Browsing by Author "Grzegorzewski, Jan"

Now showing items 1-5 of 5

2022-02-25Zeitschriftenartikel

Pharmacokinetics of Caffeine: A Systematic Analysis of Reported Data for Application in Metabolic Phenotyping and Liver Function Testing

Grzegorzewski, Jan; Bartsch, Florian; Köller, Adrian; König, Matthias

Caffeine is by far the most ubiquitous psychostimulant worldwide found in tea, coffee, cocoa, energy drinks, and many other beverages and food. Caffeine is almost exclusively metabolized in the liver by the cytochrome P-450 ...
2021-11-22Zeitschriftenartikel

Physiologically Based Modeling of the Effect of Physiological and Anthropometric Variability on Indocyanine Green Based Liver Function Tests

Köller, Adrian; Grzegorzewski, Jan; König, Matthias

Accurate evaluation of liver function is a central task in hepatology. Dynamic liver function tests (DLFT) based on the time-dependent elimination of a test substance provide an important tool for such a functional assessment. ...
2023-09-01Kumulative Dissertation

Physiologically based pharmacokinetic (PBPK) modeling for dynamical liver function tests and CYP phenotyping

Grzegorzewski, Jan

Die Phänotypisierung von Cytochrom P450 (CYP) und Leberfunktionstests sind wichtige Methoden in der Klinik. Die Methoden nutzen die Pharmakokinetik (PK) von Testsubstanzen und ihren Metaboliten, um Einblicke in die ...
2022-10-24Zeitschriftenartikel

Physiologically based pharmacokinetic (PBPK) modeling of the role of CYP2D6 polymorphism for metabolic phenotyping with dextromethorphan

Grzegorzewski, Jan; Brandhorst, Janosch; König, Matthias

The cytochrome P450 2D6 (CYP2D6) is a key xenobiotic-metabolizing enzyme involved in the clearance of many drugs. Genetic polymorphisms in CYP2D6 contribute to the large inter-individual variability in drug metabolism and ...
2021-11-22Zeitschriftenartikel

Prediction of Survival After Partial Hepatectomy Using a Physiologically Based Pharmacokinetic Model of Indocyanine Green Liver Function Tests

Köller, Adrian; Grzegorzewski, Jan; Tautenhahn, Hans-Michael; König, Matthias

The evaluation of hepatic function and functional capacity of the liver are essential tasks in hepatology as well as in hepatobiliary surgery. Indocyanine green (ICG) is a widely applied test compound that is used in ...