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2009-04-14Zeitschriftenartikel DOI: 10.18452/12463
Intrathecal synthesis of tumor markers is a highly sensitive test in the diagnosis of leptomeningeal metastasis from solid cancers
dc.contributor.authorCorsini, Elena
dc.contributor.authorBernardi, Gaetano
dc.contributor.authorGaviani, Paola
dc.contributor.authorSilvani, Antonio
dc.contributor.authorGrazia, Ugo de
dc.contributor.authorCiusani, Emilio
dc.contributor.authorCroci, Danilo
dc.contributor.authorSalmaggi, Andrea
dc.date.accessioned2017-06-17T11:44:34Z
dc.date.available2017-06-17T11:44:34Z
dc.date.created2010-07-01
dc.date.issued2009-04-14
dc.identifier.issn1437-4331
dc.identifier.urihttp://edoc.hu-berlin.de/18452/13115
dc.description.abstractBackground: Identification of neoplastic cells in cerebrospinal fluid (CSF) by cytological analysis is the key diagnostic feature of leptomeningeal metastasis (LM). Because of the lack of sensitivity of this test, considerable efforts have been made to identify alternative diagnostic markers. Data from the literature suggest that measurement of tumor markers (TM) in CSF may be helpful for improving the diagnosis. Methods: We analyzed the concentrations of the TM carcinoembryonic antigen (CEA), CA15.3, CA125 and CA19.9 in both CSF and serum from 18 patients with neoplastic meningitis diagnosed by CSF cytology. We also performed these same measurements in 50 patients affected by other neurological diseases (OND) in order to evaluate putative intrathecal synthesis. In addition, CSF and serum concentrations of the proangiogenic factor VEGF (vascular endothelial growth factor) were evaluated. Results: All LM patients showed intrathecal synthesis for at least one TM. In one patient, a negative CSF cytology after treatment paralleled normalization of tumor marker synthesis. None of the OND patients displayed intrathecal TM synthesis. The VEGF Index (CSF/serum VEGF relative to CSF/serum albumin ratios) was significantly higher in LM patients compared with the control group. However, significant overlap between LM patients and values seen in those with OND was observed. Conclusions: Evaluation of intrathecal TM synthesis is a specific, sensitive, reliable, and reproducible diagnostic tool, and is useful to support diagnosis of carcinomatous meningitis. Clin Chem Lab Med 2009;47:874–9.eng
dc.language.isound
dc.publisherKooperation de Gruyter
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.titleIntrathecal synthesis of tumor markers is a highly sensitive test in the diagnosis of leptomeningeal metastasis from solid cancers
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-100159114
dc.identifier.doihttp://dx.doi.org/10.18452/12463
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-year2009
dc.description.versionPeer Reviewed
dcterms.bibliographicCitation.doi10.1515/CCLM.2009.183
dcterms.bibliographicCitation.journaltitleClinical Chemistry and Laboratory Medicine
dcterms.bibliographicCitation.volume47
dcterms.bibliographicCitation.issue7
dcterms.bibliographicCitation.originalpublishernamede Gruyter
dcterms.bibliographicCitation.pagestart874
dcterms.bibliographicCitation.pageend879

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