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Browsing by Author "Khorovodov, Alexander"
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2021-11-02ZeitschriftenartikelA Novel Method to Stimulate Lymphatic Clearance of Beta-Amyloid from Mouse Brain Using Noninvasive Music-Induced Opening of the Blood–Brain Barrier with EEG Markers Semyachkina-Glushkovskaya, Oxana; Khorovodov, Alexander; Fedosov, Ivan; Pavlov, Alexey; Shirokov, Alexander; Sharif, Ali Esmat; Dubrovsky, Alexander; Blokhina, Inna; Terskov, Andrey; Navolokin, Nikita; Evsukova, Arina; Karandin, Georgy; Elovenko, Dariya; Tzoy, Maria; Ageev, Vasily;The lymphatic system of the brain meninges and head plays a crucial role in the clearance of amyloid-β protein (Aβ), a peptide thought to be pathogenic in Alzheimer’s disease (AD), from the brain. The development of methods ...
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2023-02-06ZeitschriftenartikelBrain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases Semyachkina-Glushkovskaya, Oxana; Fedosov, Ivan; Penzel, Thomas; Li, Dongyu; Yu, Tingting; Telnova, Valeria; Kaybeleva, Elmira; Saranceva, Elena; Terskov, Andrey; Khorovodov, Alexander; Blokhina, Inna; Kurths, Jürgen; Zhu, DanEmerging evidence suggests that an important function of the sleeping brain is the removal of wastes and toxins from the central nervous system (CNS) due to the activation of the brain waste removal system (BWRS). The ...
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2023-02-08ZeitschriftenartikelLow-Level Laser Treatment Induces the Blood-Brain Barrier Opening and the Brain Drainage System Activation: Delivery of Liposomes into Mouse Glioblastoma Semyachkina-Glushkovskaya, Oxana; Bragin, Denis; Bragina, Olga; Socolovski, Sergey; Shirokov, Alexander; Fedosov, Ivan; Ageev, Vasily; Blokhina, Inna; Dubrovsky, Alexander; Telnova, Valeria; Terskov, Andrey; Khorovodov, Alexander; Elovenko, Daria; Evsukova, Arina; Zhoy, Maria;The progress in brain diseases treatment is limited by the blood-brain barrier (BBB), which prevents delivery of the vast majority of drugs from the blood into the brain. In this study, we discover unknown phenomenon of ...
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2022-10-13ZeitschriftenartikelMusic improves the therapeutic effects of bevacizumab in rats with glioblastoma: Modulation of drug distribution to the brain Semyachkina-Glushkovskaya, Oxana; Diduk, Sergey; Anna, Eroshova; Elina, Dosadina; Artem, Kruglov; Khorovodov, Alexander; Shirokov, Alexander; Fedosov, Ivan; Dubrovsky, Alexander; Blokhina, Inna; Terskov, Andrey; Navolokin, Nikita; Evsukova, Arina; Elovenko, Daria; Adushkina, Viktoria;Background The development of new methods for modulation of drug distribution across to the brain is a crucial step in the effective therapies for glioblastoma (GBM). In our previous work, we discovered the phenomenon of ...
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2021-11-24ZeitschriftenartikelNight Photostimulation of Clearance of Beta-Amyloid from Mouse Brain: New Strategies in Preventing Alzheimer’s Disease Semyachkina-Glushkovskaya, Oxana; Penzel, Thomas; Blokhina, Inna; Khorovodov, Alexander; Fedosov, Ivan; Yu, Tingting; Karandin, Georgy; Evsukova, Arina; Elovenko, Dariya; Adushkina, Viktoria; Shirokov, Alexander; Dubrovskii, Alexander; Terskov, Andrey; Navolokin, Nikita; Tzoy, Maria;The deposition of amyloid-β (Aβ) in the brain is a risk factor for Alzheimer’s disease (AD). Therefore, new strategies for the stimulation of Aβ clearance from the brain can be useful in preventing AD. Transcranial ...
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2022-11-26ZeitschriftenartikelPhotodynamic Opening of the Blood–Brain Barrier and the Meningeal Lymphatic System: The New Niche in Immunotherapy for Brain Tumors Semyachkina-Glushkovskaya, Oxana; Terskov, Andrey; Khorovodov, Alexander; Telnova, Valeria; Blokhina, Inna; Saranceva, Elena; Kurths, JürgenPhotodynamic therapy (PDT) is a promising add-on therapy to the current standard of care for patients with glioblastoma (GBM). The traditional explanation of the anti-cancer PDT effects involves the PDT-induced generation ...
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2019-12-19ZeitschriftenartikelPhotodynamic Opening of the Blood−Brain Barrier Using Different Photosensitizers in Mice Semyachkina-Glushkovskaya, Oxana; Borisova, Ekaterina; Mantareva, Vanya; Angelov, Ivan; Eneva, Ivelina; Terskov, Andrey; Mamedova, Aysel; Shirokov, Alexander; Khorovodov, Alexander; Klimova, Maria; Agranovich, Ilana; Blokhina, Inna; Lezhnev, Nikita; Kurths, JurgenIn a series of previous studies, we demonstrated that the photodynamic therapy (PDT), as a widely used tool for treatment of glioblastoma multiforme (GBM), also site-specifically opens the blood–brain barrier (BBB) in ...