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2009-06-22Zeitschriftenartikel DOI: 10.1515/CCLM.2009.258
Detection of Meningeosis neoplastica by real-time quantitation of telomerase activity
dc.contributor.authorAssmann, Gunter
dc.contributor.authorWerner, Christian
dc.contributor.authorHerrmann, Markus
dc.contributor.authorMomber, Dunja
dc.contributor.authorKrenn, Thomas
dc.contributor.authorLothschütz, Daniela
dc.contributor.authorFischer, Lars
dc.contributor.authorHess, Sandra
dc.contributor.authorKetter, Ralf
dc.contributor.authorFeiden, Wolfgang
dc.contributor.authorJung, Stefan
dc.contributor.authorHerrmann, Wolfgang
dc.contributor.authorSchubert, Jörg
dc.contributor.authorPfreundschuh, Michael
dc.contributor.authorWidmann, Thomas
dc.date.accessioned2017-06-17T02:41:24Z
dc.date.available2017-06-17T02:41:24Z
dc.date.created2010-07-01
dc.date.issued2009-06-22
dc.identifier.issn1437-4331
dc.identifier.urihttp://edoc.hu-berlin.de/18452/10580
dc.description.abstractBackground: Analysis of cerebrospinal fluid (CSF) to discriminate between benign and malignant conditions is of fundamental importance for the physician and the patient because of the differential therapeutic options and resulting morbidity and mortality. Most human tumours demonstrate increased telomerase activity (TA). Recent technical advances in the detection of TA allow for sensitive and specific detection within 4 h. Thus, the detection of TA is suitable for routine clinical testing. Methods: This study examines TA in cellular proteins in CSF from 111 patients compared to cytomorphological and laboratory examination. Results: A positive result for TA in cellular proteins of CSF was correlated significantly with Meningeosis neoplastica, but not with non-malignant conditions. Telomerase was not detected in CSF supernatant, despite positive results in cellular proteins from identical patients. Furthermore, a 48-h time delay during the pre-analytic processing is not critical for detection of TA detection in native CSF when stored at room temperature. Conclusions: We conclude that TA is a promising marker for the detection of Meningeosis neoplastica and warrants further study. Clin Chem Lab Med 2009;47:1271–6.eng
dc.language.isound
dc.publisherKooperation de Gruyter
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.titleDetection of Meningeosis neoplastica by real-time quantitation of telomerase activity
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-100119661
dc.identifier.doi10.1515/CCLM.2009.258
dc.identifier.doihttp://dx.doi.org/10.18452/9928
local.edoc.container-titleClinical Chemistry and Laboratory Medicine
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-namede Gruyter
local.edoc.container-volume47
local.edoc.container-issue10
local.edoc.container-year2009
local.edoc.container-firstpage1271
local.edoc.container-lastpage1276
dc.description.versionPeer Reviewed

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