2009-06-16Zeitschriftenartikel DOI: 10.1515/CCLM.2009.242
Peroxisome proliferator-activated receptor-γ (PPARγ) Pro12Ala polymorphism and risk for pediatric obesity
Dedoussis, George V.
Hirschhorn, Joel N.
Lyon, Helen N.
Background: Variation in the peroxisome-proliferator-activated receptor γ (PPARγ) gene has been reported to alter the risk for adiposity in adults. Methods: We investigated the gender related association between the Pro12Ala variant (rs1801282) in obesity and insulin resistance traits in 794 peri-adolescent children aged 10–12 years of Greek origin from the Gene and Diet Attica Investigation (GENDAI) cohort. Results: Gender stratified analysis suggested that in peri-adolescent boys, Ala carriers exhibited lower measures of skinfold (triceps: 16.9±6.9 vs. 19.4±7.9 mm, p=0.014; subscapular: 9.6±4.5 vs. 11.2±5.4 mm, p=0.016) and lower adiponectin concentrations (3.9±1.3 vs. 4.7±2.4 μg/mL, p=0.05). In peri-adolescent girls, Ala carriers had lower insulin concentrations (7.3±3.7 vs. 8.5±4.4 μU/mL, p=0.026) and lower values of homeostasis model assessment of insulin resistance (HOMA-IR) (1.5±0.8 vs. 1.8±0.96, p=0.019). Linear regression analysis revealed that the presence of the Ala allele in boys was a nominally significant predictor of obesity indices, including skin-folds (triceps: β±SE: –2.3±1.1, p=0.032; subscapular: β±SE: –2.3±1.1, p=0.04) and adiponectin concentrations (β±SE: –0.7±0.4, p=0.05) after adjusting for potential covariates. In girls, the Ala allele was a predictor of insulin concentrations (β±SE: –1.2±0.6, p=0.037) and HOMA-IR (β±SE: –0.24±0.13, p=0.037).Conclusions: Our results suggest that adiposity in children is influenced by the Pro12Ala polymorphism in a gender specific manner. Clin Chem Lab Med 2009;47:1047–50.
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