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2009-10-12Zeitschriftenartikel DOI: 10.1515/CCLM.2010.049
Mean leukocyte telomere length and risk of incident colorectal carcinoma in women: a prospective, nested case-control study
dc.contributor.authorLin, Jennifer
dc.contributor.authorCastonguay, Amy J.
dc.contributor.authorBarton, Nathaniel S.
dc.contributor.authorBuring, Julie E.
dc.contributor.authorZee, Robert Y.L.
dc.date.accessioned2017-06-17T01:37:09Z
dc.date.available2017-06-17T01:37:09Z
dc.date.created2010-07-01
dc.date.issued2009-10-12
dc.identifier.issn1437-4331
dc.identifier.urihttp://edoc.hu-berlin.de/18452/10255
dc.description.abstractBackground: To date, no prospective epidemiological data are available, particularly in women, on mean leukocyte telomere length as a risk predictor. Methods: Using leukocyte DNA samples collected at baseline in a prospective cohort of over 28,000 initially healthy women, we examined the relationship between mean leukocyte telomere repeat copy number to single gene copy number (TSR) in 134 incident cases of colorectal carcinoma (CRC), and 357 matched controls; all were Caucasian. Results: The observed loge-transformed TSRs were similar between cases and controls (p=0.79). Using an adjusted analysis, we found no evidence for an association of the loge-TSRs with CRC risk [adjusted odds ratio (OR)=0.943, 95% confidence interval (CI)=0.647–1.376, p=0.762]. Stratified analysis by median follow-up time, or postmenopausal status also showed similar null findings. Conclusions: In concordance with our previous findings in Caucasian men, the present study in Caucasian women found no evidence for an association of mean leukocyte telomere length with risk of incident CRC, further suggesting that leukocyte telomere length may not be a useful indicator for risk assessment. Clin Chem Lab Med 2010;48:259–62.eng
dc.language.isound
dc.publisherKooperation de Gruyter
dc.titleMean leukocyte telomere length and risk of incident colorectal carcinoma in women: a prospective, nested case-control study
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-100114558
dc.identifier.doi10.1515/CCLM.2010.049
dc.identifier.doihttp://dx.doi.org/10.18452/9603
local.edoc.container-titleClinical Chemistry and Laboratory Medicine
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-namede Gruyter
local.edoc.container-volume48
local.edoc.container-issue2
local.edoc.container-year2010
local.edoc.container-firstpage259
local.edoc.container-lastpage262
dc.description.versionPeer Reviewed

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