Literaturverzeichnis

1: Greenlee, R.T. et al. (2001): Cancer statistics CA Cancer J.Clin. 51(1), Seite 15-36

2: Blohmer, J.U. und Diel, I. J. (2003): Gynäkologische Malignome Harrisons Innere Medizin, 15. Auflage, Seite 685-691, ABW Wissenschaftsverlag, Berlin

3: Deutsche Krebsgesellschaft e.V. (2003): Maligne Ovarialtumoren Qualitätssicherung in der Onkologie: Diagnose und Therapie maligner Erkrankungen 2002, Seite 284-297

4: Virchow, R. (1863): Vorlesungen über Pathologie Hirschwald , Berlin

5: Balkwill, F. und Mantovani, A. (2001): Inflammation and cancer: back to Virchow ? Lancet 357(9255), Seite 539-545

6: Hauptmann, S. (2000): The role of inflammation in tumor invasion Verh.Dtsch.Ges.Pathol. 84, Seite 77-86

7: Dvorak, H.F. (1986): Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing N.Engl.J.Med. 315(26), Seite 1650-1659

8: Ness, R.B. und Cottreau, C. (1999): Possible role of ovarian epithelial inflammation in ovarian cancer J.Natl.Cancer Inst. 91(17), Seite 1459-1467

9: Berger, S. et al. (2000): Ovarian carcinoma cell lines do not respond to IL-10: sign of an autonomous cytokine production Pathology - Research and Practice 196, Seite 450

10: Seger, R. und Krebs, E.G. (1995): The MAPK signaling cascade FASEB J. 9(9), Seite 726-735

11: Arbabi, S. und Maier, R.V. (2002): Mitogen-activated protein kinases Crit.Care Med. 30(1. Supp), Seite S74-S79

12: Chang, L. und Karin, M. (2001): Mammalian MAP kinase signalling cascades Nature 410(6824), Seite 37-40

13: Tibbles, L.A. und Woodgett, J.R. (1999): The stress-activated protein kinase pathways Cell Mol.Life Sci. 55(10), Seite 1230-1254

14: Xiao, Y.Q. et al. (2002): Cross-talk between ERK and p38 MAPK mediates selective suppression of pro-inflammatory cytokines by transforming growth factor-beta J.Biol.Chem. 277(17), Seite 14884-14893

15: Biocarta (2003) Webpage http://www.biocarta.com/genes

16: Garrington, T.P. und Johnson, G.L. (1999): Organization and regulation of mitogen-activated protein kinase signaling pathways Curr.Opin.Cell Biol. 11(2), Seite 211-218

17: Johnson, G.L. und Lapadat, R. (2002): Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases Science 298(5600), Seite 1911-1912

18: Lasa, M. et al. (2001): Dexamethasone destabilizes cyclooxygenase 2 mRNA by inhibiting mitogen-activated protein kinase p38 Mol.Cell Biol. 21(3), Seite 771-780

19: Chen, W. et al. (2002): Stimulus-specific requirements for MAP3 kinases in activating the JNK pathway J.Biol.Chem. 277(51), Seite 49105-49110

20: Chen, G. et al. (2000): The p38 pathway provides negative feedback to Ras proliferative signaling J.Biol.Chem. 275:(50), Seite 38973-38980

21: Govindarajan, B. et al. (2003): Malignant Transformation of Melanocytes to Melanoma by Constitutive Activation of Mitogen-activated Protein Kinase Kinase (MAPKK) Signaling J.Biol.Chem. 278(11), Seite 9790-9795

22: Cohen, C. et al. (2002): Mitogen-actived protein kinase activation is an early event in melanoma progression Clin.Cancer Res. 8(12), Seite 3728-3733

23: Uzgare, A.R. et al. (2003): Differential expression and/or activation of P38MAPK, erk1/2, and jnk during the initiation and progression of prostate cancer Prostate 55(2), Seite 128-139

24: Choi, K.C. et al. (2003): Adenosine triphosphate activates mitogen-activated protein kinase in pre-neoplastic and neoplastic ovarian surface epithelial cells Biol.Reprod. 68(1), Seite 309-315

25: Hoshino, R. et al. (1999): Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors Oncogene 18(3), Seite 813-822

26: Keyse, S.M. und Emslie, E.A. (1992): Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase Nature 359(6396), Seite 644-647

27: Charles, C.H. et al. (1993): The growth factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine-phosphatase Proc.Natl.Acad.Sci.U.S.A. 90(11), Seite 5292-5296

28: Keyse, S.M. (1998): Protein phosphatases and the regulation of MAP kinase activity Semin.Cell Dev.Biol. 9(2), Seite 143-152

29: Cook, S.J. et al. (1997): Regulation of mitogen-activated protein kinase phosphatase-1 expression by extracellular signal-related kinase-dependent and Ca2+-dependent signal pathways in Rat-1 cells J.Biol.Chem. 272(20), Seite 13309-13319

30: Brondello, J.M. et al. (1997): The dual specificity mitogen-activated protein kinase phosphatase-1 and -2 are induced by the p42/p44MAPK cascade J.Biol.Chem. 272(2), Seite 1368-1376

31: Bhalla, U.S. und Iyengar, R. (1999): Emergent properties of networks of biological signaling pathways Science 283(5400), Seite 381-387

32: Sun, H. et al. (1993): MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo Cell 75(3), Seite 487-493

33: Franklin, C.C. und Kraft, A.S. (1997): Conditional expression of the mitogen-activated protein kinase (MAPK) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress-activated protein kinase in U937 cells J.Biol.Chem. 272(27), Seite 16917-16923

34: Kwak, S.P. et al. (1994): Isolation and characterization of a human dual specificity protein-tyrosine phosphatase gene J.Biol.Chem. 269(5), Seite 3596-3604

35: Emslie, E.A. et al. (1994): The CL100 gene, which encodes a dual specificity (Tyr/Thr) MAP kinase phosphatase, is highly conserved and maps to human chromosome 5q34 Hum.Genet. 93(5), Seite 513-516

36: Rohan, P.J. et al. (1993): PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase Science 259(5102), Seite 1763-1766

37: Martell, K.J. et al. (1994): Chromosomal localization of four human VH1-like protein-tyrosine phosphatases Genomics 22(2), Seite 462-464

38: Ishibashi, T. et al. (1992): Expression cloning of a human dual-specificity phosphatase Proc.Natl.Acad.Sci.U.S.A. 89(24), Seite 12170-12174

39: Kamb, A. et al. (1994): Localization of the VHR phosphatase gene and its analysis as a candidate for BRCA1 Genomics 23(1), Seite 163-167

40: Misra-Press, A. et al. (1995): A novel mitogen-activated protein kinase phosphatase. Structure, expression, and regulation J.Biol.Chem. 270(24), Seite 14587-14596

41: Guan, K.L. und Butch, E. (1995): Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase J.Biol.Chem. 270(13), Seite 7197-7203

42: King, A.G. et al. (1995): Isolation and characterisation of a uniquely regulated threonine, tyrosine phosphatase (TYP 1) which inactivates ERK2 and p54jnk Oncogene 11(12), Seite 2553-2563

43: Smith, A. et al. (1997): Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7) Genomics 42(3), Seite 524-527

44: Ishibashi, T. et al. (1994): A novel dual specificity phosphatase induced by serum stimulation and heat shock J.Biol.Chem. 269(47), Seite 29897-29902

45: Muda, M. et al. (1996): MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase J.Biol.Chem. 271(8), Seite 4319-4326

46: Muda, M. et al. (1996): The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases J.Biol.Chem. 271(44), Seite 27205-27208

47: Groom, L.A. et al. (1996): Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase EMBO J. 15(14), Seite 3621-3632

48: Furukawa, T. et al. (1998): Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer Cytogenet.Cell Genet. 82(3-4), Seite 156-159

49: Martell, K.J. et al. (1995): hVH-5: a protein tyrosine phosphatase abundant in brain that inactivates mitogen-activated protein kinase J.Neurochem. 65(4), Seite 1823-1833

50: Nesbit, M.A. et al. (1997): Genomic organization and chromosomal localization of a member of the MAP kinase phosphatase gene family to human chromosome 11p15.5 and a pseudogene to 10q11.2 Genomics 42(2), Seite 284-294

51: Muda, M. et al. (1997): Molecular cloning and functional characterization of a novel mitogen-activated protein kinase phosphatase, MKP-4 J.Biol.Chem. 272(8), Seite 5141-5151

52: Tanoue, T. et al. (1999): Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5 J.Biol.Chem. 274(28), Seite 19949-19956

53: Masuda, K. et al. (2000): Expression and comparative chromosomal mapping of MKP-5 genes DUSP10/Dusp10 Cytogenet.Cell Genet. 90(1-2), Seite 71-74

54: Li, J. et al. (2001): Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation Mol.Cell Biol. 21(23), Seite 8213-8224

55: Lasa, M. et al. (2002): Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38 Mol.Cell Biol. 22(22), Seite 7802-7811

56: Imasato, A. et al. (2002): Inhibition of p38 MAPK by glucocorticoids via induction of MAPK phosphatase-1 enhances nontypeable Haemophilus influenzae-induced expression of toll-like receptor 2 J.Biol.Chem. 277(49), Seite 47444-47450

57: Laderoute, K.R. et al. (1999): Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments. A candidate MKP for the inactivation of hypoxia-inducible stress-activated protein kinase/c-Jun N-terminal protein kinase activity J.Biol.Chem. 274(18), Seite 12890-12897

58: Chu, Y. et al. (1996): The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation J.Biol.Chem. 271(11), Seite 6497-6501

59: Haneda, M. et al. (1999): Mitogen-activated protein kinase phosphatase: a negative regulator of the mitogen-activated protein kinase cascade Eur.J.Pharmacol. 365(1), Seite 1-7

60: Charles, C.H. et al. (1992): cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein Oncogene 7(1), Seite 187-190

61: Brondello, J.M. et al. (1999): Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation Science 286(5449), Seite 2514-2517

62: Lin, Y.W. et al. (2003): ERK1/2 Achieves Sustained Activation by Stimulating MAPK Phosphatase-1 Degradation via the Ubiquitin-proteasome Pathway J.Biol.Chem. 278(24), Seite 21534-21541

63: Engelbrecht, Y. et al. (2003): Glucocorticoids induce rapid up-regulation of mitogen-activated protein kinase phosphatase-1 and dephosphorylation of extracellular signal-regulated kinase and impair proliferation in human and mouse osteoblast cell lines Endocrinology 144(2), Seite 412-422

64: Chen, P. et al. (2001): Discordance between the binding affinity of mitogen-activated protein kinase subfamily members for MKP-2 and their ability to catalytically activate the phosphatase J.Biol.Chem. 276.(31), Seite 29440-29449

65: Wellbrock, C. et al. (2002): Activation of p59(Fyn) leads to melanocyte dedifferentiation by influencing MKP-1-regulated mitogen-activated protein kinase signaling J.Biol.Chem. 277(8), Seite 6443-6454

66: Magi-Galluzzi, C. et al. (1997): Mitogen-activated protein kinase phosphatase 1 is overexpressed in prostate cancers and is inversely related to apoptosis Lab.Invest. 76(1), Seite 37-51

67: Tsao, S.W. et al. (1995): Characterization of human ovarian surface epithelial cells immortalized by human papilloma viral oncogenes (HPV-E6E7 ORFs) Exp.Cell Res. 218(2), Seite 499-507

68: Lennon, G. et al. (1996): The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression Genomics 33(1), Seite 151-152

69: Magi-Galluzzi, C. et al. (1998): Mitogen-activated protein kinases and apoptosis in PIN Virchows Arch. 432(5), Seite 407-413

70: Sun, H. und Tonks, N.K. (1994): The coordinated action of protein tyrosine phosphatases and kinases in cell signaling Trends.Biochem.Sci. 19(11), Seite 480-485

71: Kazama, H. und Yonehara, S. (2000): Oncogenic K-Ras and basic fibroblast growth factor prevent Fas-mediated apoptosis in fibroblasts through activation of mitogen-activated protein kinase J.Cell Biol. 148(3), Seite 557-566

72: Loda, M. et al. (1996): Expression of mitogen-activated protein kinase phosphatase-1 in the early phases of human epithelial carcinogenesis Am.J.Pathol. 149(5), Seite 1553-1564

73: Davies, S.P. et al. (2000): Specificity and mechanism of action of some commonly used protein kinase inhibitors Biochem.J. 351(Pt 1), Seite 95-105

74: Bokemeyer, D. et al. (1996): Induction of mitogen-activated protein kinase phosphatase 1 by the stress-activated protein kinase signaling pathway but not by extracellular signal-regulated kinase in fibroblasts J.Biol.Chem. 271(2), Seite 639-642

75: Scimeca, J.C. et al. (1997): Essential role of calcium in the regulation of MAP kinase phosphatase-1 expression Oncogene 15(6), Seite 717-725

76: Mourey, R.J. et al. (1996): A novel cytoplasmic dual specificity protein tyrosine phosphatase implicated in muscle and neuronal differentiation J.Biol.Chem. 271(7), Seite 3795-3802

77: Schonwasser, D.C. et al. (1998): Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes Mol.Cell Biol. 18(2), Seite 790-798

78: Moscat, J. und Diaz-Meco, M.T. (2000): The atypical protein kinase Cs. Functional specificity mediated by specific protein adapters EMBO Rep. 1(5), Seite 399-403

79: Mao, M. et al. (2000): Inhibition of growth-factor-induced phosphorylation and activation of protein kinase B/Akt by atypical protein kinase C in breast cancer cells Biochem.J. 352(Pt 2), Seite 475-482

80: Beltman, J. et al. (1996): The selective protein kinase C inhibitor, Ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression, and activates Jun N-terminal kinase J.Biol.Chem. 271(43), Seite 27018-27024

81: Valledor, A.F. et al. (2000): Protein kinase C epsilon is required for the induction of mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages J.Immunol. 164(1), Seite 29-37

82: Bhalla, U.S. et al. (2002): MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network Science 297(5583), Seite 1018-1023

83: Unoki, M. und Nakamura, Y. (2001): Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway Oncogene 20(33), Seite 4457-4465

84: Ono, K. et al. (2000): Identification by cDNA microarray of genes involved in ovarian carcinogenesis Cancer Res. 60(18), Seite 5007-5011

85: Bang, Y.J. et al. (1998): Increased MAPK activity and MKP-1 overexpression in human gastric adenocarcinoma Biochem.Biophys.Res.Commun. 250(1), Seite 43-47

86: Xia, Z. et al. (1995): Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis Science 270(5240), Seite 1326-1331

87: Wang, H. et al. (2003): Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancer Cancer Lett. 191(2), Seite 229-237

88: Low, W. et al. (1999): JNK activation is not required for Fas-mediated apoptosis Oncogene 18(25), Seite 3737-3741

89: Valladares, A. et al. (2000): p38 mitogen-activated protein kinase mediates tumor necrosis factor-alpha-induced apoptosis in rat fetal brown adipocytes Endocrinology 141(12), Seite 4383-4395

90: Tran, S.E. et al. (2001): MAPK/ERK overrides the apoptotic signaling from Fas, TNF, and TRAIL receptors J.Biol.Chem. 276(19), Seite 16484-16490

91: Park, H.J. et al. (2002): Role of MAP kinases and their cross-talk in TGF-beta1-induced apoptosis in FaO rat hepatoma cell line Hepatology 35(6), Seite 1360-1371

92: Antlsperger, D.S. et al. (2003): Ajoene-induced cell death in human promyeloleukemic cells does not require JNK but is amplified by the inhibition of ERK Oncogene 22(4), Seite 582-589

93: Boldt, S. et al. (2003): The kinase domain of MEKK1 induces apoptosis by dysregulation of MAP kinase pathways Exp.Cell Res. 283(1), Seite 80-90

94: Chen, Y.R. et al. (1996): The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation J.Biol.Chem. 271(50), Seite 31929-31936

95: Franklin, C.C. et al. (1998): Conditional expression of mitogen-activated protein kinase phosphatase-1, MKP-1, is cytoprotective against UV-induced apoptosis Proc.Natl.Acad.Sci.U.S.A. 95(6), Seite 3014-3019

96: Guo, Y.L. et al. (1998): Inhibition of the expression of mitogen-activated protein phosphatase-1 potentiates apoptosis induced by tumor necrosis factor-alpha in rat mesangial cells J.Biol.Chem. 273(17), Seite 10362-10366

97: Jamieson, L. et al. (1999): Protein kinase Ciota activity is necessary for Bcr-Abl-mediated resistance to drug-induced apoptosis J.Biol.Chem. 274(7), Seite 3927-3930

98: Losa, J.H. et al. (2003): Role of the p38 MAPK pathway in cisplatin-based therapy Oncogene 22(26), Seite 3998-4006

99: Persons, D.L. et al. (1999): Cisplatin-induced activation of mitogen-activated protein kinases in ovarian carcinoma cells: inhibition of extracellular signal-regulated kinase activity increases sensitivity to cisplatin Clin.Cancer Res. 5(5), Seite 1007-1014

100: Sanchez-Perez, I. et al. (1998): Cisplatin induces a persistent activation of JNK that is related to cell death Oncogene 16(4), Seite 533-540

101: Mansouri, A. et al. (2003): Sustained Activation of JNK/p38 MAPK Pathways in Response to Cisplatin Leads to Fas Ligand Induction and Cell Death in Ovarian Carcinoma Cells J.Biol.Chem. 278(21), Seite 19245-19256

102: Sanchez-Perez, I. et al. (2000): CL100/MKP-1 modulates JNK activation and apoptosis in response to cisplatin Oncogene 19(45), Seite 5142-5152

103: Pfahl, M. (2003): Anti-Cancer Activities of MKP-1 and Cdc25 Phosphatase Inhibitors Albany Molecular Research: Technical Reports 8(17), Seite 3-4