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2009-06-05Zeitschriftenartikel DOI: 10.1515/JPM.2009.123
Amniotic fluid volume in intra-amniotic inflammation with and without culture-proven amniotic fluid infection in preterm premature rupture of membranes
dc.contributor.authorLee, Si Eun
dc.contributor.authorRomero, Roberto
dc.contributor.authorLee, Seung Mi
dc.contributor.authorYoon, Bo Hyun
dc.date.accessioned2017-06-17T07:33:58Z
dc.date.available2017-06-17T07:33:58Z
dc.date.created2010-07-01
dc.date.issued2009-06-05
dc.identifier.issn1619-3997
dc.identifier.urihttp://edoc.hu-berlin.de/18452/11992
dc.description.abstractObjective: Previous studies reported that the clinical significance of intra-amniotic inflammation with a negative amniotic fluid (AF) culture is similar to that of intra-amniotic inflammation with microbiologically-proven AF infection. However, the magnitude of the fetal inflammatory response in these two conditions is different as gauged by umbilical cord C-reactive protein (CRP) concentrations. We undertook this study to determine if the frequency of oligohydramnios is different in these two conditions. Methods: The amniotic fluid index (AFI) was measured in 205 patients with preterm premature rupture of membranes (PROM) (≤35 weeks). AF was cultured for aerobic and anaerobic bacteria and genital mycoplasmas. Intra-amniotic inflammation was defined as an elevated AF matrix metalloproteinase-8 (MMP-8) concentration (>23 ng/mL). Patients were divided into three groups according to the results of AF culture and the presence or absence of intra-amniotic inflammation: 1) without intra-amniotic inflammation and a negative culture (n=109); 2) with intra-amniotic inflammation and a negative culture (n=44); and 3) a positive culture (n=52). Results: Patients with a positive culture had a higher frequency of oligohydramnios and a lower median AFI than those with a negative culture but with intra-amniotic inflammation (P<0.01). However, there was no significant difference in the median AFI or in the frequency of oligo-hydramnios according to the presence or absence of intra-amniotic inflammation among patients with a negative culture (P>0.1). Conclusion: Oligohydramnios was more frequent in patients with culture-proven AF infection than in those with intra-amniotic inflammation and a negative AF culture.eng
dc.language.isound
dc.publisherKooperation de Gruyter
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.titleAmniotic fluid volume in intra-amniotic inflammation with and without culture-proven amniotic fluid infection in preterm premature rupture of membranes
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-100142119
dc.identifier.doi10.1515/JPM.2009.123
dc.identifier.doihttp://dx.doi.org/10.18452/11340
local.edoc.container-titleJournal of Perinatal Medicine
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-namede Gruyter
local.edoc.container-volume38
local.edoc.container-issue1
local.edoc.container-year2010
local.edoc.container-firstpage39
local.edoc.container-lastpage44
dc.description.versionPeer Reviewed

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