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2014-12-04Zeitschriftenartikel DOI: 10.18452/13639
Self-assembly of a cholesteryl-modified nucleoside into tubular structures from giant unilamellar vesicles
dc.contributor.authorLosensky, Luisa
dc.contributor.authorChiantia, Salvatore
dc.contributor.authorHolland, Gudrun
dc.contributor.authorLaue, Michael
dc.contributor.authorPetran, Anca
dc.contributor.authorLiebscher, Jürgen
dc.contributor.authorArbuzova, Anna
dc.date.accessioned2017-06-17T16:03:44Z
dc.date.available2017-06-17T16:03:44Z
dc.date.created2015-08-14
dc.date.issued2014-12-04
dc.date.submitted2014-09-26
dc.identifier.other10.1039/c4ra11289j
dc.identifier.urihttp://edoc.hu-berlin.de/18452/14291
dc.description.abstractWe recently reported the formation of micro- and nanometer thick tubules in a binary system of cholesteryl-modified aminouridine and a phosphatidylcholine in aqueous solution upon cooling from 70 °C to room temperature (Pescador et al., Chem. Commun, 2010, 46, 5358). To better understand the first steps of the tubular self-assembly and the role of the phospholipid, we investigated now morphological changes of phosphatidylcholine giant unilamellar vesicles upon incorporation of the conjugate at room temperature. We observed formation of needle-like structures organized in rosettes or bundles within hours to days depending on the mole fraction of the conjugate and preparation technique. Transmission electron microscopy revealed that the needle-like structures were 100–200 nm thick tubules with the inner lumen diameters of 15–40 nm. The tube self-assembly occurred at room temperature, which is important for further development of biomedical applications.eng
dc.language.isoeng
dc.publisherHumboldt-Universität zu Berlin
dc.rights(CC BY 3.0) Namensnennung 3.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/
dc.subject.ddc540 Chemie und zugeordnete Wissenschaften
dc.titleSelf-assembly of a cholesteryl-modified nucleoside into tubular structures from giant unilamellar vesicles
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:11-100231694
dc.identifier.doihttp://dx.doi.org/10.18452/13639
local.edoc.container-titleRSC Advances
local.edoc.anmerkungAvailable open access thanks to the RSC Gold for Gold initiative. Shared according to the terms set out in the CC licence.
local.edoc.type-nameZeitschriftenartikel
local.edoc.institutionInstitut für Chemie
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://pubs.rsc.org/en/journals/journalissues/ra
local.edoc.container-publisher-nameThe Royal Society of Chemistry
local.edoc.container-volume5
local.edoc.container-issue6
local.edoc.container-year2015
local.edoc.container-firstpage4502
local.edoc.container-lastpage4510
dc.description.versionPeer Reviewed

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