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Auflistung nach Autor "Gupta, Nishith"
Anzeige der Publikationen 1-7 von 7
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2018-03-22ZeitschriftenartikelA CTP Synthase Undergoing Stage-Specific Spatial Expression Is Essential for the Survival of the Intracellular Parasite Toxoplasma gondii Narvaez-Ortiz, Heidy Y.; Lopez, Andrea J.; Gupta, Nishith; Zimmermann, Barbara H.Cytidine triphosphate synthase catalyzes the synthesis of cytidine 5′-triphosphate (CTP) from uridine 5′-triphosphate (UTP), the final step in the production of cytidine nucleotides. CTP synthases also form filamentous ...
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2021-01-21ZeitschriftenartikelAminoglycerophospholipid flipping and P4-ATPases in Toxoplasma gondii Chen, Kai; Günay-Esiyok, Özlem; Klingeberg, Melissa; Marquardt, Stephan; Günther Pomorski, Thomas; Gupta, NishithLipid flipping in the membrane bilayers is a widespread eukaryotic phenomenon that is catalyzed by assorted P4-ATPases. Its occurrence, mechanism, and importance in apicomplexan parasites have remained elusive, however. ...
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2018-01-04HabilitationAn Intimate Dining – Nutritional Interactions between Obligate Intracellular Parasites and Host Cells Gupta, NishithDas zu den Protozoen gehörende Phylum der Apicomplexa umfasst nahezu 6000 Parasitenarten. Die meisten Apicomplexa haben sich an eine obligat intrazelluläre Lebensweise angepasst und infizieren verschiedenste Tiere und den ...
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2022-10-25ZeitschriftenartikelH11-induced immunoprotection is predominantly linked to N-glycan moieties during Haemonchus contortus infection Wang, Chunqun; Liu, Lu; Wang, Tianjiao; Liu, Xin; Peng, Wenjie; Srivastav, Ratnesh Kumar; Zhu, Xing-Quan; Gupta, Nishith; Gasser, Robin B.; Hu, MinNematodes are one of the largest groups of animals on the planet. Many of them are major pathogens of humans, animals and plants, and cause destructive diseases and socioeconomic losses worldwide. Despite their adverse ...
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2020-12-10ZeitschriftenartikelPhosphatidylinositol synthesis, its selective salvage, and inter-regulation of anionic phospholipids in Toxoplasma gondii Ren, Bingjian; Kong, Pengfei; Hedar, Fatima; Brouwers, Jos; Gupta, NishithPhosphatidylinositol (PtdIns) serves as an integral component of eukaryotic membranes; however, its biosynthesis in apicomplexan parasites remains poorly understood. Here we show that Toxoplasma gondii—a common intracellular ...
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2017-07-06ZeitschriftenartikelTaming Parasites by Tailoring Them Ren, Bingjian; Gupta, NishithThe next-generation gene editing based on CRISPR (clustered regularly interspaced short palindromic repeats) has been successfully implemented in a wide range of organisms including some protozoan parasites. However, ...
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2021-01-06ZeitschriftenartikelToxoplasma and Eimeria co-opt the host cFos expression for intracellular development in mammalian cells Ren, Bingjian; Schmid, Manuela; Scheiner, Mattea; Mollenkopf, Hans-Joachim; Lucius, Richard; Heitlinger, Emanuel; Gupta, NishithSuccessful asexual reproduction of intracellular pathogens depends on their potential to exploit host resources and subvert antimicrobial defense. In this work, we deployed two prevalent apicomplexan parasites of mammalian ...