Association between serum alkaline phosphatase and C-reactive protein in the United States National Health and Nutrition Examination Survey 2005–2006
dc.contributor.author | Webber, Matthew | |
dc.contributor.author | Krishnan, Aisling | |
dc.contributor.author | Thomas, Neil G. | |
dc.contributor.author | Cheung, Bernard M.Y. | |
dc.date.accessioned | 2017-06-17T01:37:21Z | |
dc.date.available | 2017-06-17T01:37:21Z | |
dc.date.created | 2010-07-01 | |
dc.date.issued | 2009-10-15 | |
dc.identifier.issn | 1437-4331 | |
dc.identifier.uri | http://edoc.hu-berlin.de/18452/10256 | |
dc.description.abstract | Background: Alkaline phosphatase (ALP) is a widely used marker for skeletal and hepatobiliary disorders, but its activity is also increased in atherosclerosis and peripheral vascular disease. It is an inflammatory marker like C-reactive protein (CRP). We therefore analyzed its relationship with CRP in the United States National Health and Nutrition Examination Survey (NHANES) 2005–2006. Methods: The analysis included 4155 men and non-pregnant women over the age of 20 years. The relationship between log-transformed ALP and plasma CRP was analyzed using univariate and multivariate models. Results: ALP activity was significantly correlated with age, waist circumference, body mass index, blood pressure, exercise, alcohol, triglycerides, and other liver enzymes after adjusting for age, gender and ethnicity (p<0.001). ALP was significantly associated with a higher frequency of cardiovascular disease (p=0.02), hypertension (p=0.01) hypercholesterolemia (p=0.04), and diabetes (p=0.02). Compared to the lowest quartile of ALP, the adjusted odds ratio (OR) associated with the highest quartile were 1.9 [95% confidence intervals (CI) 1.1–3.5], 1.6 (95% CI 1.0–2.5), 1.5 (95% CI 1.1–2.1) and 1.7 (95% CI 1.0–2.4) for cardiovascular disease, hypertension, hypercholesterolemia, and diabetes, respectively. In multivariate analysis, log ALP was an independent predictor of log CRP (p=1.0×10−6). A multivariate model that included log ALP, ethnicity, glycohemoglobin, waist circumference, albumin, apolipoprotein B, γ-glutamyltransferase and uric acid explained 40% of the variance in log CRP. Conclusions: ALP is a marker of cardiometabolic risk, but it needs to be tested as part of a multivariate model in prospective studies. Clin Chem Lab Med 2010;48:167–73. | eng |
dc.language.iso | und | |
dc.publisher | Kooperation de Gruyter | |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | |
dc.title | Association between serum alkaline phosphatase and C-reactive protein in the United States National Health and Nutrition Examination Survey 2005–2006 | |
dc.type | article | |
dc.identifier.urn | urn:nbn:de:kobv:11-100114563 | |
dc.identifier.doi | http://dx.doi.org/10.18452/9604 | |
local.edoc.type-name | Zeitschriftenartikel | |
local.edoc.container-type | periodical | |
local.edoc.container-type-name | Zeitschrift | |
local.edoc.container-year | 2010 | |
dc.description.version | Peer Reviewed | |
dcterms.bibliographicCitation.doi | 10.1515/CCLM.2010.052 | |
dcterms.bibliographicCitation.journaltitle | Clinical Chemistry and Laboratory Medicine | |
dcterms.bibliographicCitation.volume | 48 | |
dcterms.bibliographicCitation.issue | 2 | |
dcterms.bibliographicCitation.originalpublishername | de Gruyter | |
dcterms.bibliographicCitation.pagestart | 167 | |
dcterms.bibliographicCitation.pageend | 173 |