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Browsing by Author "Terskov, Andrey"
Now showing items 1-13 of 13
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2021-11-02ZeitschriftenartikelA Novel Method to Stimulate Lymphatic Clearance of Beta-Amyloid from Mouse Brain Using Noninvasive Music-Induced Opening of the Blood–Brain Barrier with EEG Markers Semyachkina-Glushkovskaya, Oxana; Khorovodov, Alexander; Fedosov, Ivan; Pavlov, Alexey; Shirokov, Alexander; Sharif, Ali Esmat; Dubrovsky, Alexander; Blokhina, Inna; Terskov, Andrey; Navolokin, Nikita; Evsukova, Arina; Karandin, Georgy; Elovenko, Dariya; Tzoy, Maria; Ageev, Vasily;The lymphatic system of the brain meninges and head plays a crucial role in the clearance of amyloid-β protein (Aβ), a peptide thought to be pathogenic in Alzheimer’s disease (AD), from the brain. The development of methods ...
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2023-02-06ZeitschriftenartikelBrain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases Semyachkina-Glushkovskaya, Oxana; Fedosov, Ivan; Penzel, Thomas; Li, Dongyu; Yu, Tingting; Telnova, Valeria; Kaybeleva, Elmira; Saranceva, Elena; Terskov, Andrey; Khorovodov, Alexander; Blokhina, Inna; Kurths, Jürgen; Zhu, DanEmerging evidence suggests that an important function of the sleeping brain is the removal of wastes and toxins from the central nervous system (CNS) due to the activation of the brain waste removal system (BWRS). The ...
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2024-01-24ZeitschriftenartikelDifferent Effects of Phototherapy for Rat Glioma during Sleep and Wakefulness Shirokov, Alexander; Blokhina, Inna; Fedosov, Ivan; Ilyukov, Egor; Terskov, Andrey; Myagkov, Dmitry; Tuktarov, Dmitry; Tzoy, Maria; Adushkina, Viktoria; Zlatogosrkaya, Daria; Evsyukova, Arina; Telnova, Valeria; Dubrovsky, Alexander; Dmitrenko, Alexander; Manzhaeva, Maria;There is an association between sleep quality and glioma-specific outcomes, including survival. The critical role of sleep in survival among subjects with glioma may be due to sleep-induced activation of brain drainage ...
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2022-12-22ZeitschriftenartikelIntranasal Delivery of Liposomes to Glioblastoma by Photostimulation of the Lymphatic System Semyachkina-Glushkovskaya, Oxana; Shirokov, Alexander; Blokhina, Inna; Telnova, Valeria; Vodovozova, Elena; Alekseeva, Anna; Boldyrev, Ivan; Fedosov, Ivan; Dubrovsky, Alexander; Khorovodov, Alexandr; Terskov, Andrey; Evsukova, Arina; Elovenko, Daria; Adushkina, Viktoria; Tzoy, Maria;The blood–brain barrier (BBB) limits the delivery of majority of cancer drugs and thereby complicates brain tumor treatment. The nasal-brain-lymphatic system is discussed as a pathway for brain drug delivery overcoming the ...
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2023-02-08ZeitschriftenartikelLow-Level Laser Treatment Induces the Blood-Brain Barrier Opening and the Brain Drainage System Activation: Delivery of Liposomes into Mouse Glioblastoma Semyachkina-Glushkovskaya, Oxana; Bragin, Denis; Bragina, Olga; Socolovski, Sergey; Shirokov, Alexander; Fedosov, Ivan; Ageev, Vasily; Blokhina, Inna; Dubrovsky, Alexander; Telnova, Valeria; Terskov, Andrey; Khorovodov, Alexander; Elovenko, Daria; Evsukova, Arina; Zhoy, Maria;The progress in brain diseases treatment is limited by the blood-brain barrier (BBB), which prevents delivery of the vast majority of drugs from the blood into the brain. In this study, we discover unknown phenomenon of ...
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2023-11-02ZeitschriftenartikelMachine Learning Technology for EEG-Forecast of the Blood–Brain Barrier Leakage and the Activation of the Brain’s Drainage System during Isoflurane Anesthesia Semyachkina-Glushkovskaya, Oxana; Sergeev, Konstantin; Semenova, Nadezhda; Slepnev, Andrey; Karavaev, Anatoly; Hramkov, Alexey; Prokhorov, Mikhail; Borovkova, Ekaterina; Blokhina, Inna; Fedosov, Ivan; Shirokov, Alexander; Dubrovsky, Alexander; Terskov, Andrey; Manzhaeva, Maria; Krupnova, Valeria;Anesthesia enables the painless performance of complex surgical procedures. However, the effects of anesthesia on the brain may not be limited only by its duration. Also, anesthetic agents may cause long-lasting changes ...
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2022-10-13ZeitschriftenartikelMusic improves the therapeutic effects of bevacizumab in rats with glioblastoma: Modulation of drug distribution to the brain Semyachkina-Glushkovskaya, Oxana; Diduk, Sergey; Anna, Eroshova; Elina, Dosadina; Artem, Kruglov; Khorovodov, Alexander; Shirokov, Alexander; Fedosov, Ivan; Dubrovsky, Alexander; Blokhina, Inna; Terskov, Andrey; Navolokin, Nikita; Evsukova, Arina; Elovenko, Daria; Adushkina, Viktoria;Background The development of new methods for modulation of drug distribution across to the brain is a crucial step in the effective therapies for glioblastoma (GBM). In our previous work, we discovered the phenomenon of ...
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2021-11-24ZeitschriftenartikelNight Photostimulation of Clearance of Beta-Amyloid from Mouse Brain: New Strategies in Preventing Alzheimer’s Disease Semyachkina-Glushkovskaya, Oxana; Penzel, Thomas; Blokhina, Inna; Khorovodov, Alexander; Fedosov, Ivan; Yu, Tingting; Karandin, Georgy; Evsukova, Arina; Elovenko, Dariya; Adushkina, Viktoria; Shirokov, Alexander; Dubrovskii, Alexander; Terskov, Andrey; Navolokin, Nikita; Tzoy, Maria;The deposition of amyloid-β (Aβ) in the brain is a risk factor for Alzheimer’s disease (AD). Therefore, new strategies for the stimulation of Aβ clearance from the brain can be useful in preventing AD. Transcranial ...
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2022-11-26ZeitschriftenartikelPhotodynamic Opening of the Blood–Brain Barrier and the Meningeal Lymphatic System: The New Niche in Immunotherapy for Brain Tumors Semyachkina-Glushkovskaya, Oxana; Terskov, Andrey; Khorovodov, Alexander; Telnova, Valeria; Blokhina, Inna; Saranceva, Elena; Kurths, JürgenPhotodynamic therapy (PDT) is a promising add-on therapy to the current standard of care for patients with glioblastoma (GBM). The traditional explanation of the anti-cancer PDT effects involves the PDT-induced generation ...
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2019-12-19ZeitschriftenartikelPhotodynamic Opening of the Blood−Brain Barrier Using Different Photosensitizers in Mice Semyachkina-Glushkovskaya, Oxana; Borisova, Ekaterina; Mantareva, Vanya; Angelov, Ivan; Eneva, Ivelina; Terskov, Andrey; Mamedova, Aysel; Shirokov, Alexander; Khorovodov, Alexander; Klimova, Maria; Agranovich, Ilana; Blokhina, Inna; Lezhnev, Nikita; Kurths, JurgenIn a series of previous studies, we demonstrated that the photodynamic therapy (PDT), as a widely used tool for treatment of glioblastoma multiforme (GBM), also site-specifically opens the blood–brain barrier (BBB) in ...
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2020-06-26ZeitschriftenartikelPhotostimulation of Extravasation of Beta-Amyloid through the Model of Blood-Brain Barrier Zinchenko, Ekaterina; Klimova, Maria; Mamedova, Aysel; Agranovich, Ilana; Blokhina, Inna; Antonova, Tatiana; Terskov, Andrey; Shirokov, Alexander; Navolokin, Nikita; Morgun, Andrey; Osipova, Elena; Boytsova, Elizaveta; Yu, Tingting; Zhu, Dan; Kurths, Jürgen;Alzheimer’s disease (AD) is an incurable pathology associated with progressive decline in memory and cognition. Phototherapy might be a new promising and alternative strategy for the effective treatment of AD, and has been ...
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2023-06-30ZeitschriftenartikelPhototherapy of Alzheimer’s Disease: Photostimulation of Brain Lymphatics during Sleep: A Systematic Review Semyachkina-Glushkovskaya, Oxana; Penzel, Thomas; Poluektov, Mikhail; Fedosov, Ivan; Tzoy, Maria; Terskov, Andrey; Blokhina, Inna; Sidorov, Victor; Kurths, JürgenThe global number of people with Alzheimer’s disease (AD) doubles every 5 years. It has been established that unless an effective treatment for AD is found, the incidence of AD will triple by 2060. However, pharmacological ...
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2023-09-05ZeitschriftenartikelTranscranial Photosensitizer-Free Laser Treatment of Glioblastoma in Rat Brain Semyachkina-Glushkovskaya, Oxana; Sokolovski, Sergey; Fedosov, Ivan; Shirokov, Alexander; Navolokin, Nikita; Bucharskaya, Alla; Blokhina, Inna; Terskov, Andrey; Dubrovski, Alexander; Telnova, Valeria; Tzven, Anna; Tzoy, Maria; Evsukova, Arina; Zhlatogosrkaya, Daria; Adushkina, Viktoria;Over sixty years, laser technologies have undergone a technological revolution and become one of the main tools in biomedicine, particularly in neuroscience, neurodegenerative diseases and brain tumors. Glioblastoma is the ...