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2014-12-04Zeitschriftenartikel DOI: 10.18452/13639
Self-assembly of a cholesteryl-modified nucleoside into tubular structures from giant unilamellar vesicles
Losensky, Luisa
Chiantia, Salvatore
Holland, Gudrun
Laue, Michael
Petran, Anca
Liebscher, Jürgen cc
Arbuzova, Anna
Institut für Chemie
We recently reported the formation of micro- and nanometer thick tubules in a binary system of cholesteryl-modified aminouridine and a phosphatidylcholine in aqueous solution upon cooling from 70 °C to room temperature (Pescador et al., Chem. Commun, 2010, 46, 5358). To better understand the first steps of the tubular self-assembly and the role of the phospholipid, we investigated now morphological changes of phosphatidylcholine giant unilamellar vesicles upon incorporation of the conjugate at room temperature. We observed formation of needle-like structures organized in rosettes or bundles within hours to days depending on the mole fraction of the conjugate and preparation technique. Transmission electron microscopy revealed that the needle-like structures were 100–200 nm thick tubules with the inner lumen diameters of 15–40 nm. The tube self-assembly occurred at room temperature, which is important for further development of biomedical applications.
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Available open access thanks to the RSC Gold for Gold initiative. Shared according to the terms set out in the CC licence.
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DOI
10.18452/13639
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https://doi.org/10.18452/13639
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