UDP-Glucuronyltransferase

Abstract

A Workshop Conference on UDP-glucuronyltransferase was held in order to bring together different investigators specialising in a particular aspect of the enzyme. The intention was to find a basis for a closer cooperation between the different groups and to exchange ideas and methods making it possible to cross the hurdles facing those who work in the field of glucuronidation of endogenous and exogenous substances. The topics which were chosen for the meeting covered the following aspects: methods of determination of UDPglucuronyltransferase activity; problems relating to the origin of the enzyme and the nature of the substrate; application of assays of UDP-glucuronyltransferase in clinical chemistry; enzyme-substrate interactions and factors influencing the enzymic reaction; the role of UDP-glucuronyltransferase in the entero-hepatic circulation of glucuronides, regulation and induction of UDP-glucuronyltransferase, with a subsection on solubilisation and purification.