Zur Kurzanzeige

2009-06-30Zeitschriftenartikel DOI: 10.18452/9934
Evaluation of a new method for the diagnosis of alterations of Lens culinaris agglutinin binding of thyroglobulin molecules in thyroid carcinoma
dc.contributor.authorKanai, Toshiharu
dc.contributor.authorAmakawa, Masao
dc.contributor.authorKato, Ryoji
dc.contributor.authorShimizu, Kayoko
dc.contributor.authorNakamura, Kenji
dc.contributor.authorIto, Ken-ichi
dc.contributor.authorHama, Yoshihisa
dc.contributor.authorFujimori, Minoru
dc.contributor.authorAmano, Jun
dc.date.accessioned2017-06-17T02:42:34Z
dc.date.available2017-06-17T02:42:34Z
dc.date.created2010-07-01
dc.date.issued2009-06-30
dc.identifier.issn1437-4331
dc.identifier.urihttp://edoc.hu-berlin.de/18452/10586
dc.description.abstractBackground: The measurement of serum thyroglobulin (Tg) is widely used as a marker for recurrence of thyroid carcinoma following total thyroidectomy. However, this method cannot differentiate between benign and malignant disease. We focused on the sugar chain in the Tg molecule and investigated the usefulness of Lens culinaris agglutinin (LCA)-reactive Tg ratios in sera and wash fluids obtained during fine-needle aspiration (FNA) for the detection of thyroid carcinoma. Methods: The study was performed using 203 serum samples (115 from patients with benign thyroid disease and 88 from patients with thyroid carcinomas) and 176 wash fluid samples (143 benign, 21 malignant, and 12 inconclusive). LCA-reactive Tg ratios were determined using an enzyme-linked immunosorbent assay, and a comparison was made between malignant and benign lesions. Results: In serum, the ratio in patients with malignancy was 79.5±6.0 [mean±standard deviation (SD)], significantly lower than in patients with benign lesions (84.9±3.5). The ratios in wash fluid from malignant lesions (75.8±18.9) were also significantly lower than those from benign lesions (85.6±3.9). Conclusions: These results suggest that this method could distinguish between benign and malignant lesions and may be useful for screening serum and wash samples. Clin Chem Lab Med 2009;47:1285–90.eng
dc.language.isound
dc.publisherKooperation de Gruyter
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.titleEvaluation of a new method for the diagnosis of alterations of Lens culinaris agglutinin binding of thyroglobulin molecules in thyroid carcinoma
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-100119724
dc.identifier.doihttp://dx.doi.org/10.18452/9934
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-year2009
dc.description.versionPeer Reviewed
dcterms.bibliographicCitation.doi10.1515/CCLM.2009.277
dcterms.bibliographicCitation.journaltitleClinical Chemistry and Laboratory Medicine
dcterms.bibliographicCitation.volume47
dcterms.bibliographicCitation.issue10
dcterms.bibliographicCitation.originalpublishernamede Gruyter
dcterms.bibliographicCitation.pagestart1285
dcterms.bibliographicCitation.pageend1290

Zur Kurzanzeige