Association of glutathione-S-transferase polymorphisms with atopic dermatitis risk in preschool age children
dc.contributor.author | Chung, Jayong | |
dc.contributor.author | Oh, Se-Young | |
dc.contributor.author | Shin, You-Kyung | |
dc.date.accessioned | 2017-06-17T14:01:23Z | |
dc.date.available | 2017-06-17T14:01:23Z | |
dc.date.created | 2010-07-01 | |
dc.date.issued | 2009-08-05 | |
dc.identifier.issn | 1437-4331 | |
dc.identifier.uri | http://edoc.hu-berlin.de/18452/13735 | |
dc.description.abstract | Background: Glutathione S-transferase (GST) enzymes are critical for detoxifying reactive oxygen species (ROS) and their products which have been implicated in the pathology of inflammatory diseases such as atopic dermatitis (AD). Methods: We investigated the effects of genetic polymorphisms of GST on the risk of AD in preschool age children. Biomarkers for oxidative stress were also evaluated with respect to GST genotype. Results: The GSTP1 Val105 allele was significantly associated with an increased risk of AD [odds ratio (OR)=1.62, p<0.05]. The combination of the GSTP1 Val105 allele and the GSTT1 null genotype further increased this risk by 2.3-fold (p<0.01). No association was observed for the GSTM1 null or GSTT1 null genotype alone. In children with AD, blood total antioxidant capacity was significantly less (p<0.001), while malondialdehyde was higher (p=0.12). Children with the GSTP1 Val105 allele had significantly lower concentrations of erythrocyte glutathione compared to GSTP1 Ile/Ile homozygotes (p=0.03). Conclusions: Our study suggests that the GSTP1 Val105 allele is an important determinant of susceptibility to AD in preschool age children and increased oxidative stress may play a role in the pathogenesis of AD. Clin Chem Lab Med 2009;47:1475–81. | eng |
dc.language.iso | und | |
dc.publisher | Kooperation de Gruyter | |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | |
dc.title | Association of glutathione-S-transferase polymorphisms with atopic dermatitis risk in preschool age children | |
dc.type | article | |
dc.identifier.urn | urn:nbn:de:kobv:11-100167602 | |
dc.identifier.doi | http://dx.doi.org/10.18452/13083 | |
local.edoc.type-name | Zeitschriftenartikel | |
local.edoc.container-type | periodical | |
local.edoc.container-type-name | Zeitschrift | |
local.edoc.container-year | 2009 | |
dc.description.version | Peer Reviewed | |
dcterms.bibliographicCitation.doi | 10.1515/CCLM.2009.336 | |
dcterms.bibliographicCitation.journaltitle | Clinical Chemistry and Laboratory Medicine | |
dcterms.bibliographicCitation.volume | 47 | |
dcterms.bibliographicCitation.issue | 12 | |
dcterms.bibliographicCitation.originalpublishername | de Gruyter | |
dcterms.bibliographicCitation.pagestart | 1475 | |
dcterms.bibliographicCitation.pageend | 1481 |