2014-06-24Zeitschriftenartikel DOI: 10.18452/13638
DNA-controlled aggregation of virus likeparticles
mimicking a tetherin-like mechanism
Institut für Chemie
Mimicking cellular processes by functional comparable structures helps to understand their molecular mechanism. We report on an oligonucleotide modified with two α-tocopherol anchors mimicking tetherin, a cellular protein reducing spreading of viruses. The lipophilic DNA was incorporated into vesicles and virus like particles; their aggregation was induced by the complement addition.
Available open access thanks to the RSC Gold for Gold initiative. Shared according to the terms set out in the CC licence.