Browsing by Author "Helma, Jonas"

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2022-01-18Zeitschriftenartikel

Bis‐ethynylphosphonamidates as an Modular Conjugation Platform to Generate Multi‐Functional Protein‐ and Antibody‐Drug‐Conjugates

Kasper, Marc-André; Lassak, Lukas; Vogl, Annette; Mai, Isabelle; Helma, Jonas; Schumacher, Dominik; Hackenberger, Christian

Bis-ethynylphosphonamidates allow for a simple chemoselective addition of two thiol-containing modules in a row. We describe four such bis-electrophiles that carry different functional O-substituents with tunable hydrophilicity ...
2020-11-18Zeitschriftenartikel

Site‐Specific Antibody Fragment Conjugates for Reversible Staining in Fluorescence Microscopy

Schwach, Jonathan; Kolobynina, Ksenia; Brandstetter, Katharina; Gerlach, Marcus; Ochtrop, Philipp; Helma, Jonas; Hackenberger, Christian; Harz, Hartmann; Cardoso, M. Cristina; Leonhardt, Heinrich; Stengl, Andreas

Antibody conjugates have taken a great leap forward as tools in basic and applied molecular life sciences that was enabled by the development of chemoselective reactions for the site‐specific modification of proteins. ...