2014-06-24Zeitschriftenartikel DOI: 10.18452/13638
DNA-controlled aggregation of virus likeparticles
mimicking a tetherin-like mechanism
Institut für Chemie
Mimicking cellular processes by functional comparable structures helps to understand their molecular mechanism. We report on an oligonucleotide modified with two α-tocopherol anchors mimicking tetherin, a cellular protein reducing spreading of viruses. The lipophilic DNA was incorporated into vesicles and virus like particles; their aggregation was induced by the complement addition.
Dateien zu dieser Publikation
Available open access thanks to the RSC Gold for Gold initiative. Shared according to the terms set out in the CC licence.