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2009-06-26Zeitschriftenartikel DOI: 10.1515/CCLM.2009.260
Serum free light chains: diagnostic and prognostic value in multiple myeloma
dc.contributor.authorSthaneshwar, Pavai
dc.contributor.authorNadarajan, Veerasekaran
dc.contributor.authorManiam, Jayaranee A.S.
dc.contributor.authorNordin, Nani
dc.contributor.authorGin, Gan Gin
dc.date.accessioned2017-06-17T05:29:33Z
dc.date.available2017-06-17T05:29:33Z
dc.date.created2010-07-01
dc.date.issued2009-06-26
dc.identifier.issn1437-4331
dc.identifier.urihttp://edoc.hu-berlin.de/18452/11422
dc.description.abstractBackground: Measurement of serum free light chains (FLCs) has recently become available for the diagnosis and monitoring of patients with plasma cell dyscrasias. The aim of this study was to investigate the performance of the serum FLC assay as a tumour marker by comparing FLC concentrations with serum protein electrophoresis (PE) results in the diagnosis of multiple myeloma (MM). In addition, we also evaluated the prognostic value of the baseline serum FLC ratio in patients with MM. Methods: We measured FLC concentrations and calculated the kappa/lambda (κ/λ) FLC ratios for three groups (control, polyclonal gammopathy and MM). Results: The FLC ratio at a cut-off threshold of 2.0 showed higher sensitivity and specificity compared with serum electrophoresis for the diagnosis of MM. We used the median FLC ratio of >57.5 and <0.04 for κ and λ secretors, respectively, for assessing survival. Survival was 30 months in patients with the κ/λ ratio of >57.5 and <0.04 compared to 47 months in patients with the ratio <57.5 and >0.04, indicating that more abnormal serum FLC ratios are associated with poorer survival (p<0.011). Conclusions: Despite the limitations of the assay, the results of our study indicate that the FLC assay in combination with serum PE has an increased sensitivity in the diagnosis of MM. Also, baseline measurement of the κ/λ ratio provides prognostic information in these same patients. Clin Chem Lab Med 2009;47:1101–7.eng
dc.language.isound
dc.publisherKooperation de Gruyter
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.titleSerum free light chains: diagnostic and prognostic value in multiple myeloma
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-100132322
dc.identifier.doi10.1515/CCLM.2009.260
dc.identifier.doihttp://dx.doi.org/10.18452/10770
local.edoc.container-titleClinical Chemistry and Laboratory Medicine
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-namede Gruyter
local.edoc.container-volume47
local.edoc.container-issue9
local.edoc.container-year2009
local.edoc.container-firstpage1101
local.edoc.container-lastpage1107
dc.description.versionPeer Reviewed

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