Browsing by Author "Semyachkina-Glushkovskaya, Oxana"

Now showing items 1-13 of 13

2021-11-02Zeitschriftenartikel

A Novel Method to Stimulate Lymphatic Clearance of Beta-Amyloid from Mouse Brain Using Noninvasive Music-Induced Opening of the Blood–Brain Barrier with EEG Markers

Semyachkina-Glushkovskaya, Oxana; Khorovodov, Alexander; Fedosov, Ivan; Pavlov, Alexey; Shirokov, Alexander; Sharif, Ali Esmat; Dubrovsky, Alexander; Blokhina, Inna; Terskov, Andrey; Navolokin, Nikita; Evsukova, Arina; Karandin, Georgy; Elovenko, Dariya; Tzoy, Maria; Ageev, Vasily;

The lymphatic system of the brain meninges and head plays a crucial role in the clearance of amyloid-β protein (Aβ), a peptide thought to be pathogenic in Alzheimer’s disease (AD), from the brain. The development of methods ...
2018-11-30Zeitschriftenartikel

Blood−Brain Barrier, Lymphatic Clearance, and Recovery: Ariadne’s Thread in Labyrinths of Hypotheses

Semyachkina-Glushkovskaya, Oxana; Postnov, Dmitry; Kurths, Jürgen

The peripheral lymphatic system plays a crucial role in the recovery mechanisms after many pathological changes, such as infection, trauma, vascular, or metabolic diseases. The lymphatic clearance of different tissues from ...
2021-06-28Zeitschriftenartikel

Brain Mechanisms of COVID-19-Sleep Disorders

Semyachkina-Glushkovskaya, Oxana; Mamedova, Aysel; Vinnik, Valeria; Klimova, Maria; Saranceva, Elena; Ageev, Vasily; Yu, Tingting; Zhu, Dan; Penzel, Thomas; Kurths, Jürgen

2020 and 2021 have been unprecedented years due to the rapid spread of the modified severe acute respiratory syndrome coronavirus around the world. The coronavirus disease 2019 (COVID-19) causes atypical infiltrated pneumonia ...
2023-02-06Zeitschriftenartikel

Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases

Semyachkina-Glushkovskaya, Oxana; Fedosov, Ivan; Penzel, Thomas; Li, Dongyu; Yu, Tingting; Telnova, Valeria; Kaybeleva, Elmira; Saranceva, Elena; Terskov, Andrey; Khorovodov, Alexander; Blokhina, Inna; Kurths, Jürgen; Zhu, Dan

Emerging evidence suggests that an important function of the sleeping brain is the removal of wastes and toxins from the central nervous system (CNS) due to the activation of the brain waste removal system (BWRS). The ...
2022-12-22Zeitschriftenartikel

Intranasal Delivery of Liposomes to Glioblastoma by Photostimulation of the Lymphatic System

Semyachkina-Glushkovskaya, Oxana; Shirokov, Alexander; Blokhina, Inna; Telnova, Valeria; Vodovozova, Elena; Alekseeva, Anna; Boldyrev, Ivan; Fedosov, Ivan; Dubrovsky, Alexander; Khorovodov, Alexandr; Terskov, Andrey; Evsukova, Arina; Elovenko, Daria; Adushkina, Viktoria; Tzoy, Maria;

The blood–brain barrier (BBB) limits the delivery of majority of cancer drugs and thereby complicates brain tumor treatment. The nasal-brain-lymphatic system is discussed as a pathway for brain drug delivery overcoming the ...
2023-02-08Zeitschriftenartikel

Low-Level Laser Treatment Induces the Blood-Brain Barrier Opening and the Brain Drainage System Activation: Delivery of Liposomes into Mouse Glioblastoma

Semyachkina-Glushkovskaya, Oxana; Bragin, Denis; Bragina, Olga; Socolovski, Sergey; Shirokov, Alexander; Fedosov, Ivan; Ageev, Vasily; Blokhina, Inna; Dubrovsky, Alexander; Telnova, Valeria; Terskov, Andrey; Khorovodov, Alexander; Elovenko, Daria; Evsukova, Arina; Zhoy, Maria;

The progress in brain diseases treatment is limited by the blood-brain barrier (BBB), which prevents delivery of the vast majority of drugs from the blood into the brain. In this study, we discover unknown phenomenon of ...
2022-10-13Zeitschriftenartikel

Music improves the therapeutic effects of bevacizumab in rats with glioblastoma: Modulation of drug distribution to the brain

Semyachkina-Glushkovskaya, Oxana; Diduk, Sergey; Anna, Eroshova; Elina, Dosadina; Artem, Kruglov; Khorovodov, Alexander; Shirokov, Alexander; Fedosov, Ivan; Dubrovsky, Alexander; Blokhina, Inna; Terskov, Andrey; Navolokin, Nikita; Evsukova, Arina; Elovenko, Daria; Adushkina, Viktoria;

Background The development of new methods for modulation of drug distribution across to the brain is a crucial step in the effective therapies for glioblastoma (GBM). In our previous work, we discovered the phenomenon of ...
2021-11-24Zeitschriftenartikel

Night Photostimulation of Clearance of Beta-Amyloid from Mouse Brain: New Strategies in Preventing Alzheimer’s Disease

Semyachkina-Glushkovskaya, Oxana; Penzel, Thomas; Blokhina, Inna; Khorovodov, Alexander; Fedosov, Ivan; Yu, Tingting; Karandin, Georgy; Evsukova, Arina; Elovenko, Dariya; Adushkina, Viktoria; Shirokov, Alexander; Dubrovskii, Alexander; Terskov, Andrey; Navolokin, Nikita; Tzoy, Maria;

The deposition of amyloid-β (Aβ) in the brain is a risk factor for Alzheimer’s disease (AD). Therefore, new strategies for the stimulation of Aβ clearance from the brain can be useful in preventing AD. Transcranial ...
2022-11-26Zeitschriftenartikel

Photodynamic Opening of the Blood–Brain Barrier and the Meningeal Lymphatic System: The New Niche in Immunotherapy for Brain Tumors

Semyachkina-Glushkovskaya, Oxana; Terskov, Andrey; Khorovodov, Alexander; Telnova, Valeria; Blokhina, Inna; Saranceva, Elena; Kurths, Jürgen

Photodynamic therapy (PDT) is a promising add-on therapy to the current standard of care for patients with glioblastoma (GBM). The traditional explanation of the anti-cancer PDT effects involves the PDT-induced generation ...
2019-12-19Zeitschriftenartikel

Photodynamic Opening of the Blood−Brain Barrier Using Different Photosensitizers in Mice

Semyachkina-Glushkovskaya, Oxana; Borisova, Ekaterina; Mantareva, Vanya; Angelov, Ivan; Eneva, Ivelina; Terskov, Andrey; Mamedova, Aysel; Shirokov, Alexander; Khorovodov, Alexander; Klimova, Maria; Agranovich, Ilana; Blokhina, Inna; Lezhnev, Nikita; Kurths, Jurgen

In a series of previous studies, we demonstrated that the photodynamic therapy (PDT), as a widely used tool for treatment of glioblastoma multiforme (GBM), also site-specifically opens the blood–brain barrier (BBB) in ...
2020-06-26Zeitschriftenartikel

Photostimulation of Extravasation of Beta-Amyloid through the Model of Blood-Brain Barrier

Zinchenko, Ekaterina; Klimova, Maria; Mamedova, Aysel; Agranovich, Ilana; Blokhina, Inna; Antonova, Tatiana; Terskov, Andrey; Shirokov, Alexander; Navolokin, Nikita; Morgun, Andrey; Osipova, Elena; Boytsova, Elizaveta; Yu, Tingting; Zhu, Dan; Kurths, Jürgen;

Alzheimer’s disease (AD) is an incurable pathology associated with progressive decline in memory and cognition. Phototherapy might be a new promising and alternative strategy for the effective treatment of AD, and has been ...
2023-06-30Zeitschriftenartikel

Phototherapy of Alzheimer’s Disease: Photostimulation of Brain Lymphatics during Sleep: A Systematic Review

Semyachkina-Glushkovskaya, Oxana; Penzel, Thomas; Poluektov, Mikhail; Fedosov, Ivan; Tzoy, Maria; Terskov, Andrey; Blokhina, Inna; Sidorov, Victor; Kurths, Jürgen

The global number of people with Alzheimer’s disease (AD) doubles every 5 years. It has been established that unless an effective treatment for AD is found, the incidence of AD will triple by 2060. However, pharmacological ...
2020-08-31Zeitschriftenartikel

Sleep as a Novel Biomarker and a Promising Therapeutic Target for Cerebral Small Vessel Disease: A Review Focusing on Alzheimer’s Disease and the Blood-Brain Barrier

Semyachkina-Glushkovskaya, Oxana; Postnov, Dmitry; Penzel, Thomas; Kurths, Jürgen

Cerebral small vessel disease (CSVD) is a leading cause of cognitive decline in elderly people and development of Alzheimer’s disease (AD). Blood–brain barrier (BBB) leakage is a key pathophysiological mechanism of amyloidal ...