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2009-09-29Zeitschriftenartikel DOI: 10.1515/CCLM.2010.037
Association between serum uric acid and non-alcoholic fatty liver disease in Korean adults
dc.contributor.authorLee, Yong-Jae
dc.contributor.authorLee, Hye-Ree
dc.contributor.authorLee, Jung-Hyun
dc.contributor.authorShin, Youn-Ho
dc.contributor.authorShim, Jae-Yong
dc.date.accessioned2017-06-17T01:35:39Z
dc.date.available2017-06-17T01:35:39Z
dc.date.created2010-07-01
dc.date.issued2009-09-29
dc.identifier.issn1437-4331
dc.identifier.urihttp://edoc.hu-berlin.de/18452/10247
dc.description.abstractBackground: Increased uric acid is associated with the metabolic syndrome, conditions linked to oxidative stress and insulin resistance. Non-alcoholic fatty liver disease (NAFLD) is now considered a hepatic manifestation of insulin resistance. However, little has been written regarding the association between uric acid and NAFLD. Methods: We examined the association between uric acid and the presence of NAFLD in 3768 Koreans (2133 men, 1635 women; aged 20–75 years) in a health examination program. Uric acid quartiles were categorized separately as follows: Q1: ≤291.5, Q2: 291.6–333.1, Q3: 333.2–380.7, and Q4: ≥380.8 μmol/L for men; Q1: ≤202.2, Q2: 202.3–232.0, Q3: 231.1–267.7, and Q4: ≥267.8 μmol/L for women. Hepatic steatosis was diagnosed based on abdominal ultrasonographic findings by hyperechogenicity of liver tissue, difference of echogenicity between the liver and diaphragm, and visibility of vascular structures. The odds ratios (ORs) and 95% confidence intervals (CIs) for NAFLD were calculated across each quartile of serum uric acid. Results: The prevalence of NAFLD was 25.8% (32.2% in men and 17.4% in women). After adjustment for age, body mass index (BMI), smoking, regular exercise, blood pressure, fasting plasma glucose (FPG), triglycerides, and high-density lipoprotein (HDL) cholesterol, the ORs (95% CIs) for NAFLD according to each quartile of uric acid were 1.00, 1.55 (1.13–2.14), 1.77 (1.30–2.41), and 2.01 (1.45–2.78) for men and 1.00, 0.69 (0.40–1.20), 1.12 (0.67–1.88), and 1.94 (1.21–3.13) for women. Conclusions: Serum uric acid is independently associated with the presence of NAFLD, and uric acid may be a useful additional measure in assessing the risk of NAFLD in the clinical setting. Clin Chem Lab Med 2010;48:175–80.eng
dc.language.isound
dc.publisherKooperation de Gruyter
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.titleAssociation between serum uric acid and non-alcoholic fatty liver disease in Korean adults
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-100114471
dc.identifier.doi10.1515/CCLM.2010.037
dc.identifier.doihttp://dx.doi.org/10.18452/9595
local.edoc.container-titleClinical Chemistry and Laboratory Medicine
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-namede Gruyter
local.edoc.container-volume48
local.edoc.container-issue2
local.edoc.container-year2010
local.edoc.container-firstpage175
local.edoc.container-lastpage180
dc.description.versionPeer Reviewed

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