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Browsing by Author "König, Matthias"
Now showing items 1-9 of 9
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2023-08-02ZeitschriftenartikelA pathway model of glucose-stimulated insulin secretion in the pancreatic β-cell Deepa Maheshvare, M.; Raha, Soumyendu; König, Matthias; Pal, DebnathThe pancreas plays a critical role in maintaining glucose homeostasis through the secretion of hormones from the islets of Langerhans. Glucose-stimulated insulin secretion (GSIS) by the pancreatic β-cell is the main mechanism ...
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2017-11-14ZeitschriftenartikelComputational Modeling in Liver Surgery Christ, Bruno; Dahmen, Uta; Herrmann, Karl-Heinz; König, Matthias; Reichenbach, Jürgen R.; Ricken, Tim; Schleicher, Jana; Schwen, Lars Ole; Vlaic, Sebastian; Waschinsky, NavinaThe need for extended liver resection is increasing due to the growing incidence of liver tumors in aging societies. Individualized surgical planning is the key for identifying the optimal resection strategy and to minimize ...
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2021-11-18ZeitschriftenartikelHepatectomy-Induced Alterations in Hepatic Perfusion and Function - Toward Multi-Scale Computational Modeling for a Better Prediction of Post-hepatectomy Liver Function Christ, Bruno; Collatz, Maximilian; Dahmen, Uta; Herrmann, Karl-Heinz; Höpfl, Sebastian; König, Matthias; Lambers, Lena; Marz, Manja; Meyer, Daria; Radde, Nicole; Reichenbach, Jürgen R.; Ricken, Tim; Tautenhahn, Hans-MichaelLiver resection causes marked perfusion alterations in the liver remnant both on the organ scale (vascular anatomy) and on the microscale (sinusoidal blood flow on tissue level). These changes in perfusion affect hepatic ...
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2022-02-25ZeitschriftenartikelPharmacokinetics of Caffeine: A Systematic Analysis of Reported Data for Application in Metabolic Phenotyping and Liver Function Testing Grzegorzewski, Jan; Bartsch, Florian; Köller, Adrian; König, MatthiasCaffeine is by far the most ubiquitous psychostimulant worldwide found in tea, coffee, cocoa, energy drinks, and many other beverages and food. Caffeine is almost exclusively metabolized in the liver by the cytochrome P-450 ...
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2021-11-22ZeitschriftenartikelPhysiologically Based Modeling of the Effect of Physiological and Anthropometric Variability on Indocyanine Green Based Liver Function Tests Köller, Adrian; Grzegorzewski, Jan; König, MatthiasAccurate evaluation of liver function is a central task in hepatology. Dynamic liver function tests (DLFT) based on the time-dependent elimination of a test substance provide an important tool for such a functional assessment. ...
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2022-10-24ZeitschriftenartikelPhysiologically based pharmacokinetic (PBPK) modeling of the role of CYP2D6 polymorphism for metabolic phenotyping with dextromethorphan Grzegorzewski, Jan; Brandhorst, Janosch; König, MatthiasThe cytochrome P450 2D6 (CYP2D6) is a key xenobiotic-metabolizing enzyme involved in the clearance of many drugs. Genetic polymorphisms in CYP2D6 contribute to the large inter-individual variability in drug metabolism and ...
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2021-11-22ZeitschriftenartikelPrediction of Survival After Partial Hepatectomy Using a Physiologically Based Pharmacokinetic Model of Indocyanine Green Liver Function Tests Köller, Adrian; Grzegorzewski, Jan; Tautenhahn, Hans-Michael; König, MatthiasThe evaluation of hepatic function and functional capacity of the liver are essential tasks in hepatology as well as in hepatobiliary surgery. Indocyanine green (ICG) is a widely applied test compound that is used in ...
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2021-10-15ZeitschriftenartikelSBMLWebApp: Web-Based Simulation, Steady-State Analysis, and Parameter Estimation of Systems Biology Models Yamada, Takahiro; Ii, Kaito; König, Matthias; Feierabend, Martina; Dräger, Andreas; Funahashi, AkiraIn systems biology, biological phenomena are often modeled by Ordinary Differential Equations (ODEs) and distributed in the de facto standard file format SBML. The primary analyses performed with such models are dynamic ...
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2019-10-10ZeitschriftenartikelSimplified Triceps Surae Muscle Volume Assessment in Older Adults Karamanidis, Kiros; Epro, Gaspar; König, Matthias; Mersmann, Falk; Arampatzis, AdamantiosTriceps surae (TS) muscle volume can be estimated in young adults by only considering the maximal anatomical cross-sectional area (ACSAmax) and the length of the muscle due to the presence of a constant muscle-specific ...
