Zweitveröffentlichungen
http://edoc.hu-berlin.de/18452/26
2024-03-19T10:15:25ZQueer Invisibility, Archival Poetry and Utopian In-Betweeness
http://edoc.hu-berlin.de/18452/29032
Queer Invisibility, Archival Poetry and Utopian In-Betweeness
Haschemi Yekani, Elahe
Sprach- und literaturwissenschaftliche Fakultät
http://dx.doi.org/10.18452/28393
2023-01-01T00:00:00ZMolecular signatures of attention networks
http://edoc.hu-berlin.de/18452/29031
Molecular signatures of attention networks
Schindler, Hanna; Jawinski, Philippe; Arnatkeviciute, Aurina; Markett, Sebastian
Lebenswissenschaftliche Fakultät
http://dx.doi.org/10.18452/28392
Attention network theory proposes three distinct types of attention—alerting, orienting, and control—that are supported by separate brain networks and modulated by different neurotransmitters, that is, norepinephrine, acetylcholine, and dopamine. Here, we explore the extent of cortical, genetic, and molecular dissociation of these three attention systems using multimodal neuroimaging. We evaluated the spatial overlap between fMRI activation maps from the attention network test (ANT) and cortex-wide gene expression data from the Allen Human Brain Atlas. The goal was to identify genes associated with each of the attention networks in order to determine whether specific groups of genes were co-expressed with the corresponding attention networks. Furthermore, we analyzed publicly available PET-maps of neurotransmitter receptors and transporters to investigate their spatial overlap with the attention networks. Our analyses revealed a substantial number of genes (3871 for alerting, 6905 for orienting, 2556 for control) whose cortex-wide expression co-varied with the activation maps, prioritizing several molecular functions such as the regulation of protein biosynthesis, phosphorylation, and receptor binding. Contrary to the hypothesized associations, the ANT activation maps neither aligned with the distribution of norepinephrine, acetylcholine, and dopamine receptor and transporter molecules, nor with transcriptomic profiles that would suggest clearly separable networks. Independence of the attention networks appeared additionally constrained by a high level of spatial dependency between the network maps. Future work may need to reconceptualize the attention networks in terms of their segregation and reevaluate the presumed independence at the neural and neurochemical level.
The article processing charge was funded by the Open Access Publication Fund of Humboldt-Universität zu Berlin.
2024-02-24T00:00:00ZWhat if I like it? Daily appraisal of technology-assisted supplemental work events and its effects on psychological detachment and work engagement
http://edoc.hu-berlin.de/18452/29028
What if I like it? Daily appraisal of technology-assisted supplemental work events and its effects on psychological detachment and work engagement
Kunz, Lea Katharina; Ducki, Antje; Hoppe, Annekatrin
Lebenswissenschaftliche Fakultät
http://dx.doi.org/10.18452/28391
Introduction: Information and communication technologies (ICT) allow employees to engage in technology-assisted supplemental work (TASW), such as continuing work tasks and being contacted by supervisors or colleagues after their official working hours. Research has found that TASW can have positive and negative effects on employee wellbeing. Yet, it remains unclear under which circumstances TASW is beneficial or harmful. Building on appraisal theories, we hypothesized that a more positive appraisal of TASW events is related to higher levels of daily psychological detachment and work engagement. We further proposed that daily psychological detachment is positively associated with daily work engagement and mediates the relationship between appraisal of TASW events and daily work engagement. Methods: To test our hypotheses, we conducted a diary study with two surveys per day over five consecutive workdays (N = 135; 245 daily observations). Results: Results of multilevel path analysis showed that a more positive appraisal of TASW was positively related to work engagement. However, appraisal of TASW events was not associated with psychological detachment and, therefore, there was no mediating effect on work engagement. Discussion: Our results contribute to existing research by investigating potential beneficial aspects of TASW and its effects on work engagement. Future research avenues and practical implications are discussed.
The article processing charge was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – 491192747 and the Open Access Publication Fund of Humboldt-Universität zu Berlin.
2024-02-16T00:00:00ZUnmapped short reads from whole-genome sequencing indicate potential infectious pathogens in German Black Pied cattle
http://edoc.hu-berlin.de/18452/29027
Unmapped short reads from whole-genome sequencing indicate potential infectious pathogens in German Black Pied cattle
Neumann, Guilherme B.; Korkuć, Paula; Reißmann, Monika; Wolf, Manuel J.; May, Katharina; König, Sven; Brockmann, Gudrun A
Lebenswissenschaftliche Fakultät
http://dx.doi.org/10.18452/28387
When resequencing animal genomes, some short reads cannot be mapped to the reference genome and are usually discarded. In this study, unmapped reads from 302 German Black Pied cattle were analyzed to identify potential pathogenic DNA. These unmapped reads were assembled and blasted against NCBI’s database to identify bacterial and viral sequences. The results provided evidence for the presence of pathogens. We found sequences of Bovine parvovirus 3 and Mycoplasma species. These findings emphasize the information content of unmapped reads for gaining insight into bacterial and viral infections, which is important for veterinarians and epidemiologists.
The article processing charge was funded by the Open Access Publication Fund of Humboldt-Universität zu Berlin.
2023-10-18T00:00:00ZTractography-based navigated TMS language mapping protocol
http://edoc.hu-berlin.de/18452/29026
Tractography-based navigated TMS language mapping protocol
Reisch, Klara; Böttcher, Franziska; Tuncer, Mehmet Salih; Schneider, Heike; Vajkoczy, Peter; Picht, Thomas; Fekonja, Lucius Samo
Cluster im Rahmen der Exzellenzinitiative
http://dx.doi.org/10.18452/28386
Introduction: This study explores the feasibility of implementing a tractography-based navigated transcranial magnetic stimulation (nTMS) language mapping protocol targeting cortical terminations of the arcuate fasciculus (AF). We compared the results and distribution of errors from the new protocol to an established perisylvian nTMS protocol that stimulated without any specific targeting over the entire perisylvian cortex. Methods: Sixty right-handed patients with language-eloquent brain tumors were examined in this study with one half of the cohort receiving the tractographybased protocol and the other half receiving the perisylvian protocol. Probabilistic tractography using MRtrix3 was performed for patients in the tractography-based group to identify the AF’s cortical endpoints. nTMS mappings were performed and resulting language errors were classified into five psycholinguistic groups. Results: Tractography and nTMS were successfully performed in all patients. The tractogram-based group showed a significantly higher median overall ER than the perisylvian group (3.8% vs. 2.9% p <.05). The median ER without hesitation errors in the tractogram-based group was also significantly higher than the perisylvian group (2.0% vs. 1.4%, p <.05). The ERs by error type showed no significant differences between protocols except in the no response ER, with a higher median ER in the tractogram-based group (0.4% vs. 0%, p <.05). Analysis of ERs based on the Corina cortical parcellation system showed especially high nTMS ERs over the posterior middle temporal gyrus (pMTG) in the perisylvian protocol and high ERs over the middle and ventral postcentral gyrus (vPoG), the opercular inferior frontal gyrus (opIFG) and the ventral precentral gyrus (vPrG) in the tractography-based protocol. Discussion: By considering the white matter anatomy and performing nTMS on the cortical endpoints of the AF, the efficacy of nTMS in disrupting patients’ object naming abilities was increased. The newly introduced method showed proof of concept and resulted in AF-specific ERs and noninvasive cortical language maps, which could be applied to additional fiber bundles related to the language network in future nTMS studies.
The article processing charge was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – 491192747 and the Open Access Publication Fund of Humboldt-Universität zu Berlin.
2022-12-09T00:00:00ZIntegrating animal tracking datasets at a continental scale for mapping Eurasian lynx habitat
http://edoc.hu-berlin.de/18452/29024
Integrating animal tracking datasets at a continental scale for mapping Eurasian lynx habitat
Oeser, Julian; Heurich, Marco; Kramer-Schadt, Stephanie
Mathematisch-Naturwissenschaftliche Fakultät
http://dx.doi.org/10.18452/28382
Aim: The increasing availability of animal tracking datasets collected across many sites provides new opportunities to move beyond local assessments to enable detailed and consistent habitat mapping at biogeographical scales. However, integrating wildlife datasets across large areas and study sites is challenging, as species' varying responses to different environmental contexts must be reconciled. Here, we compare approaches for large-area habitat mapping and assess available habitat for a recolonizing large carnivore, the Eurasian lynx (Lynx lynx). Location: Europe. Methods: We use a continental-scale animal tracking database (450 individuals from 14 study sites) to systematically assess modelling approaches, comparing (1) global strategies that pool all data for training versus building local, site-specific models and combining them, (2) different approaches for incorporating regional variation in habitat selection and (3) different modelling algorithms, testing nonlinear mixed effects models as well as machine-learning algorithms. Results: Testing models on training sites and simulating model transfers, global and local modelling strategies achieved overall similar predictive performance. Model performance was the highest using flexible machine-learning algorithms and when incorporating variation in habitat selection as a function of environmental variation. Our best-performing model used a weighted combination of local, site-specific habitat models. Our habitat maps identified large areas of suitable, but currently unoccupied lynx habitat, with many of the most suitable unoccupied areas located in regions that could foster connectivity between currently isolated populations. Main Conclusions: We demonstrate that global and local modelling strategies can achieve robust habitat models at the continental scale and that considering regional variation in habitat selection improves broad-scale habitat mapping. More generally, we highlight the promise of large wildlife tracking databases for large-area habitat mapping. Our maps provide the first high-resolution, yet continental assessment of lynx habitat across Europe, providing a consistent basis for conservation planning for restoring the species within its former range.
The article processing charge was funded by the Open Access Publication Fund of Humboldt-Universität zu Berlin.
All authors: Julian Oeser, Marco Heurich, Stephanie Kramer-Schadt, Jenny Mattisson, Miha Krofel, Jarmila Krojerová-Prokešová, Fridolin Zimmermann, Ole Anders, Henrik Andrén, Guna Bagrade, Elisa Belotti, Christine Breitenmoser-Würsten, Luděk Bufka, Rok Černe, Nolwenn Drouet-Hoguet, Martin Duľa, Christian Fuxjäger, Tomislav Gomerčić, Włodzimierz Jędrzejewski, Raido Kont, Petr Koubek, Rafał Kowalczyk, Josip Kusak, Jakub Kubala, Miroslav Kutal, John D. C. Linnell, Anja Molinari-Jobin, Peep Männil, Tomma Lilli Middelhoff, John Odden, Henryk Okarma, Teresa Oliveira, Nives Pagon, Jens Persson, Jaanus Remm, Krzysztof Schmidt, Sven Signer, Branislav Tám, Kristina Vogt, Tobias Kuemmerle
2023-10-16T00:00:00Z“So, if you ask whether fences work: they work”
http://edoc.hu-berlin.de/18452/29022
“So, if you ask whether fences work: they work”
Korte, Kristina
Kultur-, Sozial- und Bildungswissenschaftliche Fakultät
http://dx.doi.org/10.18452/28381
This paper analyzes the role of border fortifications for migration control and access to asylum based on two case studies: the Hungarian–Serbian and U.S. American–Mexican borders. The research is based on qualitative interviews on both sides of the borders. It shows that despite other options for border control, fortifications still play an important role, especially for asylum seekers. Fences fulfill a material, a symbolic and a filtering function here. The three functions contribute in different ways to preventing asylum seekers from crossing the border, thus depriving refugees of the opportunity to apply for asylum. The paper shoes that fences fulfill functions that other forms of border control (such as shifting or smart borders) cannot accomplish in the same way and it thereby contributes to understanding the ‘puzzle’ of contemporary border fencing.
The article processing charge was funded by the Open Access Publication Fund of Humboldt-Universität zu Berlin.
2023-10-02T00:00:00ZThe oral sensory organs in Bathochordaeus stygius (Tunicata Appendicularia) are unique in structure and homologous to the coronal organ
http://edoc.hu-berlin.de/18452/29021
The oral sensory organs in Bathochordaeus stygius (Tunicata Appendicularia) are unique in structure and homologous to the coronal organ
Van Le, Mai-Lee; Müller, Lisa-Marie; Stach, Thomas
Lebenswissenschaftliche Fakultät
http://dx.doi.org/10.18452/28379
Background: Appendicularia consists of approximately 70 purely marine species that belong to Tunicata the probable sister taxon to Craniota. Therefore, Appendicularia plays a pivotal role for our understanding of chordate evolution. In addition, appendicularians are an important part of the epipelagic marine plankton. Nevertheless, little is known about appendicularian species, especially from deeper water. Results: Using µCT, scanning electron microscopy, and digital 3D-reconstruction techniques we describe three pairs of complex oral sensory organs in the mesopelagic appendicularian Bathochordaeus stygius. The oral sensory organs are situated at the anterior and lateral margin of the mouth and inside the mouth cavity. A single organ consists of 22–90 secondary receptor cells that project apical cilia through a narrow hole in the epidermis. The receptor cells are innervated by branches of the second brain nerve. Conclusions: Based on position, morphology, and innervation we suggest that the oral sensory organs are homologues of the coronal organs in other tunicates. We discuss the hypothesized homology of coronal organs and the lateral line system of primary aquatic vertebrates. The complex oral sensory organs of B. stygius are unique in tunicates and could be adaptations to the more muffled environment of the mesopelagic.
The article processing charge was funded by the Open Access Publication Fund of Humboldt-Universität zu Berlin.
2023-12-15T00:00:00ZNovel 8-Methoxycoumarin-3-Carboxamides with potent anticancer activity against liver cancer via targeting caspase-3/7 and β-tubulin polymerization
http://edoc.hu-berlin.de/18452/29019
Novel 8-Methoxycoumarin-3-Carboxamides with potent anticancer activity against liver cancer via targeting caspase-3/7 and β-tubulin polymerization
Alzamami, Ahmad; Radwan, Eman M.; Abo‑Elabass, Eman; El Behery, Mohammed; Alshwyeh, Hussah Abdullah; Al‑Olayan, Ebtesam; Altamimi, Abdulmalik S.; Attallah, Nashwah G. M.; Altwaijry, Najla; Jaremko, Mariusz; M. Saied, Essa
Mathematisch-Naturwissenschaftliche Fakultät
http://dx.doi.org/10.18452/28377
In the present study, we explored the potential of coumarin-based compounds, known for their potent anticancer properties, by designing and synthesizing a novel category of 8-methoxycoumarin-3-carboxamides. Our aim was to investigate their antiproliferative activity against liver cancer cells. Toward this, we developed a versatile synthetic approach to produce a series of 8-methoxycoumarin-3-carboxamide analogues with meticulous structural features. Assessment of their antiproliferative activity demonstrated their significant inhibitory effects on the growth of HepG2 cells, a widely studied liver cancer cell line. Among screened compounds, compound 5 exhibited the most potent antiproliferative activity among the screened compounds (IC50 = 0.9 µM), outperforming the anticancer drug staurosporine (IC50 = 8.4 µM), while showing minimal impact on normal cells. The flow cytometric analysis revealed that compound 5 induces cell cycle arrest during the G1/S phase and triggers apoptosis in HepG2 cells by increasing the percentage of cells arrested in the G2/M and pre-G1 phases. Annexin V-FITC/PI screening further supported the induction of apoptosis without significant necrosis. Further, compound 5 exhibited the ability to activate caspase3/7 protein and substantially inhibited β-tubulin polymerization activity in HepG2 cells. Finally, molecular modelling analysis further affirmed the high binding affinity of compound 5 toward the active cavity of β-tubulin protein, suggesting its mechanistic involvement. Collectively, our findings highlight the therapeutic potential of the presented class of coumarin analogues, especially compound 5, as promising candidates for the development of effective anti-hepatocellular carcinoma agents.
The article processing charge was funded by the Open Access Publication Fund of Humboldt-Universität zu Berlin.
2023-12-02T00:00:00ZPersonalized tendon loading reduces muscle-tendon imbalances in male adolescent elite athletes
http://edoc.hu-berlin.de/18452/29016
Personalized tendon loading reduces muscle-tendon imbalances in male adolescent elite athletes
Domroes, Theresa; Weidlich, Kolja; Bohm, Sebastian; Mersmann, Falk; Arampatzis, Adamantios
Kultur-, Sozial- und Bildungswissenschaftliche Fakultät
http://dx.doi.org/10.18452/28370
An imbalanced adaptation of muscle strength and tendon stiffness in response to training may increase tendon strain (i.e., the mechanical demand on the tendon) and consequently tendon injury risk. This study investigated if personalized tendon loading inducing tendon strain within the effective range for adaptation (4.5%–6.5%) can reduce musculotendinous imbalances in male adolescent handball athletes (15–16 years). At four measurement time points during a competitive season, we assessed knee extensor muscle strength and patellar tendon mechanical properties using dynamometry and ultrasonography and estimated the tendon's structural integrity with a peak spatial frequency (PSF) analysis of proximal tendon ultrasound scans. A control group (n = 13) followed their usual training routine, an intervention group (n = 13) integrated tendon exercises into their training (3x/week for ~31 weeks) with a personalized intensity corresponding to an average of ~6.2% tendon strain. We found a significant time by group interaction (p < 0.005) for knee extensor muscle strength and normalized patellar tendon stiffness with significant increases over time only in the intervention group (p < 0.001). There were no group differences or time-dependent changes in patellar tendon strain during maximum voluntary contractions or PSF. At the individual level, the intervention group demonstrated lower fluctuations of maximum patellar tendon strain during the season (p = 0.005) and a descriptively lower frequency of athletes with high-level tendon strain (≥9%). The findings suggest that the personalized tendon loading program reduced muscle-tendon imbalances in male adolescent athletes, which may provide new opportunities for tendon injury prevention.
2024-01-04T00:00:00ZDiaryltriazolium Photoswitch: Reaching a Millisecond Cycloreversion with High Stability and NIR Absorption
http://edoc.hu-berlin.de/18452/29015
Diaryltriazolium Photoswitch: Reaching a Millisecond Cycloreversion with High Stability and NIR Absorption
Kolarski, Dušan; Steinbach, Pit; Bannwarth, Christoph; Klaue, Kristin; Hecht, Stefan
Mathematisch-Naturwissenschaftliche Fakultät
http://dx.doi.org/10.18452/28368
The exceptional thermal stability of diarylethene closed isomers enabled many applications but also prevented utilization in photochromic systems that require rapid thermal reversibility. Herein, we report the diaryltriazolium (DAT+) photoswitch undergoing thermal cycloreversion within a few milliseconds and absorption of the closed form in the near-infrared region above 900 nm. Click chemistry followed by alkylation offers modular and fast access to the electron-deficient DAT+ scaffold. In addition to excellent fatigue resistance, the introduced charge increases water solubility, rendering this photoswitch an ideal candidate for exploring biological applications.
2024-01-16T00:00:00ZInformation science and the inevitable: A literature review at the intersection of death and information management: An Annual Review of Information Science and Technology (ARIST) paper
http://edoc.hu-berlin.de/18452/29014
Information science and the inevitable: A literature review at the intersection of death and information management: An Annual Review of Information Science and Technology (ARIST) paper
Dinneen, Jesse David; Krtalić, Maja; Davoudi, Nilou; Hellmich , Helene ; Ochsner, Catharina; Bressel, Paulina
Philosophische Fakultät
http://dx.doi.org/10.18452/28367
Death is an inevitable part of life and highly relevant to information management: its approach often requires preparation, and its occurrence often demands a response. Many works in information science have acknowledged so much, and yet death is rarely a focused topic, appearing instead sporadically and disconnected across research. As a result there is no introduction to, overview of, or synthesis across studies on death and information. We therefore conducted an extensive literature search and reviewed nearly 300 scholarly publications at the intersection of death and information (and data) management. Covering seven topics in total, we review two groups of work directly engaging information management in relation to death (digital possessions, inheritance, and legacy; information behavior, needs, and practices around death), three engaging death and technology that require information and its management (death and the Internet, thanatosensitive design and technology-augmented death practices, and the digital afterlife and digital immortality), and two reflecting the ethical and legal dimensions unique to death and information. We then integrate the collective findings to summarize the landscape of death-related information research, outline remaining challenges for individuals, families, institutions, and society, and identify promising directions for future information science research.
2023-12-28T00:00:00ZRevisiting Peri-Aryloxyquinones: From a Forgotten Photochromic System to a Promising Tool for Emerging Applications
http://edoc.hu-berlin.de/18452/29013
Revisiting Peri-Aryloxyquinones: From a Forgotten Photochromic System to a Promising Tool for Emerging Applications
Lvov, Andrey; Klimenko, Lyubov; Bykov, Vasily N.; Hecht, Stefan
Mathematisch-Naturwissenschaftliche Fakultät
http://dx.doi.org/10.18452/28366
Emerging applications of photochromic compounds demand new molecular designs that can be inspired by some long-known yet currently forgotten classes of photoswitches. In the present review, we remind the community about Peri-AryloxyQuinones (PAQs) and their unique photoswitching behavior originally discovered more than 50 years ago. At the heart of this phenomenon is the light-induced migration of an aromatic moiety (arylotropy) in peri-aryloxy-substituted quinones resulting in ana-quinones. PAQs feature absorbance of both isomers in the visible spectral region, photochromism in the amorphous and crystalline state, and thermal stability of the photogenerated ana-isomer. Particularly noticeable is the high sensitivity of the ana-isomer towards nucleophiles in solution. In addition to the mechanism of molecular photochromism and the underlaying structure-switch relationships, we analyze potential applications and prospects of aryloxyquinones in optically switchable materials and devices. Due to their ability to efficiently photoswitch in the solid state, PAQs are indeed attractive candidates for such materials and devices, including electronics (optically controllable circuits, switches, transistors, memories, and displays), porous crystalline materials, crystalline actuators, photoactivated sensors, and many more. This review is intended to serve as a guide for researchers who wish to use photoswitchable PAQs in the development of new photocontrollable materials, devices, and processes.
2023-12-12T00:00:00ZIntegral Picard group of moduli of polarized K3 surfaces
http://edoc.hu-berlin.de/18452/29011
Integral Picard group of moduli of polarized K3 surfaces
Di Lorenzo, Andrea; Fringuelli, Roberto; Vistoli, Angelo
Mathematisch-Naturwissenschaftliche Fakultät
http://dx.doi.org/10.18452/28364
We compute the integral Picard group of the moduli stack of polarized K3 surfaces of fixed degree whose singularities are at most rational double points, and of its coarse moduli space. We also compute the integral Picard group of the stack of quasi‐polarized K3 surfaces, and of the stacky period domain.
2023-12-06T00:00:00ZTwo Allogons of an O2-activating Bis(disiloxido)ferrate(II) Accessible Selectively just by Variation of the Crystallization Temperature
http://edoc.hu-berlin.de/18452/29010
Two Allogons of an O2-activating Bis(disiloxido)ferrate(II) Accessible Selectively just by Variation of the Crystallization Temperature
Beckmann, Fabian; Woite, Philipp; Yelin, Stefan; Kass, Dustin; Usvyat, Denis; Roemelt, Michael; Limberg, Christian
Mathematisch-Naturwissenschaftliche Fakultät
http://dx.doi.org/10.18452/28363
Deprotonation of O(iPr2SiOH)2 (iPrLH2) with LiOtBu followed by reaction with FeCl2 in THF led to the complex [iPrL2Fe][Li(THF)2]2, 2, which represents a structural and spectroscopic model of the α‐Fe sites of Fe/ZSM‐5. Reaction with O2 in THF solution proceeds rather fast and is complete within 200 ms; an intermediate O2 adduct could not be identified by stopped‐flow methods. Cooling blue solutions of 2 to −80 °C led to the growth of blue crystals of 2⋅THF, the analysis of which by XRD revealed a FeO4 core that is somewhat distorted from planarity towards a tetrahedral structure. By contrast, cooling such solutions to −30 °C led to pink crystals of an allogon featuring a perfectly square planar FeO4 entity. Hence, 2 represents a unique case where two different structural isomers (allogons) can be crystallized from the same solvent selectively, controlled by the temperature. DFT calculations were performed to understand this finding.
2023-12-06T00:00:00ZTemperature elevations can induce switches to homoclinic action potentials that alter neural encoding and synchronization
http://edoc.hu-berlin.de/18452/28998
Temperature elevations can induce switches to homoclinic action potentials that alter neural encoding and synchronization
Hesse, Janina; Schleimer, Jan-Hendrik; Maier, Nikolaus; Schmitz, Dietmar; Schreiber, Susanne
Lebenswissenschaftliche Fakultät
http://dx.doi.org/10.18452/28359
Almost seventy years after the discovery of the mechanisms of action potential generation, some aspects of their computational consequences are still not fully understood. Based on mathematical modeling, we here explore a type of action potential dynamics – arising from a saddle-node homoclinic orbit bifurcation - that so far has received little attention. We show that this type of dynamics is to be expected by specific changes in common physiological parameters, like an elevation of temperature. Moreover, we demonstrate that it favours synchronization patterns in networks – a feature that becomes particularly prominent when system parameters change such that homoclinic spiking is induced. Supported by in-vitro hallmarks for homoclinic spikes in the rodent brain, we hypothesize that the prevalence of homoclinic spikes in the brain may be underestimated and provide a missing link between the impact of biophysical parameters on abrupt transitions between asynchronous and synchronous states of electrical activity in the brain.
The article processing charge was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – 491192747 and the Open Access Publication Fund of Humboldt-Universität zu Berlin.
2022-07-08T00:00:00ZAdaptation constraints in scenarios of socio-economic development
http://edoc.hu-berlin.de/18452/28990
Adaptation constraints in scenarios of socio-economic development
Theokritoff, Emily; van Maanen, Nicole; Andrijevic, Marina; Thomas, Adelle; Lissner, Tabea; Schleussner, Carl-Friedrich
Mathematisch-Naturwissenschaftliche Fakultät
http://dx.doi.org/10.18452/28357
Climate change adaptation is paramount, but increasing evidence suggests that adaptation action is subject to a range of constraints. For a realistic assessment of future adaptation prospects, it is crucial to understand the timescales needed to overcome these constraints. Here, we combine data on documented adaptation from the Global Adaptation Mapping Initiative with national macro indicators and assess future changes in adaptation constraints alongside the Shared Socioeconomic Pathways, spanning a wide range of future socio-economic development scenarios. We find that even in the most optimistic scenario, it will take until well after 2050 to overcome key constraints, which will limit adaptation for decades to come particularly in vulnerable countries. The persistence of adaptation constraints calls for stringent mitigation, improved adaptation along with dedicated finance and increasing efforts to address loss and damage. Our approach allows to ground truth indicators that can be further used in climate modelling efforts, improving the representation of adaptation and its risk reduction potential.
The article processing charge was funded by the Open Access Publication Fund of Humboldt-Universität zu Berlin.
2023-11-24T00:00:00ZConcentration of asset owners exposed to power sector stranded assets may trigger climate policy resistance
http://edoc.hu-berlin.de/18452/28989
Concentration of asset owners exposed to power sector stranded assets may trigger climate policy resistance
Dulong, Angelika von
Wirtschaftswissenschaftliche Fakultät
http://dx.doi.org/10.18452/28356
Thoroughly assessing the owners and distribution of stranded assets in a 2 °C scenario is essential to anticipate climate policy resistance. We employ novel data to analyze owners and incidence of asset stranding in the power sector globally. We show that Asia-Pacific, Europe, and the US are highly exposed to stranded assets, especially coal plants. Stranded assets are highly concentrated in a few asset owners in some countries (e.g., India). Even if owners are more equally exposed (e.g., in the US) they can vary considerably in the asset stranding timing due to differences in plant fleets’ age profile. European, US, and Chinese asset owners own large shares of stranded coal plants abroad. Listed owners may face stranded assets of up to 78% of their share price or more than 80% of their equity. Asset stranding exposure positively correlates with ownership of alternative energy assets. India stands out owning many stranded assets but little alternative energy.
The article processing charge was funded by the Open Access Publication Fund of Humboldt-Universität zu Berlin.
2023-10-13T00:00:00ZThe influence of insight on risky decision making and nucleus accumbens activation
http://edoc.hu-berlin.de/18452/28988
The influence of insight on risky decision making and nucleus accumbens activation
Becker, Maxi ; Yu, Yuhua; Cabeza, Roberto
Lebenswissenschaftliche Fakultät
http://dx.doi.org/10.18452/28355
During insightful problem solving, the solution appears unexpectedly and is accompanied by the feeling of an AHA!. Research suggests that this affective component of insight can have consequences beyond the solution itself by motivating future behavior, such as risky (high reward and high uncertainty) decision making. Here, we investigate the behavioral and neural support for the motivational role of AHA in decision making involving monetary choices. The positive affect of the AHA! experience has been linked to internal reward. Reward in turn has been linked to dopaminergic signal transmission in the Nucleus Accumbens (NAcc) and risky decision making. Therefore, we hypothesized that insight activates reward-related brain areas, modulating risky decision making. We tested this hypothesis in two studies. First, in a pre-registered online study (Study 1), we demonstrated the behavioral effect of insight-related increase in risky decision making using a visual Mooney identification paradigm. Participants were more likely to choose the riskier monetary payout when they had previously solved the Mooney image with high compared to low accompanied AHA!. Second, in an fMRI study (Study 2), we measured the effects of insight on NAcc activity using a similar Mooney identification paradigm to the one of Study 1. Greater NAcc activity was found when participants solved the Mooney image with high vs low AHA!. Taken together, our results link insight to enhanced NAcc activity and a preference for high but uncertain rewards, suggesting that insight enhances reward-related brain areas possibly via dopaminergic signal transmission, promoting risky decision making.
The article processing charge was funded by the Open Access Publication Fund of Humboldt-Universität zu Berlin.
2023-10-11T00:00:00ZShared metadata for data-centric materials science
http://edoc.hu-berlin.de/18452/28987
Shared metadata for data-centric materials science
Ghiringhelli, Luca M.; Baldauf, Carsten; Bereau, Tristan
Mathematisch-Naturwissenschaftliche Fakultät
The expansive production of data in materials science, their widespread sharing and repurposing requires educated support and stewardship. In order to ensure that this need helps rather than hinders scientific work, the implementation of the FAIR-data principles (Findable, Accessible, Interoperable, and Reusable) must not be too narrow. Besides, the wider materials-science community ought to agree on the strategies to tackle the challenges that are specific to its data, both from computations and experiments. In this paper, we present the result of the discussions held at the workshop on “Shared Metadata and Data Formats for Big-Data Driven Materials Science”. We start from an operative definition of metadata, and the features that a FAIR-compliant metadata schema should have. We will mainly focus on computational materials-science data and propose a constructive approach for the FAIRification of the (meta)data related to ground-state and excited-states calculations, potential-energy sampling, and generalized workflows. Finally, challenges with the FAIRification of experimental (meta)data and materials-science ontologies are presented together with an outlook of how to meet them.
The article processing charge was funded by the Open Access Publication Fund of Humboldt-Universität zu Berlin. Full list of authors: Luca M. Ghiringhelli, Carsten Baldauf, Tristan Bereau, Sandor Brockhauser,
Christian Carbogno, Javad Chamanara, Stefano Cozzini, Stefano Curtarolo,
Claudia Draxl, Shyam Dwaraknath, Ádám Fekete, James Kermode,
Christoph T. Koch, Markus Kühbach, Alvin Noe Ladines, Patrick Lambrix,
Maja-Olivia Himmer, Sergey V. Levchenko, Micael Oliveira, Adam Michalchuk,
Ronald E. Miller, Berk Onat, Pasquale Pavone, Giovanni Pizzi, Benjamin Regler,
Gian-Marco Rignanese, Jörg Schaarschmidt, Markus Scheidgen,
Astrid Schneidewind, Tatyana Sheveleva, Chuanxun Su, Denis Usvyat,
Omar Valsson, Christof Wöll & Matthias Scheffler
2023-09-14T00:00:00ZAbitur und Abituraufsätze zwischen 1882 und 1972
http://edoc.hu-berlin.de/18452/28984
Abitur und Abituraufsätze zwischen 1882 und 1972
Kämper-van den Boogaart, Michael; Reh, Sabine; Schindler, Christoph; Scholz, Joachim
Sprach- und literaturwissenschaftliche Fakultät
http://dx.doi.org/10.18452/28350
Kämper-van den Boogaart, Michael; Reh, Sabine; Schindler, Christoph; Scholz, Joachim
Die Beiträge des Bandes präsentieren zentrale Befunde des von der Leibniz-Gemeinschaft geförderten Projekts „Abiturprüfungspraxis und Abituraufsatz 1882 bis 1972“. Auf der Basis eines umfangreichen und in einer digitalen Forschungsumgebung bearbeiteten Korpus deutscher Abituraufsätze wurden – ergänzt durch die Analyse weiterer Quellen – Prüfungspraktiken rekon struiert und kontextualisiert. Aufgearbeitet wurden sowohl bildungshistorische, juristische und administrative Konstellationen als auch fach- und schreibdidaktische Paradigmen, die einen historischen Blick auf die sogenannte Königsdisziplin der Abiturprüfung eröffnen, die ihre Rolle auch gegenwärtig im Streit um die Erwerbsbedingungen der Allgemeinen Hochschulreife behauptet.
The publication of this work was supported by the Open Access Publication Fund of Humboldt-Universität zu Berlin.
2023-01-01T00:00:00ZSuccessful scaling of Edible City Solutions to promote food citizenship and sustainability in food system transitions
http://edoc.hu-berlin.de/18452/28980
Successful scaling of Edible City Solutions to promote food citizenship and sustainability in food system transitions
Plassnig, Sara; Pettit, Marisa; Reichborn-Kjennerud, Kristin; Säumel, Ina
Lebenswissenschaftliche Fakultät
http://dx.doi.org/10.18452/28336
Sustainable, productive and biodiversity-friendly urban landscapes are a strategic step in transitioning to future-proof, liveable and healthy cities. Edible nature-based solutions, otherwise known as “Edible City Solutions”, comprise a wide range of different forms of sustainable urban food production, distribution and consumption which use innovative principles of ecological design combined with closed material and energy flows. Edible City Solutions contribute to a local green economy, reduce cities’ overall ecological footprint, enhance social cohesion, human health and wellbeing and contribute to bridging the gap between “farm and fork”. These benefits have been tested and monitored in Living Labs where a wide portfolio of different solutions have been implemented and scaled in order to accelerate their uptake and use in urban landscapes. The study documents and analyses different scaling practices and activities of the co-created Living Labs – together with local actors within the “scaling community” in Andernach, Berlin, Havanna, Oslo and Rotterdam. We follow a mixed method approach and analyse data by applying the different scaling pathways of scaling up, scaling deep, scaling wide, scaling across and scaling soft previously identified through a systematic literature review. Results are presented as ongoing scaling stories, experiences and challenges in the Living Labs. The study also highlights examples of scaling practices beyond the Living Labs and suggests strategic plans for future scaling. Scaling processes, strategies and approaches are critically reviewed and discussed. Observations are condensed into eleven recommendations for scaling edible nature-based solutions.
2022-12-22T00:00:00ZBausteine zu einer Oral History der Wissenschaftsgeschichte
http://edoc.hu-berlin.de/18452/28976
Bausteine zu einer Oral History der Wissenschaftsgeschichte
Grote, Mathias; te Heesen, Anke; Hoffmann, Dieter
Kultur-, Sozial- und Bildungswissenschaftliche Fakultät
http://dx.doi.org/10.18452/28325
Wie kann man einen historischen Blick auf das eigene Fach werfen? Diese Frage ist nicht einfach zu beantworten – will man einerseits nicht in einer Nabelschau und Hagiographie enden, andererseits aber auch keinen umfassenden Entwurf einer zukünftigen Historiographie vorlegen. Die hier in loser Folge publizierten Interviews mit bekannten Protagonist:innen der Berliner Wissenschaftsgeschichte von ca. 1970–1990 in West und Ost rücken die Geschichte des Faches deshalb in einem bestimmten Milieu in den Fokus und versuchen, die Historiographie jenseits einer Institutionen- oder Theoriegeschichte voranzutreiben. Welche Motivationen oder Probleme bewegten einzelne Wissenschaftler:innen, sich der Geschichte ihres Faches zu widmen oder sich etwa aus der Soziologie oder Philosophie in die Wissenschaftsgeschichte zu bewegen? Welche Ausbildungspraktiken existierten in diesem heterogenen, zwischen den Disziplinen angesiedelten Feld, welche Anregungen bezog man aus welchen Kontexten? Wie war Lehre strukturiert und welche Netzwerke bildeten sich mit der Zeit? Kurz: Mit welchem Interesse kam man zur Wissenschaftsgeschichte und was wurde daraus?
Die Auswahl der Interviewees erfolgt ohne Anspruch auf Vollständigkeit oder Proporz; der Fragenkatalog der Interviews richtet sich individuell nach den Biographien und dem Werk und entfaltet sich oft spontan im Gespräch. Die Interviews wurden digital aufgezeichnet, transkribiert, der Schriftsprache angepasst, gegebenenfalls gekürzt, annotiert und von den Interviewees authentifiziert.
Wir beabsichtigen mit dieser Serie von Interviews zunächst die Dokumentation rezenter Geschichte durch eine Oral History, die subjektive Wahrnehmungen und persönliche Erlebnisse einschließt. Auf diese Weise werden Segmente einer größtenteils ungeschriebenen Geschichte anhand von Biographien erfahrbar und damit auch einer weiteren kritischen Bearbeitung und Integration in ein Gesamtbild zugänglich. Da uns im Zuge der jeweiligen Vorbereitung und Durchführung, Transkription und Abstimmung der Interviews daran gelegen war, aus Sicht der Akteur:innen wichtige Sammelbände und Aufsätze, Monographien oder auch „graue Literatur“ zu erfassen, wird nebenbei eine kommentierte Bibliographie zur Geschichte der Wissenschaftsgeschichte entstehen. Unsere Hoffnung besteht darin, mittels dieser Sammlung mit Berlin einen fruchtbaren Raum und mit den siebziger und achtziger Jahren eine produktive Zeit des Faches jenseits von Reminiszenz oder Nostalgie zu erkunden – nicht zuletzt auch, um den Blick für gegenwärtige Herausforderungen des Faches zu schärfen.
2023-11-14T00:00:00ZProposal for a Tunable Room-Temperature Single-Photon Source Based on a Plasmonic Nanoantenna Driven by Inelastic Tunneling in the Coulomb Regime
http://edoc.hu-berlin.de/18452/28975
Proposal for a Tunable Room-Temperature Single-Photon Source Based on a Plasmonic Nanoantenna Driven by Inelastic Tunneling in the Coulomb Regime
Kewes, Günter; Benson, Oliver
Mathematisch-Naturwissenschaftliche Fakultät
http://dx.doi.org/10.18452/28324
Herein, a tunnel-current-driven plasmonic nanoantenna for the generation of single photons is proposed. The proposal uses two constituents: 1) small gold nanoparticles that feature Coulomb blockade already at room temperature combined with an 2) self-similar nanorod arrangement. The Coulomb blockade allows for single-plasmon generation and the nanorod arrangement for an efficient transformation into photons. As the emission from such an electrically driven antenna follows its spectral scattering response, the color of single photons can be tuned by geometrical changes of the antenna over an extremely broad range far into the infrared. The calculations suggest high photon purities, repetition rates beyond, and efficiencies comparable to ordinary single-photon sources based on emitters like color centers or heralded single-photon sources, respectively. Given recent achievements in the field and the simplicity of the proposal, the device can be built with existing technology.
2023-11-20T00:00:00ZNMR spectroscopic investigations on the successive implementation of nickel and zinc ions to a NacNac-dibenzofuran-Br ligand precursor
http://edoc.hu-berlin.de/18452/28974
NMR spectroscopic investigations on the successive implementation of nickel and zinc ions to a NacNac-dibenzofuran-Br ligand precursor
Krause, Konstantin; Cula, Beatrice; Dallmann, André; Limberg, Christian
Mathematisch-Naturwissenschaftliche Fakultät
http://dx.doi.org/10.18452/28323
The ligand precursor HNacNac-dibenzofuran-Br, LH, was synthesized by the condensation of 6-bromo-4-dibenzofuranamine and 4-(N-(mesityl)amino)pent-3-en-2-one with the aim of preparing heterodinuclear nickel/zinc complexes in two successive steps. Reacting LH with Zn(HMDS)2, Zn(C6F5)2 and Zn(C2H5)2 led to the respective X-Zn-NacNac-dibenzofuran-Br complexes (X=HMDS (2), C6F5 (3), Et (4)). However, in case of 2 and 3 the subsequent treatment with Ni(COD)2/TMEDA did not lead to any conversion, probably as the steric bulk imposed by the NacNac-Zn-X entities was too high. 4 did react with Ni(COD)2/TMEDA, likely in the envisaged manner, but apparently the targeted product complex Et-Zn-NacNac-dibenzofuran-Ni(TMEDA)Br, once formed, immediately reacts further via a Negishi coupling reaction, so that Br-Zn-NacNac-dibenzofuran-Et (5) is formed. The reaction of 4 with triethylammonium bromide led to the formation of the Br-Zn-NacNac-dibenzofuran-Br (6) complex that could be reacted with Ni(COD)2/TMEDA successfully. All attempts to purify the product led to Zn(NacNac-dibenzofuran-Ni(TMEDA)Br)2, which is insoluble in THF and thus drives a dismutation reaction.
2023-10-06T00:00:00Z