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2009-03-26Zeitschriftenartikel DOI: 10.1515/JPM.2009.093
Amniotic fluid angiopoietin-2 in term and preterm parturition, and intra-amniotic infection/inflammation
dc.contributor.authorPacora, Percy
dc.contributor.authorRomero, Roberto
dc.contributor.authorChaiworapongsa, Tinnakorn
dc.contributor.authorKusanovic, Juan Pedro
dc.contributor.authorErez, Offer
dc.contributor.authorVaisbuch, Edi
dc.contributor.authorMazaki-Tovi, Shali
dc.contributor.authorGotsch, Francesca
dc.contributor.authorKim, Chong Jai
dc.contributor.authorThan, Nandor Gabor
dc.contributor.authorYeo, Lami
dc.contributor.authorMittal, Pooja
dc.contributor.authorHassan, Sonia S.
dc.date.accessioned2017-06-17T12:05:12Z
dc.date.available2017-06-17T12:05:12Z
dc.date.created2010-07-01
dc.date.issued2009-03-26
dc.identifier.issn1619-3997
dc.identifier.urihttp://edoc.hu-berlin.de/18452/13215
dc.description.abstractObjective: Recent observations have revealed an interaction between inflammation and angiogenesis, which may be mediated by angiopoietins and chemokines. Given the importance of inflammation in parturition, we sought to determine whether angiopoietin-2 (Ang-2) is present in amniotic fluid (AF) and if its concentration changes with gestational age, labor, and in intra-amniotic infection/inflammation (IAI) in patients with spontaneous preterm labor and intact membranes. Study design: This cross-sectional study included 486 patients in the following groups: 1) women in the mid-trimester of pregnancy (14–18 weeks) who underwent amniocentesis for genetic indications and delivered a normal neonate at term (n=52); 2) normal pregnant women at term with (n=48) and without (n=45) spontaneous labor; 3) patients with an episode of spontaneous preterm labor (PTL) and intact membranes who were classified into: a) PTL without IAI who delivered at term (n=152); b) PTL without IAI who delivered preterm (<37 weeks gestation; n=107); and c) PTL with IAI (n=82). Ang-2 concentration in AF was determined by enzyme-linked immunoassay. Non-parametric statistics were used for analysis. Results: 1) Ang-2 was detected in all AF samples; 2) the median AF Ang-2 concentration at term was significantly lower than that in the mid-trimester (1877.4 pg/mL vs. 3525.2 pg/mL; P<0.001); 3) among patients with PTL, the median AF Ang-2 concentration was significantly higher in patients with IAI than in those without IAI (4031.3 pg/mL vs. 2599.4 pg/mL; P<0.001) and those with PTL without IAI who delivered at term (4031.3 pg/mL vs. 2707.3 pg/mL; P<0.001); and 4) no significant differences were observed in the median AF Ang-2 concentration between patients with spontaneous labor at term and those at term not in labor (1722.9 pg/mL vs. 1877.4 pg/mL; P=0.6). Conclusions: 1) Ang-2, a protein involved in the process of vascular remodeling, is a physiologic constituent of the amniotic fluid and its concentration decreased with advancing gestation; 2) the median Ang-2 concentration in amniotic fluid is higher in patients with IAI than in those without; and 3) spontaneous parturition at term is not associated with changes in the AF concentration of Ang-2. These findings support the view of a link between angiopoietins and inflammation.eng
dc.language.isound
dc.publisherKooperation de Gruyter
dc.titleAmniotic fluid angiopoietin-2 in term and preterm parturition, and intra-amniotic infection/inflammation
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-100160554
dc.identifier.doi10.1515/JPM.2009.093
dc.identifier.doihttp://dx.doi.org/10.18452/12563
local.edoc.container-titleJournal of Perinatal Medicine
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-namede Gruyter
local.edoc.container-volume37
local.edoc.container-issue5
local.edoc.container-year2009
local.edoc.container-firstpage503
local.edoc.container-lastpage511
dc.description.versionPeer Reviewed

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