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2009-08-05Zeitschriftenartikel DOI: 10.18452/13083
Association of glutathione-S-transferase polymorphisms with atopic dermatitis risk in preschool age children
dc.contributor.authorChung, Jayong
dc.contributor.authorOh, Se-Young
dc.contributor.authorShin, You-Kyung
dc.date.accessioned2017-06-17T14:01:23Z
dc.date.available2017-06-17T14:01:23Z
dc.date.created2010-07-01
dc.date.issued2009-08-05
dc.identifier.issn1437-4331
dc.identifier.urihttp://edoc.hu-berlin.de/18452/13735
dc.description.abstractBackground: Glutathione S-transferase (GST) enzymes are critical for detoxifying reactive oxygen species (ROS) and their products which have been implicated in the pathology of inflammatory diseases such as atopic dermatitis (AD). Methods: We investigated the effects of genetic polymorphisms of GST on the risk of AD in preschool age children. Biomarkers for oxidative stress were also evaluated with respect to GST genotype. Results: The GSTP1 Val105 allele was significantly associated with an increased risk of AD [odds ratio (OR)=1.62, p<0.05]. The combination of the GSTP1 Val105 allele and the GSTT1 null genotype further increased this risk by 2.3-fold (p<0.01). No association was observed for the GSTM1 null or GSTT1 null genotype alone. In children with AD, blood total antioxidant capacity was significantly less (p<0.001), while malondialdehyde was higher (p=0.12). Children with the GSTP1 Val105 allele had significantly lower concentrations of erythrocyte glutathione compared to GSTP1 Ile/Ile homozygotes (p=0.03). Conclusions: Our study suggests that the GSTP1 Val105 allele is an important determinant of susceptibility to AD in preschool age children and increased oxidative stress may play a role in the pathogenesis of AD. Clin Chem Lab Med 2009;47:1475–81.eng
dc.language.isound
dc.publisherKooperation de Gruyter
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.titleAssociation of glutathione-S-transferase polymorphisms with atopic dermatitis risk in preschool age children
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-100167602
dc.identifier.doihttp://dx.doi.org/10.18452/13083
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-year2009
dc.description.versionPeer Reviewed
dcterms.bibliographicCitation.doi10.1515/CCLM.2009.336
dcterms.bibliographicCitation.journaltitleClinical Chemistry and Laboratory Medicine
dcterms.bibliographicCitation.volume47
dcterms.bibliographicCitation.issue12
dcterms.bibliographicCitation.originalpublishernamede Gruyter
dcterms.bibliographicCitation.pagestart1475
dcterms.bibliographicCitation.pageend1481

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