2009-09-16Zeitschriftenartikel DOI: 10.1515/CCLM.2010.004
Inverse relationship between serum high density lipoprotein and negative syndrome in antipsychotic-naive schizophrenia
Rao, Naren P.
Behere, Rishikesh V.
Gangadhar, Bangalore N.
Background: Recent literature suggests a role for apolipoprotein L (apoL) aberrations in the pathogenesis of schizophrenia. ApoL is almost exclusively associated with apolipoprotein A-I in high-density lipoproteins (HDLs). The objective of this study was to examine the correlation between symptom scores and serum HDL in antipsychotic-naive schizophrenia patients. Methods: In this cross-sectional study, 60 antipsychotic-naive schizophrenia patients were systematically examined for their symptom scores, with good inter-rater reliability. Concurrently, an overnight fasting serum lipid profile from these patients was assessed. Results: Serum HDL had a significant inverse correlation with a total negative syndrome score (ρ=−0.43; p=0.001). Conclusions: The study observation supports the potential role for HDL abnormalities in the genesis of negative symptoms in schizophrenia. Clin Chem Lab Med 2010;48:95–8.
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Is Part Of Series: Clinical Chemistry and Laboratory Medicine, 48, 1, 2010, pp 95-98