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2009-04-01Zeitschriftenartikel DOI: 10.1515/JPM.2009.101
Maternal serum adiponectin multimers in gestational diabetes
dc.contributor.authorVaisbuch, Edi
dc.contributor.authorErez, Offer
dc.contributor.authorMittal, Pooja
dc.contributor.authorChaiworapongsa, Tinnakorn
dc.contributor.authorKim, Sun Kwon
dc.contributor.authorPacora, Percy
dc.contributor.authorYeo, Lami
dc.contributor.authorGotsch, Francesca
dc.contributor.authorDong, Zhong
dc.contributor.authorYoon, Bo Hyun
dc.contributor.authorHassan, Sonia S.
dc.contributor.authorKusanovic, Juan Pedro
dc.date.accessioned2017-06-17T07:48:16Z
dc.date.available2017-06-17T07:48:16Z
dc.date.created2010-07-01
dc.date.issued2009-04-01
dc.identifier.issn1619-3997
dc.identifier.urihttp://edoc.hu-berlin.de/18452/12049
dc.description.abstractObjective: Adiponectin, an adipokine with profound insulin-sensitizing effect, consists of heterogeneous species of multimers. These oligomeric complexes circulate as low-molecular-weight (LMW) trimers, medium-molecular-weight (MMW) hexamers and high-molecular-weight (HMW) isoforms and can exert differential biological effects. The aims of this study were to determine whether there is a change in circulating adiponectin multimers in the presence of gestational diabetes mellitus (GDM), overweight/obesity or with a treatment with sulfonylurea or insulin in patients with GDM. Study design: This cross-sectional study included women with: 1) normal pregnancy (n=149); and 2) patients with GDM (n=72). Thirty-three patients with GDM were managed with diet alone. Among the others 39 diabetic patients, 17 were treated with Glyburide and 22 with insulin. The study population was further stratified by first trimester body mass index (BMI) (normal weight <25 kg/m2 vs. overweight/obese ≥25 kg/m2). Serum adiponectin multimers (total, HMW, MMW and LMW) concentrations were determined by ELISA. Results: 1) The median maternal serum of total, HMW, MMW and LMW were lower in patients with GDM than in those with normal pregnancies (P<0.001 for all comparisons); 2) patients with GDM had a lower HMW/total adiponectin ratio and a higher MMW/total and LMW/total adiponectin ratio than those with a normal pregnancy (P<0.001 for all comparisons); and 3) among GDM patients, there were no differences in the concentrations and relative distribution of adiponectin multimers between those who were managed with diet, and those who were treated with pharmacological agents. Conclusion: 1) GDM is characterized by a distinctive pattern of concentrations and relative distribution of adiponectin multimers akin to Type 2 diabetes mellitus; 2) dysregulation of adiponectin multimeres can provide a mechanistic basis for the association between adiposity and GDM.eng
dc.language.isound
dc.publisherKooperation de Gruyter
dc.titleMaternal serum adiponectin multimers in gestational diabetes
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-100142878
dc.identifier.doi10.1515/JPM.2009.101
dc.identifier.doihttp://dx.doi.org/10.18452/11397
local.edoc.container-titleJournal of Perinatal Medicine
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-namede Gruyter
local.edoc.container-volume37
local.edoc.container-issue6
local.edoc.container-year2009
local.edoc.container-firstpage637
local.edoc.container-lastpage650
dc.description.versionPeer Reviewed

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