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2009-07-22Zeitschriftenartikel DOI: 10.1515/CCLM.2009.305
Hypoxia related growth factors and p53 in preoperative sera from patients with colorectal cancer – evaluation of the prognostic significance of these agents
dc.contributor.authorSulkowski, Stanislaw
dc.contributor.authorWincewicz, Andrzej
dc.contributor.authorZalewski, Bogdan
dc.contributor.authorFamulski, Waldemar
dc.contributor.authorLotowska, Joanna Maria
dc.contributor.authorKoda, Mariusz
dc.contributor.authorSobaniec-Lotowska, Maria Elzbieta
dc.contributor.authorMysliwiec, Michal
dc.contributor.authorBaltaziak, Marek
dc.contributor.authorPawlak, Krystyna
dc.contributor.authorSulkowska, Mariola
dc.date.accessioned2017-06-17T06:41:47Z
dc.date.available2017-06-17T06:41:47Z
dc.date.created2010-07-01
dc.date.issued2009-07-22none
dc.identifier.issn1434-6621, 1437-4331
dc.identifier.urihttp://edoc.hu-berlin.de/18452/11762
dc.description.abstractBackground: Insulin-like growth factor-I (IGF-I) and vascular endothelial growth factor (VEGF) belong to a group of hypoxia related proteins. IGF-I induces expression of VEGF and decomposes wild type p53 in cancer cell lines. The goal of our study was to evaluate serum IGF-I, VEGF and p53 with respect to overall and disease free survival of patients with colorectal cancer (CRC) patients compared with healthy volunteers. Methods: Preoperative blood samples from 125 patients with CRC and 16 healthy volunteers were examined using ELISA for serum IGF-I, p53 and VEGF concentrations. Results: Concentrations of p53 and VEGF were significantly higher in CRC patients than in controls (p<0.0006 and p<0.0001, respectively). IGF-I was not statistically different between both groups. Serum IGF-I showed negative correlation with p53 in CRC patients (p<0.04, r=−0.193). IGF-I and VEGF showed negative correlation in poorly differentiated cancers (G3) (p<0.03, r=−0.339). Patients with VEGF concentrations that were above average for the cancer population survived for a shorter period of time (p=0.065 in evaluation of overall survival and 0.071 in estimation of disease-free survival during a 3-year follow-up) compared with patients with serum VEGF lower than the highest values seen in controls. Conclusions: Comparisons between serum IGF-I and p53 appear to confirm the metabolism of p53 by IGF-I. Serum VEGF showed prognostic significance in our study. Serum concentrations of IGF-I and VEGF did not show positive correlation, as expected due to IGF-I induction of VEGF in malignant colon cell lines. Clin Chem Lab Med 2009;47:1439–45.eng
dc.language.isound
dc.publisherKooperation de Gruyter
dc.relation.ispartofseriesClinical Chemistry and Laboratory Medicine, 47, 11, 2009, pp 1439-1445
dc.titleHypoxia related growth factors and p53 in preoperative sera from patients with colorectal cancer – evaluation of the prognostic significance of these agents
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-100137713
dc.identifier.doi10.1515/CCLM.2009.305
dc.identifier.doihttp://dx.doi.org/10.18452/11110
local.edoc.container-titleClinical Chemistry and Laboratory Medicine
local.edoc.container-issn1434-6621
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-namede Gruyter
local.edoc.container-volume47
local.edoc.container-issue11
local.edoc.container-year2009
local.edoc.container-firstpage1439
local.edoc.container-lastpage1445
dc.description.versionPeer Reviewed

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