- edoc-Server Home
- Browsing by Author
Browsing by Author "M. Saied, Essa"
Now showing items 1-20 of 25
-
2021-10-21ZeitschriftenartikelA Comprehensive Review about the Molecular Structure of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Insights into Natural Products against COVID-19 M. Saied, Essa; El-Maradny , Yousra; Osman, Alaa A.; Darwish, Amira; Abo Nahas, Hebatallah H.; Niedbała, Gniewko; Piekutowska, Magdalena; Abdel-Rahman, Mohamed; Balbool, Bassem; Abdel-Azeem, AhmedIn 2019, the world suffered from the emergence of COVID-19 infection, one of the most difficult pandemics in recent history. Millions of confirmed deaths from this pandemic have been reported worldwide. This disaster was ...
-
2022-02-27ZeitschriftenartikelAcetylsalicylic Acid Suppresses Alcoholism-Induced Cognitive Impairment Associated with Atorvastatin Intake by Targeting Cerebral miRNA155 and NLRP3: In Vivo, and In Silico Study Mohamed, Doaa I.; Alaa El-Din Aly El-Waseef, Dalia; Nabih, Enas; El-Kharashi, Omnyah A.; Abd El-Kareem, Hanaa F.; Abo Nahas, Hebatallah H.; A. Abdel-Wahab, Basel; Helmy, Yosra A.; Alshawwa, Samar; M. Saied, EssaAlcoholism is one of the most common diseases that can lead to the development of several chronic diseases including steatosis, and cognitive dysfunction. Statins are lipid-lowering drugs that are commonly prescribed for ...
-
2023-01-30ZeitschriftenartikelAntimicrobial Resistance and Recent Alternatives to Antibiotics for the Control of Bacterial Pathogens with an Emphasis on Foodborne Pathogens Helmy, Yosra A.; Taha-Abdelaziz, Khaled; Hawwas, Hanan Abd El-Halim; Ghosh, Soumya; Alkafaas, Samar Sami; Moawad, Mohamed M. M.; M. Saied, Essa; Kassem, Issmat I.; Mawad, Asmaa Mostafa MohammedAntimicrobial resistance (AMR) is one of the most important global public health problems. The imprudent use of antibiotics in humans and animals has resulted in the emergence of antibiotic-resistant bacteria. The dissemination ...
-
2021-04-24ZeitschriftenartikelCyanobacteria—From the Oceans to the Potential Biotechnological and Biomedical Applications Khalifa, Shaden A. M.; Shedid, Eslam S.; M. Saied, Essa; Jassbi, Amir Reza; Jamebozorgi, Fatemeh H.; Rateb, Mostafa E.; Du, Ming; Abdel-Daim, Mohamed M.; Kai, Guo-Yin; Al-Hammady, Montaser A. M.; Xiao, Jianbo; Guo, Zhiming; El-Seedi, Hesham R.Cyanobacteria are photosynthetic prokaryotic organisms which represent a significantsource of novel, bioactive, secondary metabolites, and they are also considered an abundant source ofbioactive compounds/drugs, such as ...
-
2024-06-11ZeitschriftenartikelDeciphering the therapeutic potential of trimetazidine in rheumatoid arthritis via targeting mi-RNA128a, TLR4 signaling pathway, and adenosine-induced FADD-microvesicular shedding: In vivo and in silico study Omran, Enas; Alzahrani, Abdullah R.; Ezzat, Samar F.; Ellithy, Ghada; Tarek, Marwa; Khairy, Eman; Ghit, Mohamed M.; Elgeushy, Ahmed; Ibrahim Al-Hazani, Tahani Mohamed; Aziz Ibrahim, Ibrahim Abdel; Falemban, Alaa Hisham; Bamagous, Ghazi A.; Elhawary, Nasser A.; Jaremko, Mariusz; M. Saied, Essa;Rheumatoid arthritis (RA) is a debilitating autoimmune condition characterized by chronic synovitis, joint damage, and inflammation, leading to impaired joint functionality. Existing RA treatments, although effective to ...
-
2022-09-23ZeitschriftenartikelDevelopment of Novel 1,3-Disubstituted-2-Thiohydantoin Analogues with Potent Anti-Inflammatory Activity; In Vitro and In Silico Assessments Khirallah, Salma; Ramadan, Heba M. M.; Shawky, Ahmed; Qahl, Safa H.; Baty, Roua; Alqadri, Nada; Alsuhaibani, Amnah Mohammed; Jaremko, Mariusz; Emwas, Abdul-Hamid; M. Saied, EssaInflammation is the main cause of several autoimmune diseases, including type I diabetes, rheumatoid arthritis, bullous pemphigoid, paraneoplastic pemphigoid, and multiple sclerosis. Currently, there is an urgent demand ...
-
2023-06-15ZeitschriftenartikelEditorial: Molecular and multi-omic approaches in understanding cancer biology and anticancer therapies: current perspectives and new challenges A. Abdel-Wahab, Basel; Helmy, Yosra A.; M. Saied, Essa
-
2023-07-20ZeitschriftenartikelExploring the antibacterial potential of plant extracts and essential oils against Bacillus thermophilus in beet sugar for enhanced sucrose retention: a comparative assessment and implications Yousef, Mohamed M.; Zohri, Abdel-Naser A.; Darwish, Amira M. G.; Shamseldin, Abdelaal; Kabeil, Sanaa A.; Abdelkhalek, Ahmed; Binsuwaidan, Reem; Jaremko, Mariusz; Alshwyeh, Hussah; Hafez, Elsayed; M. Saied, EssaSugar beet is one of the greatest sources for producing sugar worldwide. However, a group of bacteria grows on beets during the storage process, leading to a reduction in sucrose yield. Our study focused on identifying ...
-
2022-07-05ZeitschriftenartikelHepatoprotective Role of Carvedilol against Ischemic Hepatitis Associated with Acute Heart Failure via Targeting miRNA-17 and Mitochondrial Dynamics-Related Proteins: An In Vivo and In Silico Study Mohamed, Doaa I.; Ezzat, Samar F.; Elayat, Wael M.; El-Kharashi, Omnyah A.; El-Kareem, Hanaa F. Abd; Nahas, Hebatallah H. Abo; A. Abdel-Wahab, Basel; Alshawwa, Samar; Saleh, Asmaa; Helmy, Yosra A.; Khairy, Eman; M. Saied, EssaAcute heart failure (AHF) is one of the most common diseases in old age that can lead to mortality. Systemic hypoperfusion is associated with hepatic ischemia–reperfusion injury, which may be irreversible. Ischemic hepatitis ...
-
2021-01ZeitschriftenartikelIdentification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening Otsuka, Yuka; Airola, Michael; Choi, Yong-Mi; Coant, Nicolas; Snider, Justin; Cariello, Chris; M. Saied, Essa; Arenz, Christoph; Bannister, Thomas; Rahaim, Ron; Hannun, Yusuf A.; Shumate, Justin; Scampavia, Louis; Haley, John D.; Spicer, TimothyThere is interest in developing inhibitors of human neutral ceramidase (nCDase) because this enzyme plays a critical role in colon cancer. There are currently no potent or clinically effective inhibitors for nCDase reported ...
-
2020-11-09ZeitschriftenartikelLiposomal FRET Assay Identifies Potent Drug‐Like Inhibitors of the Ceramide Transport Protein (CERT) Samaha, Doaa; Hamdo, Housam H.; Cong, Xiaojing; Schumacher, Fabian; Banhart, Sebastian; Aglar, Öznur; Möller, Heiko M.; Heuer, Dagmar; Kleuser, Burkhard; M. Saied, Essa; Arenz, ChristophCeramide transfer protein (CERT) mediates non‐vesicular transfer of ceramide from endoplasmic reticulum to Golgi apparatus and thus catalyzes the rate‐limiting step of sphingomyelin biosynthesis. Usually, CERT ligands are ...
-
2021-09-28ZeitschriftenartikelNeutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects Kalinichenko, Liubov S.; Mühle, Christiane; Jia, Tianye; Anderheiden, Felix; Datz, Maria; Eberle, Anna-Lisa; Eulenburg, Volker; Granzow, Jonas; Hofer, Martin; Hohenschild, Julia; Huber, Sabine E.; Kämpf, Stefanie; Kogias, Georgios; Lacatusu, Laura; Lugmair, Charlotte;Mental disorders are highly comorbid and occur together with physical diseases, which are often considered to arise from separate pathogenic pathways. We observed in alcohol-dependent patients increased serum activity of ...
-
2021-04-15ZeitschriftenartikelNew Mononuclear and Binuclear Cu(II), Co(II), Ni(II), and Zn(II) Thiosemicarbazone Complexes with Potential Biological Activity: Antimicrobial and Molecular Docking Study Gaber, Ahmed; Refat, Moamen; Belal, Arafa A. M.; El-Deen, Ibrahim; Hassan, Nader; Zakaria, Rozan; Alhomrani, Majid; Alamri, Abdulhakeem; Alsanie, Walaa F.; M. Saied, EssaHerein, we report the synthesis of eight new mononuclear and binuclear Co2+, Ni2+, Cu2+, and Zn2+ methoxy thiosemicarbazone (MTSC) complexes aiming at obtaining thiosemicarbazone complex with potent biological activity. ...
-
2022-07-31ZeitschriftenartikelNovel 1,3-Thiazole Analogues with Potent Activity against Breast Cancer: A Design, Synthesis, In Vitro, and In Silico Study Salem, Manar G.; El-Maaty, Dina M. Abu; El-Deen, Yassmina I. Mohey; Elesawy, Basem H.; Askary, Ahmad El; Saleh, Asmaa; M. Saied, Essa; El Behery, MohammedBreast cancer is the most common cancer in women, responsible for over half a million deaths in 2020. Almost 75% of FDA-approved drugs are mainly nitrogen- and sulfur-containing heterocyclic compounds, implying the importance ...
-
2023-12-02ZeitschriftenartikelNovel 8-Methoxycoumarin-3-Carboxamides with potent anticancer activity against liver cancer via targeting caspase-3/7 and β-tubulin polymerization Alzamami, Ahmad; Radwan, Eman M.; Abo‑Elabass, Eman; El Behery, Mohammed; Alshwyeh, Hussah Abdullah; Al-Olayan, Ebtesam; Altamimi, Abdulmalik S.; Attallah, Nashwah G. M.; Altwaijry, Najla; Jaremko, Mariusz; M. Saied, EssaIn the present study, we explored the potential of coumarin-based compounds, known for their potent anticancer properties, by designing and synthesizing a novel category of 8-methoxycoumarin-3-carboxamides. Our aim was to ...
-
2022-07-31ZeitschriftenartikelNovel Exopolysaccharide from Marine Bacillus subtilis with Broad Potential Biological Activities: Insights into Antioxidant, Anti-Inflammatory, Cytotoxicity, and Anti-Alzheimer Activity A. Abdel-Wahab, Basel; F. Abd El-Kareem, Hanaa; Alzamami, Ahmad; A. Fahmy, Cinderella; Elesawy, Basem H.; Mostafa Mahmoud, Maged; Ghareeb, Ahmed; El Askary, Ahmad; H. Abo Nahas, Hebatallah; G. M. Attallah, Nashwah; Altwaijry, Najla; M. Saied, EssaIn the presented study, Bacillus subtilis strain AG4 isolated from marine was identified based on morphological, physiological, phylogenetic characteristics and an examination of 16S rRNA sequences. Novel exopolysaccharide ...
-
2024-08-16ZeitschriftenartikelNovel Insights into the Antimicrobial and Antibiofilm Activity of Pyrroloquinoline Quinone (PQQ); In Vitro, In Silico, and Shotgun Proteomic Studies Labib, Mai M.; Alqahtani, Alaa; Abo Nahas, Hebatallah H.; Aldossari, Rana M.; Almiman, Bandar; Ayman Alnumaani, Sarah; Elnablaway, Mohammad; Al-Olayan, Ebtesam; Alsunbul, Maha; M. Saied, EssaMicrobial infections pose a significant global health threat, affecting millions of individuals and leading to substantial mortality rates. The increasing resistance of microorganisms to conventional treatments requires ...
-
2020-11-20ZeitschriftenartikelNovel Papaverine Metal Complexes with Potential Anticancer Activities Gaber, Ahmed; Alsanie, Walaa F.; Kumar, Deo Nandan; Refat, Moamen; M. Saied, EssaCancer is one of the leading causes of death worldwide. Although several potential therapeutic agents have been developed to efficiently treat cancer, some side effects can occur simultaneously. Papaverine, a non-narcotic ...
-
2021-07-29ZeitschriftenartikelStereoselective Synthesis of Novel Sphingoid Bases Utilized for Exploring the Secrets of Sphinx M. Saied, Essa; Arenz, ChristophSphingolipids are ubiquitous in eukaryotic plasma membranes and play major roles in human and animal physiology and disease. This class of lipids is usually defined as being derivatives of sphingosine, a long-chain ...
-
2024-05-30ZeitschriftenartikelSupplementation of Saussurea costus root alleviates sodium nitrite-induced hepatorenal toxicity by modulating metabolic profile, inflammation, and apoptosis Elshaer, Samy E.; Hamad, Gamal M.; Sobhy, Sherien E.; Darwish, Amira M. Galal; Baghdadi, Hoda H.; H. Abo Nahas, Hebatallah; El-Demerdash, Fatma; Kabeil, Sanaa S. A.; Altamimi, Abdulmalik S.; Al-Olayan, Ebtesam; Alsunbul, Maha; Docmac, Omaima Kamel; Jaremko, Mariusz; Hafez, Elsayed; M. Saied, EssaSodium nitrite (NaNO2) is a widely used food ingredient, although excessive concentrations can pose potential health risks. In the present study, we evaluated the deterioration effects of NaNO2 additives on hematology, ...
