, S.H., Bruns, G.A. Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping. Nature 343:774-778,1990.

Haber, D.A., Sohn, R.L., Buckler, A.J., Pelletier, J., Call, K.M., Housman, D.E. Alternative splicing and genomic structure of the Wilms´tumor gene WT1. Proc. Natl. Acad. Sci. USA 88:9618-9622,1991.


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Kreidberg, J.A., Sariola, H., Loring, J.M., Maeda, M., Pelletier, J., Housman, D., Jaenisch, R. WT-1 is required for early kidney development. Cell 74:679-691, 1993.

Larsson, S.H., Charlieu, J.-P., Miyagawa, K., Engelkamp, D., Rassoulzadegan, M., Ross, A., Cuzin, F., van Heyningen, V., Hastie, N.D. Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing. Cell 81: 391-401,1995.

Maurer, U., Jehan, F., Englert, C., Hubinger, G., Weidmann, E., DeLuca, H.F., Bergmann, L. The Wilms’ tumor gene product (WT1) modulates the response to 1,25-dihydroxyvitamin D3 by induction of the vitamin D receptor (VDR). J. Biol. Chem. 276: 3727-3732,2001.

Moore, A., Mc Innes, L., Kreidberg, J., Hastie, N.D., Schedl, A. YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis. Development 126: 1845-1857,1999.

Moore, A., Schedl, A., McInnes, L., Doyle, M., Hecksher-Sorensen, J., and Hastie, N.D. YAC analysis reveals Wilms’ tumour 1 gene activity in the proliferating coelomic epithelium, developing diaphragm and limb. Mech. Dev. 79:169-184,1998.

Pritchard-Jones, K., Fleming, S., Davidson, D., Bickmore,W., Porteous, D., Gosden, C., Bard, J., Buckler, A., Pelletier, J., Housman, D., van Heyningen, V., Hastie, N. The candidate Wilms´tumour gene is involved in genitourinary development. Nature 346: 194-197,1990.

Rauscher, F.J., III, Morris, J.F., Tournay, O.E., Cook, D.M., Curran, T. Binding of the Wilms´tumor locus zinc finger protein to the EGR-1 consensus sequence. Science 250:1259-1262,1990.

Sharma, P.M., Bowman, M., Madden, S.L., Rauscher III, F.J., Sukumar, S. RNA editing in the Wilms´ tumor susceptibility gene, WT1. Genes & Dev. 8:720-731,1994.

Wagner, K.D., Wagner, N., Bondke, A., Nafz, B., Flemming, B., Theres, H., Scholz, H. The Wilms’ tumor suppressor Wt1 is expressed in the coronary vasculature after myocardial infarction. FASEB J 16:1117-1119,2002c.

Wagner, K.D., Wagner, N., Schley, G., Theres, H., Scholz, H. The Wilms’ tumor suppressor Wt1 encodes a transcriptional activator of the class IV POU-domain factor Pou4f2 (Brn-3b) Gene 305:217-213,2003a.

Wagner, K.D., Wagner, N., Sukhatme, V.P., Scholz, H. Activation of the vitamin D receptor by the Wilms’ tumor gene product mediates apoptosis of renal cells. J. Am. Soc. Nephrol. 12:1188-1196,2001.

Wagner, K.D., Wagner, N., Wellmann, S., Schley, G., Bondke, A., Theres, H., Scholz, H. Oxygen-regulated expression of the Wilms’ tumor suppressor Wt1 involves hypoxia-inducible factor-1 (HIF-1). FASEB J, 2003b, in press.


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Wagner, K.D., Wagner, N., Vidal, V.P.I., Schley, G., Wilhelm, D., Schedl, A., Englert, C., Scholz, H. The Wilms’ tumor gene Wt1 is required for normal development of the retina. EMBO J. 21:1398-1405,2002a.

Wagner, N., Wagner, K.D., Schley, G., Coupland, S., Heimann, H., Grantyn, R., Scholz, H. The Wilms’ tumor suppressor Wt1 is associated with the differentiation of retinoblastoma cells. Cell Growth Diff. 13:297-305,2002b.

Wagner, N., Wagner, K.D., Sefton, M., Rodriguez-Tebar, A., Grantyn, R. An abnormal response of retinoblastoma cells (Y-79) to neurotrophins. Invest. Ophthalmol. Vis. Sci. 41:1932-9,2000.

Wang, Z.Y., Qiu, Q.Q., Enger, K.T., Deuel, T.F. A second transcriptionally active DNA-binding site for the Wilms´tumor gene product. Proc. Natl. Acad. Sci. USA 90:8896-8900, 1993.


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